• Title/Summary/Keyword: internal parameter

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A Study on the Estimation of Regional Myocardial Blood Flow in Experimental Canine Model with Coronary Thrombosis using Rb-82 Dynamic Myocardial Positron Emission Tomography (실험 개에서 Rb-82 심근 Dynamic PET 영상을 이용한 국소 심근 혈류 예측의 기본 모델 연구)

  • Kwark, Cheol-Eun;Lee, Dong-Soo;Kang, Keon-Wook;Hwang, Eun-Kyung;Jeong, Jae-Min;Chang, Kee-Hyun;Chung, June-Key;Lee, Myung-Chul;Seo, Joung-Don;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.29 no.1
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    • pp.48-53
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    • 1995
  • This study investigates a simple mathematical model for the quantitative estimation of regional myocardial blood flow in experimental canine coronary artery thrombosis using Rb-82 dynamic myocardial positron emission tomography. The coronary thrombosis was induced using the new catheter technique by narrowing the lumen of coronary vessel gradually, which finally led to partial obstruction of coronary artery. Ten Rb-82 dynamic myocardial PET scans were performed sequentially for each experiment using our 5, 10 and 20 second acquisition protocol, respectively, and three regions of interest were drawn on the transaxial slices, one on left ventricular chamber for input function and the other two on normal and decreased perfusion segments for the flow estimation in those regions. Single compartment model has been applied to the measured sets of regional PET data, and the rate constants of influx to myocardial tissue were calculated for regional myocardial flow estimates with the three parameter fits of raw data by the Levenberg-Marquardt method. The results showed that, (1) single compartment model suggested by Kety-Schmidt could be used for the simple estimation of regional myocardial blood flow, (2) the calculated regional myocardial blood flow estimates were dependent on the selection of input function, which reflected partial volume effect and left ventricular wall motion, and (3) mathematically fitted input and tissue time activity curves were more suitable than the direct application of the measured data in terms of convergence.

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Engineering Characteristics of the Light Weight Soil Using Phosphogypsum and EPS Beads (인산석고-EPS 조각을 활용한 경량혼합토의 공학적 특성)

  • Kim, Youngsang;Suh, Dongeun;Kim, Wonbong;Lee, Woobum
    • Journal of the Korean GEO-environmental Society
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    • v.10 no.6
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    • pp.19-25
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    • 2009
  • The current study developed light-weighted mixed soil that can solve problems related with soft soil such as ground subsidence, sliding and lateral displacement of ground. By reducing weight of reclaimed soil through mixing phosphogypsum and recycled EPS beads with the weathered granite soil. A series of geotechnical laboratory tests including physical index test, compaction test, CBR test, and direct shear test were performed and engineering properties were reviewed in order to assess applicability of the light-weighted mixed soil for roads and abutment and various back-filling materials at the reclamation area. Based on the laboratory test results, it was found that the maximum dry unit weight of the light-weighted soil ranges $14.32{\sim}15.79kN/m^3$ and the optimum water content ranges 21.91~24.23%, which means there is 11~19.3% weight decrease effect when comparing with general weathered granite soil. Also it was found that the corrected CBR value ranges 10.4~18.4% satisfying the domestic regulations on road subgrade and back-filling material. In addition, as for shear strength parameter, cohesion ranges 10.79~18.64 kPa and internal frictional angle ranges $35.4{\sim}37.2^{\circ}$, which are similar with those of general construction soil and back-filling material used in Korea. So it can be concluded that light-weighted mixed soil with phosphogypsum can be used effectively for soft reclamation ground as actual filling material and back-filling material. From the current study, it was found that light-weighted mixed soil with phosphogypsum has not only weight reduction effect, but also has no special problems in shear strength and bearing capacity. Therefore, it is expected that phosphogypsum can be recycled in bulk as road subgrade and back-filling material at the reclamation area.

