• Transactions of the Korean Society of Machine Tool Engineers
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• v.17 no.5
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• pp.95-100
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• 2008

An active micro-mixer, which is composed of an oscillating micro-stirrer in the micro-channel to provide effective mixing was optimized. The effects of molecular diffusion and disturbance by the stirrer were considered with regard to two types of mixer models: the simple straight micro-channel and micro-channel with an oscillating stirrer. Two types of mixer models were studied by analyzing mixing behaviors such as their interaction after the stirrer. The mixing was calculated by Lattice Boltzmann methods using the D2Q9 model. In this study, the time-averaged mixing index formula was used to estimate the mixing performance of time-dependent flow. The mixing indices of the two models were compared. From the results, it was found that the mixer with an oscillating stirrer was much more enhanced and stabilized. Therefore, an approximate optimization of an active micro-mixer with an oscillating stirrer was performed using Kriging method with OLHD(Optimal Latin Hypercube Design) in order to determine the optimal design variables. The design parameters were established as the frequency, the length and the angle of the stirrer. The optimal values were obtained as 1.0346, 0.66D and $\pm45^{\circ}$, respectively. It was found that the mixing index of the optimal design increased by 88.72% compared with that of the original design.

• Journal of the Society of Naval Architects of Korea
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• v.29 no.4
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• pp.87-97
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• 1992

Of various design factors affecting icebreaking capability of an icebreaker, the stem angle(i.e., angle between bow stem and ice sheet) is the most important one under continuous icebreaking operation. This study focuses on the relationship between the bow stem angle of an icebreaker and its icebreaking capability. Considering relatively high loading-rate conditions with typical advancing speed of 3 to 4 knots, the material properties and deformation characteristics of sea ice are regarded as entirely elastic and brittle. In this paper the interaction process of icebreaker with level ice is simplified as a beam of finite length supported by Winkler-type elastic foundation simulating water buoyancy. The wedge type ice beam is loaded by the vertical impact forces due to the inclined bow stem of icebreaking vessels. The numerical model provides locations of maximum bending moment where extreme tensile stress arises and also possible fracture occurs. The model can predict a characteristic length of broken ice sheet upon the given environmental and design parameters.

• Journal of the Korean Chemical Society
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• v.37 no.4
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• pp.442-447
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• 1993

The thermodynamic parameters (${\Delta}$G, ${\Delta}$H and ${\Delta}$S) of lanthanides(III)-benzoylformate complexes in aqueous solution have been determined in the ionic medium of 0.1M $NaClO_4$ at 25$^{\circ}C$, using pH and enthalpy titration method. The stability constants of the lanthanide(III)-benzoylformate complexes (1 : 1) agree well with the general relationships for the bidentate ligands (e.g., log${\beta}_1$ vs. p$K_a$). Thermodynamic evidences show that the oxygen atom in ketone group is coordinated along with the carboxylate group. It is ascribed to the increasing charge density on the oxygen atom in ketone group due to the conjugation effect in the benzoylformate ligand. Thermodynamic results also indicate that the complexes are stabilized by the enthalpy effect caused by the ionic interaction of metal-oxygen bond as well as the entropy effect.

• Bulletin of the Korean Chemical Society
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• v.33 no.6
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• pp.1839-1844
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• 2012

We have investigated binding between wild-type and mutant Heat Shock Factor (HSF) DNA binding domains (DBDs) with 17-bp HSE containing a central 5'-NGAAN-3' element by equilibrium analytical ultracentrifugation using multi-wavelength technique. Our results indicate that R102 plays critical role in HSE recognition and the interactions are characterized by substantial negative changes of enthalpy (${\Delta}H^0_{\theta}=-9.90{\pm}1.13kcal\;mol^{-1}$) and entropy (${\Delta}S^0_{\theta}=-12.46{\pm}3.77cal\;mol^{-1}K^{-1}$) with free energy change, ${\Delta}G^0_{\theta}$ of $-6.15{\pm}0.03kcal\;mol^{-1}$. N105 plays minor role in the HSE interactions with ${\Delta}H^0_{\theta}$ of $-2.54{\pm}1.65kcal\;mol^{-1}$, ${\Delta}S^0_{\theta}$ of $19.28{\pm}5.50cal\;mol^{-1}K^{-1}$ and ${\Delta}G^0_{\theta}$ of $-8.35{\pm}0.05kcal\;mol^{-1}$, which are similar to those observed for wild-type DBD:HSE interactions (${\Delta}H^0_{\theta}=-3.31{\pm}1.86kcal\;mol^{-1}$, ${\Delta}S^0_{\theta}=17.38{\pm}6.20cal\;mol^{-1}K^{-1}$ and ${\Delta}G^0_{\theta}=-8.55{\pm}0.06kcal\;mol^{-1}$) indicating higher entropy contribution for both wild-type and N105A DBD bindings to the HSE.

