• Wind and Structures
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• 제21권5호
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• pp.537-564
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• 2015

Excessive motions in buildings cause occupants to become uncomfortable and nervous. This is particularly detrimental to the tenants and ultimately the owner of the building, with respect to financial considerations. Serviceability issues, such as excessive accelerations and inter-story drifts, are more prevalent today due to advancements in the structural systems, strength of materials, and design practices. These factors allow buildings to be taller, lighter, and more flexible, thereby exacerbating the impact of dynamic responses. There is a growing need for innovative and effective techniques to reduce the serviceability responses of these tall buildings. The current study considers a case study of a real building to show the effectiveness and robustness of the TLD in reducing the coupled lateral-torsional motion of this high-rise building under wind loading. Three unique multi-modal TLD systems are designed specifically to mitigate the torsional response of the building. A procedure is developed to analyze a structure-TLD system using High Frequency Force Balance (HFFB) test data from the Boundary Layer Wind Tunnel Laboratory (BLWTL) at the University of Western Ontario. The effectiveness of the unique TLD systems is investigated. In addition, a parametric study is conducted to determine the robustness of the systems in reducing the serviceability responses. Three practical parameters are varied to investigate the robustness of the TLD system: the height of water inside the tanks, the amplitude modification factor, and the structural modal frequencies.

• Computers and Concrete
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• 제24권2호
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• pp.95-102
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• 2019

Current article proposes a cheap prototype of an embedded wireless sensor to monitor concrete structures. The prototype can measure temperature and relative humidity concurrently at a controlled through smartphone time interval. It implements a maturity method to estimate in-place concrete strength, which is considered as an alternative for traditional shock impulse method and compression tests used in Kazakhstan. The prototype was tested and adequately performed in the laboratory and field conditions. Tests aimed to study the effect of internal and ambient temperature and relative humidity on the concrete strength gain. According to test results revealed that all parameters influence the strength gain to some extent. For a better understanding of how strongly parameters influence the strength as well as each other, proposed a multicolored cross-correlation matrix technique. The technique is based on the determination coefficients. It is able to show the value of significance of correlation, its positivity or negativity, as well as the degree of inter-influence of parameters. The prototype testing also recognized the inconvenience of Bluetooth control due to weakness of signal and inability to access several prototypes simultaneously. Therefore, further improvement of the prototype presume to include the replacement of Bluetooth by Narrow Band IoT standard.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1125-1125
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• 2001

Micro-scale test methods are producing small-sample size where the conventional physical and chemical tests can not be used (high standard deviation, uncertain sampling conditions, low repeatability). Different small-scale test methods were developed recently for determination of physico-chemical, functional, rheological properties of wheat or wheat dough using miniaturized instruments with sophisticated sample preparation/handling and mechanics (RVA, 2 g mixograph, micro-Z-arm mixer, small-scale noodle maker, micro-baking method etc.). The small-scale methodologies can be used as basic research tools or as technology supported measurements and can be also essential in the early selection for quality traits in breeding programs. The milling as a sample preparation step is essential procedure providing good quality flour or semolina samples from small amount of grain (5-10 g) in a reproducible and reliable way. The aim of present study was to use NIR as quality control tool, and to evaluate the recently developed and manufactured micro-scale lab mill (FQC-2000) produced by Inter-Labor Co. Ltd., Hungary. The milling characteristics of the new instrument were compared to other laboratory mills and the effects of milling action on the chemical composition of fractions were analysed. The fractions were tested with both chemical and near infrared spectroscopic methods. The micro-scale milling resulted significantly different yields, particle size distributions and different fractions from compositional point of view. The near infrared spectra were sensitive enough to distinguish the fractions obtained by different milling procedures. Quantitative NIR calibration equations were developed and tested in order to measure the chemical composition of characteristic milling fractions. Special qualification procedure the PQS (Polar Qualification System) method was used for detecting the differences between fractions obtained by macro and micro-milling procedures. The results and the limitations of PQS method in this application will be discussed.

