• Title/Summary/Keyword: intermittent ratio

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Enhancement of peri-implant bone formation via parathyroid hormone administration in a rat model at risk for medication-related osteonecrosis of the jaw

  • Park, Ji Young;Heo, Hyun A;Park, Suhyun;Pyo, Sung Woon
    • Journal of Periodontal and Implant Science
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    • v.50 no.2
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    • pp.121-131
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    • 2020
  • Purpose: Dental implant-associated medication-related osteonecrosis of the jaw has been frequently reported in patients administered bisphosphonates (BPs) to prevent osteoporosis. The aim of this study was to investigate the effect of intermittent administration of parathyroid hormone (PTH) on peri-implant bone in the maxillae of ovariectomized rats systemically administered BPs. Methods: Thirty 8-week-old female Sprague-Dawley rats were randomly divided into 3 groups. The OVX-ZP group included ovariectomized rats administered 60 ㎍/kg of zoledronate once a week for 6 weeks and 30 ㎍/kg PTH after implant installation. The OVX-Z group included ovariectomized rats administered 60 ㎍/kg of zoledronate once a week for 6 weeks and saline after implant installation, and the control group included rats that underwent a sham operation and were then administered saline. Rats were sacrificed 4 weeks after implant placement for histomorphometric and micro-computed tomography (CT) analyses. Results: The average bone area percentage was greater in the OVX-ZP group than in the OVX-Z group (53.4%±4.0% vs. 28.9%±9.5%, P=0.01). The bone-to-implant contact ratio was 50.8%±1.4% in the OVX-ZP group and 16.9%±2.4% in the OVX-Z group (P=0.012). The average bone volume ratio as shown on micro-CT was 31.3%±19.8% in the OVX-ZP group and 19.4%±9.3% in the OVX-Z group (P=0.045). The OVX-ZP and OVX-Z groups displayed similar trabecular thickness (0.06±0.004 mm vs. 0.06±0.002 mm) (P>0.05) and trabecular separation (0.21±0.02 mm vs. 0.29±0.13 mm) (P>0.05). However, the number of trabeculae in the OVX-ZP group was significantly higher than that in the OVX-Z group (4.3±1.33/㎣ vs. 2.2±0.19/㎣) (P=0.024). Conclusions: The present findings indicate that intermittently-administered PTH can promote peri-implant bone formation and suggest that PTH administration may aid in effective treatment for medication-related osteonecrosis of the jaw after dental implantation.

Optimization of Culture Conditions for Production of a High Viscosity Polysaccharide, Methylan, by Methylobacterium organophilum from Methanol. (Methylobacterium organophilum에 의한 메탄올로부터 고점도 다당류, 메틸란 생산을 위한 배양조건 최적화)

  • 최준호;이운택;김상용;오덕근;김정회
    • Microbiology and Biotechnology Letters
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    • v.26 no.3
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    • pp.244-249
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    • 1998
  • An extracellular polysaccharide, methylan, was produced under the specific conditions by Methylobacterium organophilum from methanol. The specific growth rate of cells was approximately constant regardless of C/N ratio and the specific product yield was maximum at a C/N ratio of 30. Methylan production was suppressed by the deficiency of mineral ions such as Mn$^{++}$ or Fe$^{++}$ ion. The optimal pH for cell growth and methylan production was 7. Whereas the optimal temperature for cell growth was found to be 37$^{\circ}C$, that for methylan production was 3$0^{\circ}C$. The methanol concentration above 4% completely inhibited the cell growth. The initial methanol concentration for the maximal production of methylan was 0.5% (v/v) and above this concentration, methylan production was markedly inhibited. To overcome the substrate toxicity and inhibition for both cell growth and methylan production, a fed-bach culture of intermittent feeding within 5 g/l methanol was conducted under the optimal culture condition. Methylan production of was stimulated by nitrogen limitation and methylan was accumulated up to 8.7 g/1 and cell mass also increased up to 12.4 g/l.

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Multi-Hop Vehicular Cloud Construction and Resource Allocation in VANETs (VANET 망에서 다중 홉 클라우드 형성 및 리소스 할당)

  • Choi, Hyunseok;Nam, Youngju;Lee, Euisin
    • KIPS Transactions on Computer and Communication Systems
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    • v.8 no.11
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    • pp.263-270
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    • 2019
  • Vehicular cloud computing is a new emerging technology that can provide drivers with cloud services to enable various vehicular applications. A vehicular cloud is defined as a set of vehicles that share their own resources. Vehicles should collaborate with each other to construct vehicular clouds through vehicle-to-vehicle communications. Since collaborating vehicles to construct the vehicular cloud have different speeds, directions and locations respectively, the vehicular cloud is constructed in multi-hop communication range. Due to intermittent wireless connectivity and low density of vehicles with the limited resources, the construction of vehicular cloud with multi-hop communications has become challenging in vehicular environments in terms of the service success ratio, the service delay, and the transmitted packet number. Thus, we propose a multi-hop vehicular cloud construction protocol that increases the service success ratio and decreases the service delay and the transmitted packet number. The proposed protocol uses a connection time-based intermediate vehicle selection scheme to reduce the cloud failure probability of multi-hop vehicular cloud. Simulation results conducted in various environments verify that the proposed protocol achieves better performance than the existing protocol.

