• 대한임상검사과학회지
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• 제56권1호
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• pp.1-9
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• 2024

엑소좀은 나노 크기의 세포외 소포체로 핵산, 단백질, 지질 등 다양한 생리활성 물질을 함유하고 있다. 엑소좀의 생리활성 물질들은 주변 세포나 조직으로 전달될 수 있을 뿐만 아니라 기원된 세포의 고유 특정 물질들을 지니고 있기 때문에 엑소좀 유래 물질들은 진단 및 치료를 위한 도구로 광범위하게 사용될 수 있음이 입증되고 있으며, 이러한 이유로 엑소좀은 진단을 위한 바이오마커, 약물 전달을 위한 운반체 및 치료제로 활용될 수 있는 가능성에 많은 연구자들의 관심이 높아지고 있다. 줄기세포 분야에서 엑소좀은 줄기세포를 기반으로 한 비세포 치료제로서 보다 안전한 치료제로 사용될 수 있다는 점에서 매력적인 소재가 되고 있으며, 최근에는 중간엽줄기세포 유래 엑소좀이 항염증 및 면역조절능이 있어 코로나-19 증상 완화 효능에 대한 안전성과 효능이 입증되기도 했다. 이렇게 계속적인 엑소좀에 대한 축적된 연구는 임상 진단 및 치료를 위한 차세대 혁신적 결과물들을 제공할 것으로 생각되며, 이 종설에서는 엑소좀의 다양한 가치에 초점을 두고 미래의학의 강력한 도구로 어떻게 활용될 수 있는지에 대한 엑소좀의 잠재력을 살펴보고자 한다.

• Spatial Information Research
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• 제2권1호
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• pp.15-25
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• 1994

지리정보시스템은 행정정보이 2차원화를 통해 도면이용이 잦은 지방행정업무의 과학적 수행체계를 정립하는데 유용한 수단이 되고 있다. 그러나 그 방법의 혁신성에도 불구하고 지방행정부문에 지리정보시스템의 도입은 아직 초기단계에 있다. 이는 사용자 집단의 기술에 대한 이해부족과 시범시스템의 실용성 및 잠재력을 증명할 수 있는 기본 데이타베이스의부재, 기술개발 및 이용에 대한 제도적인 뒷받침 결여, 방대한 투자규모 등 기술적, 제도적, 경제적인 요인에 그 원인이 있다. 본 연구에서는 서울시를 사례로 지리정보시스템의 유용성과 활용 가능성을 분석하고, 시스템 도입의 성공을 위한 효과적인 전략을 검토함으로써 지방행정부를 위한 GIS 시스템 도입의 기본방향을 제시하였다.

• 대한지리학회지
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• 제32권4호
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• pp.543-548
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• 1997

새로운 정보기술이 등장하고 교류가 늘어나면서 과거 간명해 보였던 개념과 현실의 관계가 다변화되고 모호하게 변하고 있다. 가상공간(cyberspace)의 출현은 가상장소(cyberplaces)가 존재함을 뜻하며, 또한 현실 세계의 공간과 장소 간의 관계에 못지 않게 가상공간과 가상장소의 관계도 복잡할 것임을 암시한다. 정보기술을 활용하여 만들어 낸 세상의 여러 장소나 과정의 복제품, 즉 가상현실(virtual reality)은 이러한 관계들을 탐색하는 실마리를 제공하낟. 그러나, 실제가상(real virtuality), 즉 정보기술을 이용하여 현실세계의 장소에 대한 경험을 강화하면 공간과 장소의 관계에 대하여 더 깊은 통찰을 얻을 수 있다. 실제가상은 지리학자로 하여금 그가 하는 일의 효율성을 높이고 영역을 넓히는 데 여러 가지 참신하고 강력한 도구를 마련해 준다. 실제가상이 널리 쓰이게 되면 지리학자들의 연구와 교육, 응용 분야에서 자료, 분석기법, 이론을 다루는 양식이 달라질 것이다.