• 대한통합의학회지
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• 제11권4호
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• pp.135-145
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• 2023

Purpose : The purpose of this study was to discover which breathing technique is more effective in improving respiratory function by applying different breathing techniques-the chest expansion respiratory technique and the abdominal expansion respiratory technique-to adults in the same aerobic exercise situation. Methods : In this study, 30 people were randomly assigned to two groups: chest expansion respiratory technique with aerobic exercise (A group) and abdominal expansion respiratory technique with aerobic exercise (B group). Group A was asked to breathe after wrapping their rib cage with an elastic band, and Group B was asked to breathe after wrapping their abdomen with an elastic band. A total of 3 sets of 30 breaths were performed, 3 times a week for 6 weeks. For statistical processing, an independent t-test was used to verify homogeneity between the two groups, and a repeated measure analysis of variance (ANOVA) was used to compare differences according to the period for each group. Results : The changes in FVC and FEV₁ for each group following 6 weeks of intervention are as follows. In comparison according to the intervention period, there was a significant increase in all groups depending on the timing of measurement (p<.05), and as a result of the inter-subject effect test, there was no significant difference between groups (p>.05). In addition, there was no interaction effect between period and group (p>.05). Conclusion : The conclusion of this study is that FVC and FEV₁ values increased according to the intervention period in both groups; therefore, it can be suggested that flexible breathing techniques can be applied depending on the patient's physical situation when applying a breathing program to improve respiratory function.

• Wind and Structures
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• 제20권4호
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• pp.549-564
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• 2015

The three-dimensional unsteady incompressible Reynolds-averaged Navier-Stokes equations and k-${\varepsilon}$ double equations turbulent model were used to investigate the effect on the measurements of anemometers due to a passing high-speed train. Sliding mesh technology in Fluent was utilized to treat the moving boundary problem. The high-speed train considered in this paper was with bogies and inter-carriage gaps. Combined with the results of the wind tunnel test in a published paper, the accuracy of the present numerical method was validated to be used for further study. In addition, the difference of slipstream between three-car and eight-car grouping models was analyzed, and a series of numerical simulations were carried out to study the influences of the anemometer heights, the train speeds, the crosswind speeds and the directions of the induced slipstream on the measurements of the anemometers. The results show that the influence factors of the train-induced slipstream are the passing head car and tail car. Using the three-car grouping model to analyze the train-induced flow is reasonable. The maxima of horizontal slipstream velocity tend to reduce as the height of the anemometer increases. With the train speed increasing, the relationship between $V_{train}$ and $V_{induced\;slipstream}$ can be expressed with linear increment. In the absence of natural wind conditions, from the head car arriving to the tail car leaving, the induced wind direction changes about $330^{\circ}$, while under the crosswind condition the wind direction fluctuates around $-90^{\circ}$. With the crosswind speed increasing, the peaks of $V_X,{\mid}V_{XY}-V_{wind}{\mid}$ of the head car and that of $V_X$ of the tail car tend to enlarge. Thus, when anemometers are installed along high-speed railways, it is important to study the effect on the measurements of anemometers due to the train-induced slipstream.

• Geomechanics and Engineering
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• 제20권6호
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• pp.537-546
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• 2020

Oil and natural gas reserves have been recognised abundantly in clayey rich rock formations in deep costal reservoirs. It is necessary to understand the sedimentary history of those reservoir rocks to well explore these natural resources. This work designs a group of laboratory experiments to mimic the physical process of the sedimentary clay-rich rock formation. It presents characterisation results of the physical properties of the artificial clayey rocks synthesized from illite clay, quartz sand and brine water by high-pressure consolidation tests. Special focus is given on the effects of illite clay content and high-stress consolidation on the physical properties. Multi-step loaded consolidation experiments were carried out with stress up to 35 MPa on mixtures constituting of the illite clay, quartz sand and brine water with five initial illite clay contents (w=85%, 70%, 55%, 40% and 25%). Compressibility and void ratio were characterised throughout the physical compaction process of the mixtures constituting of five illite clay contents and their water permeability was measured as well. Results show that the applied stress induces a great reduction of clayey rock void ratio. Illite clay contents has a significant influence on the compressibility, void ratio and the permeability of the physically synthesized clayey rocks. There is a critical illite clay content w=70% that induces the minimum void ratio in the physically synthesised clayey rocks. The SEM study indicates, in the high-pressure synthesised clayey rocks with high illite clay contents, the illite clay minerals are located in layers and serve as the material matrix, and the quartz minerals fill in the inter-mineral pores or are embedded in the illite clay matrix. The arrangements of the minerals in microscale originate the structural anisotropy of the high-pressure synthesised clayey rock. The test findings can give an intuitive physical understanding of the deep-buried clayey rock basins in energy reservoirs.

