• Food Science and Preservation
• /
• v.30 no.3
• /
• pp.538-545
• /
• 2023

This study aimed to assess the in vitro safety of a probiotics mixture (Lactobacillus acidophilus PBS066, Lactiplantibacillus plantarum PBS067, and Limosilactobacillus reuteri PBS072), along with its inhibitory effect on carbohydrate digestion. All three strains met the antibiotic resistance profile of the European Food Safety Authority (EFSA) guidelines. None of the strains exhibited hemolytic activity or cytotoxicity against Caco-2 cells. Strains PBS067 and PBS072 inhibited α-amylase activity, whereas all three strains suppressed α-glucosidase activity, indicating that the mixture might limit carbohydrate digestion in the gastrointestinal tract. These findings support the safety of this probiotics mixture and its potential to modulate carbohydrate metabolism in the gut.

• Biomedical Science Letters
• /
• v.24 no.4
• /
• pp.329-333
• /
• 2018

The purpose of this study is to investigate the anti-inflammation effect of the mixture, consisting of a series of different ratio of Ecklonia cava extract and scoria. Also, to make more functional scoria powder into cosmetic material, studies on the toxicity by cell viability assay. Scoria is found in large amounts in Jeju Island, as an adsorbent of heavy metal ions ($Ni_2{^+}$, $Zn_2{^+}$, and $Cr_3{^+}$) in an aspect of its efficient utilization. Marine plants such as Ecklonia cava contain high amounts of polyphenolic antioxidants. The purpose of this study was to examine the anti-oxidative and anti-inflammation effects of combination of mixture of Eckloina cava extrat and scoria with optimal ratio. Therefore, this study suggested that combination of mixture of Eckloina cava extrat and scoria and its attenuated the oxidative and inflammatory reactions.

• Communications for Statistical Applications and Methods
• /
• v.14 no.3
• /
• pp.517-530
• /
• 2007

We studied a modelling process for unimodal and multimodal circular data by using von Mises and its mixture distribution. In particular we suggested EM algorithm to find ML estimates of the mixture model. Simulation results showed the suggested methods are very accurate. Applications to two kinds of real data sets are also included.

• Proceedings of the Korean Radioactive Waste Society Conference
• /
• 2004.02a
• /
• pp.28-41
• /
• 2004

The study is aimed to assess the usefulness of the mixture design for spent resin immobilization in cement. Although a considerable amount of research has been carried out to determine the limits for the composition of an acceptable resin-cement mixture, no efficient experimental strategy exists that explores the full properties of waste form against composition relationship. In order to gain an overall view, this report introduces the method of mixture design and mixture analysis, and describes the design of experiment of the 5-component mixture with the constraint conditions. The mathematic models of 28-day compressive strength varying with the ingredients are fitted, and the main effect and interaction effect of two ingredients are identified quantitatively along with the graphical interpretation using the response trace plot and contour plots.

• The Korean Journal of Physiology and Pharmacology
• /
• v.25 no.1
• /
• pp.15-26
• /
• 2021

Peptides are short chain of amino acids linked by peptide bonds. They are widely used as effective and biocompatible active ingredients in cosmetic industry. In this study, we developed novel peptide mixture and identified its anti-pigmentation effect on melanocytes and keratinocytes. Our results revealed that peptide mixture inhibited melanosome biogenesis through the regulation of microphthalmia-associated transcription factor, a key factor of melanogenesis in melanocytes. And we observed that peptide mixture inhibited melanosome uptake through the reduction of protease-activated receptor 2, a phagocytosis-related receptor in keratinocytes. Furthermore, peptide mixture activated autophagy system resulting in degradation of transferred melanosomes in keratinocytes. The anti-pigmentation effect of multi-targeting peptide mixture was assessed in a human skin equivalent model (MelanoDerm). Melanin contents in epidermal layer were significantly decreased by topical treatment of peptide mixture, suggesting that it can be applied as a novel cosmetics material having a whitening function.

