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Monoamine Oxidase Inhibitor from Uncaria rhynchophylla  

Hong, Seong-Su (College of Pharmacy, Chungbuk National University)
Han, Xiang Hua (College of Pharmacy, Chungbuk National University)
Park, So-Young (College of Pharmacy, Chungbuk National University)
Choi, Woo-Hoi (College of Pharmacy, Chungbuk National University)
Lee, Myung-Koo (College of Pharmacy, Chungbuk National University,Research Center for Bioresource and Health, Chungbuk National University)
Hur, Jae-Doo (Crown Pharmaceutical Co. Ltd.)
Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
Ro, Jai-Seup (College of Pharmacy, Chungbuk National University)
Publication Information
Natural Product Sciences / v.11, no.3, 2005 , pp. 145-149 More about this Journal
Abstract
A methanol soluble extract from the dried hooks and stems of Uncaria rhynchophylla showed a strong inhibitory activity against monoamine oxidase in mouse brain. Using a bioassay-guided purification of this extract, a known ${\beta}-carboline$ type alkaloid, harman (1), was obtained as an active constituent. In addition, five known indole alkaloids, isocorynoxeine (2), isorhynchophylline (3), corynoxeine (4), cadambine (5), and $3{\alpha}-dihydrocadambine$ (6), were isolated and found to be weakly active or inactive.
Keywords
Uncaria rhynchophylla; Rubiaceae; Harman; Monoamine oxidase inhibitor;
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