• Bulletin of the Korean Chemical Society
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• v.13 no.1
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• pp.59-64
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• 1992

The contrasting behaviour of meso-and d,l-$D_3$-trishomocubylidene-$D_3$-trishomocubane (1 and 2) in the electrophilic addition reaction, the former giving rearranged spiro compound (1a and 1b) and the latter giving 1,2-adduct (2a and 2b), has been explained as arising from the secondary steric effects based on computational evidence. As the degree of out-of-plane deformation of the olefinic carbon atoms increases with reaction progress, the resulting internal congestion in the region behind the double bond becomes unbearably large in meso-1. The absence of symmetry plane across the double bond of d,l-2 helps for the closing fragments to adjust themselves.

• Magazine of korean Tunnelling and Underground Space Association
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• v.21 no.2
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• pp.117-129
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• 2019

Tunnelling in urban environments is very common nowadays as large cities are expanding and transportation demands require the use of the underground space for creating extra capacity. Inevitably, any such new construction may have significant effects on existing nearby infrastructure and therefore relevant assessment of structural integrity and soil-structure interaction is required. Foundation piles can be rather sensitive to nearby tunnel construction and therefore their response needs to be evaluated carefully. Although detailed three-dimensional continuum finite element analysis can provide a wealth of information about this behaviour of piles, such analyses are generally very computationally demanding and may require a number of material and other model parameters to be properly calibrated. Therefore, relevant simplified approaches are used to provide a practical way for such an assessment. This paper presents a simple method where the pile is modelled with beam finite elements, pile-soil interaction is modelled with soil springs and tunnelling-induced displacements are introduced as an input boundary condition at the end of the soil springs. The performance of this approach is assessed through some examples of applications.

• Asia Marketing Journal
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• v.24 no.1
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• pp.13-28
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• 2022

Despite the benefits of online shopping, we easily observe consumer behaviour when making purchases through offline channels. Why do they choose to go offline by taking the effort to go there? As a factor influencing decision-making, this study assumes that distrust of online shopping increases webrooming intentions that online consumers move to offline channels. Consumers check online reviews as well as seller information to increase their purchasing confidence. There are few studies on the effect of negative online reviews on consumers' purchasing decisions. Contrary to the pessimistic results of previous studies, the results of this study explain the mechanism by which consumers who saw negative online reviews feel distrust of online shopping and go to offline stores. It provides implications for understanding the migration phenomenon of online shoppers to offline channels and what strategies should be prepared to retain and attract customers to each channel.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 1997.11a
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• pp.542-549
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• 1997

HFC-227ea and HCFC Blend A were evaluated using full-scale fire tests to obtain information on their fire suppression performance, drop-in capability, thermal decomposition products and physical behaviour of the agent such as its flow characteristics in the piping system. Also, full-scale tests were conducted with Halon 1301 to provide a basis for comparison. Halon 1301, at concentrations of 5% to 7.5%, showed effective total-flooding fire- extinguishing performance for all test scenarios. HFC-227ea, at a design concentration of 7.6% or higher, and HCFC Blend A, at a design concentration of 12%, extinguished all fires in the test facility, however, these agents produced higher concentrations of acid gases than Halon 1301. The quantity of the acid gases generated during fire suppression was dependent on agent concentration, agent discharge time, fire type and size as well as extinguishment time.

• Journal of the Korean Society for Precision Engineering
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• v.14 no.11
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• pp.11-16
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• 1997

In the stroke sensitive shock absorber, the oil path is formed along the internal cylinder surface to make the oil flow during the piston's upper-lower reciprocation movement. In constrast with the conventional shock absorbesr which show one dynamic characteristic curve, stroke sensitive shock absorber shows two kinds of dynamic characteristics according to the stroke. In this study, in order to obtain more precise information about design and damping performance analysis, the analysis on the damping force generation process and dynamic behaviour characteristics of stroke sensitive shock absorber are performed by considering the valve characteristics.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.1
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• pp.83-92
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• 2022

Religions and beliefs can affect the shopping behaviors of its followers and practitioners. However, the knowledge about the factors that motivate, facilitate and even constrain customers' purchase of spiritual goods, such as feng shui items, is limited. Therefore, in this study, I examined the reasons, facilitators, and constraints of purchasing spiritual goods from the buyers' perspective. Two research questions directed the examination process, including (1) why users buy spiritual goods? And (2) what factors may facilitate or constrain the purchase and use of spiritual goods? Using Vietnam's feng shui market as the context, I applied the autoethnographic and ethnographic methods to collect and analyze the data. I found that the two main reasons to purchase the feng shui items were the products' meaning and beauty. In addition, I observed three groups of factors that could facilitate or constrain the purchase and use of feng shui items, including information about the products and their sellers, disposable income and life stage of the buyers, and price and authenticity of the products. Finally, based on these findings, I discussed the practical implications for managing the spiritual goods market in Vietnam.

