• 한국발생생물학회지:발생과생식
• /
• 제18권1호
• /
• pp.1-11
• /
• 2014

Early growth response 1 (Egr1) is a zinc-finger transcription factor to direct second-wave gene expression leading to cell growth, differentiation and/or apoptosis. While it is well-known that Egr1 controls transcription of an array of targets in various cell types, downstream target gene(s) whose transcription is regulated by Egr1 in the uterus has not been identified yet. Thus, we have tried to identify a list of potential target genes of Egr1 in the uterus by performing multi-step in silico promoter analyses. Analyses of mRNA microarray data provided a cohort of genes (102 genes) which were differentially expressed (DEGs) in the uterus between Egr1(+/+) and Egr1(-/-) mice. In mice, the frequency of putative EGR1 binding sites (EBS) in the promoter of DEGs is significantly higher than that of randomly selected non-DEGs, although it is not correlated with expression levels of DEGs. Furthermore, EBS are considerably enriched within -500 bp of DEG's promoters. Comparative analyses for EBS of DEGs with the promoters of other species provided power to distinguish DEGs with higher probability as EGR1 direct target genes. Eleven EBS in the promoters of 9 genes among analyzed DEGs are conserved between various species including human. In conclusion, this study provides evidence that analyses of mRNA expression profiles followed by two-step in silico analyses could provide a list of putative Egr1 direct target genes in the uterus where any known direct target genes are yet reported for further functional studies.

• Tribology and Lubricants
• /
• 제30권2호
• /
• pp.124-129
• /
• 2014

The piping system accounts for a large portion of the machinery structure of a plant, and is considered as a very important mechanical structure for plant safety. Accordingly, it is used in most energy plants in the nuclear, gas, and heavy chemical industries. In particular, the piping system for a nuclear plant is generally complicated and uses the reactor and its cooling system. The piping equipment is exposed to diverse loads such as weight, temperature, pressure, and seismic load from pipes and fluids, and is used to transfer steam, oil, and gas. In ultrasound infrared thermography, which is an active thermography technology, a 15-100 kHz ultrasound wave is applied to the subject, and the resulting heat from the defective parts is measured using a thermography camera. Because this technique can inspect a large area simultaneously and detect defects such as cracks and delamination in real time, it is used to detect defects in the new and renewable energy, car, and aerospace industries, and recently, in piping defect detection. In this study, ultrasound infrared thermography is used to detect information for the diagnosis of nuclear equipment and structures. Test specimens are prepared with piping materials for nuclear plants, and the optimally designed ultrasound horn and ultrasound vibration system is used to determine damages on nuclear plant piping and detect defects. Additionally, the detected images are used to improve the reliability of the surface and internal defect detection for nuclear piping materials, and their field applicability and reliability is verified.

• 한국분말재료학회지
• /
• 제21권3호
• /
• pp.196-201
• /
• 2014

In this study, nanocrystalline Cu-Ni bulk materials with various compositions were cold compacted by a shock compaction method using a single-stage gas gun system. Since the oxide layers on powder surface disturbs bonding between powder particles during the shock compaction process, each nanopowder was hydrogen-reduced to remove the oxide layers. X-ray peak analysis shows that hydrogen reduction successfully removed the oxide layers from the nano powders. For the shock compaction process, mixed powder samples with various compositions were prepared using a roller mixer. After the shock compaction process, the density of specimens increased up to 95% of the relative density. Longitudinal cross-sections of the shock compacted specimen demonstrates that a boundary between two powders are clearly distinguished and agglomerated powder particles remained in the compacted bulk. Internal crack tended to decrease with an increase in volumetric ratio of nano Cu powders in compacted bulk, showing that nano Cu powders has a higher coherency than nano Ni powders. On the other hand, hardness results are dominated by volume fraction of the nano Ni powder. The crystalline size of the shock compacted bulk materials was greatly reduced from the initial powder crystalline size since the shock wave severely deformed the powders.

