• Communications for Statistical Applications and Methods
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• v.26 no.4
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• pp.411-430
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• 2019

Tumor development is driven by complex combinations of biological elements. Recent advances suggest that molecularly distinct subtypes of breast cancers may respond differently to pathway-targeted therapies. Thus, it is important to dissect pathway disturbances by integrating multiple molecular profiles, such as genetic, genomic and epigenomic data. However, missing data are often present in the -omic profiles of interest. Motivated by genomic data integration and imputation, we present a new statistical framework for pathway significance analysis. Specifically, we develop a new strategy for imputation of missing data in large-scale genomic studies, which adapts low-rank, structured matrix completion. Our iterative strategy enables us to impute missing data in complex configurations across multiple data platforms. In turn, we perform large-scale pathway analysis integrating gene expression, copy number, and methylation data. The advantages of the proposed statistical framework are demonstrated through simulations and real applications to breast cancer subtypes. We demonstrate superior power to identify pathway disturbances, compared with other imputation strategies. We also identify differential pathway activity across different breast tumor subtypes.

• Nuclear Engineering and Technology
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• v.51 no.2
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• pp.463-478
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• 2019

The most important non-functional requirements for dependability of any Embedded Real-Time Safety Systems are safety, availability and reliability requirements. System architecture plays the primary role in achieving these requirements. Compliance with these non-functional requirements should be ensured early in the development cycle with appropriate considerations during architectural design. In this paper, we present an application of system architecture modeling for quantitative assessment of system dependability. We use probabilistic model checker (PRISM), for dependability analysis of the DTMC model derived from system architecture model. In general, the model checking techniques do not scale well for analyzing large systems, because of prohibitively large state space. It limits the use of model checking techniques in analyzing the systems of practical interest. We propose abstraction based compositional analysis methodology to circumvent this limitation. The effectiveness of the proposed methodology has been demonstrated using the case study involving the dependability analysis of safety system of a large Pressurized Water Reactor (PWR).

• Journal of the Korea Society of Computer and Information
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• v.24 no.1
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• pp.159-166
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• 2019

Recently, the advanced development of smart devices has increased the interest in health-care, and many people are paying more attentions to disease prevention than disease treatment. Among these prevention methods, the bare body movement has received much attention, and especially walking exercise is attracting much attention because it is enjoyable without any restrictions on place and time. Walking exercise is generally divided into two types: walking on the ground and climbing the stairs. Walking up the stairs consumes much more calories compared to walking on the ground. These walking exercises have the advantage that they can be easily performed by male and female without special equipments or economic considerations. However, there is a lack of applications and systems that accurately determine such walking and stair walking and measure momentum according to stair walking. In this paper, we designed and implemented a real-time walking status analysis system using smartwatch's, pedometer, smartphone's barometer and beacons.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.2
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• pp.120-126
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• 2021

The importance of mathematics is emerging to create new values and secure competitiveness in an intelligent information society based on the Fourth Industrial Revolution. This study was conducted with the aim of improving the academic performance and increasing interest of electronics majors in mathematics subjects. In order to develop learners' mathematical capabilities in major fields that utilize mathematics that electronics majors do not prefer, we have proposed a new teaching method to promote employment in mathematics-based electronics fields. In addition, to enhance learners' self-directed learning, we developed teaching methods for efficient mathematics subjects with programming languages as tools in electronics engineering and applied them to real-world teaching sites to effectively cultivate academic performance improvement of majors. Finally, we conducted a survey and statistically analyze the effectiveness of the developed teaching methods to present effective operational measures for mathematics education, an essential tool in intelligent information technology.

• Food Science and Industry
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• v.50 no.2
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• pp.27-36
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• 2017

Today, the food packaging industry has a great interest in using active packaging to fresh food product as a solution for the future to positively provide its quality, safety and shelf life. Many researches have extensively studied functional packaging strategies in recently years. Controlled release packaging (CRP) is an innovative packaging technology in the packaging polymer matrix from which can active agents are delivered in a controlled way into the product. CRP technology is well-suited for controlling release of antimicrobial compounds and antioxidants to prevent food degradation reactions such as microbial growth and lipid oxidation. Advances in CRP technology allow food packaging manufacturers to challenge the development of better functional food packaging systems. This overview examines the most recent developments and technologies of active packaging for applying the food industry. The scope of this article has mainly been focused on controlled releasing systems.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.245.2-245.2
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• 2003

(+)-Brefeldin A (1) has been, since its isolation1 and structural elucidation2 many years ago, one of the most attractive targets for synthetic chemists due to its wide range of biological activities and well-functionalized macrolide structure. Its biological mode of action has been disclosed by a number of important discoveries. Especially the ability of brefeldin A to induce DNA fragmentation associated with apoptosis in cancer cells has stimulated a great deal of recent interest in its preclinical development as an anticancer agent. (omitted)

• KEPCO Journal on Electric Power and Energy
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• v.7 no.1
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• pp.85-91
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• 2021

With the social atmosphere of respect for human life and the increasing interest in safety of field workers, research and development is underway in various ways to transform direct live method into indirect live method in the field of distribution. As part of this measure, it was necessary to convert electric pole and complex facilities work from machining power distribution to indirect live operation, and install a straight connecting sleeve that connects cut wires for by-pass method, but it failed to meet the tensile strength standard when constructing a sleeve constructed by direct method. In this paper, the design factors were derived based on the case of overseas similar sleeves and the tensile strength evaluation of each variable was performed, based on the analysis of these test results, the method for securing tensile strength of straight-line access sleeves for indirect running was presented.

• Journal of Sensor Science and Technology
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• v.30 no.3
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• pp.181-184
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• 2021

Interest in healthcare and wearable devices has been increasing recently. A strain sensor is required in various wearable devices. With respect to such devices, studies on resistance changes in strain sensors using flexible materials are in progress. However, the resistance of the rest area in a strain sensor should not change according to the applied strain. So, an electrode with resistance to stretching, bending, and torsion is required in such strain sensors. Tension, bending, and torsion can be realized through structural shape control, rather than by using flexible materials. Further, such an electrode that maintains electrical properties has been developed and manufactured. This electrode can be used in various applications such as foldable devices, e-papers, batteries, and multifunctional wearable devices.

• Journal of the Semiconductor & Display Technology
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• v.20 no.2
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• pp.51-55
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• 2021

With the recent development of various smartphone designs in the smartphone market, the use of curved cover glass has been required, and interest in curved glass production has increased. In this paper, we designed a pressurization system that simplified the size of the system using a wedge amplification mechanism for smartphone curved glass molding systems. The pressurization system consisted of a linear motor, a wedge, and a force sensor. The wedge was used to amplify the force, and the piezoelectric sensor was used to measure the force. In addition, the proposed amplification mechanism was confirmed to have an error of 1.27% through an experiment compared to the simulation, and the pressurization error of 0.76% for the pressurization profile 3,500N was verified through an experiment.

• Journal of the Semiconductor & Display Technology
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• v.20 no.2
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• pp.56-60
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• 2021

Recently, technologies for internet of things have been rapidly advanced with development of network. Also interest in smart healthcare that informs about motion information of users has been growing. In this paper, a system that is monitoring the weight on both feet by using aduino and FSR(Force Sensitive Resistor) Sensor is implemented. A 4-channel sensor driver module was implemented to measure a more accurate weight value. It is monitoring the weight on both feet by the using an application for either your PC or mobile device. Mobile applications can contribute to reducing human damage by sending messages along with location in emergency situations, such as injuries caused by falls during outdoor activities.