• Asian Pacific Journal of Cancer Prevention
• /
• 제16권8호
• /
• pp.3285-3291
• /
• 2015

Background: Non-synonymous polymorphisms in XRCC1 hase been shown to reduce effectiveness of DNA repair and be associated with risk of certain cancers. In this study we aimed to clarify any association between XRCC1 Arg399Gln and colorectal cancer (CRC) risk by performing a meta-analysis of published case-control studies. Materials and Methods: PubMed and Google Scholar were searched to explore the association between XRCC1 and CRC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength. Publication bias was assessed by Egger's and Begg's tests. Results: Up to January 2015, 35 case control studies involving 9,114 CRC cases and 13,948 controls were included in the present meta-analysis. The results showed that the Arg399Gln polymorphism only under an allele genetic model was associated with CRC risk (A vs. G: OR 0.128, 95% CI 0.119-0.138, p<0.001). Also, this meta-analysis suggested that the XRCC1 Arg399Gln polymorphism might associated with susceptibility to CRC in Asians (A vs G: OR 0.124, 95% CI 0.112-0.138, p<0.001) and Caucasian (A vs G: OR 0.132, 95% CI 0.119-0.146, p<0.001) only under an allele genetic model. Conclusions: This meta-analysis confirms the association between XRCC1 Arg399Gln polymorphism and CRC risk and suggests that the heterogeneity is not strongly modified by ethnicity and deviation from the Hardy-Weinberg equilibrium.

• 한국정보통신학회논문지
• /
• 제18권3호
• /
• pp.761-769
• /
• 2014

본 논문에서는 군 특수성을 고려한 정보보호 관리체계를 기존 ISMS를 기반으로 개선된 M(Military)-ISMS 모델을 제시한다. 이는 ISMS에서 논의 되지 않은 군 특수성을 고려한 '내부 보안감사'와 '대외활동 관리'부분이 주요 연구대상이다. 내부 보안감사 부분은 민간에서 중요하게 다루는 가용성보다 기밀성이 중요하기 때문에 기밀성과 관련된 보안감사의 6가지 통제항목을 추가하였다. 또한 대외활동 관리부분은 해당 군사자료가 비밀로서 가치가 사라졌을 경우 보안관리 기준 수립과 수준유지에 관한 통제항목 등을 추가하였다. 본 논문에서 제안된 M-ISMS는 기존의 ISMS에서 제공하는 다양한 장점들과 민간 침해사고 사례를 활용하여 군의 특수성을 고려한 신속하고 미래지향적인 보안 침해사고를 사전에 예방할 수 있는 효과가 있다.

• 대한한방내과학회지
• /
• 제40권6호
• /
• pp.1081-1100
• /
• 2019

Objectives: This study is an overview of the meta-analysis and systematic review of randomized controlled trials investigating the clinical effectiveness and safety of pharmacopuncture for patients with stroke. Methods: Core electronic databases were searched from their inception to 21 May 2019. A measurement tool to assess systematic reviews (AMSTAR 2) was applied to screen high-quality studies. The results of these studies were summarized, and additional meta-analysis was conducted. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to evaluate the certainty of evidence. Results: Sixteen studies met eligibility criteria. Four were excluded owing to insufficiency of AMSTAR 2 or low data reliability. The finally selected 12 studies were about pharmacopuncture using either a single herb extract, such as Dengzhan xixin, Sanch, Ginkgo biloba, or Acanthopanax, or a mixture of herbs, such as Compound danshen, Shenxiong, Xingnaojing, or Mailuoning. Most of the patients were from China, with acute ischemic stroke. All the studies using a pharmacopuncture versus a non-pharmacopuncture design reported the significant superiority of pharmacopuncture on every outcome measure. On the other hand, in a few studies, pharmacopuncture was inferior to active control in improving neurological deficit. Few studies reported adverse events. Conclusions: It is difficult to apply the results of this study directly to Korea, because the level of evidence is generally low and the clinical settings and social acceptance of pharmacopuncture therapy differ in Korea and China. Further studies are warranted to confirm the domestic applicability of evidence generated in China and to create evidence that supports the domestic situation.

