• Archives of Pharmacal Research
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• v.21 no.6
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• pp.645-650
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• 1998

The dual drug-loaded alginate beads simultaneously containing drug in inner and outer layers were prepared by dropping plain (single-layered) alginate beads into $CaCl_2$ solution. The release characteristics were evaluated in simulated gastric fluid for 2 h followed by intestinal fluids thereafter for 12 h. The surface morphology and cross section of dual drug-loaded alginate beads was also investigated using scanning electron microscope (SEM). The poorlv water-soluble ibuprofen was chosen as a model drug. The surface of single-layered and dual drug-loaded alginate beads showed very crude and roughness, showing aggregated particles, surface cracks and rough crystals. The thickness of dual drug-loaded alginate beads surrounded by outer layer was ranged from about 57 to 329mcm. The distinct chasm between inner and outer layers was also observed. In case of single-layered alginate bead, the drug was not released in gastric fluid but was largely released in intestinal fluid. However, the release rate decreased as the reinforcing $Eudragit^{\circledR}$ polymer contents increased. When the plasticizers were added into polymer, the release rate largely decreased. The release rate of dual drug-loaded alginate beads was stable in gastric fluid for 2 h but largely increased when switched in intestinal fluid. The drug linearly released for 4 h followed by another linear release thereafter, showing a distinct biphasic release characteristics. There was a difference in the release profiles between single-layered and dual drug-loaded alginate beads due to their structural shape. However, this biphasic release profiles were modified by varying formulation compositions of inner and outer layer of alginate beads. The release rate of dual drug-loaded alginate beads slightly decreased when the outer layer was reinforced with $Eudragit^{\circledR}$ RS1OO polymers. In case of dual drug-loaded alginate beads with polymer-reinforced outer layer only, the initial amount of druc released was low but the initial release rate (slope) was higher due to more swellable inner cores when compared to polymer-reinforced inner cores. The current dual drug-loaded alginate beads may be used to deliver the drugs in a time dependent manner.

• Structural Engineering and Mechanics
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• v.86 no.3
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• pp.417-430
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• 2023

As the key part in the reinforced concrete column-steel beam (RCS) frame, the beam-column joints are usually subjected the axial force, shear force and bending moment under seismic actions. With the aim to study the seismic behavior of RCS joints with and without RC slab, the quasi-static cyclic tests results, including hysteretic curves, slab crack development, failure mode, strain distributions, etc. were discussed in detail. It is shown that the composite action between steel beam and RC slab can significantly enhance the initial stiffness and loading capacity, but lead to a changing of the failure mode from beam flexural failure to the joint shear failure. Based on the analysis of shear failure mechanism, the calculation formula accounting for the influence of RC slab was proposed to estimate shear strength of RCS joint. In addition, the finite element model (FEM) was developed by ABAQUS and a series of parametric analysis model with RC slab was conducted to investigate the influence of the face plates thickness, slab reinforcement diameter, beam web strength and inner concrete strength on the shear strength of joints. Finally, the proposed formula in this paper is verified by the experiment and FEM parametric analysis results.

• Structural Engineering and Mechanics
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• v.55 no.5
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• pp.953-964
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• 2015

A model has been proposed that can predict the ultimate torsional strength of single-box multi-cell reinforced concrete box girder under combined loading of bending, shear and torsion. Compared with the single-cell box girder, this model takes the influence of inner webs on the distribution of shear flow into account. According to the softening truss theory and thin walled tube theory, a failure criterion is presented and a ultimate torsional strength calculating procedure is established for single-box multi-cell reinforced concrete box girder under combined actions, which considers the effect of tensile stress among the concrete cracks, Mohr stress compatibility and the softened constitutive law of concrete. In this paper the computer program is also compiled to speed up the calculation. The model has been validated by comparing the predicted and experimental members loaded under torsion combined with different ratios of bending and shear. The theoretical torsional strength was in good agreement with the experimental results.

