• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3265-3268
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• 2012

Nanoparticles (NPs) are increasingly used in consumer products, which have aroused many concerns and debates regarding their fate in biological systems from a point of their safety/toxicity. Although a number of studies on the biological effects of NPs have been published, these are often complicated by the possible toxicity of conventional NPs, caused by contamination with chemical precursors or additives during their synthesis and/or purification procedures. To explicitly understand the toxicity basis of NPs, it is necessary to directly address a main problem related to their intrinsic/inherent toxicity and/or incompatibility with biological objects. The present study is designed to take advantage of a novel laser-assisted method called laser ablation to generate Ag, Au, Co, and Cu NPs in biocompatible aqueous solution, and to evaluate the toxicity of the resulting ultra-pure NPs. Our results show that the ultra-pure NPs with nascent surfaces possess moderate cytotoxicity to human cells in a cell-dependent manner.

• 한국군사과학기술학회지
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• 제17권6호
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• pp.773-785
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• 2014

For decades, modeling of pilots has been intensively studied due to its advantages in reducing costs for training and enhancing safety of pilots. In particular, research for modeling of pilots' non-kinetic behaviors which refer to the decisions made by pilots is beneficial as the expertise of pilots can be inherent in the models. With the recent growth in the amount of combat logs accumulated, employing statistical learning methods for the modeling becomes possible. However, the combat logs consist of heterogeneous data that are not only continuous or discrete but also sequence independent or dependent, making it difficult to directly applying the learning methods without modifications. Therefore, in this paper, we present a kernel function named hybrid sequence kernel which addresses the problem by using multiple kernel learning methods. Based on the empirical experiments by using combat logs obtained from a simulator, the proposed kernel showed satisfactory results.

• 한국전산구조공학회논문집
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• 제18권1호
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• pp.61-69
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• 2005

장경간화되고 경량화된 데크 바닥판 구조물은 부재가 유연하기 때문에 거주자의 움직임에 의하여 진동이 크게 발생할 수 있으며, 이러한 바닥판 진동은 건축물의 안전성뿐만 아니라 건축물의 사용성에도 많은 영향을 끼치므로 건축물의 품질 평가기준으로 사용되고 있다. 데크 바닥판 구조물의 올바른 사용성 평가를 위해서는 정확한 진동해석과 응답평가가 수반되어야한다. 본 논문에서는 데크 바닥판 구조물의 직교이방성을 고려한 여러 가지 모형화 방법을 적용하여 진동해석을 수행하였으며 모형화 방법에 따른 진동응답을 비교 분석하였다. 본 논문에서 제시한 데크 골 방향 강성에 대한 등가두께 모형화방법은 간단한 방법으로 데크 바닥판 구조물의 직교이방성을 간단한 방법으로 고려할 수 있으며, 정확한 진동응답을 얻을 수 있으므로 실무에서 실용적으로 활용할 수 있다.

• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 1998년도 춘계 학술발표회 논문집
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• pp.235-242
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• 1998

Aiming at one of decisive alternatives for long term aspect of nuclear power concerns, an integral and closed nuclear system, AMBIDEXTER (Advanced Molten-salt Break-even Inherently-safe Dual-mission Experimental and TEst Reactor) concept is under development. The AMBIDEXTER complex essentially comprises two mutually independent loops of the radiation/material transport and the heat/energy conversion, centered at the integrated reactor assembly, which enables one to utilize maximum benefits of nuclear energy under minimum risks of nuclear radiation. And it provides precious radioisotopes and radiation sources from its waste stream. Also the reactor operates at very low level of fission products inventory throughout its lifetime. The nuclear and thermalhydraulic characteristics of the molten TH/$^{233}$ U fuel salt extend the capability of the self-sustaining AMBIDEXTER fuel cycle to enhance resource security and safeguard transparency. The reactor system is consisted of a single component module of the core, heat exchangers and recirculation pumps with neither pipe connections nor active valves in between, which will significantly improve inherent features of nuclear safety. States of the core technologies associated with designing and developing the AMBIDEXTER concept are mostly available in commercialized form and thus demonstration of integral aspects of the concept should be the prime area in future R＆D programs.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2005년도 춘계학술대회논문집
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• pp.572-575
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• 2005

A novel pneumatic artificial muscle actuator (PAM actuator), which has achieved increased popularity to provide the advantages such as high strength and high power/weight ratio, low cost, compactness, ease of maintenance, cleanliness, readily available and cheap power source, inherent safety and mobility assistance to humans performing tasks, has been regarded during the recent decades as an interesting alternative to hydraulic and electric actuators. In order to realize satisfactory control performance, a variable damper Magneto Rheological Brake (MRB), Is equipped to the Joint of the manipulator. Superb mixture of conventional PID controller and a phase plane switching control method brings us a novel controller. This proposed controller is appropriate for a kind of plants with nonlinearity, uncertainties and disturbances. The experiments were carried out in practical PAM manipulator and the effectiveness of the proposed control algorithm was demonstrated through experiments, which had proved that the stability of the manipulator can be improved greatly in a high gain control by using MRB with phase plane switching control method and without regard for the changes of external inertia loads.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(환경)
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• pp.417-425
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• 1994

