• 대한예방한의학회지
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• 제18권1호
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• pp.83-92
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• 2014

Objective : This study was performed to investigate the antineoplastic effect of Astragalus membranaceus, Angelica gigas, Rhus verniciflua Stokes and Trichosanthes kirilowii on SNU-80 anaplastic thyroid carcinoma cell line. Method : We examined whether our herbal medicines decreases cell growth rate of SNU-80 using MTT assay. We performed western blot analysis to verify that our herbal medicines induces apoptosis via caspase-dependent mechanism. We also performed wound healing assay and transwell invasion assay to investigate whether our herbal medicines affects the migration and invasion of anaplastic cancer cells, SNU-80. We also carried out ELISA assay to know our herbal medicines suppresses the expression of proinvasive molecules, such as VEGF and MMP-2 secreted from SNU-80. Results : MTT assay demonstrates that Angelica gigas, Rhus verniciflua Stokes, and Trichosanthes kirilowii suppressed strongly the growth of SNU-80. Western blot analysis demonstrates that Trichosanthes kirilowii induces apoptosis activating the cleavages of caspases (caspase-8, caspase-3) and PARP. Wound healing assay demonstrates that Rhus verniciflua Stokes, and Trichosanthes kirilowii inhibited the migration of SNU-80. Transwell invasion assay demonstrates that Rhus verniciflua Stokes, and Trichosanthes kirilowii inhibited the invasion of SNU-80. Elisa assay demonstrates that Astragalus membranaceus, Angelica gigas, Rhus verniciflua Stokes, and Trichosanthes kirilowii suppressed the expression of VEGF and MMP-2. Conclusion : We could conclude that several herbal medicines suppresses the growth and inhibits the migration and invasion of SNU-80 which is anaplastic thyroid cancer cells. Especially, Rhus verniciflua Stokes, Trichosanthes kirilowii had stronger anti-cancer effect suggesting that we can apply them to treat anaplastic thyroid cancer.

• 한국인구학
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• 제21권1호
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• pp.42-79
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• 1998

1960년 이래 한국사회는 빠른 속도로 인구변천을 경험했다. 인구변천으로 인한 인구구조의 변화는 한국사회의 전반적인 현상이기는 하지만, 특히 이 기간중 많은 인구를 도시로 내보내지 않으면 안되었던 농촌지역에서 그 변화의 폭이 더욱 클 수밖에 없다. 이와 같은 관점에서 이 연구는 주로 최근 농촌사회에서 관찰되는 인구구조의 왜곡현상이 주로 농촌-도시로의 인구이동에 원인이 있으며, 지역단위별로 차별적인 영향을 받을 것이라는 점에 착안하여 농촌의 지역단위별 인구특성에 따른 인구분포의 변화를 비교분석하는 데 초점을 두었다. 이 연구결과 밝혀진 결과를 종합해 보면 농촌은 각 지역단위(군)별로 인구구조상의 격차가 매우 크다는 것이 확인되었다. 따라서 각 지역단위별 인구구조의 변화로 예상되는 농촌의 문제는 군부나 면부의 총괄분석을 통해 알려진 농촌 문제보다 각 지역단위별로 분석할 때 알 수 있는 농촌문제가 훨씬 더 심각함을 알 수 있었다. 이 결과는 농촌을 위한 정책수립 과정에서 지역단위별로 특수성이 고려될 수 있어야 한다는 점을 말해준다.