• Fashion & Textile Research Journal
• /
• v.13 no.5
• /
• pp.790-796
• /
• 2011

This study was designed to investigate the influence of ratio of anionic/nonionic surfactant mixture on detergency of particulate soil under various solutions. The detergency of the particulate soil was determined by adhesion of particle to fabric and its removal from fabric separately. The PET fabric and ${\alpha}-Fe_2O_3$were used as materials of textile and model of particulate soil, respectively. The detergency was investigated as a function of surfactants concentration, ionic strength, kinds of electrolyte and mole numbers of oxyethylene ether of nonionic surfactant in different ratio of anionic/nonionic surfactant mixture. Although some deviations exist, the adhesion of particle to fabric generally increased with decreasing its removal from fabric. The detergency of particulate soil on PET fabric was relatively higher in anionic/nonionic surfactant mixed solution than in each single surfactant solution, but the influence of ratio of anionic/nonionic surfactant mixture on detergency of particulate soil was low. Generally the detergency of particulate soil on fabric was at its maximum at 0.1% surfactant concentration, $1{\times}10^{-3}$ ionic strength, $Na_5P_3O_{10}$ electrolytes and 10 mole numbers of oxyethylene ether of nonionic surfactant, regardless of ratio of anionic/nonionic surfactant mixture.

• Journal of the Korean Society of Combustion
• /
• v.6 no.2
• /
• pp.8-14
• /
• 2001

The effects of unsteady combustion are experimentally studied using forced pulsating mixture supply. It was shown that unsteady combustion used in this experiment plays an important role in controlling self-excited combustion oscillations. It may also have desirable performances, from a practical point of view, such as high combustion load, augmented heat transfer, reduced pollutant emissions and so on. We examined the characteristics of unsteady combustion driven by forced pulsating mixture supply in a small duct-combustor with a rearward-facing step. Further, we found its influence on the onset of self-excited combustion oscillations, the possibility of suppressing self-excited combustion oscillations and the reason why the self-excited combustion oscillation was suppressed using the forced pulsating mixture supply, comparing with the steady mixture supply.

• 한국연소학회:학술대회논문집
• /
• 2000.05a
• /
• pp.169-177
• /
• 2000

The catalytic heat exchanger, which integrates two functions of heat generation and heat exchange into one equipment, was designed and its characteristics were investigated by the experiment and numerical simulation. The surface of the fin tube was deposited with Pd catalyst. The conversion of the mixture in the catalytic heat exchanger was more significantly affected by the inlet velocity of the mixture than by the inlet temperature and equivalence ratio of the mixture. It was found that the catalytic surface area of the fin tubes should be sufficiently increased to make the combustion intensity of the catalytic heat exchanger as high as possible. Results showed that the fin tubes, placed in the triangularly staggered form, should be adjusted so that the mixture flows uniformly over all the catalytic fin surfaces. Numerical simulation results demonstrated that the flow pattern of the mixture significantly affected the conversion of the mixture.

• Communications for Statistical Applications and Methods
• /
• v.24 no.1
• /
• pp.97-113
• /
• 2017

This paper proposes a method for sufficient dimension reduction (SDR) of mixture data. We consider mixture data containing more than one component that have distinct central subspaces. We adopt an approach of a model-based sliced inverse regression (MSIR) to the mixture data in a simple and intuitive manner. We employed mixture probabilistic principal component analysis (MPPCA) to estimate each central subspaces and cluster the data points. The results from simulation studies and a real data set show that our method is satisfactory to catch appropriate central spaces and is also robust regardless of the number of slices chosen. Discussions about root selection, estimation accuracy, and classification with initial value issues of MPPCA and its related simulation results are also provided.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2005.05b
• /
• pp.525-528
• /
• 2005

This study determines the best composite grade to minimize the void of aggregate mixture based on the maximum density theory in an attempt to suggest a mix proportion method design for asphalt mixtures. Study results show that the grading curve with the maximum mass per unit capacity of each aggregate mixture satisfied the KS standards and the optimum AP content to meet the optimal asphalt mixture void rate of 4$\%$ was 5.7$\%$, less than the optimum AP content of 6.5$\%$ suggested in the Marshal mix proportion method design. At the same time, the asphalt mixture produced based upon the suggested mix proportion method had a flow value 17$\%$ lower than that of asphalt mixture produced according to the Marshal method, while its density was greater by 0.06$\～$0.09. This suggests that the introduced mix proportion method design helps to improve the shape flexibility and crack-resistance of asphalt concrete.