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http://dx.doi.org/10.1016/j.jgr.2021.03.009

Korean Red Ginseng exerts anti-inflammatory and autophagy-promoting activities in aged mice  

Kim, Jin Kyeong (Department of Integrative Biotechnology, Sungkyunkwan University)
Shin, Kon Kuk (Department of Integrative Biotechnology, Sungkyunkwan University)
Kim, Haeyeop (Department of Integrative Biotechnology, Sungkyunkwan University)
Hong, Yo Han (Department of Integrative Biotechnology, Sungkyunkwan University)
Choi, Wooram (Department of Integrative Biotechnology, Sungkyunkwan University)
Kwak, Yi-Seong (R&D Headquarters, Korea Ginseng Corporation)
Han, Chang-Kyun (R&D Headquarters, Korea Ginseng Corporation)
Hyun, Sun Hee (R&D Headquarters, Korea Ginseng Corporation)
Cho, Jae Youl (Department of Integrative Biotechnology, Sungkyunkwan University)
Publication Information
Journal of Ginseng Research / v.45, no.6, 2021 , pp. 717-725 More about this Journal
Abstract
Background: Korean Red Ginseng (KRG) is a traditional herb that has several beneficial properties including anti-aging, anti-inflammatory, and autophagy regulatory effects. However, the mechanisms of these effects are not well understood. In this report, the underlying mechanisms of anti-inflammatory and autophagy-promoting effects were investigated in aged mice treated with KRG-water extract (WE) over a long period. Methods: The mechanisms of anti-inflammatory and autophagy-promoting activities of KRG-WE were evaluated in kidney, lung, liver, stomach, and colon of aged mice using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (qRT-PCR), and western blot analysis. Results: KRG-WE significantly suppressed the mRNA expression levels of inflammation-related genes such as interleukin (IL)-1β, IL-8, tumor necrosis factor (TNF)- α, monocyte chemoattractant protein-1 (MCP-1), and IL-6 in kidney, lung, liver, stomach, and colon of the aged mice. Furthermore, KRG-WE downregulated the expression of transcription factors and their protein levels associated with inflammation in lung and kidney of aged mice. KRG-WE also increased the expression of autophagy-related genes and their protein levels in colon, liver, and stomach. Conclusion: The results suggest that KRG can suppress inflammatory responses and recover autophagy activity in aged mice.
Keywords
Korean Red Ginseng (KRG); anti-inflammatory effect; autophagy; aging;
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