• 대한지리학회지
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• 제51권2호
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• pp.185-200
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• 2016

지리학은 대체적으로 인간과 환경 간의 상호연관에 대해 관심을 가지고 있다. 특히, 인간과 환경 간의 연관성은 작은 도서국가의 환경이 변화하는 모습에서 나타난다. 태평양의 저지대 산호도인 투발루는 기후변화의 원인에 주된 책임을 갖고 있지 않지만 투발루의 인구압은 지속적으로 기후변화로 인한 자원의 이용불가능과 환경적 불안정성에 영향을 받고 있다. 환경지리학과 인구지리학의 맥락 속에서 투발루의 환경적 위기와 이주민에 대한 주변 태평양 도서국과의 관계를 살펴보려 한다. 투발루인의 이주는 인구과잉과 직면된 수용 능력면에서 어떠한 어려움을 겪고 있으며 국내, 국외 이주민의 정착상황에 대해 알아볼 것이다. 이 연구는 환경 변화의 관계에서 투발루인의 이주패턴, 담론 및 전망을 분석하면서 인구지리학적인 맥락에서 현대이주문헌을 조사하려 한다.

• 한국세라믹학회지
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• 제35권11호
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• pp.1121-1129
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• 1998

Reactions between Ag-Pd internal electrode materials and{{{{ { {Bi }_{2 }O }_{3 } }} in multilayer chip varistor were in-vestigated. For more than 1 mol%{{{{ { {Bi }_{2 }O }_{3 } }} in varistor composition internal electrode structure was destroyed due to the reaction between internal electrode and{{{{ { {Bi }_{2 }O }_{3 } }} But for typical varistor compositions (below 1 mol% of{{{{ { {Bi }_{2 }O }_{3 } }} content) microstructural changes around the internal electrode were not observed. However SEM-EDS and TEM-EDS analysis showed the uneven distribution of{{{{ { {Bi }_{2 }O }_{3 } }} in the internal electrode which was due to the migration of{{{{ { {Bi }_{2 }O }_{3 } }} to the electorde during sintering. As a results the nonlinear coefficient of multilayer varistor showed very large distribution as well as the breakdown voltage.

• 한국해양학회지
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• 제10권1호
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• pp.1-6
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• 1975

A marine geological investigation of the glass sand deposit in the beach along the west coast of Ahnmyeon Island, South Chung Cheong Province, Korea was carried out to solve the problen of sand material migration, textural properties of the sands and the glass sand reserve for future exploitation. Several bos coring analyses by means of the internal sedimentary structure.i.e., cross- stratification show significantly that most sands are moving and accumulation along the mean vector direction of $N20^{\circ}E-N60^{\circ}$ E in the area investigated. The average mean size of the sand sediments in the area studied ranges from 0.212mm to 0.275mm. The mechanism of sand migration in the area is considered to be interplay between longshore drift and flood tidal current. The sorting value of the sands ranges from 0.24 to 0.50. Therefore, these sand sediments are characteristic to be "well sorted". The average chemical composition of the glass sand in the area is the following: $SiO\_2$:-90.8%, $Al_2O_3$: -2.18%, $Fe_2O_3$:-0.73%, CaO:-1.79. The binocular microscope examination of the sands show that most of the sands are characteristically ice- clear quartz in mineral composition and their count percentage is mostly 92% or 96%.

• 대한의생명과학회지
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• 제17권1호
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• pp.89-93
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• 2011

Asthma is an inflammatory airway disease and is characterized by the releases of inflammatory mediators including chemokines. They are mainly associated with the recruitment, activation and dysregulation of specific inflammatory cells, especially neutrophils in neutrophilic asthma. CC chemokines bind to CC chemokine receptors (CCRs) in the surface of their target cells. The aims of this study are to examine the CCR expression in neutrophils of bronchoalveolar lavage fluid (BALF) of asthmatic patients and to determine the alternation of migration and apoptosis of neutrophils by the BALF. We demonstrate that CCR3 strongly expresses in BALF neutrophils of asthmatic patients as compared to other CCRs and increases during apoptosis of the BALF neutrophils. The migration of asthmatic blood neutrophils increases in response to asthmatic BALF as compared to BALF of normal volunteer. In addition, asthmatic BALF includes the higher levels of IL-8 protein than normal BALF and it has no effect on apoptosis of asthmatic blood neutrophils. Taken together, our results indicate that CCR3 expression may be associated with unknown function of asthmatic BALF neutrophils and BALF may be involved in the recruitment of neutrophils into the airway, but not in the neutrophils apoptosis.

