• 동의생리병리학회지
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• 제17권3호
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• pp.633-642
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• 2003

A pain is the symptom which defends against noxious stimulus about a human body, it is known that if the periphery of perceptive nerve were stimulated by a physical or chemical factors, the stimulation is induced by transmission to pain center in the cerebral cortex according to pain conduction tract. The treatment of pain is to decrease a stimulus that causes a pain or block off a nerve transmitting a stimulus or puts on a way to calm down pain center, but It is for adjustment of a pain to be the most representative in acupuncture among various ways to cure a pain in Oriental medicine. However, the analgesic effect of an individual response to acupuncture stimulation shows marked individual variations, so these days genetic a few approach is attempted. On this the author determined that the responding group was appointed those whose tail flick latency (TFL) responding time delayed the minimum of 30 % comparing with basal reaction time. For those whose TFL time had shorter than 30 % was grouped as a non-responding group. And then the hypothalamus of each group was dissected and RNA was further purified. After synthesizing cDNA using oligo dT primer, products were finally applied to the PCR. The results were as follows; The ratio of responding group to non-responding group was 6:4. Ach T (acetylcholinesterase T subunit), BF-I (Brain factor-I), DBH (Dopamine β-hydroxylase) and PNM (Phosphotidylethanolamine N-Methyltransferase) were revealed significantly in the responding group. Cathepsin B and Tau were revealed significantly in the non-responding group. The PCR results show that Ach T, BF-I, DBH and PNM are expressed abundantly in the responding group, where as cathepsin B and tau are abundant in the non-responding group. These results suggest that the analgesic effect on acupuncture stimulation is related to regulation of neurotransmitter as well as neurodegeration of cerebrum.

• 동의생리병리학회지
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• 제16권5호
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• pp.845-850
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• 2002

This paper suggest a methodology for representation of findings which can be called as signs and symptoms. A finding consists of unit signs and unit symptoms, and moreover findings which appear in one individual patient have so many different relationship each other. So, it is nat appropriate to list all of possible findings as medical standard or to fill findings as independent things in paper for medical record. We try to distinguish finding item from finding list, and suggest the methodology by which we can make finding list from finding items. That is, we suggest finding item[Concept], value types, relationship, logical operator, and syntax as a component of representation. And by using urinary symptom, we make the example for representation methodology. Finally, we mention the background knowledge, brief research process of related area.

• 동의생리병리학회지
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• 제21권5호
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• pp.1285-1290
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• 2007

The present study aims to identify and characterize genes that cause differen genes between non-responders and responders to electroacupuncture (EA) on mechanical allodynia following peripheral nerve injury. Under sodium pentobarbital anesthesia, animals were subjected to unilateral transection of the superior caudal trunk at the level between S1 and S2 spinal nerves. EA stimulation (2Hz, 0.3 ms, 0.2-0.3 mA) was delivered to Zusanli (ST36) for 30 min 2 weeks after the surgery. The degree of mechanical allodynia was assessed quantitatively by touching the tail with von Frey hair (2.0 g) at 10 min intervals. The rats, which showed an EA-induced decrease of response frequencies under 10 %, were classified as non-responders and those displaying an EA-induced decrease of response frequencies 20 % or more were classified as responders. Results from oligonucleotide microarray, to which cDNAs from the spinal dorsal horn (DH) were applied, showed that hemoglobin beta chain complex and chondroitin sulfate proteoglycan-5 decreased and limbic system-associated membrane protein increased in the non-responder group, whereas calcium-independent alpha-Iatrotoxin receptor homolog-3 increased in the responder group. These results suggest that The functional abnormality of molecules regulating cell adhesion, intracellular signal transduction and cell differentiation in the spinal DH may be involved in the anti-allodynic effect of EA.

• 동의생리병리학회지
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• 제26권3호
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• pp.351-359
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• 2012

This study aims to evaluate the student satisfaction of problem-based learning(PBL) in Korean medical curriculum. A questionnaire was given to clinical clerkship students of Pusan National University School of Korean medicine. These items covered overall evaluation of module & learning environment, tutoring, individual learning, group learning and effectiveness for clinical clerkship in PBL. By most of all respondents, PBL was recognized as a more effective learning method. Most respondents were satisfied with the group learning, individual learning and effectiveness for clinical clerkship. However, satisfaction was lower for tutors and module. The results of this study demonstrated that the students had a high level of satisfaction in PBL. It might be concluded that PBL was successfully implemented into the Korean medical curriculum.

• 동의생리병리학회지
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• 제36권2호
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• pp.79-87
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• 2022

In this study, extracts of Boswellia serrata gum resin, Curcuma longa rhizome, and Terminalia chebula fruit were combined in different ratios, and their anti-osteoarthritis effects were compared to determine which combination had the best synergistic effect. B. serrata, C. longa, and T. chebula extracts in a 2:1:2 ratio exhibited higher antioxidative activity in scavenging DPPH radicals than did the individual extracts alone or the other extract combinations. Additionally, the 2:1:2 combination significantly improved the levels of enzymatic antioxidants and antioxidant-related proteins. Moreover, this same combination ratio decreased the protein levels of matrix metalloproteinase (MMP) 3 and MMP13 in interleukin-1β-stimulated human articular chondrocytes (HCHs) and increased those of aggrecan and collagen type II alpha 1 chain (COL2A1). Analysis of the underlying mechanisms revealed that the 2:1:2 combination significantly inhibited the phosphorylation of nuclear factor kappa B (NF-κB) p65, extracellular regulated protein kinase (ERK), and p38 mitogen-activated protein kinase (MAPK). Therefore, the 2:1:2 combination of these three plant extracts has the best potential for use as an effective dietary supplement for improving joint health compared with the individual extracts and their other combination ratios.

