• 대한약침학회지
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• 제18권1호
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• pp.56-62
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• 2015

Objectives: The purpose of the study is to assess both the approximate lethal dose and the single dose intramuscular injection toxicity of Danggui (Angelica gigantis radix) pharmacopuncture (DGP) in Sprague-Dawley (SD) rats. Methods: The experiments were conducted at the good laboratory practice (GLP) laboratory, Biotoxtech Co., which is a laboratory approved by the ministry of food and drug safety (MFDS). The study was performed according to the GLP regulation and the toxicity test guidelines of the MFDS (2009) after approval of the institutional animal care and use committee of Biotoxtech. Single doses of DGP were injected intramuscularly into the rats in three test groups of 6 week old SD rats (5 male and 5 female rats per groups) in the amounts of 0.1, 0.5, and 1.0 mL/animal for groups 2, 3, and 4, respectively, and normal saline solution in the amount of 1.0 mL/animal was injected intramuscularly into the rats (5 male and 5 female rats) in the control group. Observations of the general symptoms and weight measurements were performed during the 14 day observation period after the injection. Hematologic and serum biochemical examination, necropsy, and a local tolerance test at the injection site were done after the observation period. Results: No death was observed in three test groups (0.1, 0.5 and 1.0 mL/animal group). In addition, the injection of DGP had no effect on general symptoms, weights, hematologic and serum biochemical examination, and necropsy. The results from the local tolerance tests at injection site showed no treatment related effects in the SD rats. Conclusion: The results of single dose intramuscular injection of DGP suggest that the approximate lethal dose is above 1.0 mL/animal for both male and female SD rats and that intramuscular injection of DGP may be safe.

• Biomolecules & Therapeutics
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• 제2권3호
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• pp.247-255
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• 1994

As a series of safety studies of DA-3030, a new rhO-CSF, its local irritancy was examined in the rabbits after the following treatment; application into the conjunctival sac of the eye(single), subcutaneous injection(single), intramuscular injection(single), and intravenous injection(8-day repeated). In addition, paravenous irritation of DA-3030 was investigated in mice. The results obtained were as follows. 1. In the result of ocular irritation test, 0.03% solution of DA-3030 could be considered as a non-irritating material. 2. The local irritation of DA-3030 by an injection of 0.5mι of its solution subcutaneously or intramuscularly was negligible and not so much different from that of saline. 3. In the vascular irritancy test, macro- and microscopic observations revealed that the irritating activity of DA-3030 in blood vessels was not different from that of saline when they were injected once a day into vein retroauricularis of rabbits for 8 days.4. The paravenous administration of DA-3030 did not induce any abnormal changes at injection sites except mild swelling in 1 mouse at 3 hours after injection which was thought to be due to slow absorption. The above-mentioned results suggest that DA-3030 has no irritating activity when injected through intravenous or subcutaneous route for clinical practice as 0.03% solution.

• 한국지반공학회논문집
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• 제19권2호
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• pp.217-225
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• 2003

지반보강 그라우팅은 대상지반의 공학적 특성 및 사용 목적에 따라 주입재 종류, 주입압력, 주입량 등을 적절히 선택해야 효율적이고 경제성 있는 시공이 될 수 있다. 특히, 압력 그라우팅 공법을 견고한 암반층이 아닌 일반 토사층에 적용시 압력이 높은 경우 수압파쇄에 의한 주입재 이탈 등의 문제가 발생하기 쉬우므로 현장조건에 알맞는 주입압력을 미리 설정하는 것이 필요하다. 이 연구는 느슨 내지 중밀 정도의 쇄석과 모래를 이용한 실험실 모형시험을 통하여 적정 주입압과 주입방법을 밝히기 위해 수행되었다. 최적 주입압, 주입량 그리고 주입시간을 조사하기 위해 실험과정에서 주입조건을 변화시켰다. 시험결과로부터 쇄석 및 모래지반에서 압력그라우팅의 최적 주입압은3~4kg/$cm^2$ 임을 알 수 있었다.

• 대한임베디드공학회논문지
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• 제7권3호
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• pp.135-142
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• 2012

The Quality of embedded system depends on the embedded software. As the complexity and the size of embedded software have been increasing, it is more likely that the software may include faults, and the reliability and stability issues are getting more important. In this paper, we propose a remote test tool for software based on VxWorks by using fault injection method. The test tool consists of test server and test client for testing on the cross development environment. The test server operates in the host system and user can not only test but also monitor the software by using it. The test client operates in the target system and it controls kernel objects and sends the input data into the software when receiving the control and data from the test server. We developed the prototype software and demonstrated the ability of testing software robustness by injecting faults.

• 항공우주시스템공학회지
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• 제7권2호
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• pp.55-59
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• 2013

Before avionics equipment are installed in aircraft, several environmental tests such as temperature, vibration, lightning, fire etc. must be conducted. One of the environmental tests is to substantiate protection designs of lightning indirect effect. It can be showed through RTCA DO-160G, section22 "Lightning Induced Transient Susceptibility" test. An additional test of aircraft level is required as well after installation of avionics equipment.

• 한국자동차공학회논문집
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• 제11권5호
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• pp.43-49
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• 2003

The common-rail fuel injection system is becoming a common technology for High Speed Direct Injection(HSDI) diesel engines. The injection timing and rate are important factors for combustion control and pollutants formation mechanisms during engine operation. This paper introduces an estimation methodology of the injection timing and rate of a common-rail injector for HSDI diesel engines. A sliding mode observer that is based on the nonlinear mathematical model of the common-rail injector is designed to overcome the model uncertainties. The injector model and the estimator we verified by relevant injection experiments in an injector test bench. The simulation and the experimental results show that the proposed sliding mode observer can effectively estimate the injection rate of the common-rail injector.

