• Korean Journal of Clinical Pharmacy
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• v.21 no.2
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• pp.90-99
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• 2011

Health Insurance Review & Assessment Service (HIRA) claims database has a high potential to detect signals of new drug interactions. The aim of this study was to evaluate the usefulness of information component (IC) and relative risk (RR) as a tool for signal detection, and to analyze the possible drug interactions caused by clopidogrel using HIRA claims database. This study was performed in elderly patients over 65 years of age who administered clopidogrel from January 2005 to June 2006 in South Korea. Serious Adverse Events (SAEs) as drug interactions of clopidogrel were defined as any ambulatory hospitalization for ischemic diseases within comcomitant medication period of clopidogrel. Information Component (IC) and Relative Risk (RR) were calculated to compare the proportion of drug-SAE pairs in order to select drug specific SAEs. IC and RR signals of clopidogrel drug interaction were screened when IC's 95% confidence interval was greater than 0 and RR's 95% confidence interval was greater than 1 respectively. All detected signals were compared to references such as $Micromedex^{(R)}$ and 2010 Drug Interaction $Facts^{TM}$. Sensitivity, specificity, positive predicted value and negative predicted value were used to evaluate usefulness of this method. Among 13,252,930 cases of elderly patients who co-administered clopidogrel and other drugs, 47,485 cases were detected as SAE. Of these, one-hundred nine cases were detected by the IC-based data-mining approach and ninety one cases were detected by the RR-based data-mining approach. Total One-hundred sixty three unrecognized signals were detected by IC or RR. Twelve signals from IC-based data-mining (57.1%) were corresponded with drug interactions from references and eight signals from RR-based data-mining (38.1%) were corresponded with drug interactions from references. These signals include proton pump inhibitors, calcium channel blockers and HMG CoA reductase Inhibitors, which were known to affect CYP450 metabolism. Further studies using HIRA claims database are necessary to develop appropriate data-mining measure.

• Journal of Astronomy and Space Sciences
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• v.25 no.2
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• pp.157-166
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• 2008

We have investigated a statistical relationship between sawtooth oscillations and geomagnetic storms during 2000-2004. First of all we selected a total of 154 geomagnetic storms based on the Dst index, and distinguished between different drivers such as Coronal Mass Ejection (CME) and Co-rotating Interaction Region (CIR). Also, we identified a total of 48 sawtooth oscillation events based on geosynchronous energetic particle data for the same 2000-2004 period. We found that out of the 154 storms identified, 47 storms indicated the presence of sawtooth oscillations. Also, all but one sawtooth event identified occurred during a geomagnetic storm interval. It was also found that sawtooth oscillation events occur more frequently for storms driven by CME $({\sim}62%)$ than for storms driven by CIR $({\sim}30%)$. In addition, sawtooth oscillations occurred mainly $({\sim}82%)$ in the main phase of storms for CME-driven storms while they occurred mostly $({\sim}78%)$ during the storm recovery phase for CIR-driven storms. Next we have examined the average characteristics of the Bz component of IMF, and solar wind speed, which were the main components for driving geomagnetic storm. We found that for most of the sawtooth events, the IMF Bz corresponds to -15 to 0 nT and the solar wind speed was in the range of $400{\sim}700km/s$. We found that there was a weak tendency that the number of teeth for a given sawtooth event interval was proportional to the southward IMF Bz magnitude.

• International Journal of Industrial Entomology and Biomaterials
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• v.12 no.2
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• pp.51-56
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• 2006

Use of products containing phytoecdysteroid (PE) as active principle has become popular in prominent sericultural areas of India for hastening larval maturation events and synchronizing cocoon spinning activities as an obvious advantage is assured. At times, the present recommendation of administering PE at the onset of spinning results in peak labour requirement at odd hrs. To enable making recommendation for the use of PE on $multi{\times}bivoltine$ silkworm hybrids based on the climatic conditions prevailing in different areas especially with regard to temperature, the experiment was taken up to determine proper treatment times so that the induced spinning will be more orderly and the labour can be leveraged more efficiently. Different brackets of low ($18-22^{\circ}C$), medium ($24-28^{\circ}C$) and high ($29-32^{\circ}C$) temperature were simulated during the latter half of V larval instar and cocoon spinning. PE was administered to $multi{\times}bivoltine$ silkworm ($BL67{\times}CSR101$) hybrid batches as per the recommended dose at three different times viz., 10 am, 4 pm and 10 pm. Three replicates of 100 larvae were maintained for each treatment. Absolute controls were also maintained in each temperature range to compare the results. Cumulative maturation percentage was recorded at 6 hrs interval to ascertain peak mounting span. The influence of the treatment on the cocoon traits also was studied. Based on the peak mounting span, it was evident that in low temperature 10 pm treatment would be better. In medium and high temperature, treatment at 4 pm proved to be a better option. The influence of the treatment times at different temperature range on labour management is discussed.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.63.3-64
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• 2015