• 한국철도학회논문집
• /
• 제17권2호
• /
• pp.100-105
• /
• 2014

해중철도 부근에서 테러나 사고에 의해 수중폭발이 발생하였을 경우, 함체에 치명적인 손상을 가할 수 있으므로, 충분한 강도를 확보해야 한다. 본 연구에서는 설계 목적으로 해중철도 인근에서 수중폭발이 발생한 경우, 경험에 기초한 공식을 이용하여 충격압을 추정하고, 충격압에 의한 해중철도의 응답을 해석할 수 있는 간이 해석 방법을 제안하였다. 해중철도 함체를 탄성 지지된 보로 이상화하고, 초기 최대 충격압이 작용하는 보에 대해 정적 유한요소해석을 실시한 후, 동하중 계수와 조합함으로 최대 변위 및 굽힘 모멘트를 계산한다. 간이해석 결과는 상용 유한요소해석 소프트웨어를 이용한, 시간에 따른 과도응답해석 결과와 비교하여 양호한 일치를 보임을 확인하였다.

• Nuclear Engineering and Technology
• /
• 제39권5호
• /
• pp.637-646
• /
• 2007

An UET (ultrasound excited thermography) has been used for several years for a remote non-destructive testing in the automotive and aircraft industry. It provides a thermo sonic image for a defect detection. A thermograhy is based On a propagation and a reflection of a thermal wave, which is launched from the surface into the inspected sample by an absorption of a modulated radiation. For an energy deposition to a sample, the UET uses an ultrasound excited vibration energy as an internal heat source. In this paper the applicability of the UET for a realtime defect detection is described. Measurements were performed on two kinds of pipes made from a copper and a CFRP material. In the interior of the CFRP pipe (70mm diameter), a groove (width - 6mm, depth - 2.7mm, and length - 70mm) was engraved by a milling. In the case of the copper pipe, a defect was made with a groove (width - 2mm, depth - 1mm, and length - 110 mm) by the same method. An ultrasonic vibration energy of a pulsed type is injected into the exterior side of the pipe. A hot spot, which is a small area around the defect was considerably heated up when compared to the other intact areas, was observed. A test On a damaged copper pipe produced a thermo sonic image, which was an excellent image contrast when compared to a CFRP pipe. Test on a CFRP pipe with a subsurface defect revealed a thermo sonic image at the groove position which was a relatively weak contrast.

• 한국해양공학회지
• /
• 제29권3호
• /
• pp.231-240
• /
• 2015

FPSO model tests of mooring line failure were carried out in the ocean basin at KRISO. The characteristics of the motions and mooring lines were investigated. The FPSO ship was moored using an internal turret and catenary mooring. The test model was 1/60 scale. The mooring lines were designed to satisfy the characteristics of the original mooring lines using the truncation method. The experiments were conducted under various environments: a safe wave, current and wind condition; single broken mooring line condition; and transient mode condition. The moment of the break was determined based on experimental test results. The results showed that the FPSO behavior and mooring line tensions were acceptable under the failure condition.

• 한국통신학회논문지
• /
• 제23권8호
• /
• pp.2064-2071
• /
• 1998

휴대용 기기에서 자체 발진하여 클럭원으로 사용되는 TCXO의 출력과 같은 작은 진폭(400mV)의 정현파 입력을 내부 논리회로의 클럭원으로 사용하기 위한 파형정형 및 50%의 듀티 비(duty ratio)의 출력을 가지는 새로운 디지털 클럭레벨 변환기를 설계, 개발 하였다. 정, 부 두 개의 비교기, RS 래치, 차아지 펌프, 기준 전압 발생기로 구성된 새로운 신호 변환회로는 출력파형의 펄스 폭을 감지하고, 이 결과를 궤환루프로 구성하여 입력 비교기 기준 전압단자로 궤환시킴으로서 다지털 신호레벨의 정확한 50%의 듀티 비를 가진 출력을 생성할 수 있다. 개발한 레벨변환기는 ADC등의 샘플링 클럭원, PLL 또는 신호 합성기의 클럭원으로 사용할 수가 있다. 설계는 $0.8\mu\textrm{m}$ double metal double poly analog CMOS 공정을 사용하고, BSIM3 model을 사용하였으며, 실험결과 370mV의 정현파 입력율 50 + 3%의 듀티 비를 가진 안정된 논리레벨 출력 동작특성을 얻을 수 있었다.

