• Archives of Pharmacal Research
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• 제28권12호
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• pp.1350-1357
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• 2005

Nuclear factor kappa B (NF-$\kappa$B) regulates the expression of multiple cytokines, chemokines, and cell adhesion molecules that are involved in the pathogenesis of asthma. We investigated the anti-asthmatic effects and the mechanism of action of DA-9201, an extract of the black rice, in a mouse model of asthma. Mice immunized with ovalbumin (OVA) were administered with DA-9201 (30, 100 or 300 mg/kg) or dexamethasone (DEXA, 3 mg/kg) for 2 weeks and challenged with aerosolized OVA during the last 3 days. Anti-asthmatic effects were assessed by means of enhanced pauses, level of total lgE and Th2 cytokines in plasma or bronchoalveolar lavage fluid (BALF), the percentage of eosinophils in BALF, and histopathological examination. The expression of NF-$\kappa$B in nuclear and cytoplasmic fraction and its DNA-binding activity in lung tissues were analyzed by means of Western blotting and electrophoretic gel mobility shift assay (EMSA), respectively. DA-9201 significantly reduced airway hyperrespon-siveness (AHR), total lgE level in plasma and BALF, IL-4, IL-5, and IL-13 levels in BALF, and the percentage of eosinophils in BALF. Tissue inflammation was significantly improved by DA­9201 treatment. In addition, DA-9201 dramatically suppressed the expression of NF-$\kappa$B and its DNA-binding activity. These results suggest that DA-9201 may be useful for the treatment of asthma and its efficacy is related to suppression of NF-$\kappa$B pathway.

• The Korean Journal of Physiology and Pharmacology
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• 제23권3호
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• pp.161-169
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• 2019

Fumigaclavine C (FC), an active indole alkaloid, is obtained from endophytic Aspergillus terreus (strain No. FC118) by the root of Rhizophora stylosa (Rhizophoraceae). This study is designed to evaluate whether FC has anti-adipogenic effects in 3T3-L1 adipocytes and whether it ameliorates lipid accumulation in high-fat diet (HFD)-induced obese mice. FC notably increased the levels of glycerol in the culture supernatants and markedly reduced lipid accumulation in 3T3-L1 adipocytes. FC differentially inhibited the expressions of adipogenesis-related genes, including the peroxisome proliferator-activated receptor proteins, CCAAT/enhancer-binding proteins, and sterol regulatory element-binding proteins. FC markedly reduced the expressions of lipid synthesis-related genes, such as the fatty acid binding protein, lipoprotein lipase, and fatty acid synthase. Furthermore, FC significantly increased the expressions of lipolysis-related genes, such as the hormone-sensitive lipase, Aquaporin-7, and adipose triglyceride lipase. In HFD-induced obese mice, intraperitoneal injections of FC decreased both the body weight and visceral adipose tissue weight. FC administration significantly reduced lipid accumulation. Moreover, FC could dose-dependently and differentially regulate the expressions of lipid metabolism-related transcription factors. All these data indicated that FC exhibited anti-obesity effects through modulating adipogenesis and lipolysis.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2021년도 제64차 하계학술대회논문집 29권2호
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• pp.117-122
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• 2021

In order to reveal the co-research relationship with key research institutes in the computer field in Korea, which have high competitiveness in the ICT field, this paper analyzes the co-author network of research institutes based on the papers of Korean journals. For this study, 15 computer journals published in Korea were selected and collected for the past 5 years. In addition, authors, affiliated institutions, and country information were extracted from the papers, and experimental data were produced using institutional identification data and SNA analysis techniques. Through this, statistical analysis was performed on researchers, research institutes, and countries, and the centrality of research institutes was measured through co-authored network analysis and visualized as a map. The results of the research that analyzed the co-author relationship based on the papers in computer science journals published in Korea are as follows. First, the status of co-author relations among researchers was statistically analyzed in detail. The number of authors, the number of co-authors, and statistics by co-authoring countries, as well as the ratio of co-authored research by institution and the ratio of co-authored by country were revealed. The co-authoring status of papers in English journals was analyzed separately to compare and analyze characteristics. Second, the centrality of each individual was measured through the co-authored network analysis of the identified researchers, institutions and countries affiliated with the institution, and the frequency of connection between data by level was identified. In addition, the co-authorization network between research institutes was visualized and presented as a map so that the overall view of the co-authoring network was presented, and the connection frequency between the institutes was checked. It is possible to recommend a research partner based on the co-authoring behavior of Korean computer researchers and the co-authoring relationship between major research institutes. For this, additional research is needed to analyze the subject areas of each institution.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2018년도 공동국제학술발표회
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• pp.61-61
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• 2018

