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http://dx.doi.org/10.15230/SCSK.2020.46.3.219

Evaluation of Physical Properties and Biocompatibility of HA-Dex Fusion Hydrogel Patch for Atopic Healing Ability  

Hong, Gyeong Sik (Department of Bio-fibers and Materials Science, Kyungpook National University)
Choi, Jeong Yeon (Safety System R&D Group, Korea Institute of Industrial Technology (KITECH))
Choi, Jin Hyun (Department of Bio-fibers and Materials Science, Kyungpook National University)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.46, no.3, 2020 , pp. 219-229 More about this Journal
Abstract
Recently, since atopic dermatitis is sensitive to skin irritation, it has been suggested that the development of a patch that can effectively exhibit adhesion and absorption to a specific local area while minimizing skin irritation, and capable of appropriate drug release should be given priority. In this study, we tried to develop a hydrogel patch that minimizes skin irritation, adheres effectively to a specific area, and promotes absorption. The atopic patch was formulated into a super-absorbent hydrogel sheet using a freeze drying method. Cell viability assay was carried out using keratinocytes (HaCaT cell) and fibroblasts (L929 cells). In order to investigate the physical properties, FT-IR, FE-SEM, porosity analysis and swelling behavior were investigated. As a result, the newly prepared HA-Dex hydrogel patch was verified by biocompatibility and physical evaluation. In addition, the manufactured hydrogel patch has sufficient moisture absorption capacity and can relieve itching of atopic skin, and is expected to be applied to various drug delivery products for the treatment of atopic dermatitis in the future.
Keywords
atopic dermatitis; hydrogel patch; hyaluronic acid; dextran; BDDE;
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