• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5207-5214
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• 2014

Background: To study the relationship of susceptibility to lung cancer with the gene polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1, GSTP1 and smoking status in Han and Mongolian populations of Inner Mongolia, an autonomous region of China. Materials and Methods: PCR-RFLP, allele-specific and multiplex PCR were employed to identify the genotypes of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 in a case-control study of 322 lung cancer patients diagnosed by bronchoscopy and 456 controls free of malignancy. Results: There is a significant difference in genotypic frequency of GSTT1 of healthy Mongolian and Han subjects. A statistically prominent association was found between CYP1A1 Msp1 (vt/vt) (OR=4.055, 95%CI:2.107-7.578, p=0.000), GSTM1 (-) (OR=2.290, 95%CI:1.467-3.573, p=0.000) and lung cancer in Mongolians. Similarly, in the Han population, CYP1A1 Msp1 (vt/vt) (OR=3.194, 95%CI:1.893-5.390, p=0.000) and GSTM1 (-) (OR=1.884, 95%CI:1.284-2.762, p=0.001) carriers also had an elevated risk of lung cancer. The smokers were more susceptible to lung cancer 2.144 fold and 1.631 fold than non-smokers in Mongolian and Han populations, respectively. The smokers who carried with CYP1A1 Msp1 (wt/vt+vt/vt), exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) respectively were found all to have a high risk of lung cancer. Conclusions: CYP1A1 Msp1 (vt/vt) and GSTM1 (-) are risk factors of lung cancer in Han and Mongolian population in the Inner Mongolia region. The smokers with CYP1A1 Msp1 (wt/vt+vt/vt), CYP1A1 exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) genotypes, respectively, are at elevated risk of lung cancer.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집D
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• pp.382-389
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• 2001

In the present study, local heat transfer rates for co-rotating disks with two modified hubs having ventilation holes are investigated for Rossby number of 0.04, 0.1 and 0.35 to evaluate the influence of incoming flows through hub holes. A naphthalene sublimation technique is employed to determine the detailed local heat/mass transfer coefficients on the rotating disks using the heat and mass transfer analogy. Flow field measurements are conducted using Laser Doppler Anemometry (LDA) and numerical calculations are performed simultaneously to analyze the flow patterns induced by the disk rotation. The basic flow structure in a cavity between co-rotating disks consists of three regions; the solid-body rotating inner region, the outer region with turbulence vortices and the shroud boundary layer region. The heat/mass transfer. rates on the co-rotating disks are very low near the hub due to the solid-body rotation and those increase rapidly in the outer region due to turbulence mixing. The modified hubs with ventilation holes enhances significantly the heat/mass transfer rates on the region near the hub. The results also show that the heat transfer of Hub-2 is superior to that of Hub-1, but Hub-1 is more profitable for destructing the solid-body rotating inner region.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 추계학술대회논문집B
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• pp.467-472
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• 2000

Most of the past experimental or analytical studies were performed for the curved bend with a square cross-section. Velocity profiles and Reynolds stresses of the turbulence flow in the 270 degree bend with circular cross-section were measured by a hot-wire anemometer. The mean velocity of primary flowing direction effected by the downstream of bend in the entry region of the bend. The flow in the inner part of the bend slowed the distribution velocity relatively large and unsymmetric phenomenon. In the strong secondary flow occurred when the flow passed in the region of 45 degree to 90 degree. The secondary flow appeared very large value in the neighbor region of inner wall.

• Applied Science and Convergence Technology
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• 제26권6호
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• pp.189-194
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• 2017

Effects of gas injection scheme and rf driving current configuration in a dual turn inductively coupled plasma (ICP) system were analyzed by 3D numerical simulation using CFD-ACE+. Injected gases from a tunable gas nozzle system (TGN) having 12 horizontal and 12 vertical nozzles showed different paths to the pumping surface. The maximum velocity from the nozzle reached Mach 2.2 with 2.2 Pa of Ar. More than half of the injected gases from the right side of the TGN were found to go to the pump without touching the wafer surface by massless particle tracing method. Gases from the vertical nozzle with 45 degree slanted angle soared up to the hottest region beneath the ceramic lid between the inner and the outer rf turn of the antenna. Under reversed driving current configuration, the highest rf power absorption region were separated into the two inner islands and the four peaked donut region.

• 한국항만학회지
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• 제9권1호
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• pp.57-63
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• 1995

In this paper we examine the mass transport within the boundary layer near the sea bottom. The fluid domain is seperated into inner and outer region of boundary layers. In outer region, the wave field is assumed to be inviscid and irrotational. When the incident waves enter the arrays of circular cylinders, the scattering of water waves by an array of N bottom mounted vertical circular cylinders is solved using the method proposed by Linton & Evans under the potential theory. In inner region, the Navier-Stokes equation must be satisfied with boundary conditions at the boundary later and bottom is to be represented by the sum of the Eulerian mean drift and the Stokes' drift.

