• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6201-6206
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• 2015

The epithelial-mesenchymal transition (EMT) is a cellular process though which an epithelial phenotype can be converted into a phenotype of mesenchymal cells. Under physiological conditions EMT is important for embryogenesis, organ development, wound repair and tissue remodeling. However, EMT may also be activated under pathologic conditions, especially in carcinogenesis and metastatic progression. Major signaling pathways involved in EMT include transforming growth factor ${\beta}(TGF-{\beta})$, Wnt, Notch, Hedgehog and other signaling pathways. These pathways are related to several transcription factors, including Twist, Smads and zinc finger proteins snail and slug. These interact with each other to provide crosstalk between the relevant signaling pathways. This review lays emphasis on studying the relationship between EMT and signaling pathways in carcinogenesis and metastatic progression.

• Journal of Bio-Environment Control
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• v.3 no.1
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• pp.66-71
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• 1994

In order to understand the mechanism of the wide occurrence of tipburn phenomenon in Chinese cabbage grown under protected cultivation, Chinese cabbage cultivated in two experimental plots was analyzed based on the distribution of some mineral elements by region in the plant and in the soil. The following results were obtained : 1) The occurrence of tipburn is not related to the concentration of Ca in the soil. 2) The concentration of Ca by region in the plant increased in the order such as inner leaf < middle leaf < outer leaf and inner vein < middle vein < outer vein. 3) From this results the cause of occurrence of tipburn phenomenon in Chinese cabbage which occurred at fixed times in the growth and development of the plant can be controlled by modifying environmental factors in order to prevent excessive transpiration in the inner leaf.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.142.2-142.2
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• 2011

Hydrodynamic simulations of gas clouds in the central hundred parsecs region of the Milky Way that is modeled with a three-dimensional bar potential are presented. Our simulations consider realistic gas cooling and heating, star formation, and supernova feedback. A ring of dense gas clouds forms as a result of $X_1-X_2$ orbit transfer, and our potential model results in a ring radius of ~200 pc, which coincides with the extraordinary reservoir of dense molecular clouds in the inner bulge, the Central Molecular Zone (CMZ). The gas clouds accumulated in the CMZ can reach high enough densities to form stars, and with an appropriate choice of simulation parameters, we successfully reproduce the observed gas mass and the star formation rate (SFR) in the CMZ, ${\sim}2{\times}10^7\;M_{\odot}$ and ${\sim}0.1\;M_{\odot}/yr$. Star formation in our simulations takes place mostly in the outermost $X_2$ orbits, and the SFR per unit surface area outside the CMZ is much lower. These facts suggest that the inner Galactic bulge may harbor a mild version of the nuclear star-forming rings seen in some external disk galaxies. We also find that the stellar population resulting from sustained star formation in the CMZ would be enlogated perpendicularly to the main bar, and this "inner bar" can migrate the gas in the CMZ further down to the central parsecs region.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.67.2-67.2
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• 2019

We present the results of KVN and ALMA observations toward WX Psc (IRC+10011) which is a long-period variable OH/IR star. The SiO masers of v=1 and v=2, J=5-4, and the SiO thermal emission of v=0, J=5-4 were observed together with H2O v2=1 (232.6 GHz) and continuum emission at ALMA Band 6 in October 2017 (Cycle 5). This observation aims to investigate the physical association between the inner and outer parts of the circumstellar envelope (CSE) swept by the stellar winds, which is very crucial to understand the asymmetric outward motions developed during the evolutionary phases from the asymptotic giant branch (AGB) stars to the planetary nebulae (PNe). The strong SiO maser features and thermal emissions are detected together with the continuum emission in ALMA observation, which imply the elongated morphology of the CSE of WX Psc. While the spatial resolution of about 20 mas in ALMA observation cannot clearly resolve the detailed characteristics of the inner part of the CSE, the Korean VLBI Network (KVN) observations show the spatial distributions of the v=1 J=1-0, J=2-1, J=3-2 SiO masers emitted from the inner regions of CSE, which are the complementary to the ALMA results. Therefore, we expect these results reveal how the bipolar features of the 22 GHz H2O maser are connected to the innermost region of CSE through the dust condensation region, which is closely related to the enormous mass ejection of the evolved stars.

• Journal of The Korean Astronomical Society
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• v.53 no.6
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• pp.117-123
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• 2020

We investigate the plausibility of mass return, from stellar mass loss processes within the central ~100 pc region of the Milky Way (the inner nuclear bulge), as a mass supply mechanism for the Circumnuclear Disk (CND). Gas in the Galactic disk migrates inward to the Galactic centre due to the asymmetric potential caused by the Galactic bar. The inward migration of gas stops and accumulates to form the central molecular zone (CMZ), at 100-200 pc from the Galactic center. It is commonly assumed that stars have formed in the CMZ throughout the lifetime of the Galaxy and have diffused inward to form a 'r-2 stellar cusp' within the inner nuclear bulge. We propose that the stars migrating inward from the CMZ supply gas to the inner nuclear bulge via stellar mass loss, resulting in the formation of a gas disk along the Galactic plane and subsequent inward migration down to the central 10 pc region (CND). We simulate the evolution of a gas distribution that initially follows the stellar distribution of the aforementioned stellar cusp, and illustrate the potential gas supply toward the CND.

