• 제목/요약/키워드: internal stability

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초고압 추출 처리에 의한 마황과 당귀의 항암 활성 증진 (Enhancement of Anticancer Activities of Ephedra sinica, Angelica gigas by Ultra High Pressure Extraction)

  • 정향숙;한재건;하지혜;김영;오성호;김승섭;정명훈;최근표;박욱연;이현용
    • 한국약용작물학회지
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    • 제17권2호
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    • pp.102-108
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    • 2009
  • This study was performed to enhance anticancer activities of E. sinica, and A. gigas by ultra high pressure extraction process. The cytotoxicity of E. sinica and A. gigas on human kidney cell (HEK293) was as low as 24.94% and 25.3% in adding 1.0 $mg/m{\ell}$ of the sample extracted at 500 Mpa for 15 minute. Generally, the inhibition of cancer cell growth on A549 and MCF-7 was increased over 20% in the ultra high pressure samples, compared to the conventional extraction process. Under the extracts from ultra high pressure process showed not only the strongest anticancer activities, but also had better stability than normal extracts. It was also found that the extracts of A. gigas reduced the hypertrophy of the internal organs, such as adrenal and spleen caused stresses in several mouse models.

콜레스테릴옥시카본화 그리고 (콜레스테릴옥시카보닐)알카노화 셀룰로오스들의 열방성 액정 특성 (Thermotropic Liquid Crystalline Properties of Cholesteryloxycarbonated and (Cholesteryloxycarbonyl) alkanoated Celluloses)

  • 정승용;마영대
    • 폴리머
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    • 제32권2호
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    • pp.169-177
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    • 2008
  • 셀룰로오스 트리콜레스테릴옥시카보네이트(CCE0)와 셀룰로오스 트리(콜레스테릴옥시카보닐)알카노에이트들(CCEn, $n=2{\sim}8$,10, 스페이서중의 메틸렌 단위들의 수)의 열 및 광학 특성을 검토하였다. CCE0는 쌍방성 콜레스테릭 상을 형성하는 반면 모든 CCEn은 단방성 콜레스테릭 상들을 형성하였다. $n=3{\sim}8$인 CCEn은 온도상승에 의해 광학피치들(${\lambda}_m's$)이 감소하는 좌측방향의 나선구조를 지닌 콜레스테릭 상들을 형성하였다. 한편, CCE0 그리고 n=2 혹은 10인 CCEn은 콜레스테릭 상의 전 범위에서 반사색깔을 나타내지 않았다. 이러한 사실은 콜레스테릴 그룹에 의한 나선의 비틀림력은 콜레스테릴 그룹과 주사슬을 연결하는 스페이서의 길이에 민감하게 의존함을 시사한다. CCEn에서 관찰되는 액정 상의 열적 안정성과 질서도 그리고 ${\lambda}_m$의 온도의존성은 n에 민감하게 의존하였다. 이들의 결과를 주사슬의 가소화, 곁사슬 그룹의 배열 그리고 분자들의 입체형태의 차이들의 견지에서 검토하였다.

3차원 고세장비 공동 주위의 난류유동 및 음향 특성에 관한 수치적 연구 (NUMERICAL ANALYSIS FOR TURBULENT FLOW AND AERO-ACOUSTICS AROUND A THREE DIMENSIONAL CAVITY WITH HIGH ASPECT RATIO)