• 동의생리병리학회지
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• 제21권5호
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• pp.1337-1340
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• 2007

Pulse diagnosis is one of the typical examination methods in traditional oriental medicine. However, it is necessary to obtain the objectivity for the standardization of this diagnosis. For this purpose, the pulse analyzer has been devised and studied, and the tonometric pulse analyzer displaying the pulse wave and its variables was developed recently. In this study, we investigated the effect of the sexuality of the individuals on the differences of the pulse wave as well as the correlation between the weight and the pulse wave to interrogate whether the pulse difference is not caused by the difference of sex but the size of individual.

• 사상체질의학회지
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• 제15권2호
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• pp.24-37
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• 2003

Sasang Constitutional Medicine, which argues that physiology, pathology, diagnosis, medical cure depend on individual's constitution, is different from a previous traditional oriental medicine. Recently the idea of fitted medicine, made by concepts based on genome project, is similar to constitution of Sasang Constitutional Medine in that both of them take the individual difference Into consideration. Sasang Constitutional Medicine is able to contribute to explanation of function of genes, because the same food acts differently on individual's constitution in Sasang Constitutional Medicine In 'Dongmu Yugo Yaksungga(동무유고 약성가)' it is said that A lotus, adlay, ginko nut, chest nut open stomach-Qi of Taeumin, help to digest, and give a better appetite. But this is different from the explanations of a previous traditional oriental medicine. All of them help to digest of Taeumin, but a adlay, ginko nut, chest nut distinguishing clearness-unclearness(淸濁) and spouting unclearness(濁)-Qi, has commonness of promoting digestion. But in the early days, a ginko nut is thought to be helpful to digest, the latter days, it is used for Mahwangjungchuntang which cures breast-stomachache(胸腹痛)and asthma(喘氣 哮喘病); It shows the change of recognition.

• 동의생리병리학회지
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• 제20권1호
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• pp.202-208
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• 2006

The goal of this study is to develop knowledge representation method for the construction and evaluation of ontology for diagnosis in oriental medicine. To develop the expert system for decision making on diagnosis and treatment, the systematic and structural knowledge which can be processible in EMR(Electronic Medical Record) must be precedent, and the Computational Process which control the system as well. This study set up an ontology as a trial model to represent the oriental medical knowledge into the machine processible one. Protege 2.1 has been used to build the ontology, and the serialization format of our ontology is the XML document based on OWL. The components of oriental medical diagnosis was arranged with the combination of symptoms which belong to the certain symptom patterns. Then natural language which expresses the oriental medical diagnosis components were converted into the logical sentence, and individual characteristic symptoms into each values of specific properties. In addition to the study, the diagnosis software for oriental medicine was developed and it used the ontology which we developed. Sequently, we tested the software to confirm the appropriateness of ontology. The result of the test shows that diagnostic questions are automatically formulated according to the diagnosis components of this ontology and that as such diagnostic results are induced. Therefore, the ontology system in this study will be efficient to develop the diagnosis program and useful as a tool for doctors to make decision. But, it is not recommendable to apply the system to the clinical environment until the clear diagnosis standards are introduced, and the more reliable diagnosis program can be developed based on the more appropriate ontology mentioned above.

• 동의생리병리학회지
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• 제25권6호
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• pp.975-981
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• 2011

The aim of this study was to observe the effect of moxibustion at matched acupoints of ST36, ST37 and ST39 in rats with sex and age. This study measured small intestinal motility in rats. First, cauterize with moxa was applied to the ST36, ST37 and ST39 in rats classified by sex and age under enflurane anesthesia. And then same treatment is done to matched acupoints of ST36, ST37 and ST39. In each groups of ST36, ST37 and ST39, the small intestinal motility was increased in 5, 6, 8 weeks male and 5 weeks female rats at ST36, 6, 7 weeks male and 5, 6, 8 weeks female rats at ST37, 5, 6 weeks male and 5 weeks female rats at ST39. In matched acupoints, the small intestinal motility was increased in 5, 8 weeks male and 5, 6, 7, 8 weeks female rat at ST36+ST37, 5 weeks male and 6, 7, 8 weeks female rats at ST36+ST39, 5, 7 weeks male and 5, 8 weeks female rats at ST37+ST39. The effects of moxibustion at each acupoints decreased by advancing age and when these acupoints were combined, the effective results were shown in female rats of all age group. These results suggest that when each acupoints and matched acupoints was chosen in moxibustion treatment, the sex and age of individual is worth consideration.

• 의철학연구
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• 제15권
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• pp.3-37
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• 2013

조르주 캉길렘의 의철학에서 의학은 기술이라고 주장된다. 이는 실용적 의미가 아니라 인간의 전체성을 반영하는 가치론적 지평에서 제시된다. 이러한 의학의 특징이 캉길렘의 철학적 사유의 동기가 된다. 의학적 지식은 생리학의 단순한 응용이 아니라 환자 개인의 체험에 기초한 임상적 관찰에서 비롯한다. 의학이 과학이고 그 실행이 순수 지식의 응용이라면 환자는 수동적 대상에 머물게 된다. 그러나 환자는 질병에 수동적으로 노출되기보다는 자신의 생애를 통해 이미 습득된 능동적 태도에 의해 질병의 위협에 대처한다. 캉길렘은 이 점을 '규범성'이라고 특징짓는다. 규범성은 개인의 삶의 핵심이지만 실증주의 의학은 이를 설명할 수 없다. 여기서 캉길렘의 의학사상의 생기론적 특징이 나타난다. 캉길렘의 규범성 개념은 일인칭 주관과 관련되기 때문에 기계론적 설명방식을 벗어난다. 캉길렘의 독창성은 개체성과 가치 그리고 규범에서 의학의 본질을 도출하는 데 있다.