• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2007년도 하계학술대회 논문집 Vol.8
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• pp.532-532
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• 2007

UV 경화형 ink를 inkjet printing을 통해 PCB에 patterning 하는 방법에 관한 연구이다. UV 경화형 ink는 일반적으로 ink의 투명도, 색깔, 두께에 따라 완전경화가 밀어나지 않을 수도 있는데 본 연구에서 사용한 UV ink는 particle이 첨가되어 있고 후막 인쇄를 목적으로 하기 때문에 완전경화가 어려웠다. 일반적으로 이러한 UV 경화형 ink의 문제점들을 해결하기 위하여 열경화성 첨가제를 일부 첨가하여 UV에 의한 표면경화와 얼에 의한 속 경화를 진행하는 hybrid system이 사용되고 있지만 본 연구는 PCB를 target으로 하기 때문에 열에 약한 PCB 내의 많은 소자들 때문에 열처리가 쉽지 않은 문제가 있다. 이러한 여러 제약적인 환경에서 UV ink의 완전경화를 위해 경화 process를 최적화 하였으며 10~20um의 후막 인쇄에도 ink가 완전 경화하여 연필경도 9H를 확보하는데 성공하였다.

• 한국도서관정보학회지
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• 제39권3호
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• pp.457-477
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• 2008

본 연구는 전통(傳統) 제묵법(製墨法)의 부원(復元)을 위한 묵(墨)의 제조법(製造法)에 관하여 고구(考究)한 것으로, 그 주요 내용(內容)은 다음과 같다. (1) 묵(墨)은 탄분(炭粉)(그을음)과 아교(阿膠)를 섞어서 고체(固體)로 제조한 묵괴(墨塊)로 송연묵(松烟墨)과 유연묵(油煙墨)으로 구분된다. (2) 송연묵(松烟墨)은 소나무를 태운 탄분(炭粉)에, 유연묵(油煙墨)은 식물성이나 동물성 및 광물성의 기름을 태운 탄분(炭粉)에 아교를 섞어서 고체로 굳힌 묵(墨)이다. (3) 우리나라 전통(傳統)의 제묵법(製墨法)은 여러 문헌기록(文獻記錄)으로 전래되고 있으며 오늘날 전통(傳統)의 제묵법(製墨法)은 단절(斷絶)되어 더 이상 계승(繼承)되지 않고 있으나, 현대에 들어서 관심있는 묵장(墨匠)들에 의해 전통적(傳統的)인 제묵법(製墨法)이 부원(復元)되고 있다.

• 한국정밀공학회지
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• 제28권10호
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• pp.1146-1152
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• 2011

Ink transfer process is very important to determine quality of printed pattern, therefore its mechanism should be understood to control printing quality. Although there have been many attempts to understand ink transfer mechanism by numerical simulation and experimental studies, their model was too much simple to model realistic printing process and our understanding is not enough yet. In this paper we designed ink transfer visualization system to present flow visualization of ink transfer process for gravure offset printing. We considered rotational effect of blanket roll which is related with printing speed and used non-Newtonian fluid as working fluid such as Ag paste. For printing unit, cantilever-type blanket roll is used for convenient visualization of ink transfer. Serial images were captured continuously by using high-speed CMOS camera and long range microscope. We investigated the effects of various design parameters such as printing speed and pattern angle on the ink transfer process. We found more stretched ink filament for non-Newtonian fluid than Newtonian fluid. As increasing printing speed, length of stretched ink filament and height of break-up point are also increased. We also compared ink transfer process between CD and MD pattern and its relationship with ink transfer mechanism.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2006년도 PAN PACIFIC CONFERENCE vol.2
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• pp.215-225
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• 2006