• The Korean Journal of Pain
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• 제14권2호
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• pp.186-192
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• 2001

Background: Epidural test doses containing epinephrine are an incomplete marker for the detection of inadvertent intravascular injection. Therefore, many investigators have attempted to find a more reliable marker as an alternative to epinephrine in adult patients anesthetized with enflurane. The present study was designed to test whether two different simulated intravenous test doses of isoproterenol could be used as a reliable marker for the detection of inadvertent intravascular injection in adult patients anesthetized with $O_2-N_2O$-enflurane. Methods: Forty healthy adult patients were anesthetized with 1% end-tidal enflurane and nitrous oxide after endotracheal intubation and were randomized to one of two groups according to the dose of isoproterenol. Group 1 and 2 (n = 20 each) received 3 ml of 1.5% lidocaine with 3 and 5 g isoproterenol intravenously, respectively, to simulate an intravascularly administered test dose. Heart rate (HR) and systolic blood pressure (SBP) were measured at 20-second intervals for 4 min after injection. Results: Mean maximal HR increases were $24{\pm}17$, $35{\pm}11$ bpm (P < 0.05), mean maximal SBP increases were $14{\pm}8$, $13{\pm}9$ mmHg and mean maximal SBP decreases $20{\pm}11$, $22{\pm}9$ mmHg following the IV injection of 3, $5{\mu}g$ isoproterenol, respectively. The incidence of hypotension was similar in both groups. Isoproterenol 3 and $5{\mu}g$ produced 75%, 100% sensitivity in the HR criteria ($\geq$ 20 bpm increase) and 60%, 70% sensitivity in the SBP criteria ($\geq$ 15 mmHg), respectively. Conclusions: These results indicate that based on the HR response, the epidural test dose containing $5{\mu}g$ isoproterenol to simulate an intravascular administration is a more reliable marker than $3{\mu}g$ isoproterenol in adult healthy patients during enflurane anesthesia.

• Journal of Positioning, Navigation, and Timing
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• 제7권3호
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• pp.127-138
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• 2018

Spoofing attacks including meaconing can provide a bogus position to a victim GPS receiver, and those attacks are notably difficult to detect at the point of view on the receiver. Several countermeasure techniques have been studied to detect, classify, and cancel the spoofing signals. Based on the countermeasure techniques, we have developed an anti-spoofing equipment that detects and mitigates or eliminates the spoofing signal based on raw measurements. Although many anti-spoofing techniques have been studied in the literatures, the evaluation test system is not deeply studied to evaluate the anti-spoofing equipment, which includes detection, mitigation, and elimination of spoofing signals. Each study only has a specific test method to verify its anti-spoofing technique. In this paper, we propose the performance evaluation test system that includes both spoofing signal injection system and its injection scenario with the constraints of stand-alone anti-spoofing techniques. The spoofing signal injection scenario is designed to drive a victim GPS receiver that moves to a designed position, where the mitigation and elimination based anti-spoofing algorithms can be successively evaluated. We evaluate the developed anti-spoofing equipment and a commercial GPS receiver using our proposed performance evaluation test system. Although the commercial one is affected by the test system and moves to the designed position, the anti-spoofing equipment mitigates and eliminates the injected spoofing signals as planned. We evaluate the performance of anti-spoofing equipment on the position error of the circular error probability, while injecting spoofing signals.

• 대한정형외과 초음파학회지
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• 제8권1호
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• pp.1-5
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• 2015

목적: 본 연구는 수평 내전 검사로 인해 견관절 후방부 동통의 악화를 보이는 환자에 대해서 초음파 유도 하에 스테로이드를 이용한 극하근 주사 치료 후 그 유용성에 대하여 평가하고자 하였다. 대상 및 방법: 2013년 5월부터 2014년 5월까지 견관절 후방부 통증을 주소로 내원한 환자 중 수평 내전 검사 시 동통의 악화를 보이는 21명을 대상으로 하였다. 외래에서 초음파 유도하에 극하근에 스테로이드 주사 치료를 시행하였으며 시술 전, 시술 후 3개월, 6개월로 나누어 VAS 통증 점수, UCLA 점수를 평가하였다. 결과: 스테로이드를 이용한 극하근 주사 치료 3개월 경과 시 환자들의 VAS 점수, UCLA 점수에서 임상적으로 유의하게 향상되었다(p<0.05). 시술 후 3개월과 6개월을 비교하면 VAS 점수와 UCLA 점수는 유의한 차이는 없었다(p>0.05). 6개월 추시 후 증상의 호전이 있는 완쾌 및 호전은 14예(67%)이었고, 호전이 없는 비호전 및 악화는 7예(33%)이었다. 결론: 초음파 유도 하에 스테로이드를 이용한 극하근 주사요법은 견관절 후방 통증이 있으며 수평 내전 시 통증이 악화되는 증상이 있는 환자들에게 유용한 시술이라고 생각된다.

• 대한기계학회논문집B
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• 제20권9호
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• pp.2924-2932
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• 1996

As the environmental pollution can be greatly reduced and the waste heat can be also recovered through a combustion of municipal solid waste, the incineration begins to be highlighted recently in our country. But it is very difficult to be operated with constant combustion conditions for a long time as the domestic waste is composed of various components, contains a large percentage of water, and has a low heating value. Therefore, the cold flow test and partial hot flow test were conducted in the incinerator by use of injection angles of a secondary air affecting fluid flow as the first action to maintain the optimum combustion conditions. A model to a scale of 1:10 was designed and manufactured through the similarity of model and prototype flows. Velocities and temperatures were measured through the experiment. From the results, fluid flows of secondary air obtained from partial hot flow test correspond almost well with those of main flow obtained from cold flow test. Consequently, injection angles of secondary air are proved to affect main flow decisively.