• Korean Journal of Radiology
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• v.21 no.10
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• pp.1115-1125
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• 2020

Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a primary liver cancer (PLC) with both hepatocytic and cholangiocytic phenotypes. Recently, the World Health Organization (WHO) updated its histological classification system for cHCC-CCA. Compared to the previous WHO histological classification system, the new version no longer recognizes subtypes of cHCC-CCA with stem cell features. Furthermore, some of these cHCC-CCA subtypes with stem cell features have been recategorized as either hepatocellular carcinomas (HCCs) or intrahepatic cholangiocarcinomas (ICCs). Additionally, distinctive diagnostic terms for intermediate cell carcinomas and cholangiolocarcinomas (previous cholangiolocellular carcinoma subtype) are now recommended. It is important for radiologists to understand these changes because of its potential impact on the imaging-based diagnosis of HCC, particularly because cHCC-CCAs frequently manifest as HCC mimickers, ICC mimickers, or as indeterminate on imaging studies. Therefore, in this review, we introduce the 2019 WHO classification system for cHCC-CCA, illustrate important imaging features characteristic of its subtypes, discuss the impact on imaging-based diagnosis of HCC, and address other important considerations.

• JSTS:Journal of Semiconductor Technology and Science
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• v.13 no.2
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• pp.157-169
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• 2013

Scale Invariant Feature Transform (SIFT) generates image features widely used to match objects in different images. Previous work on hardware-based SIFT implementation requires excessive internal memory and hardware logic [1]. In this paper, a new hardware organization is proposed to implement SIFT with less memory and hardware cost than the previous work. To this end, a parallel Gaussian filter bank is adopted to eliminate the buffers that store intermediate results because parallel operations allow all intermediate results available at the same time. Furthermore, the processing order is changed from the raster-scan order to the block-by-block order so that the line buffer size storing the source image is also reduced. These techniques trade the reduction of memory size with a slight increase of the execution time and external memory bandwidth. As a result, the memory size is reduced by 94.4%. The proposed hardware for SIFT implementation includes the Descriptor generation block, which is omitted in the previous work [1]. The addition of the hardwired descriptor generation improves the computation speed by about 30 times when compared with the previous work.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.15 no.3
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• pp.1-17
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• 2020

The Fourth Sector has been attracting attention as a means to solve the various problems plaguing modern society; it emerged to overcome the Third Sector's issues such as excessive reliance on the government and service model isomorphism, represented by social economy enterprises (Meadows, 1972; Howaldt & Schwarz, 2010). Social venture companies have been mentioned as key agents of the Fourth Sector (Gyeonggi Research Institute, 2018). However, the academic and policy concepts related to social ventures continue to be vague. Therefore, this study aims to clarify the concept of social ventures as part of the Fourth Sector, and research development strategies for the vitalization of the social venture ecosystem in an effort to encourage inclusive growth of society. To achieve these goals, it establishes the concept of social ventures differentiated from the Third Sector, based on previous studies, and presents the importance of an intermediate support organization for the ecosystem's vitalization. Furthermore, to propose strategies for said vitalization, the study derives detailed forms of social venture intermediate support organizations, and provides suggestions regarding their importance and roles through social innovation levels.

• Journal of Korean Society of Rural Planning
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• v.21 no.2
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• pp.149-162
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• 2015

Korean sixth industrialization policy is similar to that of Japanese such as goal of policy, setup and promotion method of specific policy projects as it benchmarked a Japanese case. First of all, the certification systems of both countries, the most representative policy, are very alike that the governments officially certificate management bodies, prepare the ground for continuous sixth industrialization, devide intermediate support organization into the central unit and regional unit, and have the function of support and control of sixth industrialization management bodies. Furthermore, both countries create fund for sixth industrialization as an investment support policy, and push forward with the phased support policy businesses such as individual support and connected support for management bodies. However, there are some differences between certification systems of both countries such as process-oriented or result-oriented for certification, subtle differences of the role in support organization, and the range and rate of support.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2004.05b
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• pp.739-743
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• 2004

The Grid VO(Virtual Organization) is temporary VO where gather indivisual, authority, or system resource, differ from previous VO concept that controled by internal principal and policy set. It have many problems in case of indivisuals, authorities, or system resources that became member of some Grid VO at same time and combination followed changing condition of system resource for building Grid VO. This paper propose lightweighted Grid VO authentication system based on XML security to solve the authentication of the problems occuring in building Grid VO. In this paper, Grid VO authentication system is including Grid VO authentication module that is intermediate management system in PKI to previous authentication service structure and provide effective authentication service to Grid VO.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4357-4361
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• 2015