CO2 Methanation Characteristics over Ni Catalyst in a Pressurized Bubbling Fluidized Bed Reactor (가압 기포 유동층 반응기에서의 Ni계 촉매 CO2 메탄화 특성 연구)

  • Son, Seong Hye;Seo, Myung Won;Hwang, Byung Wook;Park, Sung Jin;Kim, Jung Hwan;Lee, Do Yeon;Go, Kang Seok;Jeon, Sang Goo;Yoon, Sung Min;Kim, Yong Ku;Kim, Jae Ho;Ryu, Ho Jeong;Rhee, Young Woo
    • Korean Chemical Engineering Research
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    • v.56 no.6
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    • pp.871-877
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    • 2018
  • Storing the surplus energy from renewable energy resource is one of the challenges related to intermittent and fluctuating nature of renewable energy electricity production. $CO_2$ methanation is well known reaction that as a renewable energy storage system. $CO_2$ methanation requires a catalyst to be active at relatively low temperatures ($250-500^{\circ}C$) and selectivity towards methane. In this study, the catalytic performance test was conducted using a pressurized bubbling fluidized bed reactor (Diameter: 0.025 m and Height: 0.35 m) with $Ni/{\gamma}-Al_2O_3$ (Ni70%, and ${\gamma}-Al_2O_3$30%) catalyst. The range of the reaction conditions were $H_2/CO_2$ mole ratio range of 4.0-6.0, temperature of $300-420^{\circ}C$, pressure of 1-9 bar, and gas velocity ($U_0/U_{mf}$) of 1-5. As the $H_2/CO_2$ mole ratio, temperature and pressure increased, $CO_2$ conversion increases at the experimental temperature range. However, $CO_2$ conversion decreases with increasing gas velocity due to poor mixing characteristics in the fluidized bed. The maximum $CO_2$ conversion of 99.6% was obtained with the operating condition as follows; $H_2/CO_2$ ratio of 5, temperature of $400^{\circ}C$, pressure of 9 bar, and $U_0/U_{mf}$ of 1.4-3.

Experimental Study on Characteristics of Steam Condensation in a Sub-cooled Water Pool (과냉각수조에서 증기응축 특성에 관한 실험적 연구)

  • Kim, Hwan-Yeol;Cho, Seok;Song, Chul-Hwa;Chung, Moon-Ki;Choi, Sang-Min
    • Journal of Energy Engineering
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    • v.8 no.2
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    • pp.298-308
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    • 1999
  • Experimental study on characteristics of direct contact condensation of steam discharged into a sub-cooled water pool has been performed using five different sizes of horizontal nozzle over a wide range of steam mass fluxes and pool temperatures. Steam condensation phenomena have been observed visually and by taking pictures of steam jets using a high speed video camera. Two different steam jet shapes such as ellipsoidal shape and conical shape were typically observed for a stable steam jet, depending on the steam mass flux and pool temperature. The steam jet expansion ratio and the steam jet length as well as the condensation heat transfer coefficients were determined. The effect of steam mass flux, pool temperature, and nozzle diameter on these parameters were also discussed. Empirical correlations for the steam jet lengths and the condensation heat transfer coefficients as a function of steam mass flux and condensation driving potential were established. The axial and radial temperature distributions in steam jet and in surrounding water were measured. The effect of steam mass flux, pool temperature, and nozzle diameter were also discussed. The condensation regime map, which consists of six regimes such as chugging, transient chugging, condensation oscillation, stable condensation, bubble condensation oscillation, and intermittent oscillation condensation, were established. In addition, the dynamic pressures at the pool wall were measured. The close relation of dynamic pressure and steam condensation mode, which is also dependent on steam mass flux and pool temperature, was found.

