• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.30 no.8
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• pp.120-125
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• 2002

In the preceding tests using the KSR-III Sub.(I) engines, it was observed that the heat resistant capability of the engines was not enough for the mission. So Sub.(I) Mod. engines were designed and tested. The Sub.(I) Mod. engines have three major design parameters - the arrangement of main injectors, the impinging angle of main injectors and thermal barrier coating. More than twenty experiments were carried on to evaluate engine performance and heat resistance capability with respect to design parameters. In this study, the test results are introduced. Analysing the result of Sub.(I) engine tests, it is found that decreasing the impinging angle, adopting the H-type arrangement(rather than radial type arrangement) and adopting the thermal barrier coating can increase heat resistance capacity substantially. Also, engine performance evaluation is conducted using specific impulse and characteristic velocity parameter. The results show that the performance variation is small(about 5%) and the performance is better in the case of radial arrangement. It is suspected that these phenomena are caused by the change of flame structure atomization mixing characteristic of sprays and the distortion of recirculation zone. Also from the low frequency instability point of view, it is observed that reducing the impinging angle and adopting the H type arrangement can increase the instability characteristics.

• Journal of the Korean GEO-environmental Society
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• v.16 no.5
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• pp.55-66
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• 2015

Big tidal differences, which range from 3.0 m to 8.0 m, exist with regional locations at south and west shores of Korea. Under this ocean circumstance, since a large scour may occur due to multi-directional tidal current and transverse stress of the wind, the scour surrounding the wind turbine structure can make instability of the system due to unexpected system vibration. The hydraulic resistance capacity of soils consolidated under different pressures are evaluated by Erosion Function Apparatus (EFA) under unidirectional and bi-directional flows in this study. It was found that the flow direction change affects significantly on the sour rate and critical shear stress, regardless of soil types while the consolidation pressure affects mainly cohesive soil. Among geotechnical parameters, the undrained shear strength can be well-correlated with the hydraulic resistance capacity, regardless soil type while the shear wave velocity shows the proportional relationships with the hydraulic resistance capacities of fine grained soil and coarse grained soil, respectively.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2027-2033
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• 2014

Background: We aimed to assess RET proto-oncogene polymorphisms in three different Iranian families with medullary thyroid cancer (MTC), and performed molecular dynamics simulations and free energy stability analysis of these mutations. Materials and Methods: This study consisted of 48 patients and their first-degree relatives with MTC confirmed by pathologic diagnosis and surgery. We performed molecular dynamics simulations and free energy stability analysis of mutations, and docking evaluation of known RET proto-oncogene inhibitors, including ZD-6474 and ponatinib, with wild-type and mutant forms. Results: The first family consisted of 27 people from four generations, in which nine had the C.G2901A (P.C634Y) mutation; the second family consisted of six people, of whom three had the C.G2901T (P.C634F) mutation, and the third family, who included 12 individuals from three generations, three having the C.G2251A (P.G691S) mutation. The automated 3D structure of RET protein was predicted using I-TASSER, and validated by various protein model verification programs that showed more than 96.3% of the residues in favored and allowed regions. The predicted instability indices of the mutated structures were greater than 40, which reveals that mutated RET protein is less thermo-stable compared to the wild-type form (35.4). Conclusions: Simultaneous study of the cancer mutations using both in silico and medical genetic procedures, as well as onco-protein inhibitor binding considering mutation-induced drug resistance, may help in better overcoming chemotherapy resistance and designing innovative drugs.

• Sleep Medicine and Psychophysiology
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• v.6 no.1
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• pp.19-25
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• 1999

