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The Effect of Antibiotics in Combination with EDTA-Tris on the Methicillin-Resistant Major Pathogens of Bovine Mastitis in Milk (유즙내에서 메티실린 내성을 지닌 젖소 유방염 주요 원인균에 대한 항생제와 EDTA-Tris의 병합의 효과)

  • Yoo, Jong-Hyun;Park, Hee-Myung
    • Journal of Veterinary Clinics
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    • v.25 no.5
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    • pp.346-354
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    • 2008
  • The combined effects of EDTA-Tris and eighteen antimicrobial agents have been evaluated in eight clinically isolated methicillin-resistant bacteria (Staphylococcus aureus, Escherichia coli, Streptococcus uberis and Streptococcus agalactiae) from bovine mastitis. The antimicrobial activity was evaluated by measuring the minimal bactericidal concentration (MBC) for the antibiotics alone or in combination with EDTA-Tris in Mueller-Hilton broth and milk. Combined use of EDTA-Tris and antibiotics potentiated or antagonized activity of antibiotics against mastitic pathogens. Milk increased the antibiotic potency of erythromycin and spiramycin on S. aureus. Culture in milk changed patterns of EDTA-Tris combinational effects compared with that in standard Mueller-Hilton broth. Combined with EDTA-Tris in milk, synergic effects were observed in colistin, dihydrostreptomycin, kanamycin, erythromycin, gentamycin, oxytetracycline, streptomycin to E. coli, Str. uberis, and Str. agalactiae. However, significant antagonistic effects of milk on antibiotic susceptibility in combination with EDTA-Tris were noted in neomycin, streptomycin, penicillin, roxithromycin, and amoxicillin. This study indicates that combination therapy of EDTA-Tris with antibiotics in bovine mastitis should be used with caution because of the possible antagonistic effects of antibiotic combination with EDTA-Tris on mastitic pathogens. In addition, antibiotic susceptibility test in combination with EDTA-Tris in milk culture condition can be benefit in search of effective treatment regimen for some antibiotic-resistant bacteria of mastitis.

A Survey on Ancient Literature Records on Woohwangchungsim-won and its potential clincial application (우황청심원의 고문헌기록 및 실험적 연구결과 분석을 통한 임상응용 확대의 필요성 고찰)

  • Oh, Young-Taeck;Oh, Hyeon-Muk;Kim, Seo-Woo;Kim, Won-Yong;Son, Chang-Gue;Cho, Jung-Hyo
    • Journal of Haehwa Medicine
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    • v.26 no.1
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    • pp.1-10
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    • 2017
  • Objectives: The aim of this study is (1) to investigate the historic changes and pharmacological efficacies of Woohwangchungsim-won and (2) to discuss the necessities for Woohwangchungsim-won's clinical applications. Methods: This study was performed through (1) investigating the ancient literature records related with Woohwangchungsim-won and analyzing Woohwangchungsim-won's composition, dosage and indications, (2) searching articles about Woohwangchungsim-won on 10 major Korean web and 3 major foreign web article search engines and analyzing Woohwangchungsim-won's pharmacological efficacies and indications. Results: Woohwangchungsim-wom has been used for cerebrovascular diseases such as stroke and palpitation. Also, there are some ancient literature records of Woohwangchungsim-won's clinical applications in neuropsychiatric disorders such as depression and bipolar disorder. In addition, there have been a number of experimental studies which demonstrate Woohwangchungsim-won's neuroprotective effect on cerebral cortex and hippocampus injury. So, it is possible to infer that Woohwangchungsim-won can be used for the treatments of neuropsychiatric disorders associated with neuronal cell death in cerebral cortex and hippocampus. But there have been no or less experimental studies which demonstrate the pharmacological efficacy of Woohwangchungsim-won on such disease. Conclusion: It is necessary that further experimental studies which demonstrate Woohwangchungsim-won's pharmacological efficacy on neuropsychiatric disorders should be done and Woohwangchungsim-won's clinical applications should be expanded on the basis of those related experimental results.

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Acupuncture and Moxibustion for Primary Dysmenorrhea in Korean Literatures: A Systematic Review of Randomized Controlled Trials (원발성 월경곤란증에 대한 침구치료 관련 무작위배정 임상시험의 체계적 고찰: 한국 문헌을 중심으로)

