• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.4
• /
• pp.1209-1215
• /
• 2012

Background and Aim: Oxaliplatin hypersensitivity is a well-known adverse reaction but the prevalence varies and data for frequency and clinical features have not been reported for Korea. Here we evaluates the prevalence and risk factors for hypersensitivity reactions to oxaliplatin after chemotherapy. Methods: Clinical information on all patients treated with oxaliplatin was retrospectively reviewed in electronic medical records between August 2009 and July 2010 in Seoul National University Bundang Hospital. Patients who experienced hypersensitivity reactions to oxaliplatin were compared with those who did not. Results: A total of 393 patients received oxaliplatin, with 42 (10.7%) experiencing hypersensitivity reactions including three cases of anaphylaxis. Median cycle of the first hypersensitivity reaction was 8. Reactions correlated with lower dexamethasone doses. Other variables were not significant. Conclusions: The prevalence of hypersensitivity reactions was 10.7%, symptoms being mostly mild and cutaneous. Lower dexamethasone doses could be a predictor for hypersensitivity reactions to oxaliplatin.

• Korean Journal of Child Studies
• /
• v.29 no.5
• /
• pp.215-226
• /
• 2008

The purpose of this study was to identify dangerous routes by which the experience of victimization leads to bullying behavior and to clarify the intrapersonal moderating variables which control the routes. Subjects were 1,086 students of elementary and middle schools in Seoul and Gyeonggi Province. Data were analyzed by simple regression analysis and multiple moderating regression analysis. The major findings of this study were that (1) the experience of victimization was an important factor predicting bullying behavior; and (2) self esteem and internal locus of control were moderating variables between the experience of victimization and bullying behavior. This study provides effective information to protect students from bullying by finding some moderating variables.

• International Journal of Aeronautical and Space Sciences
• /
• v.18 no.4
• /
• pp.780-787
• /
• 2017

The propellant grain configuration is a design variable that determines the shape and performance of a solid rocket motor. Grain configuration variables have complicated effects on the motor performance; so the global optimization problem has to be solved in order to design the configuration variables. The grain performance has been analyzed by means of the grain burn-back and internal ballistic analysis, and the optimization technique searches for the configuration variables that satisfy the requirements. The deterministic and stochastic optimization techniques have been applied for the grain optimization, but the results are imperfect. In this study, the optimization design of the configuration variables has been performed using the hybrid optimization technique, which combines those two techniques. As a result, the hybrid optimization technique has proved to be efficient for the grain optimization design.

• Journal of the Korean Society of Safety
• /
• v.21 no.1 s.73
• /
• pp.28-34
• /
• 2006

A procedure of estimating failure probability is demonstrated for a pressurized pipe of CrMo steel used at $538^{\circ}C$. Probabilistic fracture mechanics were employed considering variations of pressure loading, material properties and geometry. Probability density functions of major material variables were determined by statistical analyses of implemented data obtained by previous experiments. Distributions of the major variables were reflected in Monte Carlo simulation and failure probability as a function of operating time was determined. The creep crack growth life assessed by conventional deterministic approach was shown to be conservative compared with those obtained by probabilistic one. Sensitivity analysis for each input variable was also conducted to understand the most influencing variables to the residual life analysis. Internal pressure, creep crack growth coefficient and creep coefficient were more sensitive to failure probability than other variables.

• Tuberculosis and Respiratory Diseases
• /
• v.73 no.4
• /
• pp.224-230
• /
• 2012