In our previous work (Kim et al., 2015), we suggested a new classification scheme, which categorizes the SPEs into four groups based on association with flare or CME inferred from onset timings as well as proton acceleration patterns using multienergy observations. In this study, we have tried to find whether there are any typical characteristics of associated events and acceleration sites in each group using 42 SPEs from 1997 to 2012. We find: (i) if the proton acceleration starts from a lower energy, a SPE has a higher chance to be a strong event (>5000pfu) even if the associated flare and CME are not so strong. The only difference between the SPEs associated with flare and CME is the location of the acceleration site. For the former, the sites are very low (~1Rs) and close to the western limb, while the latter has a relatively higher and wider acceleration sites. (ii) When the proton acceleration starts from the higher energy, a SPE tends to be a relatively weak event (<1000pfu), in spite of its associated CME is relatively stronger than previous group. (iii) The SPEs categorized by the simultaneous proton acceleration in whole energy range within 10 minutes, tend to show the weakest proton flux in spite of strong related eruptions. Their acceleration heights are very close to the locations of type II radio bursts. Based on those results, we suggest that the different characteristics of the four groups are mainly due to the different mechanisms governing the acceleration pattern and interval, and different condition such as the acceleration location.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3589-3593
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• 2012

Objective: Evaluation and assessment of response rate, duration and toxicity in patients subjected to 5-FU based chemotherapy. Background: The therapeutic ratio shifts with different 5FU/LV regimens and none yet serve as the internationally accepted Gold Standard. A bimonthly regimen of high dose leucovorin is reported to be less toxic and more effective than monthly low dose regimens. We here compare therapeutic responses and survival benefit of the two regimens in poor prognosis patients with advanced colorectal carcinoma. Patients and Methods: A total of 35 patients with histologically confirmed colorectal carcinoma were subjected to de Gramont and Mayo Clinic regimen. Nineteen patients were treated with high dose folinic acid ($200mg/m^2$), glucose 5%, 5-FU ($400mg/m^2$) and 22 hr. CIV ($600mg/m^2$) for two consecutive days every two weeks. These patients had failed responses to previous chemotherapy and were above sixty years of age with poor general status. Sixteen patients (six below 60 years) with progressive disease were subjected to low dose folinic acid ($20mg/m^2$)for five days, 5FU($425mg/m^2$) injection bolus for 5 days, every five weeks. An initial evaluation was made in sixty days and responders were reevaluated at sixty days interval or earlier in case of clinical impairment. Based on positive prognosis, the therapy was continued. Evaluation of treatment response was made on the basis of WHO criteria. Results: The response rate was 44% in thirty four evaluable patients, with 4 complete responses (11.8%) and 11 (32.4%) partial responses. The two schedules were well tolerated, whereas, mild toxicity without WHO Grade ${\geq}2$ events was assessed. The response duration was extended (12 months) in a few patients with age above sixty years treated by high dose bimonthly regimen of 5FU/LV. Conclusion: The regimens are safe and effective in advanced colorectal carcinoma patients with poor general status.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3237-3241
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• 2013

Background: Under-ascertainment and over-ascertainment are common phenomena in surveillance and registry systems of health-related events. Capture-recapture is one of the methods which is applied to determine the sensitivity of surveillance or registry systems to recognize cancer cases. This study aimed to estimate the number of cancers using data available both in the Cancer Registry Center of Northwestern Iran and in the Population-based Cancer Registry Center of Iran. Material and Methods: The studied population consisted of all cancerous cases in the northwest of Iran from 2008 to 2010. All data were extracted from two resources and entered into Microsoft Excel software. After removing common and repeat cases the data were statistically analyzed using a capture-recapture studies' specific software "CARE 1.4". Estimations were calculated by Chapman and Petersen methods with the approximate confidence interval of 95%. Results: From 2008 to 2010, the number of all cancer cases was estimated to be 21,652 (CI 95%: 19,863-22,101). Sensitivity rate of all cancer cases was 83.9% and that of Population-based Cancer Registry Center of Iran was 52%. It was 93.1% considering both resources. Conclusion: Using two resources and the capture-recapture method rather than a single resource may be a more reliable method to estimate the number of cancer cases.

