• The Korean Journal of Zoology
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• v.32 no.1
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• pp.48-54
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• 1989

Several proteolytic activities and the level of and-trypsin in neoplastic tissues of human cervix and liver were compared to those in normal tissues to examine if any correlation exists between malignant behavior of the tumors and the changes in overall proteolytic capacity. Proteolysis against casein and insulin in cervix tumor was increased to 2-to 3-fold while that in liver tumor was reduced to one-tenth to one-half. By contrast, the level of anti-trypsin in cervix tumor was lowered to nearly one-tenth of that in normal tissues while the level rose to about 2-fold in malignant tissues of liver. On the other hand, the activities of plasmin-like protease and plasminogen activator were enhanced 10-20% over the activities in normals. These results suggest that the changes in proteolytic capacity are at least in part due to outbalance in either of proteolytic or its inhibitory activity over the other and occur distinctively to each tumor systems for their malignant behavior.

• The Korean Journal of Zoology
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• v.31 no.3
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• pp.185-190
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• 1988

To investigate whether malignant behavior of skin tumor correlates with changes in the level of proteolytic activities in skin tumors, rats were treated with 7,12-dimethylbenzanthracene followed by photbor ester. Tumors induced upon the treatrnents exhibited more than 20-fold increase in the activity of plasminogen activator and about 3-fold of plasmin-like activity. as compared to those in treated controls. Furthermore, the former activity was raised to about 6-fold even in the preneoplastic dssues of the skin tissues. On the other hand, the proteolytic activity against casein and insulin decreased to several-fold in the tumor tissues while antitrvpsin activity remained similar in both tumor and controls. Thus, the increase in the activities of plasmInogen activator and plasminlike enzyme appears to occur as a charaderistic to skin cancer and may involve in invasion and metsstasis of the tumor.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.41 no.2
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• pp.117-124
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• 2017

The performance of the colored Gauss-Seidel solver on CPU and GPU was investigated for the two- and three-dimensional heat conduction problems by using different mesh sizes. The heat conduction equation was discretized by the finite difference method and finite element method. The CPU yielded good performance for small problems but deteriorated when the total memory required for computing was larger than the cache memory for large problems. In contrast, the GPU performed better as the mesh size increased because of the latency hiding technique. Further, GPU computation by the colored Gauss-Siedel solver was approximately 7 times that by the single CPU. Furthermore, the colored Gauss-Seidel solver was found to be approximately twice that of the Jacobi solver when parallel computing was conducted on the GPU.

• Journal of the Korean Applied Science and Technology
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• v.34 no.4
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• pp.1104-1111
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• 2017

In this study, the authors aimed to give careful consideration to the circulation of bioenergy (Qi) by using cardiorespiratory massage technique. Finding enlightenment in harmony with nature thousands of years ago, our ancestors created Qi using natural breathing and tried to achieve good health and long life by controling the up and down movement. Experiencing the importance of the abdomen during the hungry times, also, grandmothers cured diseases by rubbing the abdomen, which is the ocean of life with their soft, soothing touch of hand. Naval breathing therapy was formed, based on natural breathing, emotional recognition of grandmothers' soft, soothing touch, and the Theory of Unified Reason and Energy that is the key of Oriental medicine. Natural breathing and Yakson massage are kinds of naturopathy to change body and mind, cure diseases naturally, and maintain the improvement in physical functions by taking care of the abdomen through the creation of Qi and the up and down movement and keeping dynamic balance between the natural world and the inside and outside of human body. It is anticipated that this study could contribute to the practical spread for an active application of naval breathing therapy and be broadly used in scientific clinical researches.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.1
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• pp.37-45
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• 2022