Sleep alters both breathing pattern and the ventilatory responses to external stimuli. These changes during sleep permit the development or aggravation of sleep-related hypoxemia in patients with respiratory disease and contribute to the pathogenesis of apneas in patients with the sleep apnea syndrome. Fundamental effects of sleep on the ventilatory control system are 1) removal of wakefulness input to the upper airway leading to the increase in upper airway resistance, 2) loss of wakefulness drive to the respiratory pump, 3) compromise of protective respiratory reflexes, and 4) additional sleep-induced compromise of ventilatory control initiated by reduced functional residual capacity on supine position assumed in sleep, decreased $CO_2$ production during sleep, and increased cerebral blood flow in especially rapid eye movement(REM) sleep. These effects resulted in periodic breathing during unsteady non-rapid eye movement(NREM) sleep even in normal subjects, regular but low ventilation during steady NREM sleep, and irregular breathing during REM sleep. Sleep-induced breathing instabilities are divided due primarily to transient increase in upper airway resistance and those that involve overshoots and undershoots in neural feedback mechanisms regulating the timing and/or amplitude of respiratory output. Following ventilatory overshoots, breathing stability will be maintained if excitatory short-term potentiation is the prevailing influence. On the other hand, apnea and hypopnea will occur if inhibitory mechanisms dominate following the ventilatory overshoot. These inhibitory mechanisms include 1) hypocapnia, 2) inhibitory effect from lung stretch, 3) baroreceptor stimulation, 4) upper airway mechanoreceptor reflexes, 5) central depression by hypoxia, and 6) central system inertia. While the respiratory control system functions well during wakefulness, the control of breathing is commonly disrupted during sleep. These changes in respiratory control resulting in breathing instability during sleep are related with the pathophysiologic mechanisms of obstructive and/or central apnea, and have the therapeutic implications for nocturnal hypoventilation in patients with chronic obstructive pulmonary disease or alveolar hypoventilation syndrome.

• International Journal of Highway Engineering
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• v.18 no.1
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• pp.33-41
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• 2016

PURPOSES : This study primarily focused on evaluating the performance characteristics of 4.75-mm nominal maximum aggregate size (NMAS) asphalt mixtures for their more effective implementation to a layered flexible pavement system. METHODS : The full-scale pavements in the FDOT's accelerated pavement testing (APT) program, including 4.75-mm mixtures at the top with different thicknesses and asphalt binder types, were considered for the faster and more realistic evaluation of the rutting performance. The results of superpave indirect tensile (IDT) tests and hot-mix asphalt fracture mechanics (HMA-FM) based model predictions were used for cracking performance assessments. RESULTS : The results indicated that the rutting performance of pavement structures with 4.75-mm mixtures may not be as good as to those with the typical 12.5-mm mixtures, and pavement rutting was primarily confined to the top layer of 4.75-mm mixtures. This was likely due to the relatively higher mixture instability and lower shear resistance compared to 12.5-mm mixtures. The energy ratio (ER) and HMA-FM based model performance prediction results showed a potential benefit of 4.75-mm mixtures in enhanced cracking resistance. CONCLUSIONS : In relation to their implementation, the best use of 4.75-mm mixtures seem to be as a surface course for low-traffic-volume applications. These mixtures can also be properly used as a preservation treatment that does not necessarily last as long as 12.5-mm NMAS structural mixes. It is recommended that adequate thicknesses and binder types be considered for the proper application of a 4.75-mm mixture in asphalt pavements to effectively resist both rutting and cracking.

• Nuclear Engineering and Technology
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• v.39 no.3
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• pp.193-206
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• 2007

The Korea Atomic Energy Research Institute has developed an advanced fast reactor concept, KALIMER-600, which satisfies the Generation IV reactor design goals of sustainability, economics, safety, and proliferation resistance. The concept enables an efficient utilization of uranium resources and a reduction of the radioactive waste. The core design has been developed with a strong emphasis on proliferation resistance by adopting a single enrichment fuel without blanket assemblies. In addition, a passive residual heat removal system, shortened intermediate heat-transport system piping and seismic isolation have been realized in the reactor system design as enhancements to its safety and economics. The inherent safety characteristics of the KALIMER-600 design have been confirmed by a safety analysis of its bounding events. Research on important thermal-hydraulic phenomena and sensing technologies were performed to support the design study. The integrity of the reactor head against creep fatigue was confirmed using a CFD method, and a model for density-wave instability in a helical-coiled steam generator was developed. Gas entrainment on an agitating pool surface was investigated and an experimental correlation on a critical entrainment condition was obtained. An experimental study on sodium-water reactions was also performed to validate the developed SELPSTA code, which predicts the data accurately. An acoustic leak detection method utilizing a neural network and signal processing units were developed and applied successfully for the detection of a signal up to a noise level of -20 dB. Waveguide sensor visualization technology is being developed to inspect the reactor internals and fuel subassemblies. These research and developmental efforts contribute significantly to enhance the safety, economics, and efficiency of the KALIMER-600 design concept.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.5
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• pp.682-687
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• 2014