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Development of Improvement Effect Prediction System of C.G.S Method based on Artificial Neural Network (인공신경망을 기반으로 한 C.G.S 공법의 개량효과 예측시스템 개발)

  • Kim, Jeonghoon;Hong, Jongouk;Byun, Yoseph;Jung, Euiyoup;Seo, Seokhyun;Chun, Byungsik
    • Journal of the Korean GEO-environmental Society
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    • v.14 no.9
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    • pp.31-37
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    • 2013
  • In this study installation diameter, interval, area replacement ratio and ground hardness of applicable ground in C.G.S method should be mastered through surrounding ground by conducting modeling. Optimum artificial neural network was selected through the study of the parameter of artificial neural network and prediction model was developed by the relationship with numerical analysis and artificial neural network. As this result, C.G.S pile settlement and ground settlement were found to be equal in terms of diameter, interval, area replacement ratio and ground hardness, presented in a single curve, which means that the behavior pattern of applied ground in C.G.S method was presented as some form, and based on such a result, learning the artificial neural network for 3D behavior was found to be possible. As the study results of artificial neural network internal factor, when using the number of neural in hidden layer 10, momentum constant 0.2 and learning rate 0.2, relationship between input and output was expressed properly. As a result of evaluating the ground behavior of C.G.S method which was applied to using such optimum structure of artificial neural network model, is that determination coefficient in case of C.G.S pile settlement was 0.8737, in case of ground settlement was 0.7339 and in case of ground heaving was 0.7212, sufficient reliability was known.

A Study on the Stress-Strain Prediction of Silty Clay (점성토(粘性土)의 응력(應力) - 변형(變形) 추정(推定)에 관(關)한 연구(硏究))

  • Cho, Seong Seup;Kang, Yea Mook;Chung, Seong Gyu;Yun, Hyun Chung
    • Korean Journal of Agricultural Science
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    • v.19 no.1
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    • pp.65-78
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    • 1992
  • The paper describes the comparison between observed and predicted stress-strain characteristics of marine silty clay in Dangjin district. For prediction, the hyperbolic model which is applied the parameters acquiring by physical and triaxial compression test was adopted, and the obtained results were summarized as follows: 1. The Young's modulus were increased with decreasing of moisture contents and increasing of dry density. 2. The most affective factor to hyperbolic model is lateral stress and dry density. and than cohesion and internal friction angle. 3. The comparision between the statistical and hyperbolic values of maximum deviator stress have few accordance. and the statisticals is lower than the hyperbolics. 4. Without. much labor and tiresome procedures, effective computer program was made and applied, but technical procedure for prevents test errors of parameter calculation is importants.

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Effect of Doxycycline on the Acute Lung Injury Induced by Gut Ischemia/Reperfusion (장의 재관류로 유도된 급성폐손상에서의 Doxycyclin의 효과)

  • Lee, Young Man;Kwon, Sung Chul;Lee, Sang Chae
    • Tuberculosis and Respiratory Diseases
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    • v.54 no.5
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    • pp.532-541
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    • 2003
  • Background : Phospholipase $A_2$ ($PLA_2$) has been known to be involved in the pathogenesis of acute lung injury (ALI) including ARDS. Since doxycycline has the property of inhibiting secretory group II $PLA_2$, the therapeutic effect of doxycycline hyclate was investigated for gut ischemia/reperfusion (I/R)-induced ALI in Sprague-Dawley rats. Methods : ALI was induced in Sprague-Dawley rats by clamping of the superior mesenteric artery for 60 min, followed by 120 min of reperfusion. To confirm the pathogenetic mechanisms of this ALI associated with neutrophilic oxidative stress, we measured bronchoalveolar lavage (BAL) protein content and lung MPO, and performed cyto-chemical electron microscopy for detection of free radicals, assay of $PLA_2$ activity and cytochrome-c reduction assay. Results : In gut I/R-induced ALI rats, protein leakage, pulmonary neutrophil accumulation, free radical production and lung $PLA_2$ activity were all increased. These effects were reversed by doxycycline hyclate. Conclusion : Doxycycline appears to be effective in ameliorating the gut I/R-induced ALI by inhibiting $PLA_2$, thereby decreasing the production of free radicals from neutrophils.

