The Korean Journal of Zoology (한국동물학회지)
- Volume 31 Issue 3
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- Pages.185-190
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- 1988
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- 0440-2510(pISSN)
Relation of the Activities of Plasminogen Activator and Plasmin-like Protease with Malignant Behavior of Skin Tumor of Rats
Plasminogen Activator 및 Plasmin-like Protease활성도의 변화와 쥐 피부암의 악성
- Yun Kee (Department of Zoology, College of Natural Sciences Seoul National University) ;
- Park, Sang C. (Department of Biochemistry, School of medicine Seoul National University) ;
- Doo B. Ha (Department of Zoology, College of Natural Sciences Seoul National University) ;
- Chin H. Chung (Department of Zoology, College of Natural Sciences Seoul National University)
- Published : 1988.07.01
Abstract
To investigate whether malignant behavior of skin tumor correlates with changes in the level of proteolytic activities in skin tumors, rats were treated with 7,12-dimethylbenzanthracene followed by photbor ester. Tumors induced upon the treatrnents exhibited more than 20-fold increase in the activity of plasminogen activator and about 3-fold of plasmin-like activity. as compared to those in treated controls. Furthermore, the former activity was raised to about 6-fold even in the preneoplastic dssues of the skin tissues. On the other hand, the proteolytic activity against casein and insulin decreased to several-fold in the tumor tissues while antitrvpsin activity remained similar in both tumor and controls. Thus, the increase in the activities of plasmInogen activator and plasminlike enzyme appears to occur as a charaderistic to skin cancer and may involve in invasion and metsstasis of the tumor.
피부암의 형성과 피부 조직에서 나타나는 단백질 분해활성의 변화와의 상과관계를 조사하기 위하여, 쥐의 피부에 7,12-dimethylbenzanthracene과 photbor ester를 차례로 처리하였다. 이 결과, 암이 유발된 피부 조직에서는 대조군에 비하여 plasminogen Activator(PA)의 활성도는 약 3배가 높게 나타났다. 더우기, PA의 활성도는 암 유발전(proteolytic activity)의 조직에서도 약6배가 정도 증가하였다. 반면,casein과 insulin의 분해활성도는 암조직에서 현저히 감소되었고 anti-trypsin의 활성도는 대조군의 것과 거의 비슷하게 나타났다. 따라서, PA 및 PLP활성도의 증가현상은 피부암에서 특징적으로 나타나는 것으로 보이며, 이 암의 전이 및 침투에 밀접한 관계가 있는 것으로 사료된다.