• Molecular & Cellular Toxicology
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• 제1권1호
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• pp.40-45
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• 2005

Ursodeoxycholic acid (UDCA) has long been used as an adjuvant or first choice of therapy for liver disease. Commonly, UDCA has been reported to play a role in improving hyperbilirubinemia and disorder of bromsulphalein. More commonly, UDCA has been used in reducing the rate of cholesterol level in bile juice that can cause cholesterol stone. The effects on the promotion of bile acid release that leads an excretion of toxic materials and wastes produced in liver cells as well as various arrays of liver disease such as hepatitis. Other than already reported in clinical use, immunosuppressive effect has been studied, especially in transplantation. In the study, we hypothesized that UDCA might have a certain role in anti-inflammation through a preventive effect of pro-inflammatory potentials in the brain macrophages, microglia. We found that the treatment of $200\;{\mu}g/ml$ UDCA effectively suppressed the pro-inflammatory mediators (i.e. nitric oxide and interleukin-$1{\beta}$) in rat microglia compared to comparators. Interestingly, RT-PCR analysis suggested that UDCA strongly attenuated the expression of $IL-1{\beta}$ that was comparable with cyclosporine A at 48 h incubation. Conclusively, we found that UDCA may playa cytoprotective role in microglial cells through direct or indirect pathways by scavenging a toxic compound or an anti-inflammatory effect, which are known as major causes of neurodegenerative diseases.

• 대한임상독성학회지
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• 제2권2호
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• pp.129-132
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• 2004

Ethylene glycol poisoning can cause profound morbidity and is almost universally fatal if untreated. Central nervous system depression, pulmonary edema, and acute oligulic renal failure with crystalluria are among the most commonly encountered complication of ingestion. Ingestion of ethylene glycol may be an important contributor in patients with metabolic acidosis and subsequent renal failure. The diagnosis of ethylene glycol poisoning is based on nonspecific clinical symptoms and signs and indirect and direct laboratory measurement of ethylene glycol. As a result, diagnosis and treatment sometimes can be delayed. We describe 52-year-old man who visited to emergency department with mental change of unknown origin. The patient has high anion gap metabolic acidosis and renal failure due to ingestion of antifreeze that contained ethylene glycol. We used hemodialysis for elimination technique. The patient was discharged with minimal complication.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.378-383
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• 2007

As the Minimally Invasive Surgery (MIS) is developed, an interventional procedure becomes the major of the spine surgery in the world. Despite of the use of the expensive medical equipments, the success chance of the nucleoplasty is about 30%. The reason is that the shape of the cannular needle is similar to that of the conventional injector and looks like the straight. Because the tip of these straight needles is not able to reach in the vicinity of the disc bulging or the protrusion, which are the cause of the low back pain and because the far indirect plasma discharge results in the decompression, the nucleoplasty has the limit. Many incurable diseases has not been solved due to the unexistence of the advanced technique for the MIS human body cannula device. If 3-D direction controllable cannular catheter (whose direction is accurately controlled after inserting into the bodies to cure the lesion) is developed, it is expected that new devised cannular catheter can cure many incurable diseases simultaneously. Therefore, the aims of this research are to develop the new devised cannular catheter of SMA direction controller for the medical situation, which has been produced through many previous trial-error procedures, and to produce the commercial medical device.

• 한국컴퓨터정보학회논문지
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• 제21권10호
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• pp.91-98
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• 2016

Outbreaks of highly contagious livestock diseases can cause direct and indirect economic impacts such as lower productivity of cattle farms, fall in tourism in damaged areas and countries, and decline in exports. They also incur tremendous social costs associated with disease elimination and restoration work. Thus, it is essential to prevent livestock diseases through monitoring and prediction efforts. Currently, however, it is still difficult to provide accurate predictive information regarding occurrences of livestock diseases, because existing cattle health monitoring or forecasting systems are only limited to monitor environmental conditions of livestock barns and check activities of cattle by using a pedometer or thermal image. In this paper, we present a biosensor-based cattle health monitoring system capable of collecting bio-signals of farm animals in an effective way. For the presented monitoring system, we design an integrated monitoring device consisting of a sensing module to measure bio-signals of cattle such as the heartbeat, the breath rate and the momentum, as well as a Zigbee module designed to transmit the biometric data based on Wireless Sensor Network (WSN). We verify the validity of the monitoring system by the comparison of the correlations of designed device with a commercial ECG equipment through analyzing the R-peak of measured signals.

• 대한족부족관절학회지
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• 제12권2호
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• pp.230-233
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• 2008

The avulsion fracture of the calcaneal tuberosity is rare injury. Usually, it occurs from indirect trauma in old patients with osteoporosis or in patients with diabetic neuropathy. Especially, the bone and joint damage occurred in active patient with severe sensory loss or arthropathy related to nerve damage regardless of the cause is referred to neuropathic arthropathy. Generally, a patient with nondisplacement or minimally displacement is treated by conservative therapy and a patient with severe displacement is treated by open reduction and internal fixation. We experienced a 33 years-old woman with diabetes mellitus who had the displaced avulsion fracture of the calcaneal tuberosity without significant trauma and did not treat. We report upon this case at the 2 years follow-up.