Although animal studies have been used most often for quantitative risk assessment, it is generally recognized that well-conducted epidemiologic studies would provide the best basis for estimating human risk. However, there are several features related to the design and analysis of epidemiologic studies that frequently limit their usefulness for quantitating risks. The lack of accurate information on exposure in epidemiologic studies is perhaps the most frequently cited limitation of these studies for risk assessment. However. other features of epidemiologic study design, such as statistical power, length of follow-up, confounding, and effect modification, may also limit the inferences that can be drawn from these studies. Furthermore, even when the aforementioned limitations are overcome, substantial uncertainty exists concerning the choice of an appropriate statistical (or biologic) model for extrapolation beyond the range of exposures observed in a particular study. This paper focuses on presenting a review and discussion of the methodologic issues involved in using epidemiologic studies for risk assessment. This review concentrates on the use of retrospective, cohort, mortality studies of occupational groups for assessing cancer risk because this is the most common application of epidemiologic data for quantitative risk assessment (QRA). Epidemiologic data should not be viewed as a panacea for the problems inherent in using animal bioassay data for QRA. Rather, information that can be derived from epidemiologic and toxicologic studies complement one another, and both data sources need to be used to provide the best characterization of human risk.

• 대한인간공학회지
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• 제30권4호
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• pp.525-534
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• 2011

This paper describes the current status of musculoskeletal disorders(MSDs) and its ergonomic risk factors, including the preventive intervention in terms of the working conditions and health promotion among agricultural workers. Korean agricultural workers have been exposed to the poor working condition. They have suffered from a variety of work-related injury and diseases more than the general population or the other occupational group. MSDs are one of the most prevalent problems threatening the agricultural worker's health and quality of life. Low back pain, osteoarthritis of hip and knee joint and carpal tunnel syndrome are well known MSDs that was found easily and frequently among agricultural workers. MSDs are worsened by poor ergonomic working conditions such as heavy weight lifting, repetitive movement and awkward posture which involves squatting with long sitting work on the ground, long working hours and heavy workload which are inherent in the greater part of agricultural works. Even though Korean agricultural workers are very weak population in terms of occupational safety and health, no many studies were conducted in the past and no many social and institutional supports were provided sufficiently. We need more interests and efforts in agricultural fields to improve its working condition and to promote health status of agricultural workers.

• 한국도로학회논문집
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• 제19권4호
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• pp.1-7
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• 2017

PURPOSES : This study aims to improve complex modeling of multivariable, nonlinear, and overdispersion data with an artificial neural network that has been a problem in the civil and transport sectors. METHODS: Deep learning, which is a technique employing artificial neural networks, was applied for developing a large bus fuel consumption model as a case study. Estimation characteristics and accuracy were compared with the results of conventional multiple regression modeling. RESULTS : The deep learning model remarkably improved estimation accuracy of regression modeling, from R-sq. 18.76% to 72.22%. In addition, it was very flexible in reflecting large variance and complex relationships between dependent and independent variables. CONCLUSIONS : Deep learning could be a new alternative that solves general problems inherent in conventional statistical methods and it is highly promising in planning and optimizing issues in the civil and transport sectors. Extended applications to other fields, such as pavement management, structure safety, operation of intelligent transport systems, and traffic noise estimation are highly recommended.

• Smart Structures and Systems
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• 제16권2호
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• pp.367-382
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• 2015

This paper aims to conduct the reliability-based assessment of the welded joint in the orthotropic steel bridge deck by use of a mesh-insensitive structural stress (MISS) method, which is an effective numerical procedure to determine the reliable stress distribution adjacent to the weld toe. Both the solid element model and the shell element model are first established to investigate the sensitivity of the element size and the element type in calculating the structural stress under different loading scenarios. In order to achieve realistic condition assessment of the welded joint, the probabilistic approach based on the structural reliability theory is adopted to derive the reliability index and the failure probability by taking into account the uncertainties inherent in the material properties and load conditions. The limit state function is formulated in terms of the structural resistance of the material and the load effect which is described by the structural stress obtained by the MISS method. The reliability index is computed by use of the first-order reliability method (FORM), and compared with a target reliability index to facilitate the safety assessment. The results achieved from this study reveal that the calculation of the structural stress using the MISS method is insensitive to the element size and the element type, and the obtained structural stress results serve as a reliable basis for structural reliability analysis.

• Earthquakes and Structures
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• 제14권5호
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• pp.389-398
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• 2018

The seismic isolation system makes a structure isolated from ground motions to protect the structure from seismic events. Seismic isolation techniques have been implemented in full-scale buildings and bridges because of their simplicity, economic effectiveness, inherent stability and reliability. As for the responses of an isolated structure due to seismic events, it is well known that the most uncertain aspects are the seismic loading itself and structural properties. Due to the randomness of earthquakes and uncertainty of structures, seismic response distributions of an isolated structure are needed when evaluating the seismic fragility assessment (or probabilistic seismic safety assessment) of an isolated structure. Seismic response time histories are useful and often essential elements in its design or evaluation stage. Thus, a large number of non-linear dynamic analyses should be performed to evaluate the seismic performance of an isolated structure. However, it is a monumental task to gather the design or evaluation information of the isolated structure from too many seismic analyses, which is impractical. In this paper, a new methodology that can evaluate the seismic fragility assessment of an isolated structure is proposed by using stochastic response database, which is a device that can estimate the seismic response distributions of an isolated structure without any seismic response analyses. The seismic fragility assessment of the isolated nuclear power plant is performed using the proposed methodology. The proposed methodology is able to evaluate the seismic performance of isolated structures effectively and reduce the computational efforts tremendously.