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Influence of Lighting Schedule and Nutrient Density in Broiler Chickens: Effect on Growth Performance, Carcass Traits and Meat Quality

  • Li, Wen-Bin;Guo, Yan-Li;Chen, Ji-Lan;Wang, Rong;He, Yao;Su, Dong-Ge
    • Asian-Australasian Journal of Animal Sciences
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    • v.23 no.11
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    • pp.1510-1518
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    • 2010
  • The study was conducted to evaluate the effect of lighting schedule and nutrient density on growth performance, carcass traits and meat quality of broiler chickens. A total of 576 day old Arbor Acre male chickens was used with a $4{\times}2$ factorial arrangement. The four lighting schedules were continuous (23 L:1 D, CL), 20 L:4 D (12 L:2 D:8 L:2 D), 16 L:8 D (12 L:3 D:2 L:3 D: 2 L:2 D) and 12 L:12 D (9 L:3 D:1 L:3 D:1 L:3 D:1 L:3 D) and provided by incandescent bulbs. The two nutrient densities were high (H, starter diet: 13.39 MJ/kg apparent metabolisable energy (AME), 23.00% crude protein (CP); finisher diet: 13.39 MJ AME/kg, 19.70% CP) and low energy and protein level (L, starter diet: 12.03 MJ AME/kg, 20.80% CP; finisher diet: 12.14 MJ AME/kg, 18.30% CP). Houses with dark curtains and solid sidewalls were used. Chickens were randomly allocated to the 8 treatments with each treatment comprising 6 replicates of 12 chickens. Feed and water were available ad libitum. Lighting schedules showed no difference (p>0.05) in growth performance at the end of the experiment. 12 L:12 D significantly reduced (p<0.05) the concentration of malondialdehyde (MDA) compared to 23 L:1 D treatment. Intermittent lighting (IL) schedules produced higher protein content (p<0.001) in breast meat. Birds on high density diets had higher body weight (BW), feed intake (FI) (p<0.001), and feed conversion ratio (FCR) (p<0.001) throughout the experiment with the exception of 36 to 42 d. High nutrient density increased (p<0.05) abdominal fat, decreased (p<0.05) the moisture loss of meat, and reduced percentage of wings and legs. There was a significant lighting schedule${\times}$diet interaction (p<0.001) on FCR for days 8 to 14 and 15 to 21. Results indicated that IL can give similar growth performance in comparison with CL, meanwhile with positive effects on meat quality by increasing protein content and decreasing the concentration of MDA. High nutrient density resulted in greater growth performance.

Effect of Water Management and Lime Application on the Growth and Copper Uptake of Paddy Rice (수도(水稻)의 동피해(銅被害)에 대한 물관리(管理) 및 석회물질(石灰物質)의 효과(效果))

  • Kim, Kyu-Sik;Kim, Bok-Young;Lee, Min-Hyo;Han, Ki-Hak;Kim, Maun-Soo
    • Korean Journal of Environmental Agriculture
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    • v.4 no.2
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    • pp.102-107
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    • 1985
  • A pot experiment was conducted to find out the effects of water management, slaked lime and wollastonite on growth and Cu uptake of rice at Cu added soil. The soil was adjusted to 0, 50, 100 and 200 ppm concentration of Cu. The application amount of slaked lime was the lime requirement plus 150 ㎏/l0a and wollastonite 200 ㎏/10a, respectively. The copper concentration in soil which reduced yield significantly was 133.1 ppm for submersion and 136.8 ppm for intermittent irrigation. The application of lime and wollastonite reduced Cu content in brown rice as well as increased rice yields compared to that of no lime. The copper content in plant was increased with increasing soil Cu concentration, however, reduced with submersion and application of slaked lime, and increased with increasing the ratio of Cu/Ca+Mg equivalent in soil.

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Comparative Studies on Static Windrow and Aerated Static Pile Composting of the Mixtures of Cattle Manure and Rice Hulls -I. Variation of Physico-chemical Parameters (우분뇨와 왕겨 혼합물의 퇴비화에서 정치식과 통기퇴적식의 비교연구 -I. 퇴비재료의 이화학적 환경변화)

  • Sohn, Bo-Kyoon;Hong, Ji-Hyung;Park, Keum-Joo
    • Korean Journal of Soil Science and Fertilizer
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    • v.29 no.4
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    • pp.403-410
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    • 1996
  • Variations of temperature and physicochemical environment during composting of a mixtures(2:1, v/v) of cattle manure and rice hulls(CMR) in two different composting methods, static windrow(SW) and aerated static pile system(ASPS), were monitored for evaluating the efficient composting system in greenhouse. The pH of composting materials increased to around 8.9 initially, then decreased and stabilized slowly to the neutral value. Composting materials in ASPS showed a rapid stabilization in pH value from the 4th week comparing to the speed in SW. Thermophilic stage for ASPS Lasted at 3 week whereas 6 weeks for WS. Required time to get thermophilic zone in compost was shorter in ASPS than in WS. Reduction rate in total carbon(T-C) was higher in ASPS than in WS. Organic matter was reduced more rapidly in ASPS than in SW showing 9 percent difference after the 6th week. Total nitrogen(T-N) increased while composting process, showing 9 percent after 6th week in WS and 1.8 percent after 7th week in ASPS. C/N ratio was stabilized after 6th week showing 17 and 21 level in WS and ASPS each. Quantity of ash and mineral content increased during composting in both system, showing higher content in ASPS. Composting process by intermittent, aerated static pile system in greenhouse had a significant effect on the reduction of required period for composting.