• 대한기계학회논문집B
• /
• 제35권10호
• /
• pp.1041-1046
• /
• 2011

본 연구에서는 레이저 쇼크 피닝으로부터 생성되는 마이크로 충격파를 정량적으로 측정하고 그 특성을 분석하였다. 레이저 쇼크 피닝은 금속 재료에서 압축 응력을 생성시키며 그 크기가 표면에서 극대화되는 특징을 가지고 있다. 펄스 Nd:YAG 레이저를 이용하여 스틸표면에 피닝 공정을 수행하였고 이에 따른 마이크로 충격파의 정량화 및 재료의 기계적 성질 변화에 대해 평가하였다. 실험적 접근으로 피에조소자를 사용하였으며 이를 통한 실제 충격파의 정량화를 제시하였다. 또한 재료 구조 특성, 재료 강도, 인장 시험 등의 기계적 특성을 분석하였다.

• Smart Structures and Systems
• /
• 제4권6호
• /
• pp.727-740
• /
• 2008

A down hole vertical seismic array is a sequence of instruments installed at various depths in the earth to record the ground motion at multiple points during an earthquake. Numerous studies demonstrate the unique utility of vertical seismic arrays for studying in situ site response and soil behavior. Examples are given of analyses made at two sites to show the value of data from vertical seismic arrays. The sites examined are the Lotung, Taiwan SMART1 array and a new site installed at Jingliao, Taiwan. Details of the installation of the Jingliao array are given. ARX models are theoretically the correct process models for vertical wave propagation in the layered earth, and are used to linearly map deeper sensor input signals to shallower sensor output signals. An example of Event 16 at the Lotung array is given. This same data, when examined in detail with a Bayesian inference model, can also be explained by nonlinear filters yielding commonly accepted soil degradation curves. Results from applying an ARMAX model to data from the Jingliao vertical seismic array are presented. Estimates of inter-transducer soil increment resonant frequency, shear modulus, and damping ratio are presented. The shear modulus varied from 50 to 150 MPa, and damping ratio between 8% and 15%. A new hardware monitoring system - TerraScope - is an affordable 4-D down-hole seismic monitoring system based on independent, microprocessor-controlled sensor Pods. The Pods are nominally 50 mm in diameter, and about 120 mm long. An internal 16-bit micro-controller oversees all aspects of instrumentation, eight programmable gain amplifiers, and local signal storage.

• 한국가스학회지
• /
• 제14권4호
• /
• pp.56-62
• /
• 2010

본 논문은 LPG 엔진의 전자제어센서에 대한 고장사례를 분석하고 고찰한 연구이다. LP가스의 연료 분사량을 컨트롤하는 크랭크 각도센서의 기능이상은 불규칙하고 불균일한 파형형태로 나타나고 있다. 크랭크 각도센서의 노이즈에 관련된 파형은 톱니형의 불규칙한 피크형상으로 나타났고, 2.46V 정도의 노이즈 레벨이 간헐적으로 발생하고 있다. 1번 TDC센서의 내부불량으로 인해 발생한 고장사례는 엔진의 출력을 떨어뜨리고 시동을 간헐적으로 꺼지게 하는 문제점을 초래한다. 산소센서의 성능이상은 센서의 배선에서 연결이 단절되었기 때문에 발생한 것으로 차량의 울컥거리는 현상과 엔진의 부조화 현상이 나타나고 있다. 에어 크리너를 이종품으로 사용한 경우는 신기가 정상적으로 공급되지 못했기 때문에 차량의 가속불량과 엔진의 부조화 현상이 발생하는 원인으로 작용하고 있었다.