Today's requirements for print-press runnability and print quality demand an optimised absorption and adhesion of printing ink on the paper surface. Modern coating concepts for high glossing offset grades use ultra fine pigments, whereas binder level has continuously been decreased to a minimum in recent years to achieve the highest possible sheet gloss development and for economical reasons. Both the ultra fine pigments and the reduced binder levels lead in many cases to a faster ink setting rate. On the other hand, matt paper grades use relatively coarse pigments leading to a slow ink setting compared to the high glossing papers. Both too fast and too slow ink setting properties implicate drawbacks in print quality and print press runnability. The mechanisms behind the interactions between ink and coating have been presented in many previous publications. The purpose of this study was to determine and quantify how the ink setting rate is influenced by pigment system (GCC and GCC/clay blends), latex level and latex properties in the topcoat of double coated sheet fed offset paper. The roles of binder level and type in the precoat were also assessed. The effect of calendering (temperature and pressure) was studied with one formulation. The resulting ink setting characteristics were tested using three different laboratory testing instruments. The correlation amongst the different laboratory testing methods is discussed. The results show that by varying the latex properties, the pigment system and/or latex addition level, the ink tack development of ink applied to a topcoat pigment system can be significantly influenced. It can be slowed down as often desired with ultra fine pigments or speeded up in the case of coarse pigments. There was no visible effect on the ink setting rate by using different binder systems in the precoat..

• 한국인쇄학회지
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• 제21권2호
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• pp.75-87
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• 2003

Printing inks are mainly composed of pigment and vehicles. Among these components, the Vehicle affect the rheologic property of the ink the most but pigment content of characteristic also after to the fluidity property not less than the vehicle. In the study, It is tested effect to the ink fluidity and structure recovery according to change the pigment particle size. The ink fluidity have been observed by using rheometer at the various conditions and it has been tested to observe what the ink fluidity has different means. In result We have found that the viscosity value of the low shear rate range has relatively higher value with decreasing the pigment particle size in the ink. Also, it has been found that when the pigment particle size decreases, the yield stress gradually increase. In the case of ink's structure recovery, when the pigment particle size decreases in the ink, the less changing shear rate, and it takes less time to recover.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2083-2087
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• 2014

Colorectal cancers remain to be a common cause of cancer-related death. Early-onset cases as well as those of various ethnic origins have aggressive clinical features, the basis of which requires further exploration. The aim of this work was to examine the expression patterns of $p15^{INK4b}$ and SMAD4 in colorectal carcinoma of different ethnic origins. Fifty-five sporadic colorectal carcinoma of Egyptian origin, 25 of which were early onset, and 54 cancers of Finnish origin were immunohistochemically stained with antibodies against $p15^{INK4b}$ and SMAD4 proteins. Data were compared to the methylation status of the $p15^{INK4b}$ gene promotor. $p15^{INK4b}$ was totally lost or deficient (lost in ${\geq}50%$ of tumor cell) in 47/55 (85%) tumors of Egyptian origin as compared to 6/50 (12%) tumors of Finnish origin (p=7e-15). In the Egyptian cases with $p15^{INK4b}$ loss and available $p15^{INK4b}$ promotor methylation status, 89% of cases which lost $p15^{INK4b}$ expression were associated with $p15^{INK4b}$ gene promotor hypermethylation. SMAD4 was lost or deficient in 25/54 (46%) tumors of Egyptian origin and 28/48 (58%) tumors of Finnish origin. 22/54 (41%) Egyptian tumors showed combined loss/deficiency of both $p15^{INK4b}$ and SMAD4, while $p15^{INK4b}$ was selectively lost/deficient with positive SMAD4 expression in 24/54 (44%) tumors. Loss of $p15^{INK4b}$ was associated with older age at presentation (>50 years) in the Egyptian tumors (p=0.04). These data show for the first time that $p15^{INK4b}$ loss of expression marks a subset of colorectal cancers and ethnic origin may play a role in this selection. In a substantial number of cases, the loss was independent of SMAD4 but rather associated with $p15^{INK4b}$ gene promotor hypermethylation and old age which could be related to different environmental exposures.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6239-6244
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• 2012

Background: The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. $p15^{INK4b}$ is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of $p15^{INK4b}$ protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of $p15^{INK4b}$ expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that $p15^{INK4b}$ could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate $p15^{INK4b}$ protein expression in BCCs. Materials and Method: Protein expression of $p15^{INK4b}$ in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach. Results: The expression of $p15^{INK4b}$ was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and $p15^{INK4b}$ protein expression. Conclusions: Our finding may indicate that $p15^{INK4b}$ protein expression does not play a role in the genesis of BCC.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5115-5118
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• 2015