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An Early Experience of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in the Republic of Korea: A Retrospective Multicenter Study

  • Park, Joonhyeon;Jang, Sung Woo;Yu, Byungchul;Lee, Gil Jae;Chang, Sung Wook;Kim, Dong Hun;Chang, Ye Rim;Jung, Pil Young
    • Journal of Trauma and Injury
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    • v.33 no.3
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    • pp.144-152
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    • 2020
  • Purpose: This retrospective multicenter study analyzed trauma patients who underwent resuscitative endovascular balloon occlusion of the aorta (REBOA) in the Republic of Korea. Methods: This study was conducted from February 2017 to May 2018 at three regional trauma centers in the Republic of Korea. The patients were divided into two groups (cardiopulmonary resuscitation [CPR] and No-CPR) for comparative analysis based on two criteria (complication and mortality) for logistic regression analysis (LRA). Results: There were significant differences between the CPR and No-CPR groups in mortality (p=0.003) and treatment administered (p=0.016). By LRA for complications, total occlusion has significantly lesser risk than intermittent or partial occlusion in both univariate (odds ratio [OR] 0.06, 95% confidence interval [CI] 0.00-0.36, p=0.01) and multivariate (OR 0.05, 95% CI 0.00-0.38, p=0.01) analyses. The Rescue had a higher risk than the Coda or Reliant in univariate analysis (OR 4.91, 95% CI 1.14-34.25, p=0.05); however, it was not statistically significant in multivariate analysis (OR 6.98, 95% CI 1.03-74.52, p=0.07). By LRA for mortality, the CPR group was the only variable that had a significantly higher risk of mortality than the No-CPR group in both univariate (OR 17.59, 95% CI 3.05-335.25, p=0.01), and multivariate (OR 24.92, 95% CI 3.77-520.51, p=0.01) analyses. Conclusions: This study was conducted in the early stages of REBOA implementation in the Republic of Korea and showed conflicting results from studies conducted by multiple institutions. Therefore, additional research with more accumulated data is needed.

A Clinical Study of Branchial Apparatus Anomalies (새성기형 50예의 임상적 고찰)

  • Gam Bong-Soo;Joo Jong-Soo;Kim Sang-Hyo;Paik Nak-Whan
    • Korean Journal of Head & Neck Oncology
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    • v.8 no.1
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    • pp.6-13
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    • 1992
  • Branchial apparatus anomaly is rarely encountered congenital neck disease, it presents a palpable non-tender mass or fistulous opening existed at any site from external auditory canal or mandible angle to lower part of neck We have reviewed the records of 50 patients operated upon for branchial cleft anomaly, at Department of Surgery, Inje University Hospital, between 1981 and 1990, and the following results were obtained. I) In the classificiation of branchial cleft anomaly, first branchial fistula was 1 case, second branchial cyst 32 cases, second branchial sinus 11 cases, second branchial fistula 5 cases and third branchial fistula 1 case. 2) There were 20 men and 30 women in this series and male to female ratio was 2:3. 3) The age at first clinical presentation was 1st decade 15 cases, 2nd decade 10 cases, 3rd decade 17 cases, 4th decade 5 cases and 5th decade 3 cases. The peak age incidence was 3rd decade in overall, but the cyst was most common in 2nd decade, and majority of sinus or fistula was seen below 10 years old age. 4) The prevalent side of this anomaly was right side in 19 cases, left side in 29 cases and bilateral 2 cases, and so left side was more common than right. 5) The clinical presentation was characterized by the lesion along anterior border of sternocleido muscle, non-tender palpable mass were 28 cases, drainage sinus 18 cases, recurrent abscess and drainage 5 cases and intermittent ear discharge 1 case. 6) The mean size of cyst was about 4cm that containing turbid white-yellowish fluid but discharge from sinus or fistula was clear mucoid. 7) The culture of cyst fluid was no bacteria, but 2 cases showed staphyloccoci suggesting secondary infection. 8) The surgical procedure were complete excision of cyst 32 cases, sinus excision 11 cases, fistula excision 6 cases and I&D 1 case. And the recurrent 1 case was that fistula tract could not be identified due to severe scar from previous several operations.

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