A Structural Model for Health Promotion and Life Satisfaction of Life in College Students in Korea (대학생들의 건강증진행위와 삶의 만족도에 대한 구조모형)

  • Hong, Youn-Lan;Yi, Ga-Eon;Park, Hyun-Sook
    • Research in Community and Public Health Nursing
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    • v.11 no.2
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    • pp.333-346
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    • 2000
  • The purpose of this study was designed to test and develope the structural model that explains health promoting behaviors among college students in Korea. The hypothetical model was constructed on the Pender's Health promotion Model(l996) and the inclusion of some influential factors for life satisfaction. The conceptual framework was built around eight constructs. Exogenous variables included in the model were self-esteem, perceived health status, self-efficacy, internal locus of control, chance locus of control. powerful other locus of control. Endogenous variables were health promotion behaviors and life satisfaction. The results are as follows; 1. The overall fit of the hypothetical model to the data was moderate <$x^2$=4.18(df=11. p=0.041), GFI= 0.99, AGFI= 0.76, RMR= 0.019, CFI= 0.99, CN= 248.50> 2. Path and variable of the model were modified by considering both its theoretical implication and statistical significance of parameter estimates. Compared to the hypothetical model. the revised model has become parsimonious and had a better fit to the data expected in a chi-square value <$x^2$=8.43( df= 16, p=0.21), GFI= 0.99, AGFI= 0.92., RMR= 0.024, CFI= 0.99, CN= 312.01> 3. Some of the predictive factors. especially self efficacy. self esteem. powerful others locus of control. perceived health status revealed the direct effects on health promoting behaviors. Of these variables. self-efficacy was the most signigicant factor. These predictive variables of health promoting behaviors explained 59% of total variances in the model. 4. Health promoting behaviors, self-esteem. and perceived health status revealed direct effect on the life satisfaction. Self-efficacy was identified as an important variable that contributed indirectly to improve life satisfaction by enhancing health promoting behaviors. These predictive variables of life satisfaction explained 42% of total variances in the model. In conclusion. the derived model in this study is considered appropriate in explaining and predicting health promoting models and life satisfaction among college students in Korea and could effectively be used as a reference model for further studies by suggesting a direction in health promoting nursing practices.

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Construction of Parent attachment Scale for Children (초등학생용 부모애착척도의 구성)

  • Lee, Hyun-Sook;Hong, Sang-Hwang
    • The Korean Journal of Elementary Counseling
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    • v.9 no.2
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    • pp.143-162
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    • 2010
  • The purpose of this study is to construct Parent Attachment Scale for Children. Adapting the item consisting method used in Experiences in Close Relationships-Revised(ECR-R), Parent Attachment Scale for Children was constructed to measure child's attachment style with their parent, reliably and validly. Also, reliability and item trait informations based on item response theory were reviewed. First preliminary items were derived from the original items of ECR-R and existing Attachment Inventories. These items were modified and complemented to be easier and keep the original meaning of each item. Second preliminary items were administrated to 4~6th grades students(N=576). Finally, Parent Attachment Scale for Children were consisted with 30 items based on two-parameter graded response model. Internal consistency ranges of the scales of Parent Attachment Scale for Children are as follows : Avoidance scale is .94~.96; Anxiety scale is .85~.88. Test-retest reliability ranges are as follows; Avoidance scale is .71~.80; Anxiety scale is .53~.68. Item discrimination and item information value were within an appropriated range. Hierarchical cluster analysis with Ward's Method revealed four types of attachment style : Secure, Dismissing, Preoccupied, Fearful. Other implications and limitations of this study were discussed.

