• BMB Reports
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• 제49권4호
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• pp.238-243
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• 2016

The efficacy of anticancer drugs depends on a variety of signaling pathways, which can be positively or negatively regulated. In this study, we show that SETDB1 HMTase is down-regulated at the transcriptional level by several anticancer drugs, due to its inherent instability. Using RNA sequence analysis, we identified FosB as being regulated by SETDB1 during anticancer drug therapy. FosB expression was increased by treatment with doxorubicin, taxol and siSETDB1. Moreover, FosB was associated with an increased rate of proliferation. Combinatory transfection of siFosB and siSETDB1 was slightly increased compared to transfection of siFosB. Furthermore, FosB was regulated by multiple kinase pathways. ChIP analysis showed that SETDB1 and H3K9me3 interact with a specific region of the FosB promoter. These results suggest that SETDB1-mediated FosB expression is a common molecular phenomenon, and might be a novel pathway responsible for the increase in cell proliferation that frequently occurs during anticancer drug therapy.

• 한국공간구조학회논문집
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• 제15권2호
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• pp.51-59
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• 2015

In this study, a shape design and an analysis considering structural stability were investigated to develop an icosahedron-based hemispherical modular dome. To design this modular dome, a program that can perform icosahedron shape modeling, modularization of joint connection members, and the analysis of structural stability was developed. Furthermore, based on the adopted numerical model, the eigen buckling mode, unstable behavior characteristics according to load vector, and the critical buckling load of the modular dome under uniformly distributed load and concentrated load were analyzed, and the resistance capacities of the structure according to different load vectors were compared. The analysis results for the modular dome suggest that the developed program can perform joint modeling for shape design as well as modular member design, and adequately expressed the nonlinear behaviors of structured according to load conditions. The critical buckling load results also correctly reflected the characteristics of the load conditions. The uniformly distributed load was more advantageous to the structural stability than concentrated load.

• Journal of Gastric Cancer
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• 제24권1호
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• pp.29-56
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• 2024

In recent years, remarkable progress has been made in the molecular profiling of gastric cancer. This progress has led to the development of various molecular classifications to uncover subtype-specific dependencies that can be targeted for therapeutic interventions. Human epidermal growth factor receptor 2 (HER2) is a crucial biomarker for advanced gastric cancer. The recent promising results of novel approaches, including combination therapies or newer potent agents such as antibody-drug conjugates, have once again brought attention to anti-HER2 targeted treatments. In HER2-negative diseases, the combination of cytotoxic chemotherapy and programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitors has become the established standard of care in first-line settings. In the context of gastric cancer, potential biomarkers such as PD-L1 expression, Epstein-Barr virus, microsatellite instability, and tumor mutational burden are being considered for immunotherapy. Recently, promising results have been reported in studies on anti-Claudin18.2 and fibroblast growth factor receptor 2 treatments. Currently, many ongoing trials are aimed at identifying potential targets using novel approaches. Further investigations will be conducted to enhance the progress of these therapies, addressing challenges such as primary and acquired resistance, tumor heterogeneity, and clonal evolution. We believe that these efforts will improve patient prognoses. Herein, we discuss the current evidence of potential targets for systemic treatment, clinical considerations, and future perspectives.

• Geomechanics and Engineering
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• 제9권6호
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• pp.793-813
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• 2015

Characterization of discontinuous media is an endeavor that poses great challenge to engineers in practice. Since the inherent defects in cracked domains can substantially influence material resistance and govern its behavior, a lot of work is dedicated to efficiently model such effects. In order to overcome difficulties of material instability problems, one needs to comprehensively represent the geometry of cracks along with their impact on the mechanical properties of the intact material. In the present study, stress-strain results from laboratory experiments on Inada granite was used to derive crack tensor as a tool for the evaluation of fractured domain stability. It was found that the formulations proposed earlier could satisfactorily be employed to attain crack tensor via the invariants of which judgment on cracks population and induced anisotropy is possible. The earlier criteria based on crack tensor analyses were reviewed and compared to the results of the current study. It is concluded that the geometrical parameters calculated using mechanical properties could confidently be used to judge the anisotropy as well as strength of the cracked domain.

• 한국분말재료학회지
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• 제25권6호
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• pp.507-513
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• 2018

This study investigates the viability of using a Na-ion battery with a tin(Sn) anode to mitigate the vulnerability caused by volume changes during discharge and charge cycling. In general, the volume changes of carbon material do not cause any instability during intercalation into its layer structure. Sn has a high theoretical capacity of $847mAh\;g^{-1}$. However, it expands dramatically in the discharge process by alloying Na-Sn, placing the electrode under massive internal stress, and particularly straining the binder over the elastic limit. The repeating strain results in loss of active material and its electric contact, as well as capacity decrease. This paper expands the scope of fabrication of Na-ion batteries with Sn by fabricating the binder as an auxetic structure with a unique feature: a negative Poisson ratio (NPR), which increases the resistance to internal stress in the Na-Sn alloying/de-alloying processes. Electrochemical tests and micrograph images of auxetic and common binders are used to compare dimensional and structural differences. Results show that the capacity of an auxetic-structured Sn electrode is much larger than that of a Sn electrode with a common-structured binder. Furthermore, using an auxetic structured Sn electrode, stability in discharge and charge cycling is obtained.

