• Tuberculosis and Respiratory Diseases
• /
• 제66권6호
• /
• pp.471-476
• /
• 2009

과민성 폐장염은 감수성 있는 사람이 특정 유발물질에 노출됨으로써 폐실질과 말초 기관지에 육아종성 염증을 일으키는 면역질환이다. 과민성 폐장염은 동물성 및 식물성 항원, 저분자 화학 물질, 세균 및 곰팡이 등의 미생물 흡인에 의해 유발 될 수 있으나 본 증례처럼 주사제에 의한 사례는 매우 드물다. 저자들은 특별한 노출력 없는 건강한 여성에서 태반 추출물 주사 후 발생한 과민성 폐장염의 첫 사례를 경험하여 보고하는 바이다.

• 대한핵의학회지
• /
• 제1권2호
• /
• pp.41-59
• /
• 1967

This study was aimed; firstly to observe various clinical symptomatology with reiation to the number of Ancylostoma duodenale larvae orally given to the human beings, secondly to evaluate the effects of some drugs like steroid hormones, antihistaminic3 and antitussives, and, thirdly to study the influences of some iron compounds in prevention and treatment of anemia of such origin. Ten healthy volunteers free from the previous history of hookworm infection were divided into 4 groups, to whom various numbers of actively moving filariform Ancylostoma duodenale larvae were orally given; 500 to 4 cases, 250 to 3 cases and 100 to 3 cases. Following were the results: 1. Clinical symptomatology 1. The most frequently encountered symptoms and signs were general malaise, cough and hoar seness. The tracheal itching and pain low back pain, arthralgia, sputum and salivation, acid belching, loss of appetite, abdominal pain and vomiting were also noted. 2. If the larger number of the larvae was given, the clinical symtomatology was more severe. 3. Prednisolone medication caused some improvement of such symptomatology, while the antihistaminics and antitussives like codeine or ephedrine were ineffective. 4. In volunteers whose nutritional conditions were rather poor appeared to show more severe symptomatology. 2. Effects of iron compounds 1. The oral administration of ferrous fumarate induced a slight increase of serum iron levels in the initial stage of the infection, then a decrease from $15{\sim}20$ days later and a recovery after 2 months. 2. The intravenous administration of saccharated ferric oxide induced a steady upkeep of the serum iron levels. 3. The hemoglobin contents also showed the upkeeps after either the oral or intravenous administration of the iron compounds. 4. The iron compounds, therefore, are considered to have the preventive as well as the therapeutic effects on hookworm anemia, which may strongly suggest that hookworm anemia is essentially the iron deficiency type. 3. Hematological changes 1. The severity of hookworm anemia generally correlated with the number of larvae given. 2. The moderate leucocytosis was observed in all cases regardless of the number of larvae given, which reached to a peak in $25{\sim}35$ days. 3. Eosinophilia was observed in all cases, but was more severe in cases given larger number of larvae, which was slightly less evident after the medication of prednisolone. 4. Red cell survival time The red cell survival time determined by $^{51}Cr$ was generally in the normal ranges except for the severe anemia patients.

• 대한화장품학회지
• /
• 제46권3호
• /
• pp.219-229
• /
• 2020

최근, 아토피 피부염은 피부 자극에 민감하므로 피부 자극을 최소화하면서도, 특정한 국소 부위에 대한 점착력과 흡수력을 효과적으로 발휘할 수 있으며 적절한 약물 방출을 거동할 수 있는 패치 개발이 우선시 되어야 한다고 제안되기도 하였다. 따라서 본 연구는 피부 자극을 최소화하고 특정 부위에 효과적으로 접착 및 흡수 할 수 있는 하이드로겔 패치를 개발코자 하였다. 아토피 패치는 동결 건조법을 이용하여 고흡수성 하이드로겔 시트를 제형화 하였다. 인간각질세포(HaCaT cells) 및 섬유아세포(L929 cells) 사용하여 세포 안정성을 수행하였다. 물리적 성질을 조사하고자 FT-IR, FE-SEM, 다공성 분석, 팽윤성 거동을 조사 하였다. 그 결과, 새롭게 제조된 HA-Dex 하이드로겔 패치는 생체 적합성 및 물리적 평가에 의해 입증하였다. 또한 제조된 하이드로겔 패치는 충분한 수분 흡수력과 아토피성 피부의 가려움증을 완화시킬 수 있으며, 향후 아토피 성 피부염 치료에 다양한 약물 전달 제품에 적용될 수 있을 것으로 기대된다.