• Earthquakes and Structures
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• v.5 no.6
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• pp.703-731
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• 2013

In order to verify the applicability of buckling restrained braces (BRB's) and fiber reinforced polymer (FRP) sheets to the seismic strengthening of a low-rise RC building having the irregularities of a soft/weak story and torsion at the ground story, a series of earthquake simulation tests were conducted on a 1:5 scale RC building model before, and after, the strengthening, and these test results are compared and analyzed, to check the effectiveness of the strengthening. Based on the investigations, the following conclusions are made: (1) The BRB's revealed significant slips at the joint with the existing RC beam, up-lifts of columns from RC foundations and displacements due to the flexibility of foundations, and final failure due to the buckling and fracture of base joint angles. The lateral stiffness appeared to be, thereby, as low as one seventh of the intended value, which led to a large yield displacement and, therefore, the BRB's could not dissipate seismic input energy as desired within the range of anticipated displacements. (2) Although the strengthened model did not behave as desired, great enhancement in earthquake resistance was achieved through an approximate 50% increase in the lateral resistance of the wall, due to the axial constraint by the peripheral BRB frames. Finally, (3) whereas in the original model, base torsion was resisted by both the inner core walls and the peripheral frames, the strengthened model resisted most of the base torsion with the peripheral frames, after yielding of the inner core walls, and represented dual values of torsion stiffness, depending on the yielding of core walls.

• Journal of the Korean Society for Advanced Composite Structures
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• v.4 no.3
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• pp.13-21
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• 2013

In this study, uniaxial compression tests were performed to investigates the stress-strain relations of Double Skinned Composite Tubular Columns reinforced with steel tube. The confined concrete has been known as the strength of concrete increases significantly. Specimens reinforced with outer and inner steel tube were tested by uniaxial compression test. To investigate the influence of concrete strength increase by confining conditions in steel tubes, 8 specimens with different thickness of tube, hollowness ratio and concrete strength were tested and compared with other researcher's concrete material model.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.5A
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• pp.317-325
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• 2012

In this study, to evaluate the shrinkage behavior of ultra high performance fiber reinforced concrete (UHPFRC) under restrained condition, restrained shrinkage test was performed according to ring-test mostly used at home and abroad. Ring-test was performed with the various thicknesses and radii of inner steel ring to give different degree of restraint. Free shrinkage and tensile tests were carried out simultaneously to estimate the degree of restraint, stress relaxation, and shrinkage cracking potential. Test results indicated that the average steel strain and residual tensile stress were reduced as the thicker inner steel ring was used, whereas degree of restraint was increased. The steel strain, residual tensile stress and degree of restraint were hardly affected by the size of radius of inner ring. In the case of all ring specimens, shrinkage crack did not occur because the residual tensile stress was lower than the tensile strength. About 39~65% of the elastic shrinkage stress was relaxed by the sustained interface pressure, and the maximum relaxed stress was increased as the thicker inner ring was applied. Finally, the degree of restraint with age was predicted by performing non-linear regression analysis, and it was in good agreement with the test results.

• Advances in concrete construction
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• v.2 no.4
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• pp.261-280
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• 2014

In many parts of the world, reinforced concrete (RC) buildings, designed and built in accordance with older codes, have suffered severe damage or even collapse as a result of recent near-fault earthquakes. This is particularly due to the deficiencies of most of the older (and even some of the recent) codes in dealing with near fault events. In this study, a tested three-storey frame designed for gravity loads only was selected to represent those deficient buildings. Nonlinear time history analyses were performed, followed by damage assessment procedures. The results were compared with experimental observation of the same frame showing a good match. Damage and fragility analyses of the frame subjected to 204 pulse-type motions were then performed using a selected damage model and inter-storey drifts. The results showed that the frame located in near-fault regions is extremely vulnerable to ground motions. The results also showed that the damage model better captures the damage distribution in the frame than inter-storey drifts. The first storey was identified as the most fragile and the inner columns of the first storey suffered most damage as indicated by the damage index. The findings would be helpful in the decision making process prior to the strengthening of buildings in near-fault regions.

