• Title/Summary/Keyword: inducing current

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Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications

  • Seungbo Yoo;Sang-Jun Ha
    • IMMUNE NETWORK
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    • v.16 no.1
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    • pp.52-60
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    • 2016
  • Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate and adaptive immune responses, thereby leading to immune activation. DCs have been known to recognize pathogen-associated molecular patterns such as lipopolysaccharides (LPS) and nucleic acids via their pattern recognition receptors, which trigger signaling of their maturation and effector functions. Furthermore, DCs take up and process antigens as a form of peptide loaded on the major histocompatibility complex (MHC) and present them to T cells, which are responsible for the adaptive immune response. Conversely, DCs can also play a role in inducing immune suppression under specific circumstances. From this perspective, the role of DCs is related to tolerance rather than immunity. Immunologists refer to these special DCs as tolerogenic DCs (tolDCs). However, the definition of tolDCs is controversial, and there is limited information on their development and characteristics. In this review, we discuss the current concept of tolDCs, cutting-edge methods for generating tolDCs in vitro, and future applications of tolDCs, including clinical use.

A Study on the Meridians for treat the miscellaneous diseases in Jap ByoungPyeon(雜病篇) of the Young Chu(靈樞) (영추(靈樞).잡병편(雜病篇)의 잡병치료경락(雜病治療經絡)에 대한 연구(硏究))

  • Lee Moon-Og;Yuk Sang-Won
    • Korean Journal of Acupuncture
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    • v.20 no.4
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    • pp.99-119
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    • 2003
  • Objectives : The Jap Byoung(雜病) of the Young Chu(靈樞), one of the classical book of oriental medicine contains symptoms and remedies for various diseases that can be seen on human body. But it is too difficult to understand the Jap Byoung(雜病), because it is written in old chinese and there are many printer's error and omissions or adds in this book. As a consequence of above reason, the writer of this article has researched to find out the exact meaning of that. Methods : So in this part we study a woodblock-printed book of successive generation and view of annotators, and add adding notes, adjustment, translation to exact comprehension of the original text. Results & conclusions : The principle ideas of the thesis can be summarized as follows: The Jap Byoung(雜病) is consist of five part. In chapter 1, we present symptoms occurred by the upstream current of Qi(氣逆) and their treatments by taking meridian flowing the body parts on which the symptoms occur. In chapter 2, we deal with symptoms such as ikgun(?乾), a pain of the knee(膝中痛), huby(喉痺), epistaxis(?血), lumbago(腰痛), anger(怒), a pain of the jaw(痛), a pain of the nape(項痛) and their remedies. In chapter 3, since abdominal inflation occurs when the Qi(氣) of the five viscera(五臟) is damaged or go upstream, I discussed that the treatment should be given by taking the meridian accordingly. In chapter 4, we deal with the remedy for heartache, and different meridians to be taken by symptom, and parts on which needle to be used, and detailed remedies. In chapter 5, we present other diseases, detailed body parts to be cured and remedies by referring symptoms for a pain of the jaw(痛), the upstream current of Qi(氣逆), hiccup, etc. Especially, we introduce a part of Doinbup(導引法) for wegurl(?厥) and remedies for hiccup such as inducing sneeze by stimulating nostrils, holding one's breath, etc.

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Fabrication of Ultra Fine β-phase Ti-Nb-Sn-HA Composite by Pulse Current Activated Sintering

  • Woo, Kee-Do;Wang, Xiaopeng;Kang, Duck-Soo;Kim, Sang-Hyuk;Woo, Jeong-Nam;Park, Sang-Hoon;Liuc, Zhiguang
    • Journal of Powder Materials
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    • v.17 no.6
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    • pp.443-448
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    • 2010
  • The $\beta$ phase Ti-Nb-Sn-HA bio materials were successfully fabricated by high energy mechanical milling and pulse current activated sintering (PCAS). Ti-6Al-4V ELI alloy has been widely used as biomaterial. But the Al has been inducing Alzheimer disease and V is classified as toxic element. In this study, ultra fine sized Ti-Nb-Sn-HA powder was produced by high energy mechanical milling machine. The $\beta$ phase Ti-Nb-Sn-HA powders were obtained after 12hr milling from $\alpha$ phase. And ultra fine grain sized Ti-Nb-Sn-HA composites could be fabricated using PCAS without grain growth. After sintering, the microstructures and phase-transformation of Ti-Nb-Sn-HA biomaterials were analyzed by scanning electron microscope (SEM) and X-ray diffraction (XRD). The relative density was obtained by Archimedes principle and the hardness was measured by Vickers hardness tester. The $\beta$-Ti phase was obtained after 12h milling. As result of hardness and relative density, 12h milled Ti-Nb-Sn-HA composite has the highest values.