  • Kim, Jung Wan;Park, Bong Ki;Jeon, Jong Ik;Yim, Yun Kyoung
    • Journal of Acupuncture Research
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    • v.32 no.2
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    • pp.123-130
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    • 2015
  • Objectives : Primary dysmenorrhea is one of the most common female gynecological diseases. Acupuncture and moxibustion therapy have been used to treat dysmenorrhea in Korea. The aim of this review was to examine the effectiveness of acupuncture and moxibustion therapy for primary dysmenorrhea as described in studies in Korea. Methods : A total of 8 databases were searched, with the search concluding February 15, 2015. These were the Oriental Medicine Advanced Searching Integrated System, DBpia, Korean Studies Information Service System, National Digital Science Library, Korean Traditional Knowledge Portal, Research Information Sharing Service, and Pubmed. Randomized controlled Trails(RCTs) comparing acupuncture or moxibustion therapy with non acupoints stimulation or medication were selected. Data abstraction and assessment of methodology was conducted by authors and disagreements were resolved by discussion. Results : 7 trials were included in this review, with a total of 308 participants. 4 trials reported on acupuncture, 1 trial reported on acupress by magnet, 1 trial reported on pharmacopuncture, and the other trial reported on moxibustion. Quality of methodology was low. 2 trials showed that experimental therapy was effective for pain relief compared to the controlled group. However, 5 trials did not show a significant difference in pain relief. Conclusions : Acupuncture and moxibustion therapy may reduce period pain, however, it is needed for well designed RCTs in Korea.

Model Test of Dual-Buoy Wave Energy Converter using Multi-resonance (다중 공진을 이용한 이중 부이 파력발전장치의 모형실험)

  • Kim, Jeong-Rok;Hyeon, Jong-Wu;Koh, Hyeok-Jun;Kweon, Hyuck-Min;Cho, Il-Hyoung
    • Journal of Ocean Engineering and Technology
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    • v.29 no.2
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    • pp.191-198
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    • 2015
  • In this study, we proposed a new type of dual-buoy wave energy converter (WEC) exploiting multi-resonance and analyzed the experimental results from a model test in a 2-D wave flume. A dual-buoy WEC using multi-resonance has two advantages: high efficiency at the resonant frequencies and the potential to extend the frequency range available to extract wave power from the WEC. The suggested WEC was composed of an outer buoy and an inner buoy sliding vertically inside the outer buoy. As the power take-off device, a linear electric generator (LEG) consisting of permanent magnets and coils fixed at each buoy was adopted. Electricity was produced by the relative heave motion between the two buoys. To search for the optimal shape of a dual-buoy WEC, we conducted experiments on the heave motion of a two-body system in regular waves without an LEG installed. Model tests with six combinations of experimental models were conducted in order to find the motion characteristics of a dual-buoy WEC. It was found that model 2, which included a ring-shaped appendage to move the resonant frequency of the outer buoy toward a high value, showed a higher relative heave response amplitude operator (RAO) curve than model 1. In addition, the double-peak shape of the heave RAO curve shown for model 2 indicated the extension of the frequency range for extracting wave power in irregular waves.

Design and Realization of Retrieval Engine On Demand Using a Dynamic Robot Agent (동적 로봇에이전트를 이용한 주문형 검색엔진의 설계 및 구현)

  • Kim, Sung;Park, Chol-Woo;Lee, Chung-Seok;Park, Kyoo-Seok
    • The KIPS Transactions:PartD
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    • v.8D no.5
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    • pp.631-636
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    • 2001
  • The technologies relevant to e-business have rapidly developed during very short period of time and recently it is expanding to the area of B2B. Keeping pace with this development in e-business, the information of comparison or analysis on commodities of a lot of sites is also required. Though the information on price comparison among internal shopping malls are now being offered, its not efficient for its renewing intervals are long and, due to some indiscreet collection of information for the purpose of fast renewal, much loads are being generated on the pertinent shopping malls. In this article, the retrieval engine on demand is designed and realized using a dynamci robot agent changing kinetically on the status of the pertinent shopping malls that can offer the customized service and presents the shopping malls with the lowest price for each commodity under e-business after the shortest time of collection and analysis while not giving loads to the pertinent shopping malls.

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Research Activities of Transpiration Cooling for Liquid Rocket and Air-breathing Propulsions (액체로켓과 공기흡입식 추진기관을 위한 분출냉각의 연구동향)

  • Hwang, Ki-Young;Kim, You-Il;Song, In-Hyuck
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2010.11a
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    • pp.235-240
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    • 2010
  • Transpiration cooling is the most effective cooling technique for liquid rocket and air-breathing engines operating in aggressive environments with higher pressures and temperatures. Combustor liners and turbine vanes are cooled by the coolant(air or fuel) passing through their porous walls and also the exit coolant acting as an insulating film. However, its practical implementation has been hampered by the limitations of available porous materials. The search for more practical methods of increasing the internal heat transfer within the walls has led to the development of multi-laminate porous structures, such as Lamilloy$^{(R)}$ and Transply$^{(R)}$. This paper reviews recent research activities of transpiration cooling for the propulsions of liquid rocket, gas turbine, and scramjet.