We have performed reverse gate bias stress tests on AlGaN/GaN-on-Si Heterostructure FETs (HFETs). The shift of threshold voltage ($V_{th}$) and the reduction of on-current were observed from the stressed devices. These changes of the device parameters were not permanent. We investigated the temporary behavior of the stressed devices by analyzing the temperature dependence of the instabilities and TCAD simulation. As the baseline temperature of the electrical stress tests increased, the changes of the $V_{th}$ and the on-current were decreased. The on-current reduction was caused by the positive shift of the $V_{th}$ and the increased resistance of the gate-to-source and the gate-to-drain access region. Our experimental results suggest that electron-trapping effect into the shallow traps in devices is the main cause of observed instabilities.

• Journal of Power Electronics
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• v.19 no.4
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• pp.869-880
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• 2019

Due to the inherent feedforward of load current, capacitor current (CC) control shows a fast transient response that makes it suitable for the power supplies used in various portable electronic devices. However, considering the effect of the outer voltage loop, the stable range of the duty-cycle is significantly diminished in CC controlled buck converters. To investigate the stability effect of the outer voltage loop on buck converters, a CC controlled buck converter with a proportion-integral (PI) compensator is taken as an example, and its second-order discrete-time model is established. Based on this model, the instability caused by the duty-cycle is discussed with consideration of the outer voltage loop. Then the dynamical effects of the feedback gain of the PI compensator and the equivalent series resistance (ESR) of the output capacitor on the CC controlled buck converter with a PI compensator are studied. Furthermore, the design-oriented closed-loop stability criterion is derived. Finally, PSIM simulations and experimental results are supplied to verify the theoretical analyses.

• Structural Engineering and Mechanics
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• v.89 no.1
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• pp.13-22
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• 2024

The nonlinear snap-through buckling of functionally graded (FG) carbon nanotube reinforced composite (CNTRC) curved tubes is analytically investigated in this research. It is assumed that the FG-CNTRC curved tube is supported on a three-parameter nonlinear elastic foundation and is subjected to the uniformly distributed pressure and thermal loads. Properties of the curved nanocomposite tube are distributed across the radius of the pipe and are given by means of a refined rule of mixtures approach. It is also assumed that all thermomechanical properties of the nanocomposite tube are temperature-dependent. The governing equations of the curved tube are obtained using a higher-order shear deformation theory, where the traction free boundary conditions are satisfied on the top and bottom surfaces of the tube. The von Kármán type of geometrical non-linearity is included into the formulation to consider the large deflection in the curved tube. Equations of motion are solved using the two-step perturbation technique for nanocomposite curved tubes which are simply-supported and clamped. Closed-form expressions are provided to estimate the snap-buckling resistance of FG-CNTRC curved pipes rested on nonlinear elastic foundation in thermal environment. Numerical results are given to explore the effects of the distribution pattern and volume fraction of CNTs, thermal field, foundation stiffnesses, and geometrical parameters on the instability of the curved nanocomposite tube.

• Wind and Structures
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• v.30 no.6
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• pp.649-662
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• 2020

The existence of a dam has potential effects on the surrounding wind environment especially when it is located in mountainous areas. In this situation, the long-span bridge over the reservoir can easily be exposed to non-uniform incoming flows, affecting its wind-resistance performance. This paper presents a study on the aerostatic stability of such a bridge. Wind tunnel tests were first carried out to investigate the wind environment above a mountainous reservoir. The results show that the angle of attack and the wind speed along the bridge axis show obvious non-uniform characteristics, which is related to the inflow direction. When winds come from the south where the river is winding, the angle of attack varies along the span direction significantly. The finite element model for the bridge was established using ANSYS software, and effects of non-uniform wind loads on the aerostatic stability were computed. Non-uniform angle of attack and wind speed are unfavorable to the aerostatic stability of the bridge, especially the former. When the combined action of non-uniform angle of attack and wind speed is considered, the critical wind speed of aerostatic instability is further reduced. Moreover, the aerostatic stability of the bridge is closely related to the dam height.