Numerical Analysis of Intense Electric Current Pulse to Disperse Shaped Charge Metal Jet (성형작약탄 금속제트 산란을 위한 대전류 펄스의 수치해석적 연구)

  • Park, Hyeong Gyu;Kim, Dong Kyu;Kim, Si Woo;Joo, Jae Hyun;Song, Woo Jin;Kim, Jeong
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.39 no.1
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    • pp.55-62
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    • 2015
  • The electromagnetic force induced by an intense electric current pulse, which generates an electromagnetic field around the metal jet originating from a shaped charge, can disperse and scatter the high-speed metal jet. An electric device consisting of an RLC circuit applies an intense electric current pulse that flows in the circuit while the metal jet passes between two electrodes. In this study, the metal jet formation was simulated using the ALE technique in 2-D, and a 3-D finite element model was mapped using 2-D simulation results to induce the electric current directly. The deformed shapes of the metal jet and the electromagnetic force were calculated using a finite element analysis by inducing the electric current directly, and the major parameters of the intense electric current pulse for breaking up the metal jet were examined.

Simplified Depth Modeling in HEVC-based 3D Video Coding (HEVC-기반 3차원 비디오 부호화에서 깊이 모델링 간소화 방법)

  • Song, Yunseok;Ho, Yo-Sung
    • Smart Media Journal
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    • v.2 no.2
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    • pp.28-32
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    • 2013
  • In this paper, we present a method to reduce complexity of depth modeling modes (DMM) that are used in the current 3D-HEVC standardization. DMM adds four modes to the existing HEVC intra prediction modes for accurate object edge representation in the depth map. Especially, Mode 3 requires distortion calculation of numerous pre-defined wedgelets, inducing high complexity. The proposed method employs absolute differences of neighboring pixels in the sides of the reference block to find high intensity changing positions. Based on such positions, the number of wedgelet candidates is reduced to six and distortion calculation is skipped for irrelevant wedgelets. Experimental results show complexity reduction by 3.1% on average, while maintaining similar coding performance.

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Effect of Thiourea on the Copper Electrodeposition (구리 전기 도금에 Thiourea가 미치는 효과)

  • Lee, Joo-Yul;Yim, Seong-Bong;Hwang, Yang-Jin;Lee, Kyu-Hwan
    • Journal of the Korean institute of surface engineering
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    • v.43 no.6
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    • pp.289-296
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    • 2010
  • The effect of organic additives, thiourea (TU), on the copper electroplated layer of large rectangular size was investigated through physical and various electrochemical techniques. It was found that TU had strong adsorption characteristics on the Ni substrate and affected the initial electroplating process by inducing surface reaction instead of mass transfer in the bulk solution. TU additives had its critical micelle concentration at 200 ppm in copper sulphate solution and showed abrupt change in morphological and electrochemical impedance spectroscopic results around this concentration, which could be related with the destruction of adsorption structure of TU-Cu(I) complex formed at the Ni substrate surface. By conducting a commercial electroplating simulation, when TU additives was included at cmc in the plating solution, it acted as a depolarizer for copper electrodeposition and was effective to reduce the unevenness of copper deposits between centre and edge region at high current densities of 10 ASD.

A Case Study on the Planning of Charnel House (납골당 계획에 관한 사례조사 연구)

  • 손계중;김영훈
    • Korean Institute of Interior Design Journal
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    • no.13
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    • pp.72-77
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    • 1997
  • The funeral and grave system in Korea has issued that our country will become a grave. This is a result of being in favor of the funeral and grave process of burial based on long time traditions and customs. The government is allowing construction and use of charnels on a large scale in order to improve this system after analyzing the problems of the current grave system; However, those results are very few and slight because the image of existing charnels have been regarded as abomination utilities and it has been projected not to be closed to the public easily. In this stduy, we first looked at these problems using sample research and analysis. Second, we made comparisons and analysis to suggest solutions in the projecting method and feature of those spaces by carrying out a sample research project. This project was based on 3 of the biggest charnels built recently, which are out of the 54 charnels in Korea. After assaying the image according to the interior designing elements, and then proposing various several alternatives, we would like to tell how to build the future-oriented and opened charnels as the purpose of this study. Therefore, when projecting charnels, we would like to suggest the alternative solution that diminishes abomonation and closeness in the interior of the charnel through the designing consideration and increases the usage of this building by inducing traditional limitations and maintaining vertical dignity and piety by making the central axis adapting to the nature.

