• Clinical and Experimental Pediatrics
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• v.48 no.12
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• pp.1389-1389
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• 2005

The long arm duplication of chromosome 3 was reported for the first time in 1966 by Falek et al., and Hirschhorn et al. came to identify the duplication of 3q21${\rightarrow}$qter region in 1973. In most cases of duplication 3q syndrome patients, pure duplication of 3qter is believed to be rare and is often reported accompanied with deletion of another segment of the chromosome. Approximately 75 percent of parents of the patient in the meantime have been demonstrated to have unbalanced translocations or inversions of the chromosome. Partial deletion of the distal part of the short arm of chromosome 3 was first reported by Verjaal and De Nef in 1978 and terminal deletion of chromosome 3 (3p25-qter) has been observed in most cases. In karyotyping of chromosomes of immature infants showing the manifestations of flat occiputs, low set ears, hypertelorism, broad nasal roots, thin lips, web necks, hypotonia, hypertrichosis skin, cryptorchidism etc, we experienced a case diagnosed as 46,XY, rec(3)dup(3)(q21)del(3)(p25)inv(3)(p25q21).

• Economic and Environmental Geology
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• v.29 no.3
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• pp.345-355
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• 1996

The effectiveness of various electrode configurations in horizontal mappings and 1-D inversions of vertical sounding data for delineating 2-D structures was studied. Apparent resistivity values of three point, dipole-dipole, Wenner, and Schlumberger mappings were simulated for such structures as vertical dyke, tabular prism, buried vertical fault, ramp and complex structure by finite difference method (FDM) and they were compared with each other. Also 2-D cross sections for three structures obtained by interpolation of 1-D inverted sounding data in terms of three layers were compared for Schlumberger and Wenner arrays. On these cross sections, horizontal and vertical resistivity interfaces of the 2-D structures are revealed relatively clearly. Apparent resistivity curves of Schlumberger mapping show vertical resistivity discontinuities very well. On the whole, Schlumberger array is superior to the other arrays in electric sounding as well as mapping. This study clearly indicates that interpretations of 2-D structures based on 1-D inversion are possible.

• The Korean Journal of Zoology
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• v.14 no.2
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• pp.75-84
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• 1971

Genetic analysis of a new wing mutant, Surf wings (Srf), was performed. Mutant flies were extracted from a wild population of Drosophila melanogaster at the vicinity of Atomic Energy Research Institute, Seoul in August-September 1969. 1. The distal half of wings of heterozygotes (Srf/+) turned upwards about 40 degree from body axis, but flying ability was not disturbed. They overlap Cy in low frequency when they are grown below $22^{\circ}C$. This resembles with Si or j series, but wing margins are not rolled and diversed. Postscutellars are erected slightly, but they, in general, are not crossed. Any other external pleiotropic effects were not observed. 2. Penetrance and expressivity of both sexes are not complete. Their extents are variable with sex and temperature. These characters show maximum tendencies when the development is made at $22^{\circ}C$ (female: P = 0.996, E = 0.932, male:P = 0.961, E = 0.698). 3. The preliminary locus of Srf was determined to be 66.8 on the right arm of second chromosome by using recessive maker gene cn bw. 4. The homozygous flies(Srf/Srf) have shown perfect lethality. The heterozygotes (Srf/+), on the other hand, have shown to be viable and fertile. Srf chromosomes are kept in a balanced lethal system with Pm chromosomes which are associated with inversions. Hence, it is partially reasonable to suppose that Srf may persist in a natural population by the same mechanism. 5. Allelism test with Cy was also conducted. The fact that combination with Cy in the trans-phase (+ Srf/Cy +) is viable in contrast to the lethality of Srf/Srf and Pm/Pm indicates that Srf and Cy are not functionally allelic.