• 한국식품위생안전성학회지
• /
• 제20권2호
• /
• pp.77-82
• /
• 2005

본 연구에서는 식품 단일섭취 또는 식품과 일반의약품으로서의 복합비타민제의 병용섭취를 통해 niacin을 섭취한다는 노출시나리오를 설정하여 우리나라 성인의 niacin 1일 평균섭취량을 산출하였으며, 인체독성자료를 근거로 niacin의 상한섭취량(UL)을 제안하였고 그 값을 비교하여 niacin에 대한 위해지수를 산출하였다. 그 결과 식품 단일섭취 시 위해지수는 0.53,식품과 복합비타민제의 병용섭취 시 위해지수는 0.81-6.24라는 값이 얻어졌다. 일반적으로 위해지수가 1이상이면 건강한 인구집단에서 부작용 발생이 우려됨을 나타낸다 그러므로, 복합비타민제를 병용섭취 하는 일부경우에서는 악영향이 발생할 가능성이 있다고 할 수 있다. 식품을 통한 자연적인 niacin의 섭취로는 악영향이 보고되고 있지 않으나$^{3), 12),}$ 복합비타민제 또는 최근 소비량이 급증하고 있는 비타민 강화 건강기능식품 및 영양보조제 등의 섭취를 통해 niacin으로 인한 악영향의 발생이 우려되므로 지속적이고 세심한 위해성평가와 함께 민감그룹 및 임산부, 수유부 등 특정그룹에 대한 UL설정연구가 이루어져야 할 것으로 생각된다.

• 성인간호학회지
• /
• 제12권2호
• /
• pp.196-208
• /
• 2000

The purpose of the study was to explore the effect of 2 hour infusion of vancomycin(1g) in 200ml of isotonic saline every 12 hour on the frequency of "red man syndrome", phlebitis and length of peripheral catheter placement of infected patients, in order to provide safe infusion method for reducing vancomycinin-duced RMS and phlebitis. The subjects of the study consisted of 16 hospitalized patients; 3 oncology and gastro-intestinal patients, 1 neurological patient, 6 thoracic surgical patients and 6 orthopedic patients, who had received vancomycin from July to October in 1999 at S-hospital. The dependent variables were the incidence of RMS, phlebitis and the length of peripheral catheter placement. The incidence of RMS was checked by an inspector at the first night whenever the infusion method of vancomycin was changed. RMS was observed every 15 minutes during an hour for symptoms of RMS such as itching, erythema, chest pain and systolic blood pressure. Incidence of phlebitis was assessed by inspector twice a day from the insertion of peripheral catheter to the removal of the catheter. The data were analyzed by percentage, mean, $X^2$-test, t-test, repeated ANOVA, and logistic regression analysis using the SPSSWIN program. The results are summarized as follows; 1. No significant difference was identified in frequency of RMS between the experimental group and control group. 2. There was no significant difference in the change of systolic blood pressure as the time goes on between the experimental group and control group. 3. The incidence of phlebitis was significantly lower in the experimental group than in the control group. 4. The length of peripheral catheter placement was significantly longer in the experimental group than in the control group. 5. Other drugs administrated with vancomycin didn't influence the occurrence of phlebitis. However, the infusion method of vancomycin influenced the occurrence of phlebitis. The results suggest that 2 hour infusion of vancomycin(1g) in 200ml of isotonic saline every 12 hours may decrease the incidence of phlebitis and increase the length of peripheral catheter placement compared to 1 hour infusion of vancomycin(1g) in 100ml of isotonic saline every 12 hours. However, it does not reduce the incidence of RMS.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권1호
• /
• pp.85-88
• /
• 2016

