• 분석과학
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• 제6권4호
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• pp.395-399
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• 1993

혈압 강하제로 쓰이는 생약인 조구등(Uncaria hooks)으로부터 네 가지 알칼로이드(corynoxeine, rhyncophylline, isocorynoxeine, isorhynchophylline)들을 분리하고 이들을 HPLC를 이용하여 정량하였다. 그 결과 조구등내 함량은 isocorynoxeine 0.21%, isorhynchophylline 0.16%, corynoxeine 0.28%, rhynchophylline 0.23%인 것으로 나타났다. 또한 corynoxeine과 isocorynoxeine, rhynchophylline과 isorhynchophylline은 열처리에 의하여 상호 변환하였으며 물로 열처리하여 추출하였을 때 corynoxeine과 rhynchophylline의 상대적인 양이 증가하였다.

• 약학회지
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• 제40권1호
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• pp.36-40
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• 1996

Chemical constituents of Uncaria hooks were studied. Four compounds were isolated from the ether soluble fraction by chromatographic purification process. They were ident ified as isocorynoxeine-N-oxide, anti-isorhynchophylline-N-oxide, physcion and ursolic acid by spectral evidences. Their contents analyzed by HPLC or GC method were physcion 0.04%, ursolic acid 0.26%, isocorynoxeine-N-oxide 0.04% and anti-isorhynchophylline-N-oxide 0.03% respectively. Isocorynoxeine-N-oxide was not reported in nature so far.

• Natural Product Sciences
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• 제11권3호
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• pp.145-149
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• 2005

A methanol soluble extract from the dried hooks and stems of Uncaria rhynchophylla showed a strong inhibitory activity against monoamine oxidase in mouse brain. Using a bioassay-guided purification of this extract, a known ${\beta}-carboline$ type alkaloid, harman (1), was obtained as an active constituent. In addition, five known indole alkaloids, isocorynoxeine (2), isorhynchophylline (3), corynoxeine (4), cadambine (5), and $3{\alpha}-dihydrocadambine$ (6), were isolated and found to be weakly active or inactive.