• Journal of the Korean Wood Science and Technology
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• 제31권1호
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• pp.32-40
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• 2003

항산화활성이 우수한 주목 심재 에탄올 추출물로부터 Sephadex LH-20, centrifugal partition chromatography (CPC), silica gel column chromatography 등을 이용하여 5종의 화합물을 단리하였으며, NMR, Mass spectrometry 등의 기기분석 결과 taxane 화합물인 taxusin를 비롯하여 lignan인 isolariciresinol (4, 4', 9, 9'-tetrahydroxy-3', 5-dimethoxy-2, 7'-cyclolignan), lariciresinol (4, 4', 9-trihydroxy-3, 3'-dimethoxy-7, 9'-epoxylignan), taxiresinol (3, 4, 4', 9-tetrahydroxy-3'-methoxy-7, 9'-epoxylignan) 및 isotaxiresinol (3', 4, 4', 9, 9'-pentahydroxy-5-methoxy-2, 7'-cyclolignan)을 각각 동정하였다. 이들 단리된 화합물의 프리라디칼 소거능을 측정하여 항산화활성을 검정한 결과 taxusin을 제외한 3종의 lignan 화합물인 isolariciresinol, lariciresinol, isotaxiresinol 모두 천연항산화제 및 합성항산화제보다 높은 라디칼 소거능을 나타내어 항산화활성이 우수한 것으로 판명되었다. 이상의 결과 주목의 심재 에탄올 조추출물의 높은 항산화활성은 이들 성분에 기인하는 것으로 사료되었다.

• Archives of Pharmacal Research
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• 제13권3호
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• pp.289-291
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• 1990

A lignan (+) isolariciresinol, was isolated from Rubia akane Nakai. This is the first reporting form Rubiaceae.

• Natural Product Sciences
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• 제16권1호
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• pp.15-19
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• 2010

A new 2,7'-cyclolignan named lonicerinol (1) along with eight known lignans, (-)-epipinoresinol (2), (-)-pinoresinol (3), $9{\alpha}$-hydroxypinoresinol (4), 7R,8S-dihydrodehydrodiconiferyl alcohol (5), ($\pm$)-neo-olivil (6), (+)-isolariciresinol (7), 3-methoxy-8,4'-oxyneoligna-3',4,7,9,9'-pentol (8), and (-)-pinoresinol 4-O-glucoside (9), were isolated from the caulis of Lonicera japonica THUNB. (Caprifoliaceae). All of these constituents except for (-)-pinoresinol (3) and $9{\alpha}$-hydroxypinoresinol (4) are reported for the first time from the genus Lonicera. The structures and absolute configurations of these compounds were determined on the basis of spectroscopic analysis, including CD and 1D- and 2D-NMR techniques and chemical methods.

• Natural Product Sciences
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• 제17권3호
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• pp.175-180
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• 2011

Eleven compounds were isolated from fresh leaves of Abies koreana (Pinaceae), and structures of these compounds were determined to be 3-hydroxy-2-methyl-4-pyrone (1), maltol-3-O-${\beta}$-D-glucoside (2), (-)-epicatechin (3), naringenin 7-O-${\beta}$-D-glucopyranoside (4), naringenin-7-O-rhamnoglucoside (5), kaempferol 3-O-${\beta}$-D-glucopyranoside (6), (+)-isolariciresinol (7), secoisolariciresinol (8), rhododendrol (9), ferulic acid (10) and 4-(4-hydroxyphenyl)butan-2-one (rheosmin) (11) by comparing $^1H$-, $^{13}C$-NMR and MS spectroscopic data with reference values. Compounds 3, 5, 7, 8, 9, 10, 11 were isolated for the first time from A. koreana. Among eleven isolates, compounds 1, 7 and 11 showed inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglia in a concentration dependent manner.