Background: The $p16^{INK4a}$ is a protein that expressed in Liquid-based cervical cytology specimens and has been proved link to cervical cancer. The $p16^{INK4a}$ could be detection by piezoelectric immunosensor and the immobilization of the $p16^{INK4a}$ antibody influence the sensitivity of the piezoelectric immunosensor. Materials and Methods: $5{\mu}L$ mouse polyclonal antibody against $p16^{INK4a}$ was bound onto the surface of immonosensor through two methods. (directly immobilized method; protein A method). Absorb of the $p16^{INK4a}$ antibody on the surface of immonosensor caused a shift in the resonant frequency of the immunosensor and The frequency changes recorded showed a better reproducibility. The activity of the immobilization antibody with the directly method and protein A method was tested with $p16^{INK4a}$ antigen. Results: The resonant frequency for different antibody immobilization methods were different, and the sensitivity for $p16^{INK4a}$ detection also different. Conclusions: The protein A method was found to be much more better than the directly method for the immobilization of the p16INK4A antibody on the gold electrode of the quartz crystal for cervical lesion detection. The Protein A method created more reproducible and stable immobilization antibody layers with p16INK4A antigen.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.253-258
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• 2015

Background: Development of squamous cell cancer of head and neck (SCCHN) is associated with human papillomavirus (HPV) infection, which in turn is closely related with expression of $p16^{INK4A}$. Loss of $p16^{INK4A}$ expression by deletion, mutation, or hypermethylation is common in SCCHN. We here evaluated $p16^{INK4A}$ as a prognostic marker of treatment response and survival in our SCCHN patients with laryngeal, hypopharyngeal or nasopharyngeal cancers. Materials and Methods: 131 patients diagnosed with SCCHN between January 2,2006 and July 17, 2010 were examined for $p16^{INK4A}$. The median age was 60 years (15-82 years). Fifty one patients were stage I-II and 80 were stage III-IV. Immunohistochemical expression of $p16^{INK4A}$ was analyzed in pretreatment paraffin-embedded tumor blocks. The influence of $p16^{INK4A}$ status on disease-free survival, and overall survival after treatment was evaluated. Results: $p16^{INK4A}$ positivity was found in 58 patients (44%). Tumor-positivity for$ p16^{INK4A}$ was correlated with improved disease free survival (70.1 months vs 59 months) and improved overall survival (2, 3 and 5-year values; 77% vs 72%, 70% vs 63% and, 63% vs 55%; respectively). On multivariate analysis, stage was determined as independent prognostic factor for disease-free survival. Conclusions: Stage was the major prognostic factor on treatment response and survival in our patients. $p16^{INK4A}$ status predicts better outcome in laryngeal, hypopharyngeal or nasopharyngeal cancer cases treated with surgery plus adjuvant radiochemotherapy as well as with definitive radiation therapy and/or chemotherapy.

• 대한기계학회논문집A
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• 제36권5호
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• pp.545-553
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• 2012

본 논문은 옵셋인쇄용 잉크를 자동적으로 교반할 수 있는 시스템의 개발과정을 소개하고 있다. 교반 공정은 페인트, 잉크 등 색을 다루는 많은 산업 분야에서 필요하고, 특히 소량의 고점성 잉크를 섞어서 별색을 제조하기 위한 자동화된 시스템은 해당 산업체에서 크게 필요로 하고 있다. 본 연구에선 공전과 자전에 의한 회전과 벨트 전동 방식으로 잉크를 교반할 수 있는 시스템의 설계, 제작, 실험이 수행 되었다. 회전 방향, 속도, 교반용기의 각도 및 잉크 양 등 다양한 조건에서 실험을 수행함으로써 교반시스템의 성능을 검증하였다. 또한 실험을 통해 잉크 교반에 적합한 조건을 찾음으로써 옵셋 인쇄업체에서 별색 제조용으로 사용이 가능한 방법을 제시하였다.