• 한국인구학
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• 제11권1호
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• pp.117-130
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• 1988

Though most of East European coutries seem to hold a pronatalist policy, they approve of family planning and provide contraceptive services. One of the most popular contraceptive method has traditionally been the coitus interruptus in these countries. One of the major reasons for adopting family planning is to decrease the incidence of induced abortion has been closely related to the popular use of coitus interruptus in these countries. Most of the East European countries liberalized induce abortion legally mainly to neutralize the wide practice of illegal abortion. However, the practice of induced abortion is under the strict control of the public health authorities in these countries. Migration and redistribution of population of population are mostly under the control of the state in these socialist countries. Policies on migration and redistribution are usually carried out to achieve the general goal of socio-economic development plan of the states. Both incentive measures and control measures are mobilized to affect the internal migration and redistribution of population. With respect to public health East European countries are characterized by the socialized medicine following the Soviet model. Public health measures and medical practice are controlled by the state and highly centralized in many countries except Yugoslavia. They place much emphasis on preventive medicine, primary health care, occupatinal and industrial medicine, and health education. Private sectors in medical practice do not exist in these countries of Eastern Europe.

• 한국가시화정보학회지
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• 제19권1호
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• pp.74-80
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• 2021

Cells regulate their shapes and motility by sensing the cues from the internal and external microenvironment. Under different circumstances, microglia, the brain resident immune cells, undergo dynamic phenotypic changes, one of which is a remarkable periodic oscillatory migration in vitro. However, very little is known about the kinematic and dynamic perspectives of this oscillatory behavior. In this study, we tracked the changes in cell morphology and nuclear displacement, and visualized the forces using traction force microscopy (TFM). By correlation analyses, we confirmed that the lamellipodia formation preceded the nuclear translocation. Moreover, traction, developed following lamellipodia formation, was found to be localized and fluctuated at two ends of the oscillating cells. Taken together, our results imply that oscillatory microglial cells feature a viscoelastic migration, which will contribute to the field of cell mechanics.

• 대한영상의학회지
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• 제84권4호
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• pp.934-940
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• 2023

뇌실-복강 단락술은 가장 널리 사용되고 있는 수두증의 수술적 치료 방법이다. 단락술과 관련된 합병증은 비교적 흔하게 발생하며, 높은 단락장치 교정술 시행률과 관련이 있다. 그러나 원위도관이 다른 장기 내로 전위되는 경우, 특히 심장 및 혈관 내 전위는 드물게 보고되었다. 드물지만 잠재적으로 위험한 합병증에 대해 알고 있는 것은 신속한 처치를 통해 위중한 상황을 예방할 수 있기 때문에 중요하다. 저자들은 뇌실-복강 단락술 시행 2개월 후 원위도관이 좌측 내경정맥을 통해 심장 및 양측 폐동맥 내로 전위되었던 23세 남자 환자의 증례를 보고하고, 발생 가능한 기전과 치료에 관해 논의해 보고자 한다.

• Advances in Traditional Medicine
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• 제7권5호
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• pp.518-526
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• 2008

Recently a major goal in asthma therapy is to reduce or prevent the inflammatory response of airway. Eosinophilic accumulation in the tissue is a prominent feature of allergic diseases including asthma. Production of chemokines by bronchial epithelial cells may contribute to the allergic inflammation by recruiting eosinophils. In this study we evaluated the inhibitory effect of Gamichungsangbohatang (GMCSBHT), used traditionally in treating asthma, on secretion of chemokines for eosinophils in human A549 epithelial cells. Chemokines such as eotaxin, RANTES, IL-8 were inhibited in a dose-dependent manner, but IL-16 showed no inhibition by GMCSBHT. These findings indicate that GMCSBHT might be a therapeutic value in treating asthma by suppression of chemokines secretion associated with local accumulation of eosinophils.