• 대한한방내과학회지
• /
• 제42권1호
• /
• pp.53-66
• /
• 2021

Objective: The purpose of this study was to collect and evaluate evidence of herbal medicine treatments for the residual effects of COVID-19. Methods: Nine electronic databases, namely PubMed, Science Direct, CINAHL, CNKI, Wanfang, J-STAGE, CiNii, OASIS, and Science ON, were searched with the following keywords: 'COVID-19'; 'sequelae'; 'Convalescence' for 'P (Population)' and 'Medicine, Chinese Traditional'; 'Korean medicine'; 'Herbal medicine' for 'I (Intervention)'. For the selected studies, various clinical data were extracted including patient symptoms, pattern identification, herbal medicines prescribed, and treatment results. Results: A total of nine clinical studies were identified (two case control trials; one case series; and six case reports). Various residual symptoms had been detected in the recovery stage of COVID-19 with the most commonly used pattern identifications being deficiency in both lung and spleen and in both qi and yin. Any herbal medicine prescriptions were written using these patterns. We found several reports of the positive effect of herbal medicines in that it improved symptoms, lung function, and lung inflammation. No adverse events were reported. Conclusions: The results indicate that treatment with herbal medicines has a possible therapeutic effect on the residual symptoms of COVID-19. Large-scale studies are necessary to confirm the effectiveness of these approaches.

• Journal of Hospice and Palliative Care
• /
• 제24권4호
• /
• pp.226-234
• /
• 2021

Purpose: The accessibility of medical facilities for cancer patients affects both their comfort and survival. Patients in rural areas have a higher socioeconomic burden and are more vulnerable to emergency situations than urban dwellers. This study examined the feasibility and effectiveness of a cancer care model integrating a regional cancer center (RCC) and public health center (PHC). Methods: This study analyzed the construction of a safety care network for cancer patients that integrated an RCC and PHC. Two public health institutions (an RCC in Gyeongnam and a PHC in Geochang County) collaborated on the development of the community care model. The study lasted 13 months beginning in February 2019 to February 2020. Results: The RCC developed the protocol for evaluating and measuring 27 cancer-related symptoms, conducted education for PHC nurses, and administered case counseling. The staff at the PHC registered, evaluated, and routinely monitored patients through home visits. A smartphone application and regular video conferences were incorporated to facilitate mutual communication. In total, 177 patients (mean age: 70.9 years; men: 59%) were enrolled from February 2019 to February 2020. Patients' greatest unmet need was the presence of a nearby cancer treatment hospital (83%). In total, 28 (33%) and 44 (52%) participants answered that the care model was very helpful or helpful, respectively. Conclusion: We confirmed that a combined RCC-PHC program for cancer patients in rural areas is feasible and can bring satisfaction to patients as a safety care network. This program could mitigate health inequalities caused by accessibility issues.

• 한국IT서비스학회지
• /
• 제15권3호
• /
• pp.33-50
• /
• 2016

In a dynamic IT environment, employees often utilize external IT resources to work more efficiently and flexibly. However, the use of external IT resources beyond its control may cause difficulties in the company. This is known as "Shadow IT." In spite of efficiency gains or cost savings, Shadow IT presents problems for companies such as the outflow of enterprise data. To address these problems, appropriate measures are required to maintain a balance between flexibility and control. Therefore, in this study, we developed a new information security management system called AIIMS (Advanced IT service & Information security Management System) and the Shadow IT Evaluation Model. The proposed model reflects a Shadow IT's attributes such as innovativeness, effectiveness, and ripple effect. AIIMS consists of five fields: current analysis; Shadow IT management plans; management process; education and training; and internal audit. There are additional management items and sub-items within these five fields. Using AIIMS, we expect to not only mitigate the potential risks of Shadow IT but also create successful business outcomes. Now is the time to draw to the Light in the Shadow IT.