• Geophysics and Geophysical Exploration
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• v.22 no.4
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• pp.195-201
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• 2019

The logarithmic objective function used in waveform inversion minimizes the logarithmic differences between the observed and modeled data. Laplace-domain waveform inversions usually adopt the logarithmic objective function and the diagonal elements of the pseudo-Hessian for optimization. In this case, we apply the Levenberg-Marquardt algorithm to prevent the diagonal elements of the pseudo-Hessian from being zero or near-zero values. In this study, we analyzed the diagonal elements of the pseudo-Hessian of the logarithmic objective function and showed that there is no zero or near-zero value in the diagonal elements of the pseudo-Hessian for acoustic waveform inversion in the Laplace domain. Accordingly, we do not need to apply the Levenberg-Marquardt algorithm when we regularize the gradient direction using the pseudo-Hessian of the logarithmic objective function. Numerical examples using synthetic and field datasets demonstrate that we can obtain inversion results without applying the Levenberg-Marquardt method.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.287-293
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• 2004

A numerical simulation is presented for investigating the effects of pressure ratio of $D_2$ injector to supersonic nozzle on the population inversion in the DF chemical laser cavity, while a lasing concurrently takes place. The laser beam is generated between the mirrors in the cavity and it is important to obtain stronger population inversion and more uniform distribution of the excited molecules in the laser cavity in order to produce high power laser beam with good quality. In this study, these phenomena are investigated by means of analyzing the distributions of the DF excited molecules and the F atom used as an oxidant, while simultaneously estimating the maximum small signal and saturated gains and power in the DF chemical laser cavity. For the numerical solution, an 11-species (including DF molecules in various excited states of energies), 32-step chemistry model is adopted for the chemical reaction of the DF chemical laser system. The results are discussed by comparison with two $D_2$injector pressure cases; 192 torr and 388.64 torr. Major results reveal that in the resonator, stronger population inversions occur in the all transitions except DF(1)-DF(0), when the $D_2$injection pressure is lower. But, the higher $D_2$injection pressure provides a favorable condition for DF(1)-DF(0) transition to generate the higher power laser beam. In other words, as the pressure of $D_2$injector increases, the maximum small signal gain in the $V_{1-0}$ transition, which is in charge of generating most of laser power, becomes higher. Therefore, the total laser beam power becomes higher.r.

• Geophysics and Geophysical Exploration
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• v.17 no.2
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• pp.58-65
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• 2014

We studied the source mechanisms of very-long-period event recorded at seismic station WIZ near White Island Volcano, New Zealand on August 4, 2012. Since seismic data at only one station were available, we conducted moment tensor inversion using three simplified models (explosion, crack, and pipe models). To constrain the moment tensor solution of seismic event, we computed synthetic data for each model to compare with observed data. Type and orientation for the best model is a crack at a depth of 1600 m with a dip of $80^{\circ}NE$ and a strike of $N80^{\circ}W$. We interpret that a deep explosion may have opened a crack for gases to escape, and the upward gas flow triggered the surface explosions four hours later as confirmed by a webcam. The interpretation based on moment tensor inversion is consistent with previous studies of geochemical data of the volcanic island.

• Journal of Microbiology and Biotechnology
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• v.27 no.9
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• pp.1711-1715
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• 2017

In this study, we characterized the $bla_{NDM-5}$-bearing plasmid in a Klebsiella pneumoniae isolate that had lost the plasmid during serial passage. We determined the complete sequences of the plasmid pCC1410-2, which was extracted from a K. pneumoniae ST709 isolate collected at a Korean hospital from which two NDM-5-producing K. pneumoniae isolates were subsequently isolated. As a result, the pCC1410-2 plasmid had a backbone structure that was similar to those of two plasmids previously reported from the same hospital, but lacked some antibiotic resistance genes ($bla_{TEM-1}$, rmtB, mphR(A), mrx(A), and mph(A)). A 9-bp repeating unit encoding three amino acids (Gln-Gln-Pro) was inserted in TraD in pCC1410-2. Thus, the pCC1410-2 plasmid might be transferred from the previously identified carbapenem-resistant K. pneumoniae, but some delections and inversions might have occurred during the process. We compared the transfer frequency and stability of the plasmids. The relative frequency of conjugative transfer and stability in the host were significantly lower in pCC1410-2 than in previously reported $bla_{NDM-5}$-bearing plasmids in Korea. A low transfer frequency and instability in the host may cause underestimation of carbapenemase-producing Enterobacteriaceae in the clinical setting and in surveillance studies.