• Steel and Composite Structures
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• v.43 no.1
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• pp.55-66
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• 2022

To develop high-efficiency lateral force resistance components for high-rise buildings, a novel energy dissipation shear wall with concrete-filled steel tubular (CFST) column elements was proposed. An energy dissipation shear wall specimen with CFST column elements (GZSW) and an ordinary reinforced concrete shear wall (SW) were constructed, and experimented by low-cycle reversed loading. The mechanical characteristics of these two specimens, including the bearing capacity, ductility, energy dissipation, and stiffness degradation process, were analyzed. The finite-element model of the GZSW was established by ABAQUS. Based on this finite-element model, the effect of the placement of steel-plate energy dissipation connectors on the seismic performance of the shear wall was analyzed, and optimization was performed. The experiment results prove that, the GZSW exhibited a superior seismic performance in terms of bearing capacity, ductility, energy dissipation, and stiffness degradation, in comparison with the SW. The results calculated by the ABAQUS finite-elements model of GZSW corresponded well with the results of experiment, and it proved the rationality of the established finite-elements model. In addition, the optimal placement of the steel-plate energy dissipation connectors was obtained by ABAQUS.

• Steel and Composite Structures
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• v.24 no.6
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• pp.727-740
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• 2017

The present paper studies the stability analysis of the continuously graded CNT-Reinforced Composite (CNTRC) panel stiffened by rings and stringers. The Stiffened Panel (SP) subjected to axial and lateral loads is reinforced by agglomerated CNTs smoothly graded through the thickness. A two-parameter Eshelby-Mori-Tanaka (EMT) model is adopted to derive the effective material moduli of the CNTRC. The stability equations of the CNRTC SP are obtained by means of the adjacent equilibrium criterion. Notwithstanding most available literature in which the stiffener effects were smeared out over the respective stiffener spacing, in the present work, the stiffeners are modeled as Euler-Bernoulli beams. The Generalized Differential Quadrature Method (GDQM) is employed to discretize the stability equations. A numerical study is performed to investigate the influences of different types of parameters involved on the critical buckling of the SP reinforced by agglomerated CNTs. The results achieved reveal that continuously distributing of CNTs adjacent to the inner and outer panel's surface results in improving the stiffness of the SP and, as a consequence, inclining the critical buckling load. Furthermore, it has been concluded that the decline rate of buckling load intensity factor owing to the increase of the panel angle is significantly more sensible for the smaller values of panel angle.

• Bulletin of the Society of Naval Architects of Korea
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• v.6 no.1
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• pp.43-67
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• 1969

The effect of a circular hole reinforced by a ring of different material in a plate under biaxial loadings is considered. In this problem, an infinitely large flat is assumed. The reinforcing ring is of uniform rectangular cross-section of same thickness as the plate. The outer boundary of the ring is cemented to the inner boundary of the hole in the plate. The plate is subjected to hydrostatic tension and pure shear loadings. The stress distribution around the hole is obtained by means of the two dimensional theory of elasticity. To conform the validities of above solutions, a series of photo-elastic stress analysis for a composite model was carried out. Fair agreements were observed between two sets of values. The conclusions arrived at are as follows: 1) The theoretical solutions are exact ones for the case of infinitely large flat plate. 2) The solutions can be used for most case of engineering problem if the bonding between the plate and ring is perfect. 3) If the ratio of Young's moduli of the ring and the plate is increased, the stresses in the plate decrease whereas those in the ring increase. 4) The stress concentration near the hole has localized effect. 5) Under hydrostatic tension, maximum principal stress and maximum shear stress increase as the ratio of inner and outer diameters of the ring increases. 6) Under pure shear, the stresses depend upon angular orientations of the points and maximum principal stress and maximum shear stress appear at 45 degree. They increase as the ratio of inner and outer diameters of the ring increases.