Background: We evaluated the clinical outcomes and prognostic factors of patients requiring prolonged mechanical ventilation (PMV), defined as ventilator care for ${\geq}21$ days, who were admitted to the medical intensive care unit (ICU) of a university hospital in Korea. Methods: During the study period, a total of 2,644 patients were admitted to the medical ICU, and 136 patients (5.1%) were enrolled between 2005 and 2010. Results: The mean age of the patients was $61.3{\pm}14.5$ years, and 94 (69.1%) were male. The ICU and six-month cumulative mortality rates were 45.6 and 58.8%, respectively. There were 96 patients with tracheostomy placement after admission and their mean period from admission to the day of tracheostomy was $21.3{\pm}8.4$ days. Sixty-three patients (46.3%) were successfully weaned from ventilator care. Of the ICU survivors (n=74), 34 patients (45.9%) were transferred to other hospitals (not university hospitals). Two variables (thrombocytopenia [hazard ratio (HR), 1.964; 95% confidence interval (CI), 1.225~3.148; p=0.005] and the requirement for vasopressors [HR, 1.822; 95% CI, 1.111~2.986; p=0.017] on day 21) were found to be independent factors of survival on based on the Cox proportional hazard model. Conclusion: We found that patients requiring PMV had high six-month cumulative mortality rates, and that two clinical variables (measured on day 21), thrombocytopenia and requirement for vasopressors, may be associated with prognostic indicators.

• Journal of Yeungnam Medical Science
• /
• v.24 no.2
• /
• pp.197-205
• /
• 2007

Background : The occurrence of atrial fibrillation after ablation of atrial flutter is clinically important. We investigated variables predicting this evolution in ablated patients without a previous atrial fibrillation history. Materials and Methods : Thirty-six patients (Male=28) who were diagnosed as atrial flutter without previous atrial fibrillation history were enrolled in this study. Group 1 (n=11) was defined as those who developed atrial fibrillation after atrial flutter ablation during 1 year follow-up. Group 2 (n=25) was defined as those who has not occurred atrial fibrillation during same follow-up term. Echocardiogram was performed to all patients. We measured left atrial size, left ventricle end diastolic and systolic dimension, ejection fraction and left atrial volume index before and after ablation of atrial flutter. The differences of each variables were compared and analyzed between two groups. Results : The preablation left ventricular ejection fraction (preLVEF) and postablation left ventricular ejection fraction (postLVEF) are $54{\pm}14%$, $56{\pm}13%$ in group 1 and $47{\pm}16%$, $52{\pm}13%$ in group 2. The differences between each two groups are statistically insignificant ($2.2{\pm}1.5$ in group 1 vs $5.4{\pm}9.8$ in group 2, p=0.53). The preablation left atrial size (preLA) and postablation left atrial size (postLA) are $40{\pm}4mm$, $41{\pm}4mm$ in group1 and $44{\pm}8mm$, $41{\pm}4mm$ in group 2. The atrial sizes of both groups were increased but, the differences of left atrial size between two groups before and after flutter ablation were statistically insignificant ($0.6{\pm}0.9mm$ in group 1 vs $-3.8{\pm}7.4mm$ in group 2, p=0.149). The left atrial volume index before flutter ablation was significantly reduced in group 1 than group 2 ($32{\pm}10mm^3/m^2$, $35{\pm}10mm^3/m^2$ in group 1 and $32{\pm}10mm^3/m^2$, $29{\pm}8mm^3/m^2$ in group 2, p<0.05). Conclusion : The difference between left atrial volume index before and after atrial flutter ablation is the robust predictor of occurrence of atrial fibrillation after atrial flutter ablation without previous atrial fibrillation.

• Journal of Families and Better Life
• /
• v.3 no.1
• /
• pp.69-76
• /
• 1985

This study was attempted to investigate the relationship between the academic achievement and the internal and external motivation of academic achievement. Here, the internal motivation of academic achievement refers to the case that a student feels the necessity of study and h satisfaction, expects rewards, or has interest in his study; external motivation of academic achievement means that a student has outward motivation such as other's recognition, rewards, or compulsion. As the result of this study, there showed significant difference in the academic achievement in proportion as the level of internal and external academic achievement motivation (P<.001). the students with the higher internal motivation and the lower external motivation turned out to have the highest effect of academic achievement; on the other hand, the students with the lower internal motivation and the higher external motivation showed the least academic achievement. There was 11.60 points-difference on the average between those two groups in terms of grade. The academic achievement and the internal motivation shows significant correlation(r=.25, P<.001) while academic achievement and the external motivation presents negative tendency (r=-.10). Through the results of regression analysis, the estimation of the academic achievement by the two variables to academic achievement motivation was 6.22%(P=.0001)