  • 문바울;김재수
    • 한국전산유체공학회지
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    • 제15권2호
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    • pp.7-13
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    • 2010
  • Flight vehicles such as wheel wells and bomb bays have many cavities. The flow around a cavity is characterized as an unsteady flow because of the formation and dissipation of vortices brought by the interaction between the free stream shear layer and the internal flow of the cavity. The resonance phenomena can damage the structures around the cavity and negatively affect the aerodynamic performance and stability of the vehicle. In this study, a numerical analysis was performed for the cavity flows using the unsteady compressible three-dimensional Reynolds-Averaged Navier-Stokes (RANS) equation with Wilcox's turbulence model. The Message Passing Interface (MPI) parallelized code was used for the calculations by PC-cluster. The cavity has aspect ratios (L/D) of 5.5 ~ 7.5 with width ratios (W/D) of 2 ~ 4. The Mach and Reynolds numbers are 0.4 ~ 0.6 and $1.6{\times}10^6$, respectively. The occurrence of oscillation is observed in the "shear layer and transient mode" with a feedback mechanism. Based on the Sound Pressure Level (SPL) analysis of the pressure variation at the cavity trailing edge, the dominant frequencies are analyzed and compared with the results of Rossiter's formula. The dominant frequencies are very similar to the result of Rossiter's formula and other experimental datum in the low aspect ratio cavity (L/D = ~4.5). In the high aspect ratio cavity, however, there are other low dominant frequencies of the leading edge shear layer with the dominant frequencies of the feedback mechanism.

보행 시 농작업 종사자들의 슬관절 퇴행성 등급에 따른 지면반력 특성 분석 (Analysis of the Characteristics of Ground Reaction Force According to the Level of Knee Osteoarthritis During Gait)

  • 이경일;이철갑;홍완기;김민
    • 한국운동역학회지
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    • 제25권4호
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    • pp.393-399
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    • 2015
  • Objective : This study was conducted with an aim to use it as basic data for developing assistive devices, such as insoles that can suppress the progress of degenerative diseases and strategies, to improve early degenerative diseases by assessing walking characteristics of farm workers who were classified as KL-grade in the perspective of motor mechanics. Method : 38 male and female adults who complained of knee joint pain for more than six months were selected, and they were classified according to KL-grade. KL-grade was assessed by an orthopaedic specialist and an occupational environment health specialist. Filming equipment (FX-1, CASIO, Japan) and a ground reaction force system (AMTI OR6, AMTI, USA) were used to identify ground reaction force characteristics, and WOMAC was used for a pain rating scale. Results : There was a difference between the right and left side (axis-X) according to KL-grade, and when the grade was higher, the internal ground reaction force was also higher. Changes in COP were not affected by KL-grade of the knee joint, but it tended to increase as the grade increased. There were differences in the time required for limb support while walking according to the grades, and when the grade was higher, walking was more inefficient with long braking force and short propulsion forces. Also, pain rating scale, the right and left side, and COP changes while in support phase were related. Conclusion : There was a partial, statically significant difference in KL-grade and ground reaction force occurring during the support phase, and there were differences in ground reaction forces according to the grades of degenerative arthritis in the knee joint, indicating that this study is worthy as basic data for future studies.

TRISO 입자를 포함하는 SiC 복합소결체의 소결 및 특성 평가 (Sintering and Characterization of SiC-matrix Composite Including TRISO Particles)

  • 이현근;김대종;박지연;김원주
    • 한국세라믹학회지
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    • 제51권5호
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    • pp.418-423
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    • 2014
  • Fully ceramic micro encapsulated (FCM) nuclear fuel is a concept recently proposed for enhancing the stability of nuclear fuel. FCM nuclear fuel consists of tristructural-isotropic (TRISO) fuel particles within a SiC matrix. Each TRISO fuel particle is composed of a $UO_2$ kernel and a PyC/SiC/PyC tri-layer which protects the kernel. The SiC ceramic matrix is created by sintering. In this FCM fuel concept, fission products are protected twice, by the TRISO coating layer and by the SiC ceramic. The SiC ceramic has proven attractive for fuel applications owing to its low neutron-absorption cross-section, excellent irradiation resistivity, and high thermal conductivity. In this study, a SiC-matrix composite containing TRISO particles was sintered by hot pressing with $Al_2O_3-Y_2O_3$ additive system. Various sintering conditions were investigated to obtain a relative density greater than 95%. The internal distribution of TRISO particles within the SiC-matrix composite was observed using an x-ray radiograph. The fracture of the TRISO particles was investigated by means of analysis of the cross-section of the SiC-matrix composite.

