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http://dx.doi.org/10.7314/APJCP.2012.13.12.6239

Lack of Increased P15INK4B Protein Expression in Basal Cell Carcinomas  

Moad, Ahmed Ismail Hassan (Advanced Medical and Dental Institute, University Sains Malaysia)
Tan, Mei Lan (Advanced Medical and Dental Institute, University Sains Malaysia)
Kaur, Gurjeet (Institute for Research in Molecular Medicine, Universiti Sains Malaysia)
Mabruk, Mohamed (APRSP Institute of health Sciences, University of Brunei Darussalam)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.12, 2012 , pp. 6239-6244 More about this Journal
Abstract
Background: The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. $p15^{INK4b}$ is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of $p15^{INK4b}$ protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of $p15^{INK4b}$ expression in the majority of tissue microarray cores of cutaneous squamous cell carcinoma (SCCs), another type of non-melanoma skin cancer, indicating that $p15^{INK4b}$ could possibly be involved in the pathogenesis of cutaneous SCC. The aim of this study was to investigate $p15^{INK4b}$ protein expression in BCCs. Materials and Method: Protein expression of $p15^{INK4b}$ in 35 cases of BCC tissue arrays and 19 cases of normal human skin tissue was studied using an immunohistochemical approach. Results: The expression of $p15^{INK4b}$ was not significantly different in the BCC cases as compared with normal human skin (p=0.356; p>0.05). In addition, there were no significant relationship between clinicopathologic variables of patients (age and sex) and $p15^{INK4b}$ protein expression. Conclusions: Our finding may indicate that $p15^{INK4b}$ protein expression does not play a role in the genesis of BCC.
Keywords
Basal cell carcinoma; $p15^{INK4b}$; immunohistichemistry;
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