• Clean Technology
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• v.18 no.4
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• pp.347-354
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• 2012

In this study, simulation works have been performed for the $CO_2$ removal process contained in the DME production process using NMP (N-methyl-2-pyrrolidone) as a solvent. PRO/II with PROVISION release 9.1 at Invensys was used as a chemical process simulator and NRTL activity coefficient model with Henry's law option and Soave-Redlich-Kwong equation of state were used for thermodynamic models. For the determination of the binary interaction parameters in NRTL model, regression works have been performed to match the experimental thermodynamic data. Optimal feed tray location which minimizes the reboiler heat duty was determined.

• Membrane and Water Treatment
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• v.7 no.3
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• pp.223-240
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• 2016

In this study, poly(vinyl-alcohol) and water insoluble ${\beta}$-cyclodextrin polymer (${\beta}$-CDP) cross-linked with citric acid, have been used as macrocyclic carrier in the preparation of polymer inclusion membranes (PIMs) for aniline (as molecule model) extraction from aqueous media. The obtained membranes were firstly characterized by X-ray diffraction, Fourier transform infrared and water swelling test. The transport of aniline was studied in a two-compartment transport cell under various experimental conditions, such as carrier content in the membranes, stirring rate and initial aniline concentration. The kinetic study was performed and the kinetic parameters were calculated as rate constant (k), permeability coefficient (P) and flux (J). These first results demonstrated the utility of such polymeric membranes for environmental decontamination of toxic organic molecules like aniline. Predictive modeling of transport flux through these materials was then studied using design of experiments; the design chosen was a two level full factorial design $2^k$. An empirical correlation between aniline transport flux and independent variables (Poly ${\beta}$-CD membrane content, agitation speed and initial aniline concentration) was successfully obtained. Statistical analysis showed that initial aniline concentration of the solution was the most important parameter in the study domain. The model revealed the existence of a strong interaction between the Poly ${\beta}$-CD membrane content and the stirring speed of the source solution. The good agreement between the model and the experimental transport data confirms the model's validity.

• Journal of the Korean Magnetics Society
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• v.8 no.5
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• pp.249-254
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• 1998

In relation to the application of magnetic method to the evaluation of irradiation damage (embrittlement) changes in the magnetic parameters(hysteresis loop and Barkhausen noise) and Vickers microhardness due to neutron irradiation and heat treatment were measured and compared. In the case of irradiation $(2.3{\times}10^{19}\;n/cm^2,\; E{\ge}1\;Mev,\; 288{\circ}C)$ hysteresis loop measurements show that susceptibility decreases as coercivity increase. Saturation magnetization do not show any change. Barkhausen noise amplitude and Barkhausen noise energy have decreased while Vickers microhardness has increased. For isothermally heat treated condition of irradiated specimen at 470 $^{\circ}C$ and 540 $^{\circ}C$, Barkhausen noise energy has increased while Vickers microhardness has decreased. Results of BNE and Vickers microhardness are reversed to the results on irradiated condition. All these consistent changes in magnetic parameter and Vickers microhardness measurement, which are thought to be resulted from the interaction between irradiation-induced defects and dislocation, and magnetic domain, respectively, show a possibility that magnetic measurement may be used to the evaluation of material degradation and recovery due to neutron irradiation and heat treatment, respectively, if a relevant large database in prepared.

