• 보건행정학회지
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• 제16권2호
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• pp.96-116
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• 2006

To assess the economic value of pharmaceutical therapy with Kremezin, we investigated the maximum amount of willingness-to-pay (WTP) of patients with chronic renal failure (CRF) for a hypothetical effect of Kremezin in delaying the initiation of dialysis treatments. A face-to-face survey was carried out in a sample of 141 CRF patients from 2 dialysis centers, composed of 82 hemodialysis patients, 38 peritoneal dialysis patients, and 21 non-dialysis CRF patients. Using a bidding game method with a starting point of 320,000 Won, which is the average monthly out-of-pocket payment for dialysis treatment, we asked the study subjects how much they would pay per month to receive Kremezin therapy. The mean out-of-pocket monthly WTP for Kremezin was 310,000, 430,000, and 520,000 Won (p<0.05, repeated one-way ANOVA)) when Kremezin delays the initiation of dialysis treatments by 1, 2, and 4 years. Significant correlation between the respondent's WTP and income $(r=0.266{\sim}0.368,\;p<0.05)$ confirmed the construct validity of the WTP instrument. Regression results showed that patients with a higher education, with diabetes as a major causes of CRF, and undergoing hemodialysis treatments tended to express higher WTP for Kremezin. The economic value of WTP from the perspective of patients varied from 310,000 to 520,000 Won depending on the effect size of Kremezin. The mean WTP was higher than 32,000 Won, only when the hypothetical effect of Kremezin in delaying the initiation of dialysis is for 2 years. This implies that Kremezin might be the preferred choice of therapy by CRF patients if it delays the initiation of dialysis treatment for at least 2 years.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.278-283
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• 2005

Cell cycle is regulated cooperatively by several genes. The dynamic regulatory mechanism of protein interaction network of cell cycle will be presented taking the budding yeast as a sample system. Based on the mathematical model developed by Chen et at. (MBC, 11,369), at first, the dynamic role of the feedback loops is investigated. Secondly, using a bifurcation diagram, dynamic analysis of the cell cycle regulation is illustrated. The bifurcation diagram is a kind of ‘dynamic road map’ with stable and unstable solutions. On the map, a stable solution denotes a ‘road’ attracting the state and an unstable solution ‘a repelling road’ The ‘START’ transition, the initiation of the cell cycle, occurs at the point where the dynamic road changes from a fixed point to an oscillatory solution. The 'FINISH' transition, the completion of a cell cycle, is returning back to the initial state. The bifurcation analysis for the mutants could be used uncovering the role of proteins in the cell cycle regulation network.

• 콘크리트학회논문집
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• 제12권3호
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• pp.67-75
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• 2000

It was well recognized that the damages associated mainly with the aging of civil infrastructures were one of very serious problems for assurance of safety and reliability. Recently carbon fiber sheet(CFS) has been widely used for reinforcement and rehabilitation of damaged concrete beam. However, the fundamental mechanism of load transfer and its load-resistant for carbon fiber sheet reinforced concrete are not fully understood. In this study, three point bending test has been carried out to understand the damage progress and the micro-failure mechanism of CFS reinforced mortars. For this purpose, four different types of specimens are used, that is, mortar, steel bar reinforced mortar, CFS reinforced mortar, and steel bar and CFS reinforced morter. Acoustic Emission(AE) technique was used to evaluate the characteristics of damage progress and the failure mechanism of specimens. in addition, two-dimensional AE source location was also performed to monitor crack initiation and propagation processes for these specimens.

• Computers and Concrete
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• 제16권4호
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• pp.605-623
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• 2015

A coupled experimental and numerical study of shear fracture in the edge-notched beam specimens of quasi-brittle materials (concrete-like materials) are carried out using four point bending flexural tests. The crack initiation, propagation and breaking process of beam specimens are experimentally studied by producing the double inclined edge notches with different ligament angles in beams under four point bending. The effects of ligament angles on the shear fracturing path in the bridge areas of the double edge-notched beam specimens are studied. Moreover, the influence of the inclined edge notches on the shear-fracture behavior of double edge-notched beam specimens which represents a practical crack orientation is investigated. The same specimens are numerically simulated by an indirect boundary element method known as displacement discontinuity method. These numerical results are compared with the performed experimental results proving the accuracy and validity of the proposed study.

• 한국인터넷방송통신학회논문지
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• 제21권4호
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• pp.63-73
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• 2021

대공표적을 탐지/추적하기 위해 운용되는 레이다는 임무 특성에 따라 표적의 탐지를 목적으로 안테나 구동장치가 회전하며 운용되는 탐색레이다와 표적의 예측 위치에 주기적으로 빔을 조향하여 추적하는 추적레이다로 구분한다. 일반적으로 추적레이다는 탐색레이다에 비해 표적 정보 획득 주기가 짧은 특징이 있는데 이러한 특징으로 인하여 추적 정확도는 탐색레이다에 비해 좋지만 짧은 획득 주기로 인한 추적 초기 속도 오차로 인해 표적 예측 오차가 커짐에 따라 항적 연관에 실패하거나 빔 조향을 정상적으로 수행하지 못하여 추적 초반에 표적 추적이 실패하는 경우가 많이 발생하게 된다. 본 논문에서는 위에서 기술한 추적레이다의 추적 초반 문제점들을 해결하기 위해 기존 표적 추적을 위해 활용했던 측정치의 위치 정보(거리, 방위각, 고각) 외에 표적 시선속도 측정값을 활용한 초기 표적 정보 정확도 향상 알고리즘을 제안하고 기존에 추적 초기화 시 많이 사용하는 알고리즘인 Two Point Differential 알고리즘과 성능 비교를 통해 제안하는 알고리즘의 성능을 확인하였다.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2007년도 춘계학술대회 논문집
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• pp.364-367
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• 2007