낮은 구속응력에 대한 주문진 표준사의 강도 및 변형 특성 (The Strength and Deformation Characteristics of Jumunjin Sand under Low Confining Stresses)

  • 한영철;임현성;정상섬
    • 한국지반공학회논문집
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    • 제30권2호
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    • pp.33-42
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    • 2014
  • 매우 낮은 구속응력에서의 모래의 전단강도 및 변형특성은 상대적으로 높은 구속응력의 경우와 매우 상이한 분포를 나타낸다. 따라서 낮은 응력상태를 보이는 지반 위에 놓인 얕은 기초와 제방 등의 안정성, 토석류 혹은 얕은 파괴의 안정성 검토와 실내에서 시행하는 각종 모델시험의 경우 이에 대하여 명확히 규명할 필요가 있다. 본 연구에서는 건조된 주문진 표준사를 대상으로 구속응력을 5kPa~300kPa로 하여 배수 삼축시험을 실시하였으며, 그 결과 내부마찰각(${\phi}$) 및 변형계수($E_s$)가 구속응력(${\sigma}{_c}^{\prime}$)에 따라 크게 변하는 것을 확인하였으며, 이에 따라 구속응력에 대한 조밀 및 느슨한 모래의 내부마찰각과 변형계수의 상관관계식을 제안하였다.

도서관 기부문화 정착을 위한 기업기부 사례분석 연구 (A Study Analyzing Donation Cases for Establishing Library Corporate Donation Culture)

  • 노영희
    • 한국문헌정보학회지
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    • 제48권2호
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    • pp.109-135
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    • 2014
  • 도서관은 지역사회의 지적요구에 부응하고 정보제공, 문화향유, 평생교육 제공 등의 역할을 하는 사회적 기반 시설로서 그 중요성과 역할은 높이 평가할 만하다. 그러나 국가 및 지방자치단체의 한정된 재원으로 다양화 고급화된 도서관 이용자의 요구 및 새로이 부여받은 도서관의 역할 수행에 어려움을 겪고 있는 것이 사실이다. 이에 본 연구에서는 도서관 핵심인프라 확충과 운영의 내실화를 위한 재원확보의 한 방안으로 도서관 기부문화 정착을 제안하고 있으며, 이를 위해 도서관에의 기업기부사례를 조사 분석함으로써 기업의 기부목적, 기부내용, 기부대상, 기부캠페인 여부, 건립 및 리모델링된 도서관 수, 그리고 기업기부로 인해 도서관이 얻은 효과 등을 밝혔다. 본 연구결과는 이후 도서관이 기부기업을 유치하는데 있어 기초자료가 될 것으로 보인다.

디지털 포렌식 관점에서 SSD TRIM 명령의 선별적 복구 (Selective Recovery of the SSD TRIM Command in Digital Forensics)

  • 황현호;박동주
    • 정보처리학회논문지:컴퓨터 및 통신 시스템
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    • 제4권9호
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    • pp.307-314
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    • 2015
  • 최근 보조기억장치 스토리지 시장 추세는 HDD와 SSD가 혼용되어 사용되고 있다. 미래에는 HDD보다 SSD가 보조기억장치 역할로 더욱 많이 사용될 것으로 예상되고 있다. SSD 기술이 발달하면서 이를 효율적으로 사용하기 위해 TRIM 명령기법이 나오게 되었다. TRIM 명령기법은 과거 SSD의 문제점인 Freezing 현상을 해결하기 위해 나온 명령으로 운영체제와 SSD가 협동하여 작동한다. TRIM 명령기법은 사용자가 데이터를 삭제하였을 때 SSD 내부에서도 실제로 삭제하는 기법으로 유휴시간에 수행한다. 하지만, 디지털 포렌식 관점에서 본다면 디지털 범죄는 매년 급증하지만 데이터 미복구로 인한 검거율은 미흡하다. 본 논문에서는 기존 TRIM 명령의 장점인 안정성(Freezing Solution)과 쓰기 속도를 최대한 지원하며 선별적으로 데이터를 관리하여 삭제하는 기법을 제안한다. 실험을 통해 기존 기법과 선별된 기법의 성능을 측정하여 검증한다.

