• Journal of Ginseng Research
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• v.45 no.6
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• pp.717-725
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• 2021

Background: Korean Red Ginseng (KRG) is a traditional herb that has several beneficial properties including anti-aging, anti-inflammatory, and autophagy regulatory effects. However, the mechanisms of these effects are not well understood. In this report, the underlying mechanisms of anti-inflammatory and autophagy-promoting effects were investigated in aged mice treated with KRG-water extract (WE) over a long period. Methods: The mechanisms of anti-inflammatory and autophagy-promoting activities of KRG-WE were evaluated in kidney, lung, liver, stomach, and colon of aged mice using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (qRT-PCR), and western blot analysis. Results: KRG-WE significantly suppressed the mRNA expression levels of inflammation-related genes such as interleukin (IL)-1β, IL-8, tumor necrosis factor (TNF)- α, monocyte chemoattractant protein-1 (MCP-1), and IL-6 in kidney, lung, liver, stomach, and colon of the aged mice. Furthermore, KRG-WE downregulated the expression of transcription factors and their protein levels associated with inflammation in lung and kidney of aged mice. KRG-WE also increased the expression of autophagy-related genes and their protein levels in colon, liver, and stomach. Conclusion: The results suggest that KRG can suppress inflammatory responses and recover autophagy activity in aged mice.

• Journal of Breast Cancer
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• v.21 no.4
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• pp.391-398
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• 2018

Purpose: The aim of this study was to investigate the association of telomere length with breast cancer risk. We simultaneously explored the association between telomerase reverse transcriptase gene polymorphisms and telomere length. Methods: We used real-time quantitative polymerase chain reaction to measure relative telomere length (RTL) in genomic DNA extracted from peripheral blood from 183 breast cancer cases and 191 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. Results: Our results show that breast cancer patients had significantly shorter RTLs than control subjects (p<0.05). When the RTLs were categorized into tertiles, we found that the lowest RTL was significantly associated with increased breast cancer risk compared with the highest RTL (odds ratio [OR], 2.33; 95% confidence interval [CI], 1.40-3.90; p=0.001). Subgroup analyses indicated that risk of breast cancer was also significantly increased in the lowest RTL compared with the highest RTL in age >40 years (OR, 2.41; 95% CI, 1.31-4.43;p=0.005), body mass index ${\leq}24kg/m^2$ (OR, 2.81; 95% CI, 1.55-5.10; p=0.001), and postmenopausal women (OR, 3.94; 95% CI, 1.63-9.51; p=0.002), respectively. In addition, individuals with the AA genotype of rs2853677 have longer telomeres than those of breast cancer patients with the AG genotype (p=0.011). Conclusion: Our results suggest that shorter RTL was associated with an increased risk of breast cancer. An association was found between the AA genotype of rs2853677 and longer RTLs in the case group. Functional studies are warranted to validate this association and further investigate our findings.

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.357.2-357
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• 1998

No Abstract, See Full Text

• Proceedings of the Zoological Society Korea Conference
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• 1998.10b
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• pp.356.2-356
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• 1998

No Abstract, See Full Text

• Journal of Industrial Convergence
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• v.2 no.1
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• pp.73-89
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• 2004

This study uses theoretical perspectives and models from organizational ecology to examine the dynamics and viability of strategic groups. Integrating the ecological perspective and the contingency theoretical view of strategic management, this study developed propositions demonstrating the impact of environmental density and variation on the effectiveness of strategic groups. Justifications for linking ecological perspectives to strategic management theory are discussed and the importance of the integrative approach to strategic management is highlighted.

• Perspectives in Nursing Science
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• v.15 no.2
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• pp.70-80
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• 2018

Purpose: The aim of this study was to investigate the characteristics of intervention programs for internet/smartphone addiction among adolescents through an integrative literature review. Methods: We searched MEDLINE(PubMed), CINAHL, Embase, DBpia, RISS, and KISS using a combination of "Internet or $phone^*$," "$addicti^*$," "adolescent," and "intervention or program or therapy." The searched studies were reviewed according to the criteria and an integrative literature review was conducted on the 14 selected papers published from January 1, 2013 to November 14, 2017. Results: Through the integrative review and analysis, a total of four attributes of interventions and their effects were derived. First, the number of group-focused interventions was significantly higher than that of individual-focused ones. Second, the interventions addressed various aspects of adolescents' problems while considering the complex nature of addiction problems. Third, there was a bias for region and sexual ratio. Lastly, most studies were actively conducted in community-based counseling or psychology settings. Conclusion: It is necessary to find more effective methods for addressing internet/smartphone addiction among adolescents through multidisciplinary approaches, including the consideration of various cultural and gender characteristics. This study provides a basis for developing future programs addressing addiction problems among adolescents.

• Child Health Nursing Research
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• v.26 no.2
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• pp.309-322
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• 2020

Purpose: The purpose of this integrative review was to synthesize previous research on perceptions of school health care among school-aged children and adolescents with chronic diseases. Methods: This study was performed in accordance with Whittemore and Knafl's stages of an integrative review (problem identification, literature search, data evaluation, data analysis, and presentation of the results). Four databases (PubMed, CINAHL, Embase, and Web of Science) were used to retrieve relevant articles. Results: Eighteen articles were included in this review. We identified five thematic categories: peer-related issues, a safe school environment, self-perception of an existing disease, self-management, and a supportive school environment. Conclusion: It is necessary to establish a school health care system with a supportive environment for children and adolescents with chronic diseases.

• Journal of Microbiology and Biotechnology
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• v.5 no.3
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• pp.132-137
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• 1995

The lambda integrase (lnt) is believed to bind to several arm and core sites of attP DNA in order to facilitate intasome formation. We have done systematic mutagenic analysis on all 5 arm sites and found that P1 is absolutely required for integration while P2 is not. We also found that all 3 P' arm sites(P'1, P'2, and P'3) are required for efficient integrative recombination. P'1, which is an important binding site for excision, also seems to be crucial for integration when preincubation of attP DNA with Int and IHF is performed before recombination. Preincubation assay revealed that preincubation with Int and IHF improved the efficiency of recombination of wild type attP DNA and demolished recombinations of P'1 mutant attP DNAs.

• Natural Product Sciences
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• v.21 no.2
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• pp.82-86
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• 2015

Phytochemical constituents were isolated from the fruits of Acanthopanax chiisanensis by repeated column chromatography. Their structures were identified as $\beta$-sitosterol (1), daucosterol (2), sesamin (3), chiisanogenin (4), and $22\alpha$-hydroxy chiisanogenin (5) by spectroscopic analysis (MS, ¹H-, and ¹³C-NMR). Compounds 1 - 5 were isolated for the first time from the fruits of A. chiisanensis.

• International Journal of Contents
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• v.15 no.4
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• pp.36-43
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• 2019

This is an integrative review paper of Augmented Reality (AR)/Virtual Reality (VR) simulation programs in the mental health area including the analysis of the general characteristics, contents, and the impact of the interventions studies. The keywords used to search the studies were "AR/VR" and "medical/nursing students". The author and a postdoctoral research fellow searched four electronic databases: Web of Science, PubMed, EmBase, and CINHA, and as a result nine studies met the inclusion criteria. Among the selected studies AR/VR simulation programs in the mental health area for healthcare professionals were found to be effective in clinical skills as well as for the interpersonal relationship and the stigma of mentally ill patients. Providing an opportunity to experience a safe and effective tool is important when educating health professionals and AR/VR simulation programs are safe and effective. Thus, standardized AR/VR simulation programs are needed to be developed for health professionals.