Background: Cervical cancer is the second most common malignancy among women worldwide, and women of reproductive age in Thailand. However, information on the behavior regarding cervical cancer in rural community Thailand is sparse. Objective: To assess the knowledge, attitude, and practice regarding cervical cancer (CC) among rural community women in Nakhon Ratchasima, Thailand, using predesigned structured questionnaires. Materials and Methods: A cross-sectional survey was conducted in 8 villages of Non Sung district, Nakhon Ratchasima province, Thailand, during January to April 2015. Bloom's taxonomy was used as a framework for the study. 265 women aged between 30-60 years old were selected by simple random sampling. All participants completed predesigned questionnaires with 4 parts: demographic data, knowledge, attitude, and practice regarding cervical cancer. Descriptive statistics were used for analysis in this study. Results: The majority of participants were in the age group of 41-50 years old (42.6%) with senior secondary school level of education (32.1%), marriage status (85.0%), agricultural employment (59.6%), and family income between 6,000-10,000 baht per month (54.3%). Some 63.4% and 68.7% participants had high knowledge and moderate level of attitudes regarding CC, while 41.1%, 48.7%, and 10.2% had neem regularly, irregularly or never screened for CC, respectively. The main reasons for not screening were were shyness (44.4%) and no time (55.6%). Vaginal discharge and itching were the common signs and symptoms of participants who were screened at a health promotion hospital of sub-district. Conclusions: CC is still a health problem in the rural community. Therefore, health education is required, particularly for those who have never undergone screening.

• 대한예방한의학회지
• /
• 제8권2호
• /
• pp.55-63
• /
• 2004

Objectives : This study was designed to identify the possibility of aroma oils as the complementary medical goods specially for the effects of aromatheraphy on xerosis cutis. Materials and Methods : The participants were 23 adult patients and all participants of this study use aroma oils which is known to effect on xerosis cutis. The subjects consist of voluntary patients with xerosis cutis in Seong-So Hospital in Andong Kyoungbuk, Korea. From April 1st to April 30th, 2004 for 4 weeks, the subjects massaged aroma oils on itching parts or the whole body. Aroma oils were Lavender, Losemary, Jasmine and blended drop by drop per 10ml jojoba oil which used a carrier oil. Skin pH was measured with a skin pH meter(Model : HI98110, Se-Chang instruments, made in Portuga. After 4weeks using aroma oils, the participants answered questions about the feeling of satisfaction with aroma oils. Results : Changes in the physiological indices. The mean deviation of skin pH was $5.58{\pm}0.47$ points before using aroma oils and $5.53{\pm}0.45$ points after 2 weeks, no statistical significance was found(p=0.221). MD was $5.36{\pm}0.41$ points after 4 weeks using aroma oils, which was statistically significant decrease of 0.22 points(p=0.001) Changes on the Pruritus Score Scale. A modified scale of the Pruritus Score Scale(Duo, 1987) was used to measure the severity, location, frequency, and the inconveniences of daily life due to prurius. The maximum scale of severity was 4 points, the full marks of location was 2 points, the full marks of frequency was 3 points, the full marks of inconveniences of daily life due to pruritus was 3 points. The scores ranged from 0 to 12, with 12 indicating the most severe pruritus. There was no statistical difference in severity and frequency score at 4 weeks later(severity p=0.097, frequency p=0.633). A statistically significant difference was found in the score of location and the inconveniences of daily life due to pruritus(each p=0.003). Conclusion : Generally speaking, the patient suffering from renal itch is the higher than normal in skin pH levels. that means to show alkaline condition of skin surface. In some case in this study, skin pH levels was rather lower than normal levels when measured actually patients suffering from renal itch by skin pH meter. But in this study post-test skin pH levels decreased, showing the contribution of aromathrapy to acidic condition of skin surface in suffering from renal itch. It seems to be some help to cure a pruritus and also have no ill effects on aroma oils.

• The Korean Journal of Pain
• /
• 제1권1호
• /
• pp.53-58
• /
• 1988

암으로 인하여 상하복부 및 하지에 심한 통증을 호소하는 환자에게 지주막하강 및 경막외강에 각각 미량의 몰핀을 지속적으로 주입하여 진통효과를 얻은 바 진통효과 발현시간은 지주막 하강 투여군이 빨랐고 지속시간 별로는 큰 차이가 없었고 제통효과 면에서는 지주막하강 투여 군이 더욱 확실하였고, 지속적 몰핀 주입에 의한 내성발현 정도는 경악의장 투여군이 심하였고 합병증 발현정도로는 경막외강 투여군이 경미하였음을 봐서 내성발생문제를 앞으로 해결한 다면 장기간 몰핀 등 마약성 약물을 투여해야되는 암성통증환자에서는 경막외강 투여법이 지주막하강 투여법보다 안전한 제통방법으로 사료된다.