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Recent Research Trends in Korean Medicine Treatment of Diabetes mellitus (당뇨의 한의학적 치료에 대한 최근 연구동향)

  • Jung, Han-Sung;Yu, Jung-Suk;Song, Beom-Yong
    • Journal of Pharmacopuncture
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    • v.11 no.4
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    • pp.65-77
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    • 2008
  • Objective The purpose of this study was to analyze the directions of Korean Medicine treatment of diabetes mellitus. Methods We reviewed the 52 studies about diabetes mellitus which had been published from 2000 to 2007. We selected those studies from the search engine of the web site of five journals. Those were the Journal of Korean Oriental Medical Society, Korean Journal of Oriental Physiology & Pathology, the Journal of Korean Acupuncture & Moxibustion Society, Korean Journal of Oriental Internal Medicine and the Journal of Korean Pharmacopuncture Institute. Results 1. The types of diabetes mellitus model in studies were the model used Alloxan(2cases), the model used Streptozotocin(41cases), NOD mice(1case), ob/ob mice(1case), db/db mice(5cases) and rats fed highfat diet(2cases). 2. The types of method in studies were pharmacopuncture(8cases), herbal medcine(47case) and both pharmacopuncture and herbal medcine(3cases). the types of materials in studies were single herb(24cases), multiple herbs(32cases) and both single and multiple herbs(4cases). 3. The types of evaluation criteria in studies were glucose, pancreas, liver, kidney, serum lipid, oxidative stress, nervous system, vascular system and immunity. Conclusions There have been reported many studies of diabetes mellitus in Korean Medicine. It requires to study further types of diabetes mellitus, kinds of herbs and complications of diabetes mellitus for Korean Medicine treatment of diabetes mellitus was covered the ground.

A Review of Key Performance Indicators Using a Balanced Scorecard in the Nursing Department of Hospitals (균형성과표를 이용한 병원 간호조직의 핵심성과지표 문헌분석)

  • Lim, Ji Young;Ok, Seung Eun;Ko, Gug Jin;Lee, Hyun Hee;Park, Yeon Hong;Jang, Jin Hui;Yun, Soo Mi
    • Journal of Home Health Care Nursing
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    • v.21 no.1
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    • pp.14-25
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    • 2014
  • Purpose: The purpose of this study was to analyze key performance indicators using a balanced scorecard in the nursing department of hospitals, and to find useful suggestions for future research. Methods: Before starting the literature search clear inclusion and exclusion criteria were determined. After that, were viewed 41 studies from the RISS, KISS, National assembly library, and NDSLDB. Data were collected on October 17, 2013. Researchers developed an analytic framework for the literature review using a balanced score card development process and construction steps of previous studies. This framework had 10 steps related to the balanced score card development process. Results: A total of 10 studies met the inclusion and exclusion criteria. We identified 234 key performance indicators for the nursing department. The average number was 6.6 in finance perspective, 8.6 in perspective, 11.9 in internal process perspective, and 6.2 in learning and growth perspective. We found that 173 indicators had been cited only once. 61 indicators were cited over twice. Further, 8 indicators employed different perspectives on different studies. Conclusion: The results of the present study summarize useful information on recent trends on key performance indicators using a balanced score card in the nursing department of hospitals. These results will help develop key performance indicators and provide directions for future research.

Degradation Diagnosis of Complex System Using Regression Analysis (회귀분석을 이용한 복합 시스템의 열화진단)

  • 김성홍;박재준;김재환
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.13 no.1
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    • pp.39-45
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    • 1999
  • Because of internal voids in insulators give rise to partial discharge(PD), which cause local breakdown and even entire insulation breakdown. Treeing due to PD is one of the main causes of breakdown of the insulating materials and nrluction of the insulation life. 1berefore the necessity for establishing a rrethod to diagnose the aging of insulation materials and to predict the breakdown of insulation has becorne irrportant. From this viewpoint, our studies diagnose insulation degradation using the rrethod of computer sensing system, which has PD and acoustic emission(AE) sensing system. To use advantages of these two methods can be used effectiveiy to search for treeing location and PD in sorre materials. In analysis rrethod of degradation, we analyzed the PD and AE pulses by regression analysis, corrpared to these obtained the correlation coefficient and retermination coefficient by T-distribution and saw that PD and AE pulses show a similar pattern on the whole. This has a similar teIlrency to the results of the research by Yoshimura and Fujita.Fujita.

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Development of High Speed Scalar Product Operation System for ECC Public Key (타원곡선 공개키 생성을 위한 고속 스칼라곱 연산 시스템 구현)

  • Kim, Kap-Yol;Lee, Chul-Soo;Park, Seok-Cheon
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.14 no.2
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    • pp.394-402
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    • 2010
  • At a recent, enterprises based on online-service are established because of rapid growth of information network. These enterprises collect personal information and do customer management. If customers use a paid service, company send billing information to customer and customer pay it. Such circulation and management of information is big issue but most companies don't care of information security. Actually, personal information that was managed by largest internal open-market was exposed. For safe customer information management, this paper proposes the method that decrease load of RSA cryptography algorithm that is commonly used for preventing from illegal attack or hacking. The method for decreasing load was designed by Binary NAF Method and it can operates modular Exponentiation rapidly. We implemented modular Exponentiation algorithm using existing Binary Method and Windows Method and compared and evaluated it.