The aim of the present study was to investigate the physiological role of nicotinamide phosphoribosyltransferase (NAMPT) associated with odontogenic differentiation during tooth development in mice. Mouse dental papilla cell-23 (MDPC-23) cells cultured in differentiation media were stimulated with the specific NAMPT inhibitor, FK866, and Visfatin (NAMPT) for up to 10 days. The cells were evaluated after 0, 4, 7, and 10 days. Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The mineralization assay was performed by staining MDPC-23 cells with Alizarin Red S solution. After cultivation, MDPC-23 cells were harvested for quantitative PCR or Western blotting. Analysis of variance was performed using StatView 5.0 software (SAS Institute Inc., Cary, NC, USA). Statistical significance was set at p < 0.05. The expression of NAMPT increased during the differentiation of murine odontoblast-like MDPC-23 cells. Furthermore, the up-regulation of NAMPT promoted odontogenic differentiation and accelerated mineralization through an increase in representative odontoblastic biomarkers, such as dentin sialophosphoprotein, dentin matrix protein-1, and alkaline phosphatase in MDPC-23 cells. However, treatment of the cells with the NAMPT inhibitor, FK866, attenuated odontogenic differentiation, as evidenced by the suppression of odontoblastic biomarkers. These data indicate that NAMPT regulated odontoblastic differentiation through the regulation of odontoblastic biomarkers. The increase in NAMPT expression in odontoblasts was closely related to the formation of the extracellular matrix and dentin via the Runx signaling pathway. Therefore, these data suggest that NAMPT is a critical regulator of odontoblast differentiation during tooth development.

• The Journal of Korean Physical Therapy
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• v.34 no.5
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• pp.255-266
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• 2022

Purpose: This study sought to study the effects of cross-legged sitting posture on joint motion. It also examined the correlation between the changes in the joint range of motion, musculoskeletal symptoms, and facial asymmetry. Methods: The Acumar Digital Inclinometer (Lafayette Instrument Company, USA) was used to measure the range of motion (ROM). We measured the flexion and extension of the cervical, thoracic, and lumbar spine using a dual inclinometer, and measured the ROM of the shoulder and hip joint with a single inclinometer. The Likert scale questionnaire was used to investigate musculoskeletal symptoms and facial asymmetry. Results: The data analysis was performed using the Jamovi version 1.6.23 statistical software. After confirming the normality of the ROM with descriptive statistics, it was compared with the normal ROM through a one-sample t-test. Correlation matrix analysis was performed to confirm the association between facial asymmetry and musculoskeletal symptoms. The result of the one-sample t-test showed a significant increase in the thoracic spine extension and right and left hip external rotation (p<0.001^***), while most other joints were restricted. As per the frequency analysis, facial asymmetry was found to be 81.70%. Conclusion: The independent variable, namely cross-legged sitting posture led to an increase in ROM. The study also suggests that facial asymmetry and musculoskeletal symptoms could occur. Therefore, to prevent the increase and limitation of ROM and to prevent the occurrence of facial asymmetry and musculoskeletal symptoms, it is suggested that the usual cross-legged sitting posture should be avoided.

• Journal of Korean society of Dental Hygiene
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• v.23 no.1
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• pp.43-53
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• 2023

Objectives: We developed an integrated cognitive function improvement program comprising cognitive, emotional, and physical domains, and remotely applied it to middle-aged adults to investigate its effects on oral health, cognitive function, and mental health improvement. Methods: The experimental group underwent the program remotely, using the Zoom platform. A total of 24 participants were recruited and divided into 12 experimental and 12 control groups. The program comprised cognitive, emotional, and physical activities. The sessions lasted 90 min and were performed twice a week for 6 weeks from April to May 2022. Results: Cognitive function, arousal, physical, and mental stress were significantly improved in the experimental group after the intervention than at the baseline (p<0.05). Regarding oral health, tongue plaque decreased 1.34-fold (p<0.01) and saliva increased 1.04-fold (p<0.05) in the experimental group after the intervention than at the baseline. Moreover, the experimental group showed significant improvements in tongue plaque and saliva than the control group (p<0.05 for tongue plaque and p<0.01 for saliva). Regarding mental health, social support significantly increased 11.67-fold (p<0.05) in the experimental group than at the baseline. The experimental group also showed significantly improved social support than the control group (p<0.01). Conclusions: The non-face-to-face integrated cognitive function improvement program for middle-aged adults improved their cognitive function and oral and mental health. Based on these findings, this program may be a useful health program tool for middle-aged individuals.

