• Communications for Statistical Applications and Methods
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• v.16 no.3
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• pp.519-528
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• 2009

This paper deals with nonparametric estimation of discontinuous regression curve. Quite number of researches about this topic have been done. These researches are classified into two categories, the indirect approach and direct approach. The major goal of the indirect approach is to obtain good estimates of jump locations, whereas the major goal of the direct approach is to obtain overall good estimate of the regression curve. Thus it seems that two approaches are quite different in nature, so people say that the comparison of two approaches does not make much sense. Therefore, a thorough comparison of them is lacking. However, even though the main issue of the indirect approach is the estimation of jump locations, it is too obvious that we have an estimate of regression curve as the subsidiary result. The point is whether the subsidiary result of the indirect approach is as good as the main result of the direct approach. The performance of two approaches is compared through a simulation study and it turns out that the indirect approach is a very competitive tool for estimating discontinuous regression curve itself.

• Korean Journal of Clinical Pharmacy
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• v.33 no.3
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• pp.178-185
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• 2023

Objective: Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease. Both tralokinumab and dupilumab have been recommended in the European Guideline for the treatment of adult patients with severe AD. In Korea, dupilumab has been approved for patients with moderate to severe AD, and reimbursed for those with severe AD. Since there is no clinical trial directly comparing tralokinumab and dupilumab, we conducted indirect comparison to assess the clinical usefulness in patients with AD. Methods: We selected clinical trials for indirect comparison through a systematic literature review. Individual patient data were available for the tralokinumab clinical trial, and aggregated data were available for the dupilumab clinical trial. Therefore, we employed the Matching-Adjusted Indirect Comparison (MAIC) method. The treatment efficacy was assessed based on whether patients achieved a 75% reduction on the Eczema Area and Severity Index (EASI 75) after drug administration. Results: The difference in the proportion of patients achieving EASI 75 between tralokinumab and dupilumab was 4.7% (95% CI: -7.9 to 17.3). Considering the non-inferiority margin for the EASI 75 achievement rate is -10%, tralokinumab is deemed non-inferior to dupilumab as the lower bound of the CI for the difference in the EASI 75 achievement rate between tralokinumab and dupilumab was within -10%. Conclusion: We conducted a MAIC analysis comparing tralokinumab and dupilumab based on EASI 75 achievement. The findings of this study show that tralokinumab is non-inferior to dupilumab and can be implemented in Korean clinical settings with a therapeutic position comparable to dupilumab.

• The Korean Journal of Applied Statistics
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• v.23 no.6
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• pp.1245-1253
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• 2010

There are two main approaches for estimating the discontinuous regression function nonparametrically. One is the direct approach, the other is the indirect approach. The major goal of the two approaches are different. The direct approach focuses on the overall good estimation of the regression function itself, whereas the indirect approach focuses on the good estimation of jump locations. Apparently, the two approaches are quite different in nature. Gijbels et al. (2007) argue that the comparison of two approaches does not make much sense and that it is even difficult to choose an appropriate criterion for comparisons. However, it is obvious that the indirect approach also has the regression curve estimate as the subsidiary result. Therefore it is necessary to verify the appropriateness of the indirect approach as the estimator of the discontinuous regression function itself. Park (2009a) compared the performance of two approaches through a simulation study. In this paper, we consider a more general case and draw some useful conclusions.

• The Journal of the Korean dental association
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• v.42 no.9 s.424
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• pp.632-637
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• 2004

• Journal of Acupuncture Research
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• v.28 no.6
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• pp.139-147
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• 2011

Objectives : In this research, relatively the characteristic in the combustion according to the brands of the commercial indirect moxibustion is compared and the commercial indirect moxibustion is standardized and this result tries to be provided as necessary basic data. Methods : After adhering to the agarose gel surface in which the thermocouple is inserted, 6 kinds of commercial indirect moxibustion were burnt off and the burning behaviour of the commercial indirect device and heat quantity of stimulus was compared. Results : 1. The form of combustion did not have a difference in 6 kinds of commercial indirect moxibustion combustion. 2. As to the miximum temperature, 'Seoam' and 'Dongbang' was higher than 'Baekryoung' and 'Taeyang'. 3. It was long so that the highest temperature reaching time of 'Seoam' could note in comparison with the other brands. And the highest temperature reaching time of 'Baekryoung' was short to note in comparison with the other brands. 4. As to the quantity of heat stimulus, 'Seoam' was the biggest and 'Baekryoung' was the smallest. 5. The quantity of heat stimulus of 'Dongbang' was the most stable. Conclusions : In this research, relatively the form of combustion of 6 kinds of commercial indirect moxibustion and heat quantity of stimulus were compared. It desires to anticipate the result that it makes the skin.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.88-98
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• 2016

The Korean summer is hot and humid, and air-conditioners consume considerable amounts of electricity. In such cases, the simultaneous use of indirect evaporative coolers may help reduce the sensible heat and save electricity. In this study, heat transfer and pressure drop characteristics of indirect or regenerative evaporative coolers made from plastic/paper are investigated. The results showed that heat and mass transfer model based on the ${\epsilon}-NTU$ method predicted the indirect evaporation efficiencies, cooling capacities and pressure drops adequately. Both for indirect or regenerative evaporative cooler, the indirect evaporation efficiency increased with increasing dry channel inlet temperature or relative humidity. The indirect evaporation efficiency of the regenerative evaporative cooler was larger than that of the indirect evaporative cooler.