• 한국해양생명과학회지
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• 제9권1호
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• pp.9-21
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• 2024

마비성 패류 독소(Paralytic shellfish poisoning, PSP)는 유해 조류에 의해 생성되며, 독소에 노출된 수산물을 섭취하였을 때 중독이 발생한다. 수산물 중 PSP를 검출하는 표준 시험법인 Mouse bioassay (MBA)는 낮은 검출한계와 동물 윤리 문제로 대체 시험법의 개발 필요성이 대두되고 있다. 이러한 대체 시험법 중, PSP가 신경 세포막의 Na⁺ 채널을 차단하는 기전을 이용한 마우스 뇌신경 모세포종 세포 기반 시험법(Neuro-2a assay)의 표준화를 위한 노력이 대두되고 있다. Neuro-2a assay의 원리는 Neuro-2a 세포주에 Na⁺/K⁺ ATPase 억제제인 Ouabain(O)과 Na⁺ 채널 활성화제인 Veratridine (V)을 처리하여 과도한 Na⁺ 유입으로 인한 세포사멸을 유도한 상태에서, Na⁺ 채널 억제제인 PSP를 처리하게 되면 Na⁺ 유입이 차단되어 세포가 생존하는 것을 측정하는 것이다. 본 연구에서는 PSP 검출을 위한 Neuro-2a assay를 국내 연구 환경에 맞게 다양한 매개변수를 개선하여 최적 시험법을 확립하고자 하였다. 고려한 매개변수들은 세포밀도, 배양 조건 및 PSP 처리 조건 등으로, 그 결과는 아래와 같다. 초기 세포밀도는 40,000 cells/well로, 세포 배양시간 및 처리시간은 각각 24시간으로 설정하였다. 또한 최적 O/V 농도는 500/50 μM로 설정하였다. 본 연구에서 PSP 중 Saxitoxin (STX)에 대해서 O/V 처리가 된 상태에서 S자형 용량-반응 그래프가 도출되는 8가지 농도(368~47,056 fg/μl)를 확인하였고, Neuro-2a assay의 실험실 간 변동성 비교를 통해, 실험의 적정성 확인을 위한 5가지 Quality Control Criteria와 실험 데이터의 신뢰가능 범위(Data Criteria) 6가지를 설정하였다. 확 립된 조건으로 Neuro-2a assay를 진행한 결과 반수영향농도(EC₅₀) 값은 약 1,800~3,500 fg/μl로 나타났다. 실험실 간 변동성 비교 결과, Quality Control Criteria 값 및 Data criteria 값의 변동계수(coefficients of variation (CVs))가 1.98~29.15% 범위로 산출되어 실험의 적정성 및 재현성이 확인되었다. 본 연구를 통해 우리나라에서 활용할 수 있는 PSP 검출용 Neuro-2a assay 시험법의 최적 조건 및 5가지 Quality control 기준을 제시하였고, PSP 중 대표적인 독소인 STX을 대상으로 Neuro-2a assay를 실시한 결과 유의한 EC₅₀ 값을 산출할 수 있었으며, 향후 국내 수산물을 대상으로 MBA를 대체할 수 있는 PSP 검출법으로 활용될 것으로 기대된다.

• 분석과학
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• 제25권4호
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• pp.207-213
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• 2012

이 연구는 ISO/TC54 전문위원회(Shanghai, Sep. 14-15, 2010)의 결정에 따라 국제규격 초안으로 제안된 ISO/DIS (Draft International Standard) 25157-resolution 385 중국산 쿠스이(苦水)형 장미(Rosa sertata ${\times}$ Rosa rugosa) 정유의 기체 크로마토그래피 분석표에 대한 국제 6개국 전문가 실험실간 재현정밀도 시험 (round-robin test: RRT)의 하나로 수행되었다. GC-FID로 분석할 때 비극성인 SPB-1 컬럼에서는 총 179개 성분, 중간 극성의 DB-624 컬럼에서는 165개 성분, 극성 Supelcowax-10 컬럼에서는 총 162개 성분을 분리하였다. ${\beta}$-Citronellol (41.6~46.7%)과 geraniol (9.7~11.0%) 및 nerol (3.4~4.5%)이 쿠스이형 장미 정유의 주성분이었다. SPB-1 컬럼과 DB-624 컬럼에서는 ${\beta}$-citronellol과 nerol성분 피크가 서로 분리되지 않고 중첩하였으나, Supelcowax-10 컬럼에서는 두 성분을 분리할 수 있었다. Phenethyl alcohol의 경우 정지상 극성이 커질수록 머무름 시간이 길어짐을 확인하였다. 그런데 거의 대부분의 특성 성분들의 머무름 시간은 중국측이 ISO/DIS 25157에서 제시한 것과 일치하였으나 극성 컬럼으로 분리한 phenethyl alcohol의 머무름 시간의 경우 중국측이 제시한 것 보다 큰 차이를 보였다. 동시에 불가리아산 장미(Rosa damascena Miller) 정유와 향수에 대한 기체크로마토그래피 분석표도 비교 분석하였다. 불가리아 장미 정유의 특성 아로마 성분 함량이 중국산 쿠스이형의 함량보다 더 많았다.

