• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10985-10989
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• 2015

Background: The capability for DNA double-strand breaks (DSBs) repair is crucial for inherent radiosensitivity of tumor and normal cells. We have investigated the clinicopathologic significance of DNA repair gene expression in nasopharyngeal (NP) carcinoma. Materials and Methods: A total of 65 NP cancer patients who received radiotherapy were included. The immunopositivity to Ku 70, DNA-PKcs, MRN, RAD50, XRCC4, and LIG4 were examined in all tumor tissues. Results: The patients comprised 42 males and 23 females, with a median age of 56 years (range, 18-84). The expression levels of RAD50 (0,+1,+2,+3) were 27.7%, 32.3%, 21.5%, and 18.5%. LIG4 (${\pm}$) were 43.1% and 56.9% respectively. The 5-year OS rate of patients with LIG4 (${\pm}$) were 90% and 67.9%, respectively (p=0.035). The 5-year TTP rate of patients with LIG4 (${\pm}$) were 75.9%, 55.5%, respectively (P=0.039). Conclusions: Our results suggest the possibility of predicting the radiosensitivity of NP cancer by performing immunohistochemical analysis of LIG4.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.14 no.5
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• pp.79-92
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• 2019

When asked about the success factors of successful entrepreneurs and celebrities, he says he was lucky. The remarkable fact is that the attitude about luck is different. However, despite the fact that the belief that we believe is lucky is actually a dominant concept, there has not been much scientific verification of luck. In this study, we saw good luck not being determined randomly by the external environment, but by being able to control luck through the internal attributes of individuals. This study is significant that we have empirically elucidated what kind of efforts have gained good luck, whereas previous research has largely ended in vague logic where luck ends up with an internal locus of control among internal entrepreneurial qualities and efforts can make a successful entrepreneur. We introduced the concept of good luck belief to avoid confirmation bias, which is, to interpret my experience in a direction that matches what I want to believe, and used a good luck belief questionnaire in previous studies and tried to verify that those who have a good belief can increase entrepreneurial opportunity capability through planned happenstance skills. The reason for choosing the entrepreneurial opportunity capacity as a dependent variable was based on the conventional research, that is, the process of recognizing and exploiting the entrepreneurial opportunity is an important part of the entrepreneurship research For empirical research, we conducted a questionnaire survey of a total of 332 people, and the results of the analysis turned out that the belief of good luck has all the positive impacts of planned happenstance skills' sub-factors: curiosity, patience, flexibility, optimism and risk tolerance. Second, we have shown that only the perseverance, optimism, and risk tolerance of planned happenstance skills' sub-factors have a positive impact on this opportunity capability. Thirdly, it was possible to judge that the sub-factors of planned happenstance skills, patience, optimism, and risk tolerance, had a meditating effect between belief in luck and entrepreneurial opportunity capability. This study is highly significant in logically elucidating that people in charge of business incubation and education can get the specific direction when planning a training program for successful entrepreneur to further enhance the entrepreneurial opportunity ability, which is an important ability for the entrepreneur's success.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.101-109
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• 2004

Spatholobus suberectus belonging the family Leguminosae has been used for promoting blood circulation, removing blood stasis, tonifying the blood, relaxing tendons, stopping internal bleeding and eliminating dampness in oriental traditional medicine. This study investigates whether the water extracts of S. suberectus induce apoptotic cell death in Jurkat T-acute lymphoblastic leukemia (ALL) cells. Jurkat cells were increased inhibitions of cell viability in a concentration-dependent manner by S. suberectus, as measured by cell morphology. The capability of S. suberectus to induce apoptosis was associated with proteolytic cleavage of specific target protein such as poly (ADP­ribose)polymerase protein suggesting the possible involvement of caspases. The purpose of the present study is also to investigate the effect of S. suberectus on cell cycle progression. G1 checkpoin related gene products tested (cyclin D1, cyclin dependent kinase 4, retinoblastoma, E2Fl) were decreased in their protein levels in a dose-dependent manners after treatment of the extract. These results indicate that the increase of apoptotic cell death by S. suberectus may be due to the inhibition of cell cycle progression in wild type p53-lacking Jurkat cells.

• The Journal of Internal Korean Medicine
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• v.39 no.6
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• pp.1105-1115
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• 2018

Objectives: The aim of this review is to investigate clinical studies on Oriental medicine treatment for aphasia after cerebrovascular disease. Methods: Using the keywords 'Aphasia', 'Oriental medicine', 'Stroke' 'Cerebral infarction', 'Cerebral hemorrhage', and 'Clinic', we searched domestic databases, including "NDSL (National Discovery for Science Leaders)", "Korean Traditional Knowledge Portal", "OASIS (Oriental Medicine Advanced Searching Integrated System)", and "RISS (Research Information Sharing Service)". Each keyword was not searched individually, but combined in various ways. To investigate recent trends, we limited our search to papers published after 2000. Papers that did not include a specific treatment method or did not match the subject "Aphasia after stroke" were excluded. Results: Using the searching method, 13 studies were found. Of these, 12 studies were in the form of case reports, while one was in the form of a non-randomized controlled trial. These studies showed positive results for the use of Oriental medicine in terms of the Korean version of the Western Aphasia Battery (K-WAB), the evaluation form on functional performance capability and accuracy of articulatory organs developed by Lee, aphasia screening test refered in 'Assessment in Speech-Language Pathology' and adapted properly to Korean, the Communicative Ability in Daily Living Test (CADLT), the Korean Version-Boston Naming Test (K-BNT), and language assessment items included in CNS, and NIHSS. Conclusions: Of the 12 case reports, 11 studies showed positive results of the use of Oriental medicine for treatment of aphasia after cerebrovascular disease. However, more sophisticated and large-scale clinical research on aphasia should be conducted.