• Journal of the Korean Wood Science and Technology
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• v.48 no.4
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• pp.562-568
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• 2020

This study investigates the relationship between ultrasonic velocity and density in the direct method, the effect of distance between transducers in the indirect method, and the difference between the direct and indirect methods with transducers placed at a distance of 200 mm in nondestructive ultrasonic testing of spruce lumber. The direct method using 54 kHz ultrasonic transducers was applied to two planes, namely, radial section (LR) and tangential section (LT) of samples. The indirect method measurements were taken using the same transducers. Two velocities were measured at the top and bottom of the LT plane and at the two sides of the LR plane; the two values for each plane were averaged. The relationship between density and ultrasound velocity in the direct method demonstrated a positive correlation between the two variables. The difference between the two planes, LT and LR, was not statistically significant. Moreover, the distance between the transducers in the indirect method affected ultrasound velocity, with the ultrasonic velocity increasing as the distance between the transducers became larger. A transducer distance of 200 mm yielded a close approximation of the direct method results with a ratio of 0.87. Finally, no statistical evidence of a difference between the two planes in the indirect method was found. If the direct method, which requires access to two surfaces, is impractical, the indirect method can be applied.

• Journal of Korean Society on Water Environment
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• v.26 no.6
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• pp.963-968
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• 2010

This study has carried out to evaluate the performance of direct and indirect oxidation electrode for the purpose of decolorization of Rhodamine B (RhB) in water. Four kinds of electrodes were used for comparison: Pt and JP202 (indirect oxidation electrode), Pb and boron doping diamond (BDD, direct oxidation electrode). The effect of applied current (0.5 ~ 2.5 A), electrolyte type (NaCl, KCl, HCl, $Na_2SO_4$ and $H_2SO_4$) and electrolyte concentration (0.5 ~ 2.5 g/L), solution pH (3 ~ 11) and initial RhB concentration (25 ~ 125 mg/L) were evaluated. Experimental results showed that RhB removal efficiency were increased with increase of current, NaCl dosage and decrease of the pH. However, the effect of operating parameter on the RhB removal were different with the electrode type. JP202 electrode was the best electrode from the point of view of performance and energy consumption. The order of removed RhB concentration per energy lie in: JP202>Pt>Pb>BDD.

• Journal of Welding and Joining
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• v.29 no.4
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• pp.93-99
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• 2011

This study was performed to compare the shear strength of the bondings between stainless steel crown/direct type composite resin and stainless steel crown/indirect type composite resin. Four groups of bonding conditions were prepared. Two groups of bonding conditions were made by the indirect type composite resin system and the other two groups were made by the direct type composite resin system. The shear strength tests were carried out using universal testing machine, Model 4465 of Instron Co.. It was indicated that the bond strength values of the indirect type composite resins were higher than those of the direct type composite resins. TE-SE group was superior to the TE-ONE in indirect type resin system. These results were thought to be the high degree of the polymerization accompanied with temperature and pressure of the resin of indirect type resin. It was also found that indirect composite resin contains less amount of porosity in resin.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.8 no.3
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• pp.366-378
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• 2001

Objective: The purpose of this study was to identify differences in measurement methods for blood pressure (Direct measurement, HP automatic indirect measurement, and SE 7000 Korean made indirect measurement), and to evaluate the clinical trial of the Korean made automatic indirect blood pressure measurement. Material & Methods: From June, 1999 to February, 2000, fifty five consecutive patients were randomized into hypertension group (n=20), normotension group (n=20), and hypotension group (n= 15). Measuring blood pressure by indirect methods (HP NIBP M 1008B and SE 7000 NIBP Korean made) was done simultaneously in the same arm with arterial line for direct blood pressure measurement (HP M1006A). The procedures were repeated ten times at intervals of 2 minutes. Statistical analysis was Performed using SPSS (version 8.0 for windows) software package. Values were expressed as means and standard deviation and means were compared using t-test. Statistical significance was considered present with a p value less than 0.05. Results: In the hypertension group and noromotension group, the disparity between HP direct measurement and indirect SE 7000 NIBP did not show any differences compared to the disparity between HP direct measurement and indirect HP NIBP. In the hypotension group, the disparity in the diastolic pressure between HP direct measurement and indirect SE 7000 NIBP was significantly different compared to the disparity between HP direct measurement and indirect HP NIBP (p<0.001), however, disparities in systolic pressure did not showed any differences. Conclusion: Direct blood pressure measurement (HP M1006A) can be replaced with indirect blood pressure measurements (HP NIBP M 1008B & SE 7000 NIBP) in normotension and hypertension patients. Korean made indirect measurement was found to be more accurate compared to HP indirect measurement in hypotension Patients, but more study is needed.