• The Journal of Asian Finance, Economics and Business
• /
• v.7 no.2
• /
• pp.181-193
• /
• 2020

The midst competition makes a brand all together with its offering products and services is becoming a crucial element for company existence. This requires direct involvement from internal organizational to develop effective strategic branding. According to Asosiasi Penyelenggara Internet Indonesia (APJII), Indonesia's internet penetration is among the highest in Asia. The purpose of this research is to improve the strategic role of brand orientation within Internet Service Provider (ISP) for maximizing return on the company's financial and non-financial benefits by proposing organization change readiness variable. The data collection is taken using an online survey with a non-parametric sampling method and collected 68 qualified respondents for data analysis using SEM-PLS (Structural Equation Modeling with Partial Least Square). The result indicates partial hypotheses on the constructed model between variables brand orientation, brand commitment, and internal brand equity is acceptable. Another finding is stated hypotheses on organization change readiness as moderation is not accepted and means there is no significance to the constructed model. The main conclusion resumes associative human memory can shape up organization change readiness inside internal toward then brand. Relevant cues generate information received in the human brain then will create common associative and becoming social identity on internal brand equity.

• The Journal of Internal Korean Medicine
• /
• v.41 no.3
• /
• pp.434-446
• /
• 2020

Objectives: The cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) are non-invasive methods to evaluate cardiovascular disease and arteriosclerosis. This study investigated the relationship between CAVI, ABI, and factors related to arteriosclerosis. Methods: This study included 535 healthy adults who underwent health examinations in 2019. We analyzed the correlation between CAVI, ABI and clinical variables. Multiple regression analysis was performed on the independent clinical variables associated with CAVI and ABI. Results: The correlation analysis of CAVI showed that body mass index (BMI) and HDL-cholesterol (HDL-C) had a negative correlation, and the other variables had a significant positive correlation. The correlation analysis with ABI on the right side showed that age, diastolic blood pressure (DBP), gender, and LDL-cholesterol (LDL-C) had a significant positive correlation, while HDL-C had a significant negative correlation. There was no statistical significance on the left. In the multiple regression analysis, DBP, age, BMI, gender, and HDL-C were proved to be independent factors in CAVI (right) (R²=0.365); DBP, age, gender, BMI, fasting blood sugar, and total cholesterol in CAVI (left) (R²=0.357); and age, gender, DBP, and systolic blood pressure in ABI (right) (R²=0.133). There were no statistically significant factors in ABI (left). It could be inferred that smoking and drinking are determinants that play an important role in CAVI. Conclusion: CAVI showed a high correlation with gender, age, and blood pressure. A significant correlation between CAVI and serum lipid values could be observed, but this showed a low correlation coefficient. ABI showed a high correlation with age and DBP. These results support the use of CAVI and ABI as primary diagnostic devices in medical treatment.

• Journal of the Korean Society of School Health
• /
• v.8 no.2
• /
• pp.315-326
• /
• 1995

This study was performed to find variables which affect oral health care of infants. The subjects were 439 infants and their mothers who live in suburban area. Oral examinations for the infants were conducted and the questionnairs were given to infants' mothers. Toothbrushing frequency, oral hygiene score, the percentage of filled teeth among decayed teeth, and dental treatment experience of infants were used as dependent variable, respectively. Demographic, socio-economic variables and the other variables which might affect oral health care of infants were used as independent variables. Correlation analysis and analysis of variance were used for the independent variables of toothbrushing frequency, oral hygiene score, and the percentage of filled teeth among decayed teeth of infant. Chi-Square and Student's t-test were used for the dependent variables of dental treatment experience of infant. The obtained results were as follows; 1. Toothbrushing frequency of mother and internal locus of oral control of mother were the factors which affect toothbrusing frequency of infants. 2. Oral health belief of mother was the factor which affect oral hygiene score of infants. 3. Age of infant was the factor which affect the percentage of filled teeth among decayed teeth. 4. Age of infant and educational level of infant's mother were the factors which affect the infants' consumption of dental treatment.