• Interdisciplinary Bio Central
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• 제3권1호
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• pp.2.1-2.4
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• 2011

Arabidopsis is well-known to the world's plant research community as a model plant. Many significant resources and innovative research tools, as well as large bodies of genomic information, have been created and shared by the research community, partly explaining why so many researchers use this small plant for their research. The genome sequence of Arabidopsis was fully characterized by the end of the $20^{th}$ century. Soon afterwards, the Arabidopsis research community began a 10-year international project on the functional genomics of the species. In 2001, at the beginning of the project, the RIKEN BioResource Center (BRC) started its Arabidopsis resource project. The following year, the National BioResource Project was launched, funded by the Japanese government, and the RIKEN BRC was chosen as a core facility for Arabidopsis resource. Seeds of RIKEN Arabidopsis transposon-tagged mutant lines, activation-tagged lines, full-length cDNA over-expresser lines, and natural accessions, as well as RIKEN Arabidopsis full-length cDNA clones and T87 cells, are preserved at RIKEN BRC and distributed around the world. The major resources provided to the research community have been full-length cDNA clones and insertion mutants that are suitable for use in reverse-genetics studies. This paper provides an overview of the Arabidopsis resources made available by RIKEN BRC and examples of research that has been done by users and developers of these resources.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 추계학술대회논문집
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• pp.561-562
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• 2008

The numerical analysis of sound radiation by vibrating structure is a well known and mature technology used in many industries. Accurate methods based on the boundary or finite element method have been successfully developed over the last two decades and are now available in standard CAE tools. These methods are however known to require significant computational resources which, furthermore, very quickly increase with the frequency of interest. The low speed of most current methods is a main obstacle for a systematic use of acoustic CAE in industrial design processes. In this paper we are going to present a set of innovative techniques that significantly speed-up the calculation of acoustic radiation indicators (acoustic pressure, velocity, intensity and power; contribution vectors). The modeling is based on the well known combination of finite elements and infinite elements but also combines the following ingredients to obtain a very high performance: o a multi-frontal massively parallel sparse direct solver; o a multi-frequency solver based on the Krylov method; o the use of pellicular acoustic modes as a vector basis for representing acoustic excitations; o the numerical evaluation of Green functions related to the specific geometry of the problem under investigation. All these ingredients are embedded in the ACTRAN/AR CAE tool which provides unprecedented performance for acoustic radiation analysis. The method will be demonstrated on several applications taken from various industries.

• 한국문헌정보학회지
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• 제20권
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• pp.35-63
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• 1991

DDC, LCC, and CC can be said as the major schemes for mordern general library classification. Among these, DDC, since its publication in 1876, has been continuously studies and revised by many scholars and practitioners to publish 20th edition in 1989: LCC also has been studied and revised by the specialists in each subject, since 1904; and CC(first edition 1933) is now on the stage of 7th edition(1987). Even though studied, revised and developed by many classificationists, all these schemes maintain the general framework of the beginning, only with the partial revision and expansion to reflect the developments of the subjects. and antioipated tremendous amount of works resulted from reclassification also can be a reason that disturbs the full innovative revision of the scheme, because these are used in many libraries as a basic tools for the classification. But all these schemes mainly based on the state of the discipline at the time of their creation, the beginning of 20the century, and so in some aspect it is natural for them to have many problems. This study aims to investigate the problems in these major schemes, to find some ways to solve the problems, and to suggest the ideas for the basic design of a new modern library classification scheme. This plan is prepared to be applied to the situation of all countries equally without any revision. And in its notation, it uses two digits of Arabic numerals as centesimal, and so it is named provisionally to Plan for Centesimal Classification (PCC).