• Korean Journal of Clinical Pharmacy
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• v.20 no.1
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• pp.25-29
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• 2010

The purpose of this study was to investigate the effect of atorvastatin on the pharmacokinetics of nifedipine (6 mg/kg) after oral administration of nifedipine with or without atorvastatin (0.5 and 2.0 mg/kg) in rats, and also was to evaluate to the effect of atorvastatin on the CYP3A4 activity. The 50% inhibiting concentration ($IC_{50}$) values of atorvastatin on CYP3A4 activity is 46.1 ${\mu}M$. Atorvastatin inhibited CYP3A4 enzyme activity in a concentration-dependent manner. Coadministration of atorvastatin increased significantly (p<0.05, 2.0 mg/kg) the plasma concentration-time curve (AUC) and the peak concentration ($C_{max}$) of nifedipine compared to the control group. The relative bioavailability (RB%) of nifedipine was increased from 1.15- to 1.37-fold. Coadministration of atorvastatin did not significantly change the terminal half-life ($T_{1/2}$) and the time to reach the peak concentration ($T_{max}$) of nifedipine. Based on these results, we can make a conclusion that the significant changes of these pharmacokinetic parameters might be due to atorvastatin, which possesses the potency to inhibit the metabolizing enzyme (CYP3A4) in the liver and intestinal mucosa, and also inhibit the P-glycoprotein (P-gp) efflux pump in the intestinal mucosa. It might be suggested that atorvastatin altered disposition of nifedipine by inhibition of both the first-pass metabolism and P-glycoprotein efflux pump in the small intestine of rats. In conclusion, the presence of atorvastatin significantly enhanced the oral bioavailability of nifedipine, suggesting that concurrent use of atorvastatin with nifedipine should require close monitoring for potential drug interation.

• Steel and Composite Structures
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• v.25 no.1
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• pp.105-116
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• 2017

This paper presents the dynamic stability study of laminated composite plates with different force combinations and aspect ratios. Optimum non-diverging stacking is obtained for certain loading combination and aspect ratio. In addition, the stability force is maximized for a definite operating frequency. A dynamic version of the principle of virtual work for laminated composites is used to obtain force-frequency relation. Since dynamic stiffness governs the divergence or flutter, an efficient optimization method is necessary for the response functional and the relevant constraints. In this way, a model based on the ant colony optimization (ACO) algorithm is proposed to search for the proper stacking. The ACO algorithm is used since it treats with large number of dynamic stability parameters. Governing equations are formulated using classic laminate theory (CLT) and von-Karman plate technique. Load-frequency relations are explicitly obtained for fundamental and secondary flutter modes of simply supported composite plate with arbitrary aspect ratio, stacking and boundary load, which are used in optimization process. Obtained results are compared with the finite element method results for validity and accuracy convince. Results revealed that the optimum stacking with stable dynamic response and maximum critical load is in angle-ply mode with almost near-unidirectional fiber orientations for fundamental flutter mode. In addition, short plates behave better than long plates in combined axial-shear load case regarding stable oscillation. The interaction of uniaxial and shear forces intensifies the instability in long plates than short ones which needs low-angle layup orientations to provide required dynamic stiffness. However, a combination of angle-ply and cross-ply stacking with a near-square aspect ratio is appropriate for the composite plate regarding secondary flutter mode.

• Journal of the Korean Institute of Gas
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• v.19 no.5
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• pp.13-19
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• 2015

This paper presents a hydraulic fracture propagation model to describe propagation more realistically. In propagating the hydraulic fractures, we have used two criteria: maximum tangential stress to determine the fracture initiation angle and whether a hydraulic fracture intersects a natural fracture. The model was validated for the parameters relevant to fracture propagation, such as initiation angle and crossing ability through natural fracture. In order to check whether a hydraulic fracture crosses a natural fracture, the model results on crossing state excellently matched with the experimental data. In the sensitivity analysis for direction of maximum horizontal stress, frictional coefficient of fracture interface, and natural fracture orientation, the results show that hydraulic fracture intersects natural fracture, and then, propagated suitably with theoretical results according to fracture interaction criterion. In comparison of this model against vertical fracture approach, it was ascertained that there are discrepancies in fracture connectivity and stimulated reservoir volume.