Thunbergia Laurifolia Linn. (TL) is one of the most familiar plants in Thai traditional medicine that is used to treat various conditions, including cancer. However, the antitumor activity of TL or its constituents has never been reported at the molecular level to support the folklore claim. The present study was designed to investigate the antitumor effect of an aqueous extract of TL in human breast cancer cells and the possible mechanism(s) of action. An aqueous crude extract was prepared from dried leaves of TL. Folin-Ciocalteu colorimetric assays were used to determine the total phenolic content. Antiproliferative and cell cycle effects were evaluated in human breast adenocarcinoma MCF-7 cells by MTT reduction assay, cell growth inhibition, clonogenic cell survival, and flow cytometric analysis. Free radical generation by the extracts was detected using electron paramagnetic resonance spectroscopy. The exposure of human breast adenocarcinoma MCF-7 cells to a TL aqueous extract resulted in decreases in cell growth, clonogenic cell survival, and cell viability in a concentration-dependent manner with an $IC_{50}$ value of $843{\mu}g/ml$. Treatments with extract for 24h at $250{\mu}g/ml$ or higher induced cell cycle arrest as indicated by a significant increase of cell population in the G1 phase and a significant decrease in the S phase of the cell cycle. The capability of the aqueous extract to generate radical intermediates was observed at both high pH and near-neutral pH conditions. The findings suggest the antitumor bioactivities of TL against selected breast cancer cells may be due to induction of a G1 cell cycle arrest. Cytotoxicity and cell cycle perturbation that are associated with a high concentration of the extract could be in part explained by the total phenolic contents in the extract and the capacity to generate radical intermediates to modulate cellular proliferative signals.

• Journal of Microbiology and Biotechnology
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• v.25 no.3
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• pp.307-316
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• 2015

Beginning from the recognition of FtsZ as a bacterial tubulin homolog in the early 1990s, many bacterial cytoskeletal elements have been identified, including homologs to the major eukaryotic cytoskeletal elements (tubulin, actin, and intermediate filament) and the elements unique in prokaryotes (ParA/MinD family and bactofilins). The discovery and functional characterization of the bacterial cytoskeleton have revolutionized our understanding of bacterial cells, revealing their elaborate and dynamic subcellular organization. As in eukaryotic systems, the bacterial cytoskeleton participates in cell division, cell morphogenesis, DNA segregation, and other important cellular processes. However, in accordance with the vast difference between bacterial and eukaryotic cells, many bacterial cytoskeletal proteins play distinct roles from their eukaryotic counterparts; for example, control of cell wall synthesis for cell division and morphogenesis. This review is aimed at providing an overview of the bacterial cytoskeleton, and discussing the roles and assembly dynamics of bacterial cytoskeletal proteins in more detail in relation to their most widely conserved functions, DNA segregation and coordination of cell wall synthesis.

• Asia pacific journal of information systems
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• v.9 no.2
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• pp.39-58
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• 1999

This paper determines the interactive effects of information technologies(IT) on corporate performances. IT was measured inclusively in terms of technology level, information level, functional level, and management level. Corporate performances were composed of the effectiveness of IT and the financial performance of a corporation. The effectiveness of IT was measured in terms of satisfaction with the support of IT department and with output information, whereas financial performance of corporation was measured in terms of market growth and profitability. Theoretical and empirical analyses lead to the followings. In the theoretical aspect, IT in a corporation needs to be measured broadly. And a study of IT related to corporate performance needs to use either a conversion effectiveness model or an intermediate effect model rather than a direct effect model. In the empirical aspect, the effectiveness of IT within an organization improves with some of the interactive effect of ITs including technology level, information level, functional level, and management level. So do some of the financial performances of a corporation.

• Health Policy and Management
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• v.3 no.1
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• pp.102-123
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• 1993

This study investigates effcts of HMO internal structural arrangements on performance, specially cost reduction measured by hospitalization rate. This study formulates formalization, centralization measured by decision-making participation, differentiation, and coordination as structural factors, considering coordination as an intermediate factor between the rest of structural factors and hospitalization rate. The commonly used HMO types is assumed not effective in explaining performance differences. For the empirical test, I use bootstrap regression analyses with 48 HMOs. The results of the analyses show that HMO types fail to explain differences in hospitalization rate. However, dicision-making participation and differention effectively reduce hospiatalization rate, while frmalization increases hospitalization rate and coordination has nonessential effect on hospitalization rate. And, formalization and decision-making participation positively contribute to achieve coordination in HMO. These findings suggest that the theoretical framework derived from rational-citingency theory of formal organization better explains performance differences of HMOs than HMO types.

• Journal of Digestive Cancer Research
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• v.10 no.1
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• pp.1-8
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• 2022

The incidence of gastric neuroendocrine tumors (NET) has been increased with the improvement of endoscopy accessibility. The World Health Organization classified NET of low (G1), intermediate (G2), high (G3) grade and neuroendocrine carcinoma with poor differentiation by mitotic count and Ki-67 labeling index. Gastric NET are divided into three subtypes based on the pathophysiology, and treatment is determined according to the subtype and prognostic factors of tumor. For diagnosis, endoscopy with biopsy, endoscopic ultrasonography, abdominal pelvis computed tomography, and serum gastrin level measure are required. In general, type 3, size > 2 cm, deep submucosal infiltration, high histological grade, lymphovascular invasion and metastasis are poor prognostic factors. Type 1 or 2 without these factors are treated by endoscopic resection, and other tumors needs surgery. Endoscopic resection of early type 3 or type 1 and 2 tumors with poor prognostic factors still remains a challenge.