• Geophysics and Geophysical Exploration
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• v.1 no.1
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• pp.71-78
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• 1998

Inversion schemes of 2-D MT survey data generally take enormous computational time and computer memory. In addition, careful attention must be paid in handling MT data, especially in cases of TM mode, inversion results can be seriously distorted because of static effect caused by current channeling across inhomogeneous surface boundaries. There-fore inversion algorithm using the GRRI scheme for TM mode MT data was implemented. This scheme is based on a perturbation analysis with a locally 2-D analysis and local inversions were sequently performed over each divided section without additional forward modelings. The algorithm was applied to several synthetic data for the purpose of verification of its efficiency and applicability. With less computer resources than conventional schemes, it could handle static effect directly by including current channeling across inhomogeneous boundaries. Thus it is expected to be used for an useful tool such as a real-time inversion scheme in the field.

• Geophysics and Geophysical Exploration
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• v.13 no.1
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• pp.61-68
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• 2010

A magnetotelluric (MT) survey has been performed to delineate deeply extended fracture systems at the geothermal field in Seokmo Island, Korea. To assist interpretation of the MT data, geological surveying and well logging of existing wells were also performed. The surface geology of the island shows Cretaceous and Jurassic granite in the north and Precambrian schist in the south. The geothermal regime has been found along the boundary between the schist and Cretaceous granite. Because of the deep circulation along the fracture system, geothermal gradient of the target area exceeds $45^{\circ}C/km$, which is much higher than the average geothermal gradient in Korea. 2D and 3D inversions of MT data clearly showed a very conductive anomaly, which is interpreted as a fracture system bearing saline water that extends at least down to 1.5 km depth and is inclined eastwards. After drilling down to the depth of 1280 m, more than 4000 tons/day of geothermal water overflowed with temperature higher than $70^{\circ}C$. This water showed very similar chemical composition and temperature to those from another existing well, so that they can be considered to have the same origin; i.e. from the same fracture system. A new geothermal project for combined heat and power generation was launched in 2009 in Seokmo Island, based on the survey. Additional geophysical investigations including MT surveys to cover a wider area, seismic reflection surveys, borehole surveys, and well logging of more than 20 existing boreholes will be conducted.

• Journal of Microbiology and Biotechnology
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• v.15 no.4
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• pp.844-854
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• 2005

We constructed a defined physical and genetic map of H. pylori strain 51, previously isolated from a Korean patient with a duodenal ulcer, by combining a restriction analysis by pulse-field gel electrophoresis with the construction of a BAC library. A Notl-digest of H. pylori strain 51 genome yielded seven fragments, from which the genomic size was estimated to be 1,698$\pm$24 kb. The BAC library was constructed from 50 to 200 kb fragments of HindIII-digested genomic DNA. From 700 BAC clones, an ordered overlapping maxi-set of 82 BAC clones was assembled that covered the entire genome. The positions of 15 genes were localized in the strain 51 genome with 4-22 kb of resolution and were compared with their orthologues in strain 26695 and strain J99. The arrangement of the 15 genes was identical in strain 51 and strain J99, except for flaA and hpaA. The plasticity zone of strain 51, like that of strain J99, was located in the single region, and was shorter than those of strain 26695 and strain J99. The strain 51 plasticity zone consisted of ORFs common only to strain 51 and J99 or to strain 51 and 26695, as well as strain 51-specific ORFs. Three genetic translocations and/or inversions were found between orthologue ORFs in strain 51 and strain J99. These results show that the chromosomal organization of strain 51 differs from Western strains such as strain 26695 and strain J99.