• Tuberculosis and Respiratory Diseases
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• v.72 no.1
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• pp.63-67
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• 2012

Although advances in multi-detector computed tomography (CT) technique make it possible to evaluate peripheral subsegmental pulmonary arteries, several studies have reported that small peripheral embolisms may still be missed. Recently, some reports demonstrated that dual-energy CT improved the capability to detect peripheral pulmonary embolism. We report a case of lymphoma presenting as disseminated microvascular pulmonary tumor embolism, detected by perfusion images using dual energy CT.

• International Commerce and Information Review
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• v.12 no.2
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• pp.325-355
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• 2010

Knowledge-based exporting companies in Korea have reached a stage to develop new technological innovation and to pioneer new markets. But, developing new technologies and launching new products require an enormous sum of money for Research and Development(R&D) and there is still uncertainty in technological development and markets. Therefore, through open technological innovation, they are encouraged to actively use external technological sources and ideas. They also need to enhance the efficiency of the relatively little R&D investment. In this paper, firstly, it conducts a precedent study on the concept and influence factors of knowledge-based exporting companies and open technological innovation. Secondly, it sets a study model and estimates a regression coefficient to analyze the influence factors of open technological innovation of knowledge-based exporting companies which are using external resources on the process of innovation. Through case study and empirical analysis, we are going to find the implication of open technological innovation and prepare the way of the innovation for the knowledge-based exporting companies. According to the empirical analysis, variables such as firm size, processing degree, product life, patent registration, maintaining internal security didn't have positive effects on open innovation performance. On the other hand, research capability and market preoccupancy had positive effects. Therefore, to succeed in open innovation, knowledge-based exporting companies not only need to secure research capability through open innovation, but also need to preoccupy the market through commercialization of developed product.

• Asia pacific journal of information systems
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• v.11 no.1
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• pp.91-115
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• 2001

Faced with tougher competition in global, organizations are pressured to improve organizational productivity, including information systems(IS) departments. Especially related to IS, trying to remain competitive and up-to-date in rapidly changing world is becoming a financial burden to many organizations. Through outsourcing, organizations can provide better services and acquire and maintain a competitive advantage. In recent years IS outsourcing related researches have appeared in trade and academic literature. However the research on accounting information systems(AIS) outsourcing is very little or limited. This study attempts to empirically test the relationship between determinant factors and the degree of accounting information systems outsourcing as well as the relationship between success factors and the interactions between the degree of accounting information systems outsourcing and outsourcing success. Based on the previous studies on IS outsourcing and its related theories, determinant factors(transaction characteristic, resource performance, and risk dependence) and success factors(monitor, participation, and vendor capability) were identified and their measures were developed. Empirical results demonstrate that the change in the degree of AIS outsourcing is determined by the specificity of accounting information asset, uncertainty, the effect of internal AIS, AIS cost-effectiveness, and cost increase risks, and that monitor and vendor capability are implementation factors determining the degree of outsourcing success.

• Journal of the Korean Society for Marine Environment & Energy
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• v.2 no.1
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• pp.49-62
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• 1999

The main functions of oil booms are to prevent spreading of the oil slick and to increase the recovering efficiency of oil skimmers. The oil-containment capability of a floating boom on an open sea is affected by environmental parameters such as waves, currents and winds, as well as the motion characteristics of a boom section. In this study, a series of tests were conducted for three kinds of booms (internal foam type, air inflatable type, self-expanded type) at the open sea off Yosu, and the results are presented. Motion characteristics and oversplashing phenomenon were observed for each boom in different environmental conditions. And the tension exerted on towing line of the boom was also measured with a systematic varitation of towing speeds and gap ratios.

• Nuclear Engineering and Technology
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• v.41 no.8
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• pp.1127-1134
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• 2009

Concrete has three major properties after a penetration-reinforcing agent is applied on its surface. First, the durability is improved by the sol-gel process of synthesized material from the polycondensation of TEOS (tetra-ethoxyorthosilicate) and acrylate monomer. Second, the capability to absorb impact energy is reinforced through the formation of a soft and flexible layer of organic monomers by Tea (Tetra Ethyl Amin). Third, the capability to prevent deterioration is enhanced by adding isobutyl-orthosilicate and alcohol. The performance and application of an agent developed through the synthesis of organic and inorganic material in an effort to prevent concrete from deterioration and improve the durability of concrete structures were verified in diverse experiments. The results of these experiments showed that the application of the proposed penetration-reinforcing agent has the effect of increasing the compressive strength by filling up the internal pores of concrete with physically and chemically stable compounds after penetrating the concrete. It also improves the durability against the deterioration factors such as salt water damage, carbonation, freezing and thawing, and compound deterioration. Therefore, it is confirmed that the penetration-reinforcing agent is a useful substance for the management and repair of concrete structures.

• Journal of Technology Innovation
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• v.13 no.2
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• pp.45-70
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• 2005

Much work on innovation has focused on the manufacturing sector. In this paper, we propose a framework for analyzing innovation in services centred on capability and technology integration. We illustrate the theoretical points made by conducting a case study on an international telephone communications provider Brastel, which introduced significant innovations in international calling services, in the form of rechargeable pre-paid calling card, through effective application of standard IT. Brastel is situated against its main competitors, considering two dimensions of price and service breadth and convenience. A novel technique for measuring competitiveness based on price and service index is introduced. The following competitors were selected: NTT, KDDI, Japan Telecom, Fusion Communications, J-Call / World Link, G-Call, ASP Check, Primus, QuickPhone, and MCI. To create the service index, factors such as ease of use, convenience, number of languages in which the services are available, and additional features were taken into account. The company itself and the rechargeable card innovation were analyzed through in-depth interviews and data collection. It was shown that a competitive advantage was maintained through internal and external capabilities.