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2005년도 INTERNATIONAL SYMPOSIUM ON SOIL & GROUNDWATER ENVIRONMENT
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• pp.185-186
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• 2005

• World Technopolis Review
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• 제6권2호
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• pp.113-129
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• 2017

Universities are considered important actors and drivers of socio-economic development in the regional innovation eco-system. This article investigates the role Kenyan universities and research institutes play in the development of regional innovation eco-system in the context of triple and Quadruple helices. A model involving Government, Industry, Universities and Society (Public) linkages in the regional innovation eco-system and with Information and Communication Technology as an enabler is used as a framework for analysing the nature of linkages in Kenya. The article uses literature review and case study methods to examine how universities and research institutes can spur the development of the innovation eco-systems. The research question is: what is the role of Kenyan universities and research institutes in spurring innovation ecosystems? Six cases of Kenyan universities and research institutes are considered in the light of Government Policy on Science, Technology and Innovation (STI) which is underpinned in Kenyan constitution 2010. The study contributes to the understanding of how deep collaboration among universities, government, research institutes, Science Cities, local, regional, national and international players spurs the creation of world-class innovation ecosystems which can contribute to regional development in developing countries like Kenya.

• 기술혁신학회지
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• 제8권spc1호
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• pp.555-582
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• 2005

This is a case study on the new model of Graduate School recently established by 22 government-sponsored research institutes, focused on the University of Science and Technology(UST). It first deals with the necessity of authorized education system in government-sponsored research institutes not only for nourishing highly caliber manpower but also for activating research institutes. And then it analyzes the general status of the UST and Japanese graduate school model and its comparison. Finally it points out some suggestions for future development of the UST.

• Journal of Contemporary Eastern Asia
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• 제15권1호
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• pp.27-40
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• 2016

This study uses a network approach to investigate the structural characteristics of sub-organizations within public research institutes in order to obtain their implications for organizational structures. We construct a network based on research similarities between sub-organizations because sub-organizations generally build their own research portfolios. We examine how sub-units are organized based on their structural features. The structural features are compared between three public research institutes in different countries: the Korean the Government-funded Research Institutes (GRIs), the Max-Planck-Gesellschaft in Germany, and the National Laboratories (NLs) in the United States. The structural comparison helps to identify organizational characteristics and to differentiate between them. We found little common ground in the research areas between the GRIs because individual sub-organizations have distinct research portfolios. Therefore, the organizational hierarchy of research in the GRIs is less matured than it is in other public research institutes. This study suggests that the GRIs need to establish integrated strategies in order to strengthen the common knowledge base.

• 대한미생물학회지
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• 제18권1호
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• pp.31-38
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• 1983

1982년도 1월부터 12월 1년간 서울을 비롯한 전국 보건연구소, 검역소, 서울 시내 종합병원 임상병리실험실에서 수거한 가검물 및 분리한 세균 등 총 1,518건을 시험한 결과 이중 살모넬라균속이 687건이 동정되었다. 이중 441건이 장티푸스였으며 그외 살모넬라균이 246건이었다. 이에 대한 생화학적 특성, 혈청학적 특성, 지리적, 계절적, 성별에 대한 발생특성, 앰피실린 등 12가지 항생제에 대한 감수성 시험을 하였다.

• STI Policy Review
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• 제1권1호
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• pp.63-92
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• 2010

Recent years have seen an intensified discussion in many OECD countries about the role and mission of public research in the innovation system. This discussion takes place in quite specific national contexts, but should benefit from international experience. However, whereas voluminous literatures address the changing governance methods, organizational forms and missions of universities, much less attention has been devoted to developing a common understanding of the challenges faced by non-university public research institutions. The main goals of this paper is to contribute to clarifying the nature of these challenges, outlines possible policy answers and draws some implications for Korea. In the first section, the paper uses available internationally comparable indicators to review trends in the contribution of government research institutes (GRIs) to R&D and innovation activities. In the second section, the paper identifies the current major changes in the dynamics of innovation that may call for further adjustments in the positioning, organization and steering of public research institutes. Finally, the paper outlines some strategic objectives and orientations for the reform of public research institutes as part of the broader agenda of the Korean innovation strategy.