Integrated Tree Crops-ruminants Systems in South East Asia: Advances in Productivity Enhancement and Environmental Sustainability

  • Devendra, C.
    • Asian-Australasian Journal of Animal Sciences
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    • 제24권5호
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    • pp.587-602
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    • 2011
  • Improved efficiency in the use of natural resources, pragmatic production systems and environmental sustainability, justified by the need for improved land use systems and increased productivity, are discussed in the context of Asian integrated systems, diversification, and issues of sustainability. The importance of these are reflected by serious inadequate animal protein production throughout Asia, where available supplies cannot match current and projected human requirements up to 2050. Among the ruminant production systems, integrated tree crops-ruminant production systems are grossly underestimated and merit emphasis and expansion. As an example, integrated oil palm- based system is an important pathway for integration with ruminants (buffaloes, cattle, goats and sheep), and provides the entry point for development. The importance and benefits of integrated systems are discussed, involving animals with annual and perennial tree crops, integration with aquaculture, the significance of crop-animal interactions, stratification of the systems, production options, improved use of forages and legumes, potential for enhanced productivity, implications for improved livelihoods of the rural poor and the stability of farm households. The advances in research and development in South East Asia highlight demonstrable increased productivity from animals and meat offtakes, value addition to the oil palm crop, sustainable development, and distinct economic impacts. The results from 12 out of a total of 24 case studies concerning oil palm over the past three decades showed increased yield of 0.49-3.52 mt of fresh fruit bunches (FFB)/ha/yr; increased income by about 30%; savings in weeding costs by 47- 60% equivalent to 21-62 RM/ha/yr; and an internal rate of return of 19% based on actual field data. The results provide important socio-economic benefits for resource-poor small farmers. Potential increased offtakes and additional income exist with the integration of goats. Additionally, the potential for carbon sequestration with tree crops is an advantage. The reasons for low adoption of the syatems are poor awareness of the potential of integrated systems, resistance by the crop- oriented plantation sector, and inadequate technology application. Promoting wider expansion and adoption of the systems in the future is linked directly with coherent policy, institutional commitment, increased investments, private sector involvement, and a stimulus package of incentives.

Sloshing suppression by floating baffle

  • Kang, Hooi-Siang;Md Arif, Ummul Ghafir;Kim, Kyung-Sung;Kim, Moo-Hyun;Liu, Yu-Jie;Lee, Kee-Quen;Wu, Yun-Ta
    • Ocean Systems Engineering
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    • 제9권4호
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    • pp.409-422
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    • 2019
  • Sloshing is a phenomenon which may lead to dynamic stability and damages on the local structure of the tank. Hence, several anti-sloshing devices are introduced in order to reduce the impact pressure and free surface elevation of liquid. A fixed baffle is the most prevailing anti-sloshing mechanism compared to the other methods. However, the additional of the baffle as the internal structure of the LNG tank can lead to frequent damages in long-term usage as this structure absorbs the sloshing loads and thus increases the maintenance cost and downtime. In this paper, a novel type of floating baffle is proposed to suppress the sloshing effect in LNG tank without the need for reconstructing the tank. The sloshing phenomenon in a membrane type LNG tank model was excited under sway motion with 30% and 50% filling condition in the model test. A regular motion by a linear actuator was applied to the tank model at different amplitudes and constant period at 1.1 seconds. Three pressure sensors were installed on the tank wall to measure the impact pressure, and a high-speed camera was utilized to record the sloshing motion. The floater baffle was modeled on the basis of uniform-discretization of domain and tested based on parametric variations. Data of pressure sensors were collected for cases without- and with-floating baffle. The results indicated successful reduction of surface run-up and impulsive pressure by using a floating baffle. The findings are expected to bring significant impacts towards safer sea transportation of LNG.