Typical seamless tube production methods are an extrusion and a rotary tube piercing. The rotary piercing process is more competitive than the extrusion process form view point of productivity, quality, and flexibility. It consists of twin rolling mills, a pair of disc or flat guides, and a plug. Twin rolling mills are skewed with proper angles in two directions. A round billet is progressively fed forward and rotated due to the rotation of twin rolling mills. Internal crack initiation and growth at central area of the billet are gradually progress because of the repeating actions of tension and rotation. Design variables in the rotary piercing rolling process are the feed angle, the cross angle, the reduction ratio, and the position of plug. In this work, a rotary tube piercing machine was developed and parametric studies on design variables were carried out using finite element analysis. The Brozzo ductile fracture criterion was utilized to determine an internal crack initiation.

• 항공우주시스템공학회지
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• 제1권2호
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• pp.27-36
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• 2007

The Damage Tolerant Design is developed to help alleviate structural failure and cracking problems in aerospace structures. Recently, the Damage Tolerant Design is required and recommended for most of aircraft design. In this paper, the damage tolerant design is applied to tilt rotor UAV. First of all, the fatigue load spectrum for the tilt rotor UAV is developed and fatigue analysis is performed for the flaperon joint which has FCL (fatigue critical location). Tilt rotor UAV has two modes: helicopter mode when UAV is taking off and landing; fixed wing mode when the tilt rotor UAV is cruising. To make fatigue load spectrum, FELIX is used for helicopter mode. TWIST is used for fixed wing mode. Fatigue analysis of flaperon joint is performed using fatigue load spectrum. E-N curve approach is used for picking crack initiation point. The LEFM(Linear Elastic Fracture Method) is considered for analyzing crack growth or propagation. Finally, including the crack initiation and propagation, the fatigue life is evaluated. Therefore the Damage Tolerant Design can be done.

• 산업기술연구
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• 제21권B호
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• pp.213-222
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• 2001

In the study, the fatigue strength improvement and mechanism have been estimated by the Spot-Heating treatment on welded bead toes. For this, web-gusset specimens were made without residual stresses and the others with residual stresses imposed by Spot-Heating. The 4-point bending tests were performed in order to estimate the effect of spot-heating on fatigue strength and fatigue characteristics quantitatively for non load-carrying fillet welded joints subjected to pure bending. As a result of fatigue test, fatigue strength of As-Welded specimen for non load-carrying fillet welded joints subjected to pure bending has satisfied the grade of fatigue prescribed in specifications of korea, AASHTO and JSSC. As compare with As-Welded specimen and Spot-Heating specimen have increased about 20% for the fatigue strength at $7.7{\times}10^6$ cycles. The Spot-Heating by reformation of the residual stress on welded bead toes has greatly affected the fatigue crack propagation life, but has slightly affected the fatigue crack initiation life.

• 대한기계학회논문집A
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• 제27권1호
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• pp.8-17
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• 2003

Fracture behaviors of pipes with local wall thinning are very important for the integrity of nuclear Power Plant. In Pipes of energy Plants, sometimes, the local wall thinning may result from severe erosion-corrosion (E/C) damage. However, the effects of local wall thinning on strength and fracture behaviors of piping system were not well studied. In this paper, the monotonic bending tests were performed of full-scale carbon steel pipes with local wall thinning. A monotonic bending load was applied to straight pipe specimens by four-point loading at ambient temperature without internal pressure. From the tests, fracture behaviors and fracture strength of locally thinned pipe were manifested systematically. The observed failure modes were divided into four types; ovalization. crack initiation/growth after ovalization, local buckling and crack initiation/growth after local buckling. Also, the strength and the allowable limit of piping system with local wall thinning were evaluated.

• Computers and Concrete
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• 제7권4호
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• pp.387-402
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• 2010

From typical stress-axial strain curve and stress-volume strain curve of a concrete under uniaxial compression, the initiation and localization of microcracks within the interior of the specimen can be identified. The occurrence of random microcrack indicates the end of the linear elasticity, and the localization of microcrack implies formation of major crack, which triggers the onset of unstable crack propagation. The interval between initiation and localization of microcracks is characterized by a stable microcrack growth. Based on fracture behavior observed from a uniaxial compressive test of a concrete cylinder, a model has been developed to extract fundamental fracture properties of a concrete, i.e. the equivalent fracture toughness and the size of fracture process zone. The introduction of cracking Poisson's ratio accounts for tensile failure characteristics of concrete even under uniaxal compression. To justify the validity of the model proposed, tests on three-point bending have been performed to obtain the fracture toughness in accordance with two parameter fracture model and double-K fracture model. Surprisingly, it yields favorably comparable results and provides an encouraging alternative approach to determine fracture properties for concretes.