• 대한기계학회논문집A
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• 제27권9호
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• pp.1469-1476
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• 2003

This paper provides plastic limit load solutions of cylinders with circumferential part-through surface cracks under combined axial tension, internal pressure and global bending. Such solutions are developed based on detailed three-dimensional (3-D) finite element (FE) limit analyses using elastic-perfectly-plastic material behaviour, together with analytical solutions based on equilibrium stress fields. For the crack location, both external and internal cracks are considered. Furthermore, in terms of the crack shape, both semi-elliptical and constant-depth surface cracks are considered. The resulting limit load solutions are given in a closed form, and thus can be easily used in practical situations. Being based on detailed 3-D FE limit analysis, the present solutions are believed to most reliable, and thus to be valuable information for integrity assessment of piping.

• Nuclear Engineering and Technology
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• 제48권1호
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• pp.218-227
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• 2016

Background: Steam explosions may occur in nuclear power plants by molten fuel-coolant interactions when the external reactor vessel cooling strategy fails. Since this phenomenon can threaten structural barriers as well as major components, extensive integrity assessment research is necessary to ensure their safety. Method: In this study, the influence of yield criteria was investigated to predict the failure of a reactor cavity under a typical postulated condition through detailed parametric finite element analyses. Further analyses using a geometrically simplified equivalent model with homogeneous concrete properties were also performed to examine its effectiveness as an alternative to the detailed reinforcement concrete model. Results: By comparing finite element analysis results such as cracking, crushing, stresses, and displacements, the Willam-Warnke model was derived for practical use, and failure criteria applicable to the reactor cavity under the severe accident condition were discussed. Conclusion: It was proved that the reactor cavity sustained its intended function as a barrier to avoid release of radioactive materials, irrespective of the different yield criteria that were adopted. In addition, from a conservative viewpoint, it seems possible to employ the simplified equivalent model to determine the damage extent and weakest points during the preliminary evaluation stage.

• 한국안전학회지
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• 제29권4호
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• pp.160-167
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• 2014

To determine a proper ASIL for each hazardous event with a proper safety goal, the right classes should first be determined for the three properties of the hazardous event; (i) severity of harm from the resultant accident, (ii) exposure to the relevant operational situation, and (iii) controllability to avoid the induced risks. ASIL can be clearly determined with right classes of these three properties. But no specific methodologies or processes for their classification can be found in ISO 26262, except only a rough guideline with a simplified set of illustrative tables. In this paper, we try to present a systematic model for classifying the three properties of the hazardous event and suggest a refined procedure of ASIL determination. The proposed model provides a specific method to get a more objective ASIL compared with that in the standard. Scrutinizing the current methodology, we develop a refined method and also provide an illustrative example.

• 한국조경학회지
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• 제31권1호
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• pp.34-41
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• 2003

Connectivity is a quantitative indicator of landscape structure, and connectivity of urban green areas is an indicator of ecological integrity in urban landscapes. The purposes of this study are to assess the connectivity of urban green areas in Seoul, and to develop a method of siting new green areas for better connectivity. Diverse methods for connectivity assessment and indices of connectivity are reviewed and applied to the connectivity assesment of green areas in Seoul. The indices of connectivity of green areas in Seoul turned out to be higher than expected, maybe because many of them are rather evenly distributed, serving as stepping stones, and because there are many riparian corridors, including the Han River. Analysis also shows the optimum location of new green space patches or corridors will be those spots that would link the mainland, or large green areas outside the city, and existing green areas in the city. Restoration of urban streams as ecological corridors will significantly enhance connectivity. Three different scenarios with increasing numbers of new green areas in the city were then prepared. The changes of connectivity were measured and the possible success rates of animal dispersal were simulated. The results revealed that restoration of streams will increase the connectivity and success rates of animal dispersal.

• 한국자동차공학회논문집
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• 제6권6호
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• pp.40-52
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• 1998

A good grasp of the failure mechanisms of resistance spot weld, widely used in joining the auto-panels, in essential to the structural/crashworthy analyses and integrity assessment of the whole auto-body. In this study, We provide an estimative model describing the failure behavior of resistance spotf weld, and apply the model to the finite element analysis of crashworthiness. First, in "Part 1-Failure Criteria", to be used for the finite element analysis of spot-welded structural panels of an auto-body, (i) a methodology for quantifying the spot weld failure and the accompanying failure criteria are presented, and (ii) the coefficients of the failure equation are determined by a munimum number of appropriate experimental tests. To achieve these, we derive the functional form of the failure envelop by limit analysis, and correlate it with the form in PAM-$CRASH^{TM}$ code, and also investigate the effect of the failure coefficients on the failure envelop form. An estimative model obtained in this Part1, as spot weld failure criteria is applied to the Macroscopic finite element analysis of autobody structural panels using PAM-$CRASH^{TM}$ code in Part 2.

