• Title/Summary/Keyword: interdisciplinary

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Transcriptomic Analysis of Genes Modulated by Cyclo($\small{L}$-Phenylalanine-$\small{L}$-Proline) in Vibrio vulnificus

  • Kim, In Hwang;Son, Jee-Soo;Wen, Yancheng;Jeong, Sang-Min;Min, Ga-Young;Park, Na-Young;Lee, Keun-Woo;Cho, Yong-Joon;Chun, Jongsik;Kim, Kun-Soo
    • Journal of Microbiology and Biotechnology
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    • v.23 no.12
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    • pp.1791-1801
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    • 2013

  • Diketopiperazine is produced by various organisms, including bacteria, fungi, and animals, and has been suggested as a novel signal molecule involved in the modulation of genes with various biological functions. Vibrio vulnificus, which causes septicemia in humans, produces cyclo($\small{L}$-phenylalanine-$\small{L}$-proline) (cFP). To understand the biological roles of cFP, the effect of the compound on the expression of the total mRNA in V. vulnificus was assessed by next-generation sequencing. Based on the transcriptomic analysis, we classified the cFP-regulated genes into functional categories and clustered them according to the expression patterns resulted from treatment with cFP. From a total of 4,673 genes, excepting the genes encoding tRNA in V. vulnificus, 356 genes were up-regulated and 602 genes were down-regulated with an RPKM (reads per kilobase per million) value above 3. The genes most highly induced by cFP comprised those associated with the transport and metabolism of inorganic molecules, particularly iron. The genes negatively regulated by cFP included those associated with energy production and conversion, as well as carbohydrate metabolism. Noticeably, numerous genes related with biofilm formation were modulated by cFP. We demonstrated that cFP interferes significantly with the biofilm formation of V. vulnificus.

  • https://doi.org/10.4014/jmb.1308.08068 인용 PDF KSCI KPUBS HTML

Effect of pH and Temperature on the Electrochemical Reduction of Carbon Dioxide by Carbon Monoxide Dehydrogenase (일산화탄소탈수소화효소를 이용한 이산화탄소의 전기화학적 환원에 미치는 pH와 온도의 영향)

  • Shin, Jun-Won;Kim, You-Sung;Lee, Sang-Hee;Lee, Sang-Phil;Lee, Ho-Jun;Lim, Mi-Ran;Song, Ji-Eun;Shin, Woon-Sup
    • Journal of the Korean Electrochemical Society
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    • v.10 no.4
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    • pp.265-269
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    • 2007

  • The effects of experimental variables for the electrochemical reduction of carbon dioxide by Carbon Monoxide Dehydrogenase (CODH) were investigated. It shows the pH optimum at 6.3 where the feasibility of electro-chemical reduction and the stability of CODH compromise each other. The optimum temperature for the reduction was at $60^{\circ}C$ where the enzyme shows the optimum activity although the solubility of carbon dioxide decreases as increasing temperature.

  • https://doi.org/10.5229/JKES.2007.10.4.265 인용 PDF KSCI

Development of an Unmanned Vechile Driving System by the MPC sensors

  • Shin, Taek-Young;Ha, Sung-Ki;Jeong, Seung-Gweon;Kim, Chang-Sub;Lee, Man-Hyoung
    • 제어로봇시스템학회:학술대회논문집
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    • 2003.10a
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    • pp.1207-1210
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    • 2003

  • In this paper, studied traveling by ummaned vehicles using MPC sensor.Explain what is MPC sensor and also is threaded how on vehicles. Made use of PID controller and LQG/LTR controller that is used much in present industrial circles for control of this.

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