• 한국간호교육학회지
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• 제18권2호
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• pp.312-322
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• 2012

Objectives: The purpose of this study was to investigate the factors related to adjustment of college for nursing students and to develop a collective model for successful prediction and concrete paths of the factors. Methods: Data collection was conducted from May 19th 2010 to Jun 4th 2010. Five hundred thirty-one questionnaires were used for data analysis after distributing 560 sheets to senior students in 8 different locations. Data was analyzed with SPSS 18.0 Win program and AMOS 18.0. Results: Mother attachment does not have a direct effect on adjustment to college life but does effect psychological well-being and coping, which indirect adjustment to college life. In addition, the more psychological well-being and coping usage frequency, and the less stress of clinical practice, the higher score of adjustment to college life. According to the results, explanatory power of the model for the college nursing students' adjustment was 62.0%. Conclusions: To improve adjustment to college life, it is recommended to have a direct method of developing psychological well-being and coping improvement program to improve mother attachment. The research is meaningful in a sense that it explains the cause and effect relationship between adjustment to college life and relevant variables to predict comprehensive dimensional explanation of adjustment of college life for nursing students.

• 한국안전학회지
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• 제31권6호
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• pp.32-38
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• 2016

In general, lots of containers including various dangerous materials are transported to the port located in big cities such as Busan where massive residents live. Thus, it's really important how to make the emergency response for the leak accidents of dangerous materials and evaluate the direct or indirect damages to adjacent areas. In this study, in order to make reasonable emergency plans, CA (Consequence Analysis) is employed after selecting a key hazardous and noxious material, hydrogen fluroide. This material accounts for the third largest portion of cargo volume among all dangerous materials and can cause a huge damage in case of leakages. As a case study, Busan North port is selected as a test port since the portion of dangerous materials is higher than that of other ports in Busan. It is assumed that 1 ton of hydrogen fluoride is spilled at Busan North port. CA is performed to assess the impact of this accident. Throughout CA, the ERPG-2 range of a leak accident can be evaluated and this result can be used for decision making tools for mitigating the impact of a leak accident. To mitigate the damage of this accident, suitable a protective equipment and resident evacuation procedures should be prepared. Finally, this study can provide a systematic approach to make the emergency plan for reducing economical and personal losses.

• 한국작물학회지
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• 제34권s02호
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• pp.115-120
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• 1989

인삼의 연작장해의 증상, 원인 및 방제법에 대하여 고찰하였다. 1. 연작장해의 증상은 인삼의 생장억제 근부에 의한 근수량 저하였으며 품질에는 영향을 주지 않았다. 2. 연작장해는 토양병원미생물과 인삼유체 분해산물의 식물에 대한 직접적인 독작용, 그리고 이들 유체 및 그 분해산물에 희한 토양내 전속화합물의 용해 또는 결합에 따른 전속이온의 식물에 대한 독작용 등이 상호 복합적으로 나타난 것으로 보인다. 3. 토양은 근부유발형과 근부억제형 토양으로 구분되며, 토양이화학성이 연작장해를 조장시키지는 않았다. 4. 연작장해의 방제법은 살균제에 의한 효과는 기대하기 어렵고, 훈증제(싸이론, 크로로피크린)를 처리하여 연작할 경우 고년근에서 근부병 발생이 심하기 때문에 훈증제와 길항미생물의 혼합처리가 효과적이다. 또 답전윤환이 가능한 논에서 3∼4년간 벼를 재배한 후 인삼을 연작하는 방법이 실용화되고 있다.

• 대한정형외과스포츠의학회지
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• 제4권2호
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• pp.95-99
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• 2005

견봉쇄골관절의 손상은 대개 견관절에 직접 가해지거나 상완을 통해 간접적으로 전해지는 충격으로 인해 발생하게 되지만, 투구활동을 하는 운동선수의 경우 과 사용으로 인한 반복적인 자극이 손상을 유발할 수 있다. 견봉쇄골관절의 안정성에 관계된 인대의 손상 정도에 따라 견봉쇄골관절 손상의 방향과 정도가 결정된다. 따라서 견봉쇄골관절의 해부와 손상기전에 대한 이해를 바탕으로 한 정확한 분류를 통해, 투구 활동과 관계된 견봉쇄골관절 손상에 대한 적절한 치료 방침을 세울 수 있다.

• 한국동물위생학회지
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• 제29권1호
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• pp.1-8
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• 2006

Porcine circovirus (PCV) is a small, nonenveloped virus that contains a single-stranded circular DNA genome of about 1.76 kb and belongs to the family circoviridae. The PCV-2 has been incriminated as the cause of post-weaning multisystemic wasting syndrome (PMWS) , an emerging disease in pigs. In the present study, a PCR assay was applied to detect PCV-2 in tissue samples. The presence of PCV-2 antigen in the porcine tissues was confirmed by indirect immunofluorescence (IIF) with PCV-2 specific monoclonal antibodies. And then DNA extracted from PCV-2 positive tissues was used as a template. One oligonucleotide primer suitable for PCR was selected from a published PCV-2 sequence (Genbank). Amplified PCR product was detected the same fragment lengths of 416 bp as a control. Based on these results, it was suggested that the PCR is a simple and sensitive method for support diagnostic purposes.