• 대한화장품학회지
• /
• 제36권4호
• /
• pp.281-288
• /
• 2010

본 연구는 에탄올 농도별(0, 30, 50, 70, 100 %)로 추출한 사매추출물의 항산화 효과를 Oxygen Radical Absorbance Capacity(ORAC)로 평가한 결과 30 % 에탄올 추출물에서 가장 우수하였다. 따라서 30 % 에탄올 추출물의 주름 완화에 관련한 효능 및 효과를 확인하기 위하여 마우스 유래 섬유아세포에 대한 세포 독성, MMP-8 collagenase 억제 활성 검사를 실시하였다. 그 결과 30 % 에탄올 사매추출물을 섬유아세포에 처리한 결과 세포 독성이 없었고, 20 %의 MMP-8 collagenase 억제 활성을 보였다. 사매 추출물 1 %가 함유된 Di-Wrinkle Free Cream (DWFC)으로부터 35 ~ 50세의 21명 여성을 대상으로 하루에 2번 도포하여 8주간 인체 안전성과 주름개선 임상평가를 수행하였다. 주름 평가 방법은 3차원 입체 측정기(PRIMOS)를 이용하여 평가를 하였다. DWFC에 대한 안전성 평가는 피험자 방문 시 마다 이상반응, 부종, 인설, 가려움, 자통, 작열감, 뻣뻣함, 따끔거림이나 다른 이상반응이 발생하는지 육안평가와 문진으로 평가하였다. PRIMOS(GFM, Germany)를 이용하여 눈 주변의 주름을 분석한 결과 시험제품 사용 8주 후 통계적으로 유의하게 주름이 13 % 감소하였으며, 시험기간 동안 특별한 피부 이상반응은 관찰되지 않았다. 이와 같은 결과로 보아 사매추출물은 인체에 부작용이 없는 주름개선에 효과 있는 화장품으로 개발이 가능할 것으로 사료된다.

• 한국안광학회지
• /
• 제17권4호
• /
• pp.381-388
• /
• 2012

목적: 본 연구에서는 반복적인 건조에 의해 유발되는 실리콘 하이드로겔 렌즈의 형태 변화 및 착용시의 자 타각적 증상의 변화에 대해 알아보고자 하였다. 방법: 재질 혹은 두께가 다른 실리콘 하이드로겔 렌즈를 4회씩 건조하고 수화시킨 후 전체 직경과 베이스커브의 변화를 비교하였으며, 건조되었던 실리콘 하이드로겔 렌즈를 착용한 후 착용자의 자각적 증상 및 비침입성 눈물막 파괴시간과 순목횟수를 측정하였다. 결과: 반복되는 건조와 수화로 인하여 모든 실리콘 하이드로겔 렌즈의 전체 직경과 베이스커브가 증가하였다. 전체 직경과 베이스커브가 변하는 정도는 재질에 따라 각기 상이하였으며 두꺼운 렌즈에서는 건조수화 횟수에 따라 불규칙적인 변화가 나타났다. 실리콘 하이드로겔 렌즈의 재질이나 두께에 관계없이 건조수화 과정을 거친 렌즈를 착용하였을 때에는 착용자의 비침입성 눈물막 파괴시간은 감소하였으며, 순목횟수는 증가하였다. 또한, 반복적인 건조수화는 렌즈의 착용감에도 영향을 미쳐 가려움, 통증, 자극감, 이물감, 건조감이 증가하는 경향이 있었다. 결론: 본 연구 결과를 통하여 반복적인 건조수화로 실리콘 하이드로겔 렌즈의 형태 변화 및 이에 따른 착용감 저하 유발을 확인하였으므로 건조한 환경에 대하여 강한 내구성을 가지는 실리콘 하이드로겔 콘택트렌즈의 개발 필요성을 제안할 수 있다.