• Physical Therapy Rehabilitation Science
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• v.12 no.2
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• pp.80-91
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• 2023

Objective: The purpose of this study is to identify factors that affect the incidence of hypertension using logistic regression and decision tree analysis, and to build and compare predictive models. Design: Secondary data analysis study Methods: We analyzed 9,859 subjects from the Korean health panel annual 2019 data provided by the Korea Institute for Health and Social Affairs and National Health Insurance Service. Frequency analysis, chi-square test, binary logistic regression, and decision tree analysis were performed on the data. Results: In logistic regression analysis, those who were 60 years of age or older (Odds ratio, OR=68.801, p<0.001), those who were divorced/widowhood/separated (OR=1.377, p<0.001), those who graduated from middle school or younger (OR=1, reference), those who did not walk at all (OR=1, reference), those who were obese (OR=5.109, p<0.001), and those who had poor subjective health status (OR=2.163, p<0.001) were more likely to develop hypertension. In the decision tree, those over 60 years of age, overweight or obese, and those who graduated from middle school or younger had the highest probability of developing hypertension at 83.3%. Logistic regression analysis showed a specificity of 85.3% and sensitivity of 47.9%; while decision tree analysis showed a specificity of 81.9% and sensitivity of 52.9%. In classification accuracy, logistic regression and decision tree analysis showed 73.6% and 72.6% prediction, respectively. Conclusions: Both logistic regression and decision tree analysis were adequate to explain the predictive model. It is thought that both analysis methods can be used as useful data for constructing a predictive model for hypertension.

• The Korean Journal of Zoology
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• v.21 no.2
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• pp.59-66
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• 1978

A dispersal experiment on Culex tritaeniorhynchus females by a mark-release-recapture method was carried out at Pohgang city, Korea, in Augst 1974. The results are summarized as follows: 1. Of 23,115 females of C. tritaeniorhynchus released, 120 females were recaptured, giving 0.519% recapture rate and 0.00208 recovery ration. 2. Dispersal rates from the release site were 77.5% in 0-2km, 11.7% in 4-6 km and 5.8% in 6-8km. 3. C. tritaeniorhynchus females flew 7.5km in one day. The average of the daily mean distances was 1.55km, and it showed that the dispersal distance did not correlate with days after release.

• Korean Journal of Agricultural Science
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• v.45 no.3
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• pp.509-519
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• 2018

This study was investigated the anti-oxidant property and neuro-protective effect of Cirsium japonicum var. maackii (CJM) against oxidative stress in hydrogen peroxide ($H_2O_2$)-induced C6 glial cells. We measured the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydroxyl radical (${\cdot}OH$), and superoxide ($O_2{^-}$) radical scavenging activities of an ethanol extract and four fractions [n-Butanol, ethyl acetate (EtOAc), $CHCl_3$, and n-Hexane] from CJM. The results of this study show that the extract and all fractions from CJM had a dose-dependent DPPH radical scavenging activity. In particular, the EtOAc fraction exhibited the strongest scavenging effect with 88.23% at a concentration of $500{\mu}g/mL$. In addition, the EtOAc fraction from CJM also effectively scavenged ${\cdot}OH$ radicals and $O_2{^-}$ radicals, compared to other extract and fractions. In C6 glial cells, $H_2O_2$ markedly decreased the cell viability as well as increased lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) production. However, the EtOAc fraction of CJM attenuated the cellular damage from the oxidative stress by elevating the cell viability and inhibiting the LDH release and ROS over-production compared with the $H_2O_2$-treated control group. Our findings indicate that the EtOAc fraction from CJM has antioxidant effect and neuro-protective effect against oxidative stress, suggesting that it can be used as a natural antioxidant and therapeutic agent for the prevention of neurodegenerative disorders.