• 설비공학논문집
• /
• 제13권3호
• /
• pp.184-193
• /
• 2001

The present study develops programs simulating the internal pressure change of cars due to the change of external pressure when trains run into or passing each other in a tunnel. A new continuous ventilating system control method has been developed in order to alleviate the aural discomfort of passengers riding a high speed train. This method is based on the change of the charged and discharged flow rate by detecting the air pressures generated outside and inside of the train. When the outside and inside pressure are detected, the speed of the charge or exhaust fans and also the valve opening ratios are changed. The elementary performance of the system is checked using dta of the TGV-K high speed train at a speed of 300km/h. Moreover, applicability of the system to the Koran high speed train at a speed of 350 km/h is ascertained by simulation and its effectiveness as a means to alleviate the ear pains is confirmed. This application of the system to the Korean high speed vehicles running in the speed range of 350km/h is considered to have good prospect.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1994년도 Proceedings of the Korea Automatic Control Conference, 9th (KACC) ; Taejeon, Korea; 17-20 Oct. 1994
• /
• pp.422-427
• /
• 1994

In this paper, we propose a new design approach of a two-degrees-of-freedom compensator which assures the robust stability. First of all, we clarify the internal structure of the generalized two-degrees-of-freedom compensator. By adopting this structure, we can make a bridge between the generalized controller and the disturbance observer based controller, Secondly, based on the clarified structure we derive a robust stability condition, and propose a design algorithm of free parameter taking the condition into account. The proposed design algorithm is easy to implement and, as a result, we obtain lower order free parameter then that of the conventional design algorithm.. Thirdly, we show by adopting an appropriate coprime factorization that the clarified structure can also be regarded as an extended version of the conventional PID compensator. Finally, we apply the proposed algorithm to a three-degrees-of freedom direct drive robot, and show some experimental results to verify the effectiveness of the proposed algorithm.

• 제어로봇시스템학회논문지
• /
• 제17권2호
• /
• pp.157-163
• /
• 2011

This paper proposes a hybrid image stabilizing system which uses both optical image stabilizing system based on EKF (Extended Kalman Filter) and digital image stabilization based on SURF (Speeded Up Robust Feature). Though image information is one of the most efficient data for object recognition, it is susceptible to noise which results from internal vibration as well as external factors. The blurred image obtained by the camera mounted on a robot makes it difficult for the robot to recognize its environment. The proposed system estimates shaking angle through EKF based on the information from inclinometer and gyro sensor to stabilize the image. In addition, extracting the feature points around rotation axis using SURF which is robust to change in scale or rotation enhances processing speed by removing unnecessary operations using Hessian matrix. The experimental results using the proposed hybrid system shows its effectiveness in extended frequency range.

• Structural Engineering and Mechanics
• /
• 제64권2호
• /
• pp.195-204
• /
• 2017

Analytical and experimental studies of the innovative pipe in pipe damper have been recently investigated by the authors. In this paper, by adding lead or zinc infill or slit diaphragm inside the inner pipe, it is tried to increase the equivalent viscous damping ratio improving the cyclic performance of the recently proposed multi-level control system. The damper consists of three main parts including the outer pipe, inner pipe and added complementary damping part. At first plastic deformations of the external pipe, then the internal pipe and particularly the added core and friction between them make the excellent multi-level damper act as an improved energy dissipation system. Several kinds of added lead or zinc infill and also different shapes of slit diaphragms are modeled inside the inner pipe and their effectiveness on hysteresis curves are investigated with nonlinear static analyses using finite element method by ABAQUS software. Results show that adding lead infill has no major effect on the damper stiffness while zinc infill and slit diaphragm increase damper stiffness sharply up to more than 10 times depending on the plate thickness and pipe diameter. Besides, metal infill increases the viscous damping ratio of dual damper ranging 6-9%. In addition, obtained hysteresis curves show that the multi-level control system as expected can reliably dissipate energy in different imposed energy levels.