• Wind and Structures
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• v.37 no.4
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• pp.289-302
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• 2023

Insulating glass units (IGUs) have been widely used in buildings in recent years due to their superior thermal insulation performance. However, because of the panel reciprocating motion and fatigue deterioration of sealants under long-term wind loads, many IGUs have the problem of early failure of watertight properties in real usage. This study aimed to propose a statistical method for wind-induced deflection of IGU panels during the whole life service period, for further precise analysis of the accumulated fatigue damage at the sealed part of the edge bond. By the estimation of the wind occurrence regularity based on wind pressure return period, the events of each wind speed interval during the whole life were obtained for the IGUs at 50m height in Beijing, which are in good agreement with the measured data. Also, the wind-induced deflection analysis method of IGUs based on the formula of airspace coefficient was proposed and verified as an improvement of the original stiffness distribution method with the average relative error compared to the test being about 3% or less. Combining the two methods above, the deformation of the outer and inner panes under wind loads during 30 years was precisely calculated, and the deflection and stress state at selected locations were obtained finally. The results show that the compression displacement at the secondary sealant under the maximum wind pressure is close to 0.3mm (strain 2.5%), and the IGUs are in tens of thousands of times the low amplitude tensile-compression cycle and several times to dozens of times the relatively high amplitude tensile-compression cycle environment. The approach proposed in this paper provides a basis for subsequent studies on the durability of IGUs and the wind-resistant behaviors of curtain wall structures.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.21 no.3
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• pp.241-253
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• 2009

This study performs the investigation of a long-term variation of annual maximum surge heights(AMSH) and main characteristics of high surge events, and the statistical evaluation of the AMSH using sea level data at Yeosu and Tongyeong tidal stations over more than 30 years. It is found that the long-term uptrends based on the linear regression in the AMSH are 34.5 cm/34 yr at Yeosu and 33.6 cm/31 yr at Tongyeong, which are relatively much higher than those at Sokcho and Mukho in the Eastern Coast. 71% and 68% of the AMSH occur during typhoon's event in Yeosu and Tongyeong tidal stations, respectively, and the highest surge records are mostly produced by the typhoon. The generalized extreme value distribution taking into account of the time variable is applied to detect time trend in annual maximum surge heights. In addition, Gumbel distribution is checked to find which one is best fitted to the data using likelihood ratio test. The return level and its 90% confidence interval are obtained for the statistical prediction of the future trend. The prevention of the growing storm surge damage by the intensified typhoon requires the steady analysis and prediction of the surge events associated with the climate change.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.8
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• pp.3-12
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• 2016

Bluetooth Low Energy (BLE) protocol has attracted attention as a promising technology for low data throughput and low energy wireless sensor networks. Fast device discovery is very important in a BLE based wireless network. It is necessary to configure the network to work with minimized energy consumption because the BLE network nodes are expected to operate a long time typically on a coin cell battery. However, since it is difficult to obtain low energy and low latency at the same time, the BLE standard introduces wide range setting of parameters related to device discovery process and let the network operators to set up parameter values for the application. Therefore, it is necessary to analyze the performance of device discovery according to the related parameter values prior to BLE network operation. In this paper we analyze the expected value and the cumulative distribution function of the number of advertisements for device discovery in the BLE network. In addition, we propose a scheme for controlling the interval between advertising events that can improve the performance of device discovery without increasing energy consumption.

• Journal of Wetlands Research
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• v.11 no.1
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• pp.49-64
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• 2009

Rainfall-runoff models are used for efficient management, distribution, planning, and design of water resources in accordance with the process of hydrologic cycle. The models simplify the transition of rainfall to runoff as rainfall through different processes including evaporation, transpiration, interception, and infiltration. As the models simplify complex physical processes, gaps between the models and actual rainfall events exist. For more accurate simulation, appropriate models that suit analysis goals are selected and reliable long-term hydrological data are collected. However, uncertainty is inherent in models. It is therefore necessary to evaluate reliability of simulation results from models. A number of studies have evaluated uncertainty ingrained in rainfall-runoff models. In this paper, Meta-Gaussian method proposed by Montanari and Brath(2004) was used to assess uncertainty of simulation outputs from rainfall-runoff models. The model, which estimates upper and lower bounds of the confidence interval from probabilistic distribution of a model's error, can quantify global uncertainty of hydrological models. In this paper, Meta-Gaussian method was applied to analyze uncertainty of simulated runoff outputs from $Vflo^{TM}$, a physically-based distribution model and HEC-HMS model, a conceptual lumped model.