• 콘크리트학회논문집
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• 제25권2호
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• pp.155-163
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• 2013

이 연구는 도넛형 이방향 중공슬래브에 매입된 이형철근의 부착특성 및 부착강도 산정을 위한 기초적인 연구이다. 도넛형 이방향 중공슬래브의 철근 부착특성 및 부착강도 산정을 위해 pull-out test를 수행하였다. 도넛형 중공형성체는 슬래브 내부에 배치되어 철근과 중공형성체 사이에 내부의 피복이 형성된다. 이러한 내부피복두께는 외부피복두께보다 상대적으로 작은 피복두께를 가지며 중공형상에 따라 $2.5d_b$보다 작은 내부피복두께가 형성되기 때문에 철근의 부착에 영향을 미치게 된다. 또한 중공형성체가 일정 간격으로 떨어져 배치되어 있으므로 인장철근을 감싸고 있는 피복두께의 조건이 철근의 길이방향으로 변하게 된다. 따라서 도넛형 이방향 중공슬래브의 부착특성을 알아보기 위해서 중공형성체 형상에 따라 부착구간을 구분하였다. 구간별로 내부피복두께에 따른 부착응력-슬립 관계를 확인하였으며, 중공형성체 전 구간에 걸친 부착응력분포를 확인하여 철근의 길이방향에 따른 부착응력의 발현정도를 확인하였다. 또한 구간별 부착응력-슬립 관계를 기반으로 하여 도넛형 중공슬래브의 부착강도를 산정할 수 있는 부착강도 산정 방법을 제안하였다.

• 한국해안해양공학회지
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• 제17권4호
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• pp.269-279
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• 2005

새만금호의 방조제 완공이후와 내부 개발이후 만경강 및 동진강의 홍수량 유입과 내부 수위를 관리하기 위해 수문을 작동할 매 수리특성이 어떻게 반응할 것인가를 평가하기 위한 수치실험이 수심적분된 ADCIRC 모형을 이용하여 실시되었다. 2차원 동적하도추적에 따르면, 상류에서는 홍수수문의 시간적 변화가 민감하나 홍수파가 호 내로 유하 하면서 급확대되는 물리적 특성에 따라 호 중심부터는 안정화된다. 평상시 관리수위를 유지하기 위해 수문을 제어하는 경우, 내부개발이후가 방조제 완공직후에 비해 수문 인근영역에서 유속, 수위 등에 동적응답이 즉각적으로 보다 크게 일어나고, 외해수를 호 내측으로 받아들이면 불규칙 수면교란이 일시적으로 발생하는데 내부개발 전후에 따라 최대 10km 및 16km정도까지 상류방향으로 전파된다.

• 천문학회보
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• 제24권1호
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• pp.42-42
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• 1999

• Asian-Australasian Journal of Animal Sciences
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• 제26권11호
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• pp.1644-1650
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• 2013

Ribosomal protein (rp) S6 is the substrate of ribosomal protein S6K (S6 kinase) and is involved in protein synthesis by mTOR/S6K/S6 signaling pathway. Some S6 cDNA have been cloned in mammals in recent years but has not been identified in the goat. To facilitate such studies, we cloned the cDNA encoding Cashmere goat (Capra hircus) S6 (GenBank accession GU131122) and then detected mRNA expression in seven tissues by real time PCR and protein expression in testis tissue by immunohistochemisty. Sequence analysis indicated that the obtained goat S6 was a 808 bp product, including a 3' untranslated region of 58 bp and an open reading frame of 750 bp which predicted a protein of 249 amino acids. The predicted amino acid sequence was highly homologous to cattle, human, mouse and rat S6. Expression analysis indicated S6 mRNA was expressed extensively in detected tissues and S6 protein was expressed in testis tissue.

• Journal of Veterinary Science
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• 제22권6호
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• pp.66.1-66.9
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• 2021

Background: Maedi/Visna virus (MVV) is a contagious viral pathogen that causes considerable economic losses to the sheep industry worldwide. Objectives: In China, MVV has been detected in several regions, but its molecular characteristics and genetic variations were not thoroughly investigated. Methods: Therefore, in this study, we conducted next-generation sequencing on an MVV strain obtained from northwest China to reveal its genetic evolution via phylogenetic analysis. Results: A MVV strain obtained from Inner Mongolia (NM) of China was identified. Sequence analysis indicated that its whole-genome length is 9193 bp. Homology comparison of nucleotides between the NM strain and reference strains showed that the sequence homology of gag and env were 77.1%-86.8% and 67.7%-75.5%, respectively. Phylogenetic analysis revealed that the NM strain was closely related to the reference strains isolated from America, which belong to the A2 type. Notably, there were 5 amino acid insertions in variable region 4 and a highly variable motif at the C-terminal of the surface glycoprotein (SU5). Conclusions: The present study is the first to show the whole-genome sequence of an MVV obtained from China. The detailed analyses provide essential information for understanding the genetic characteristics of MVV, and the results enrich the MVV library.