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Effects of Transverse Reinforcement on Strength and Ductility of High-Strength Concrete Columns

  • Hwang, Sun Kyoung;Lim, Byung Hoon;Kim, Chang Gyo;Yun, Hyun Do;Park, Wan Shin
    • Architectural research
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    • v.7 no.1
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    • pp.39-48
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    • 2005
  • Main objective of this research is to evaluate performance of high-strength concrete (HSC) columns for ductility and strength. Eight one-third scale columns with compressive strength of 69 MPa were subjected to a constant axial load corresponding to 30 % of the column axial load capacity and a cyclic horizontal load-inducing reversed bending moment. The variables studied in this research are the volumetric ratio of transverse reinforcement (${\rho}_s=1.58$, 2.25 %), tie configuration (Type H, Type C and Type D) and tie yield strength ($f_{yh}=549$ and 779 MPa). Test results show that the flexural strength of every column exceeds the calculated flexural capacity based on the equivalent concrete stress block used in the current design code. Columns with 42 % higher amounts of transverse reinforcement than that required by seismic provisions of ACI 318-02 showed ductile behaviour, showing a displacement ductility factor (${\mu}_{{\Delta}u}$) of 3.69 to 4.85, and a curvature ductility factor (${\mu}_{{\varphi}u}$) of over 10.0. With an axial load of 30 % of the axial load capacity, it is recommended that the yield strength of transverse reinforcement be held equal to or below 549 MPa.

An Exploratory study on the Value Preservation of Bukhansan National Park (북한산 국립공원의 가치보전에 관한 탐색적 고찰)

  • Oh, Heung-Jin
    • The Journal of the Korea Contents Association
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    • v.9 no.5
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    • pp.293-303
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    • 2009
  • This study is to solve the problems arising from preserving the value of Bukhansan National Park as a precious tourism resource in South Korea. In order to effectively examine the value of preserving the resource, some cases of foreign countries having advanced skills and experiences in managing their national parks are examined so as to apply them to managing Bukhansan National Park. With this developed preserving method, this study mainly focuses on inducing the ways how to permanently maintain its value. Furthermore, some solutions for the problems through analyzing the current situation of Bukhansan National Park are suggested with additional proven opinions of serveral specialists interviewed. As a result, this study is expected to contribute on preserving the value of Bukhansan National Park which is one of the greatest properties in Korea.

Roles of Social Identity Verification in the Effects of Symbolic and Evaluation Relevance on Chinese Consumers' Brand Attitude

  • Choi, Nak-Hwan;Xu, Huimin;Teng, Zhuoqi
    • Asian Journal of Business Environment
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    • v.8 no.4
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    • pp.17-27
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    • 2018
  • Purpose - Current study aimed at investigating the symbolic and evaluation relevance to global luxury brands as the causes of inducing social identity verification, and also explored whether the social identity verification will affect the attitude toward the brands. Research design, data, and methodology - 323 questionaries from Chinese consumers were used to test hypotheses by structural equation model of AMOS 22.0. Results - First, social identity verification positively affected on the brand attitude. Second, both the symbolic relevance and the evaluation relevance positively affected on social identity verification. Third, the mediation roles of social identity verification were identified. Social identity verification played a full mediation role in the effect of the symbolic relevance on the brand attitude, and played a partial mediation role in the effect of the evaluation relevance on the brand attitude. Conclusions - This study could contribute to the advancement of theory concerned with the roles of consumers' social identity verification which induces positive attitude toward the global luxury brands. Global brand managers in China should try to search ways by which consumers can feel both the symbolic relevance and evaluation relevance to their luxury brands, and should make efforts to improve the symbolic relevance and evaluation relevance to their brand.