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Effect of Addition of Cosolvent γ-Butyrolactone on Morphology of Polysulfone Hollow Fiber Membranes (폴리설폰 중공사막 구조에 대한 조용매 γ-Butyrolactone 첨가 영향)

  • Yun, Sukbok;Lee, Yongtaek
    • Applied Chemistry for Engineering
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    • v.25 no.3
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    • pp.274-280
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    • 2014
  • Polysulfone (PSf) hollow fiber membranes were prepared via the nonsolvent induced phase separation technique. The cosolvent of ${\gamma}$-butyrolactone (GBL) was added to the polymer solution containing a mixture of PSf and N,N-dimethylacetamide (DMAc). Water was utilized as a precipitation nonsolvent. The morphology of prepared membranes was investigated using a field emission scanning electron microscopy. The fabricated membrane showed a typical asymmetric structure such as the dense layer on the porous support layer by the addition of GBL to the polymer solution. As the concentration of GBL increased, the asymmetric porous structure was shown to be more intensified. It was thought that the added GBL played a role of enhancing the liquid-liquid phase separation of the polymer solution, since the cosolvent of GBL might change the thermodynamic solubility parameter of the doping solution. Permeation properties through the prepared hollow fiber membranes were characterized by measuring the pure water flux and the solute rejection using $0.05{\mu}m$ polystyrene latex (PSL) beads. Experimental results revealed that the use of PEG as the internal coagulant enhanced the pure water flux up to 130 times compared to the use of EG while the rejection of the PSL beads decreased only 5%.

Design of a CCM/DCM dual mode DC-DC Buck Converter with Capacitor Multiplier (커패시터 멀티플라이어를 갖는 CCM/DCM 이중모드 DC-DC 벅 컨버터의 설계)

  • Choi, Jin-Woong;Song, Han-Jung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.9
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    • pp.21-26
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    • 2016
  • This paper presents a step-down DC-DC buck converter with a CCM/DCM dual-mode function for the internal power stage of portable electronic device. The proposed converter that is operated with a high frequency of 1 MHz consists of a power stage and a control block. The power stage has a power MOS transistor, inductor, capacitor, and feedback resistors for the control loop. The control part has a pulse width modulation (PWM) block, error amplifier, ramp generator, and oscillator. In this paper, an external capacitor for compensation has been replaced with a multiplier equivalent CMOS circuit for area reduction of integrated circuits. In addition, the circuit includes protection block, such as over voltage protection (OVP), under voltage lock out (UVLO), and thermal shutdown (TSD) block. The proposed circuit was designed and verified using a $0.18{\mu}m$ CMOS process parameter by Cadence Spectra circuit design program. The SPICE simulation results showed a peak efficiency of 94.8 %, a ripple voltage of 3.29 mV ripple, and a 1.8 V output voltage with supply voltages ranging from 2.7 to 3.3 V.

Effect of Rock Discontinuities on Dynamic Shear Stress Wave (암반 불연속면이 동적 전단응력파에 미치는 영향)

  • Son, Moorak
    • Journal of the Korean GEO-environmental Society
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    • v.19 no.12
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    • pp.25-32
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    • 2018
  • This paper investigates the effect of rock discontinuities on a shear stress wave that is induced by earthquake or blasting and provides the result of numerical parametric studies. The numerical tests of different conditions of rock and discontinuity have been carried out after confirming that the numerical approach is valid throughout a verification analysis from which the test results were compared with a theoretical solution. In-situ stress condition was considered as a rock condition and internal friction angle and cohesive value, which are the shear strength parameters, were considered as discontinuities condition. The joint inclination angle was also taken into account as a parameter. With the various conditions of different parameters, the test results showed that a shear stress wave propagating through a mass is highly influenced by the shear strength of discontinuities and the condition of joint inclination angle as well as in-situ stress. The study results indicate that when earthquake or blasting-induced dynamic loading propagates through a jointed rock mass or a stratified soil ground the effect of in-situ stress and discontinuities including a stratum boundary should be taken into account when evaluating the dynamic effect on nearby facilities and structures.