• Steel and Composite Structures
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• 제30권2호
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• pp.185-199
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• 2019

Modular construction is an emerging technology to accommodate the increasing restrictions in terms of construction period, energy efficiency and environmental impacts, since each structural module is prefabricated offsite beforehand and assembled onsite using industrialized techniques. However, some innate structural drawbacks of this innovative method are also distinct, such as connection tying inaccessibility, column instability and system robustness. This study aims to explore the theoretical and numerical stability analysis of a tenon-connected square hollow section (SHS) steel column to address the tying and stability issue in modular construction. Due to the excellent performance of composite structures in fire resistance and buckling prevention, concrete-filled steel tube (CFST) columns are also taken into account in the analysis to evaluate the feasibility of adopting composite sections in modular buildings. Characteristic equations with three variables, i.e., the length ratio, the bending stiffness ratio and the rotational stiffness ratio, are generated from the fourth-order governing differential equations. The rotational stiffness ratio is recognized as the most significant factor, with interval analysis conducted for its mechanical significance and domain. Numerical analysis using ABAQUS is conducted for validation of characteristic equations. Recommendations and instructions in predicting the buckling performance of both SHS and CFST columns are then proposed.

• 한국산학기술학회논문지
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• 제12권5호
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• pp.2019-2024
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• 2011

GMA용접 공정에서 콘택트팁의 마모가 용접비드에 미치는 영향에 대해서 연구하였다. 콘택트팁과 용접비드 사이의 연관성을 조사하기 위하여 초고속 카메라와 파형분석을 이용하여 용적이행을 관찰하였고, 저 배율의 카메라로 비드의 상태를 관찰하였다. 콘택드팁의 마모는 팁과 용접와이어 사이의 접촉 지점을 변화시켜 결과적으로 불규칙비드를 생성하였다. 이것은 마모된 콘택트팁이 용접시 용접저항의 변화를 초래하여 용접아크 불안정의 원인이 되기 때문이다.

• Journal of Korean Neurosurgical Society
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• 제29권2호
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• pp.280-285
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• 2000

Posterior transarticular screw fixation for atlantoaxial instability due to trauma or rheumatoid arthritis provides immediate rigid fixation of the C1-2 vertebral segment while preserving motion between the occiput and C1. This technique provides more resistance to translational and rotational forces than wiring technique. However, the technique of transarticular screw fixation is inherently demanding because of the complex anatomy of the occipitocervical region and vertebral artery(VA) at risk for arterial damage. VA injury may lead to serious subsequent neurological deficits and possibly death from bilateral VA injury. We report a case of a vertebral artery-to-epidural venous plexus fistula after posterior transarticular screw fixation which was treated with balloon occlusion.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.35-35
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• 2023

The main reason for its instability is sediment scouring downstream of hydraulic structures. Both physical and numerical models have been used to investigate the influence of soil properties on scour hole geometry. Nevertheless, no research has been conducted on resistance parameters that affect sedimentation and erosion. In addition, auxiliary structures like wing walls, which are prevalent in many real-world applications, have rarely been studied for their impact on morphology. The hydraulic characteristics of steady flow through a boxed culvert are calibrated using a 3D Computational Fluid Dynamics model compared with experimental data in this study, which shows a good agreement between water depth, velocity, and pressure profiles. Test cases showed that 0.015 m grid cells had the lowest NRMSE and MAE values. It is also possible to quantify sediment scour numerically by testing roughness/d₅₀ ratios (c_s) and diversion walls at a meander flume outlet. According to the findings, c_s = 2.5 indicates a close agreement between numerical and analytical results of maximum scour depth after the culvert; four types of wing walls influence geometrical deformation of the meander flume outlet, resulting in erosion at the concave bank and deposition at the convex bank; two short headwalls are the most appropriate solution for accounting for small changes in morphology. A numerical model can be used to estimate sediment scour at the meander exit channel of hydraulic structures based on the roughness parameter of soil material and headwall type.

• 산업기술연구
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• 제25권B호
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• pp.73-80
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• 2005

Durability of concrete structures is seriously compromised by cracking at early-age concretes, particularly in high-strength or high-performance concrete structures. Since early-age cracking is influenced by various factors that affect the hydration process, early-age shrinkage and stress/strain development, the behavior at early-age is highly complex and no rational methodologies for its control have yet been established. Concrete structures often present volumetrical changes particularly due to thermal and moisture related shrinkages. Volumetric instability is detrimental to the performance and durability of concrete structures because structural elements are usually restrained. These restrained shrinkages develope tensile stresses which often results in cracking in combination with the low fracture resistance of concrete. Early-age defects in high-performance concrete due to thermal and autogenous deformation shorten the life cycle of concrete structures. Thus, it is necessary to examine the behavior of early-age concrete at the stages of design and construction. The purpose of this study was to propose a shrinkage models of VES-LMC (very-early strength latex-modified concrete) at early-age considering thermal deformation and autogenous shrinkage.