• 치위생과학회지
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• 제15권4호
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• pp.393-398
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• 2015

성공적인 보철치료를 위해서 가장 필요한 선행조건 중 하나는 환자의 구강과 정확한 모형의 제작이다. 최근 치과용 캐드캠을 이용한 보철물의 제작 수요가 증가함에 따라 본 연구에서는 총의치 제작을 위한 디지털 모형의 정확도를 평가함으로써 해당 임상가(치과의사, 치과위생사, 치과기공사)들에게 참고자료를 제시하고자 하였다. 이를 위해 기존 아날로그 제작 방식에 의한 석고 모형(대조군)과 이를 스캔하여 제작한 디지털 모형(실험군)을 각각 20개씩 제작 후 정확도 평가를 위한 6개의 계측지점을 선정하였다. 두 집단의 모형에서 측정된 6개의 계측지점의 평균을 비교 평가하는 방식으로 디지털 모형의 정확도를 평가하였다. 본 연구 결과 치과용 스캐너를 이용하여 제작된 디지털 모형이 아날로그 모형보다 작게 제작된다는 것을 알 수 있었으나 이는 통계적으로 유의하지 않았다. 또한 두 집단의 모형들에서 측정된 계측거리의 평균의 차이는 계측거리 별로 0.05~0.45 mm로 조사되었는데, 이러한 차이는 기존 선행 연구들에 근거하였을 때 그 정도가 미비한 것으로써 최종 보철물의 성패에는 영향을 미치지 않는 것을 알 수 있었다. 최근 치과용 캐드캠을 이용한 보철물의 제작 수요는 증가하고 있는데 반해 디지털 모형의 정확도와 관련한 연구는 매우 부족한 것을 감안하였을 때 본 연구는 관련 실험을 통해 결과를 도출하여 해당 임상가(치과의사, 치과위생사, 치과기공사)들에게 참고자료를 제시하고자 하였다는 점에서 의의가 있다고 생각된다. 본 연구 결과들을 종합하고, 선행 연구들의 결과에 비추어 보았을 때 치과용 캐드캠을 이용한 총의치 제작 시 제작되는 디지털 모형은 임상적으로 허용이 가능할 것으로 기대된다.

• Translational and Clinical Pharmacology
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• 제26권4호
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• pp.160-165
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• 2018

Indobufen ($Ibustrin^{(R)}$), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling using $NONMEM^{(R)}$ and predicted the therapeutic doses exerting the maximal efficacy of each enantioselective S- and R-indobufen formulation. S- and R-indobufen were added individually or together to 24 plasma samples from drug-naïve healthy subjects, generating 892 samples containing randomly selected concentrations of the drugs of 0-128 mg/L. Collagen-induced platelet aggregation in platelet-rich plasma was determined using a Chrono-log Lumi-Aggregometer. Inhibitory sigmoid $I_{max}$ model adequately described the anti-platelet effect. The S-form was more potent, whereas the R-form showed less inter-individual variation. No significant interaction was observed between the two enantiomers. The anti-platelet effect of multiple treatments with 200 mg indobufen twice daily doses was predicted in the simulation study, and the effect of S- or R-indobufen alone at various doses was predicted to define optimal dosing regimen for each enantiomer. Simulation study predicted that 200 mg twice daily administration of S-indobufen alone will produce more treatment effect than S-and R-mixture formulation. S-indobufen produced treatment effect at lower concentration than R-indobufen. However, inter-individual variation of the pharmacodynamic response was smaller in R-indobufen. The present study suggests the optimal doses of R-and S-enantioselective indobufen formulations in terms of treatment efficacy for patients with thromboembolic problems. The proposed methodology in this study can be applied to the develop novel enantio-selective drugs more efficiently.