• 한국실내디자인학회논문집
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• 제26권2호
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• pp.55-63
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• 2017

Recent projects of Japanese architect, Ito Toyo have been evolved into innovative and experimental stages that are unique and different from other contemporary architects. Since Ito established his own office in 1971, there were several critical changes and developments in terms of architectural philosophy as well as design methods. Particularly, after Sendai Mediatheque, Ito has tended to focus on creating three-dimensional organic body in which architectural form, space, structure, facilities, images are merged all together. With this new type of three-dimensional structure, Ito aims to generate a new notion of architecture as 'living organism'. This paper tried to analyze Ito's new concept of architecture, design process of three-dimensional organic body and its ultimate characteristics and meanings. For the analysis, three projects were selected: Taichung Metropolitan Opera House(2005), Berkeley Art Museum and Pacific Film Archive(2007), The New Deichman Library in Oslo(2008). These projects clearly represent several types of three-dimensional organic body. After the comparative studies, it is found that, in Ito's design process and method, there are unique characters: ambivalent relationship between plan and three-dimensional form, aiming new/hyper reality through complicated collaboration of analogue and digital design tools, and contradictory relationship with surrounding urban context. Although there are some limitations and restrictions, ever-evolving Ito's design concept and methods are very much valid and meaningful in contemporary spatial design in various perspectives.

• 한국항공운항학회지
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• 제25권3호
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• pp.1-8
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• 2017

As many people all over the world increasingly take more time in exchanging with other people or acquiring information on the internet, use of social media becomes a part of their daily lives. A lot of changes of consumer culture, which have been occurring through social media, have significant effects on corporate marketing activities. Since social media's importance to airlines has been continuously increased, this study attempts to examine effects of passengers' uses of social media, who plan to select an airline, on dependence on reliance of electronic word-of mouth(EWOM) and EWOM acceptance. To this end, a questionnaire survey of passengers who use airlines and the airline's social media was conducted, and then effective data of 302 copies were analyzed by using the structural equation modeling. The findings show that social media use intensity has a significant effect on Acceptance of EWOM via reliance of EWOM, while a direct effect of social media use intensity on Acceptance of EWOM is not significant. From this study, it is found that control and management of social media and only EWOM are effective tools for marketing of airline businesses, suggesting that innovative strategies are required to preemptively cope with changes in consumers' behaviors and markets, which continue to evolve.

• KIEAE Journal
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• 제15권3호
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• pp.15-20
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• 2015

Purpose: Suggesting a working prototype of a kinetic light shelf unit and revealing its energy efficiency by a series of building performance simulations were presented. Recently, kinetic building envelope has been an emerging technology as an innovative way to control exterior building environment, but products from many researches about the facade could not been reached to the industrialization so far. That is because its initial installation, operation and maintenance costs are still too high to use for the practical field, although buildings using kinetic envelopes could decrease their energy consumption significantly. This narrow point of view needs to be reconsidered, since buildings require great amount of energies to run their functions through the whole life and using better building components can lead to achieve much more benefits in aspects of the lifecycle cost (LCC). Method: A series of certified simulation tools like Ecotect and Green Building Studio that are normally used for researches and developments in the field of architecture were utilized. Result: Based on simulation analyses, the result of the study has showed that the proposed system definitely has adaptability to the professions and positively shows practicability as advanced integrative building envelopes with renewable energy association.

• International Journal of Naval Architecture and Ocean Engineering
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• 제9권3호
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• pp.339-349
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• 2017

This paper is related to structural design evaluation of 19,000 TEU ultra large container ship, dealing with hydroelastic response, i.e. springing and whipping. It illustrates application of direct calculation tools and methodologies to both fatigue and ultimate strength assessment, simultaneously taking into account ship motions and her elastic deformations. Methodology for springing and whipping assessment within so called WhiSp notation is elaborated in details, and in order to evaluate innovative container ship design with increased loading capacity, a series of independent hydroelastic computations for container ship with mobile deckhouse and conventional one are performed with the same calculation setup. Fully coupled 3D FEM - 3D BEM model is applied, while the ultimate bending capacity of hull girder is determined by means of MARS software. Beside comparative analysis of representative quantities for considered ships, relative influence of hydroelasticity on ship response is addressed.