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.9
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• pp.1345-1352
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• 2016

The hindgut of horses is an anaerobic fermentative chamber for a complex and dynamic microbial population, which plays a critical role in health and energy requirements. Research on the gut microbiota of Mongolian horses has not been reported until now as far as we know. Mongolian horse is a major local breed in China. We performed high-throughput sequencing of the 16S rRNA genes V4 hypervariable regions from gut fecal material to characterize the gut microbiota of Mongolian horses and compare them to the microbiota in Thoroughbred horses. Fourteen Mongolian and 19 Thoroughbred horses were used in the study. A total of 593,678 sequence reads were obtained from 33 samples analyzed, which were found to belong to 16 phyla and 75 genera. The bacterial community compositions were similar for the two breeds. Firmicutes (56% in Mongolian horses and 53% in Thoroughbred horses) and Bacteroidetes (33% and 32% respectively) were the most abundant and predominant phyla followed by Spirochaete, Verrucomicrobia, Proteobacteria, and Fibrobacteres. Of these 16 phyla, five (Synergistetes, Planctomycetes, Proteobacteria, TM7, and Chloroflexi) were significantly different (p<0.05) between the two breeds. At the genus level, Treponema was the most abundant genus (43% in Mongolian horses vs 29% in Thoroughbred horses), followed by Ruminococcus, Roseburia, Pseudobutyrivibrio, and Anaeroplasma, which were detected in higher distribution proportion in Mongolian horses than in Thoroughbred horses. In contrast, Oscillibacter, Fibrobacter, Methanocorpusculum, and Succinivibrio levels were lower in Mongolian horses. Among 75 genera, 30 genera were significantly different (p<0.05) between the two breeds. We found that the environment was one of very important factors that influenced horse gut microbiota. These findings provide novel information about the gut microbiota of Mongolian horses and a foundation for future investigations of gut bacterial factors that may influence the development and progression of gastrointestinal disease in horses.

• Journal of Biosystems Engineering
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• v.27 no.4
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• pp.341-348
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• 2002

Quality evaluation of red ginsengs is determined by outer shape and inner qualities. Especially, the inner qualities are main grading criteria. Currently, red ginsengs are classified into 3-grades; heaven, earth and good. The best heaven grade must not include inner holes and sponge tissues. This study was conducted to develop a red ginseng sorting system using x-ray image processing technique. Because of lens characteristic, gray values of the central region in the x-ray image are higher and gradually decreased towards the edge regions. This difference of gray values gives trouble in segmentation and detection of inner holes in red ginseng image, so preprocessing technique is necessary. The preprocessing was done by subtracting source image from an empty background image. But, simple subtraction was not quite appropriate because of too small contrast between inner holes and sound part. Scaled subtraction images were obtained by multiplying all gray values by some numbers. However this method could not help to set threshold value because the gray values of root part are generally lower than body part when red ginseng is exposed to the x-ray. To determine threshold value for detecting inner holes, an algorithm was developed by increasing overall gray values of less clear images.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.2
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• pp.649-658
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• 1996

Small-amplitude harmonic oscillations of multi-cylinders are considered both experimentally and theoretically. For the theoretical model, the flow regime is separated into inner and outer regions. In the inner region, the flow is governed by the generalized Stokes boundary layer equation. In the outer region, the full Navier-Stokes equation for the steady streaming flow is solved numerically by using ADI scheme and FVM coupled with the boundary integral method. Flow visualization experiments are conducted by using the Laser Sheet Image Technique. The case of two circular cylinders and square cylinders with variable distances are chosen as a typical example. Although experimental results are based on the flow in the finite domain, both experimental and numerical results agree well qualitatively. As the separation of cylinders is increased, a numerical result shows the asymptotic convergence to a single cylinder case.

• Atmosphere
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• v.18 no.4
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• pp.493-506
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• 2008

In order to examine the variational features of Asian dust outbreak in recent years, observed WMO synop data were employed for the period from 1996 to 2007. We first divided Asian dust source regions into four subregions; 1) Taklamakan, 2) Gobi, 3) Inner Mongolia-Manchuria and 4) Loess, and the meteorogical variables such as wind speed, precipitation and threshold wind speed observed during the Asian dust outbreak period were compared with those during non-Asian dust period. The results showed that temporal variation of occurrence frequency of dust outbreak had a strong positive correlation with the frequency of strong wind speed and low precipitation in each of the 4 source regions. Spatial distributions of frequency of dust occurrence after 2002 showed increasing trend in Gobi and Inner Mongolia-Manchuria but decreasing trend in Loess region. This is showing a shift in main source region toward Northwest, especially since 2003.

• The Pure and Applied Mathematics
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• v.27 no.1
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• pp.43-50
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• 2020

We investigate the domain of influence of the local volatility function on the solutions of the general Black-Scholes model. First, we generate the sample paths of underlying asset using the Monte Carlo simulation. Next, we define the inner and outer domains to find the effective volatility region. To confirm the effect of the inner domain, we use the root mean square error for the European call option prices, and then change the values of volatility in the proposed domain. The computational experiments confirm that there is an effective region which dominates the option pricing.