• Journal of Information Technology Applications and Management
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• v.28 no.5
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• pp.51-60
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• 2021

The main purpose of this study is to examine the factors that influence the employee's intention to leave the current job. A descriptive survey design was conducted and primary data were collected by using questionnaire. The study was based on random sampling; a sample of 200 was drawn from the employees who work in different micro finance institutions in Nepal. For the data analysis percentage analysis and chi square-test were used. The study revealed that salary, working condition, career growth, supervisor behavior and outstation influence the job quitting process. The study also defined the association between the reasons for leaving job such as salary, working condition, career growth supervisor behaviour & outstation and satisfaction, time spent in the organisation, training & development facility, frequency of changing job & encourage from immediate boss. This study establishes the importance of intentions of employees to quit job and provides further evidence in revealing the intentions to quit among the employees.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3817-3825
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• 2015

Background: The human protein methyl-transferase DOT1L catalyzes the methylation of histone H3 on lysine 79 (H3K79) at homeobox genes and is also involved in a number of significant processes ranging from gene expression to DNA-damage response and cell cycle progression. Inhibition of DOT1L activity by shRNA or small-molecule inhibitors has been established to prevent proliferation of various MLL-rearranged leukemia cells in vitro, establishing DOT1L an attractive therapeutic target for mixed lineage leukemia (MLL). Most of the drugs currently in use for the MLL treatment are reported to have low efficacy, hence this study focused on various natural compounds which exhibit minimal toxic effects and high efficacy for the target receptor. Materials and Methods: Structures of human protein methyl-transferase DOT1L and natural compound databases were downloaded from various sources. Virtual screening, molecular docking, dynamics simulation and drug likeness studies were performed for those natural compounds to evaluate and analyze their anti-cancer activity. Results: The top five screened compounds possessing good binding affinity were identified as potential high affinity inhibitors against DOT1L's active site. The top ranking molecule amongst the screened ligands had a Glide g-score of -10.940 kcal/mol and Glide e-model score of -86.011 with 5 hydrogen bonds and 12 hydrophobic contacts. This ligand's behaviour also showed consistency during the simulation of protein-ligand complex for 20000 ps, which is indicative of its stability in the receptor pocket. Conclusions: The ligand obtained out of this screening study can be considered as a potential inhibitor for DOT1L and further can be treated as a lead for the drug designing pipeline.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.11
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• pp.2381-2390
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• 2011

This paper presents the effective and detailed secure monitoring method being used based on Secure OS. For this, the detailed secure log of process, object, user's command and database query in task server are collected by 3 kinds of log collecting module. The log collecting modules are developed by ourselves and contained as constituents of security system. Secure OS module collects process and system secure log of objective unit, Backtracker module collects user's command session log, SQLtracker module collects database query in details. When a system auditor monitors and traces the behaviour of specified user or individual user, the mutual connection method between the secure logs can support detailed auditing and monitering effectively.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.71
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• pp.325-350
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• 2016

As the new competitive environment become more global, technologically oriented and customer driven, as customers continually demand higher quality, faster response, and greater reliability of products and services, the new global market demands a more customer responsive behaviour by companies and firms have responded with innovative products and improved manufacturing processes to manufacture products. Further, the shift from traditional manufacturing and purchasing to JIT manufacturing and purchasing requires customers and suppliers to shift from adversarial relationships to strategic partnerships, and information sharing, so as to attain flexibility, reliability, and speed. SCM practices such as supplier collaboration and information sharing is considered as a key to attaining supplier network responsiveness and enhancing the product innovation and the market access time. The current research investigates the effect of SCM practices on supplier network responsiveness, the product innovation and the market access time of export companies. Thus by providing empirical evidence of the said relationships, this study offers useful guidelines for measuring and improving the supplier network responsiveness of a firm, facilitating further research in the area.