• Toxicological Research
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• 제25권1호
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• pp.1-8
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• 2009

Validation specifies and coordinates all relevant activities to ensure compliance with good laboratory practices (GLP) according to suitable international standards. This includes validation activities of past, present and future for the best possible actions to ensure the integrity of non-clinical laboratory data. Recently, validation has become increasingly important, not only in good manufacturing practice (GMP) institutions but also in GLP facilities. In accordance with the guideline for GLP regulations, all equipments used to generate, measure, or assess data should undergo validation to ensure that this equipment is of appropriate design and capacity and that it will consistently function as intended. Therefore, the implantation of validation processes is considered to be an essential step in a global institution. This review describes the procedures and documentations required for validation of GLP. It introduces basic elements such as the validation master plan, risk assessment, gap analysis, design qualification, installation qualification, operational qualification, performance qualification, calibration, traceability, and revalidation.

• 비파괴검사학회지
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• 제24권4호
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• pp.396-409
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• 2004

음향방출기술(acoustic emission technology)은 종래의 기존 비파괴검사법과는 달리 가동중인 설비의 건전성을 평가할 수 있으며 실시간으로 설비 상태의 진단이 가능한 실시간 감시기법이다. 즉 기존 비파괴검사법과는 달리 가동중인 설비에 대해 원격으로 결함을 탐지하고 결함 위치를 판정할 수 있는 연속감시 기능을 가진 비파괴 신기술로 최근 연구개발이 활발히 진행되고 있는 방법이다. 이러한 장점 때문에 대형 산업설비의 각종 기기들에 대한 감시 및 진단에 활용하고 있으며, 그 활용도가 점점 확대되고 있는 추세에 있다. 특히 종합적인 산업설비로 구성되어 있는 발전설비의 진단과 감시에 가장 효과적인 방법이라 할 수 있겠다. 본 논문에서는 원자력 화력 수력발전소 등의 발전설비에 대해 현재 적용중인 음향방출기술과 새로운 적용기술에 대해 서술하였다.

• 한국소음진동공학회논문집
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• 제13권6호
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• pp.452-459
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• 2003

The characteristics of fluid-elastic instability and effects of turbulent excitations for the KSNP steam generator tubes were investigated numerically. The information for the thermal-hydraulic data of the steam generator has been obtained by using the ATHOS3-MOD1 code and the flow-induced vibration(FIV) analysis has been conducted by using the PIAT(program for Integrity assessment of SG tube) code. The KSNP steam generator has the concentrated plugging zone at the vicinity of the stay cylinder inside the SG. To investigate the cause of the concentrated tube plugging zone, the FIV analysis has been performed for various column and row number of the steam generator tubes. From the results of FIV analysis the stability ratio due to the fluid-elastic instability and vibrational amplitude due to the turbulent excitation in the concentrated plugged zone have a trend of larger values than those of the outer concentrated tube Plugging zone.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2989-2993
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• 2016

The commonest cancer in Egyptian females occurs in the breast cfDNA is a non-invasive marker for tumor detetion and prognostic assessment in many types of cancer including breast cancer. This study aimed to assess the role of cfDNA and its fragmentation pattern in breast cancer prognosis and treatment response. Forty female patients with malignant breast tumors and a comparable group of healthy blood donors were enrolled prospectively. cfDNA levels and fragmentation patterns were investigated after cfDNA extraction, gel electrophoresis and gel analysis. The percentage of breast cancer patients positive for cfDNA (92.5%) was significantly higher than that of controls (55%). Also, mean concentration of cfDNA was significantly higher than in the control group (P<0.05). Most Her-2 positive patients had long cfDNA fragments, this being significant as compared to Her-2 negative patients (P<0.05). Metastasis was also positively linked to significantly higher cfDNA (P<0.05) and the mean cfDNA integrity index was significantly higher in non-responders compared to treatment responders (P<0.05). In conclusion, both qualitative and quantitative aspects of cfDNA and its different fragments in breast cancer patients could be related to prognosis, metastasis and treatment response. Long cfDNA fragments could be particularly useful for prediction purposes.

• Structural Engineering and Mechanics
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• 제72권1호
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• pp.31-41
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• 2019

Structural integrity assessment of piping components is of paramount important for remaining life prediction, residual strength evaluation and for in-service inspection planning. For accurate prediction of these, a reliable fracture parameter is essential. One of the fracture parameters is stress intensity factor (SIF), which is generally preferred for high strength materials, can be evaluated by using linear elastic fracture mechanics principles. To employ available analytical and numerical procedures for fracture analysis of piping components, it takes considerable amount of time and effort. In view of this, an alternative approach to analytical and finite element analysis, a model based on relevance vector machine (RVM) is developed to predict SIF of part through crack of a piping component under fatigue loading. RVM is based on probabilistic approach and regression and it is established based on Bayesian formulation of a linear model with an appropriate prior that results in a sparse representation. Model for SIF prediction is developed by using MATLAB software wherein 70% of the data has been used for the development of RVM model and rest of the data is used for validation. The predicted SIF is found to be in good agreement with the corresponding analytical solution, and can be used for damage tolerant analysis of structural components.