• Journal of the Korean Society of Propulsion Engineers
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• v.19 no.2
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• pp.9-16
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• 2015

The control law for simultaneous pressure and thrust control of solid DACS(Divert Attitude Control System) is suggested. To regulate the two variables effectively, the control structure of sequential loop closer is applied to the system considering the physical characteristics of each variable and the weighted pseudo-inverse method is suggested to allocate effective command for indeterminate system. Also, the pressure guidance law for safe and high acceleration is applied to the homing stage to verify the effectiveness of the command distribution.

• Structural Engineering and Mechanics
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• v.12 no.6
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• pp.685-698
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• 2001

In this paper, a general method for the automatic search for Strut-and-Tie (S&T) models representative of possible resistant mechanisms in reinforced concrete elements is proposed. The representativeness criterion here adopted is inspired to the principle of minimum strain energy and requires the consistency of the model with a reference stress field. In particular, a highly indeterminate pin-jointed framework of a given layout is generated within the assigned geometry of the concrete element and an optimum truss is found by the minimisation of a suitable objective function. Such a function allows us to search the optimum truss according to a reference stress field deduced through a F.E.A. and assumed as representative of the given continuum. The theoretical principles and the mathematical formulation of the method are firstly explained; the search for a S&T model suitable for the design of a deep beam shows the method capability in handling the reference stress path. Finally, since the analysis may consider the structure as linear-elastic or cracked and non-linear in both the component materials, it is shown how the proposed procedure allows us to verify the possibilities of activation of the design model, oriented to the serviceability condition and deduced in the linear elastic field, by following the evolution of the resistant mechanisms in the cracked non-linear field up to the structural failure.

• Molecules and Cells
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• v.41 no.7
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• pp.665-675
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• 2018

Rice is a facultative short-day (SD) plant in which flowering is induced under SD conditions or by other environmental factors and internal genetic programs. Overexpression of Histone Deacetylase 701 (HDT701) accelerates flowering in hybrid rice. In this study, mutants defective in HDT701 flowered late under both SD and long-day conditions. Expression levels of florigens Heading date 3a (Hd3a) and Rice Flowering Locus T1 (RFT1), and their immediate upstream floral activator Early heading date 1 (Ehd1), were significantly decreased in the hdt701 mutants, indicating that HDT701 functions upstream of Ehd1 in controlling flowering time. Transcript levels of OsINDETERMINATE SPIKELET 1 (OsIDS1), an upstream repressor of Ehd1, were significantly increased in the mutants while those of OsGI and Hd1 were reduced. Chromatin-immunoprecipitation assays revealed that HDT701 directly binds to the promoter region of OsIDS1. These results suggest that HDT701 induces flowering by suppressing OsIDS1.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.05a
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• pp.179-184
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• 2003

This study focuses on an analytical approach to calculate crane lifting forces for a sunken ship in consideration oj elongation of crane ropes. The method takes into account the relation of lifting forces acting in wire rope slings to the inclination of the ship's hull including the effect of lug positions. For lifting analysis, the Euler angles are defined to represent the inclination of a sunken ship in developing the static force and moment equations. An additional compatability condition is introduced in order to solve an indeterminate lifting analysis problem with 4 cranes and a set of lifting forces along the 4 crane ropes is calculated. A 3-dimensional example of the G/T 1500 oil tanker is analyzed and the results show that the information obtained by the method could be useful to engineers to conduct salvage work.

• Parasites, Hosts and Diseases
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• v.57 no.1
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• pp.39-41
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• 2019

In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P<0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.

• Biomolecules & Therapeutics
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• v.27 no.4
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• pp.386-394
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• 2019

Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM) has been intensely studied as a chronic inflammatory disease until recent observations reporting the role of cardio-metabolic dysfunctions. In particular, we demonstrated accumulation of lipid droplets and impaired cardiac lipid metabolism in the hearts of cardiomyopathic mice and patients, and their association with impaired mitochondrial functions and endoplasmic reticulum (ER) stress in CD mice. In the present study, we examined whether treating infected mice with an ER stress inhibitor can modify the pathogenesis of cardiomyopathy during chronic stages of infection. T. cruzi infected mice were treated with an ER stress inhibitor 2-Aminopurine (2AP) during the indeterminate stage and evaluated for cardiac pathophysiology during the subsequent chronic stage. Our study demonstrates that inhibition of ER stress improves cardiac pathology caused by T. cruzi infection by reducing ER stress and downstream signaling of phosphorylated eukaryotic initiation factor ($P-elF2{\alpha}$) in the hearts of chronically infected mice. Importantly, cardiac ultrasound imaging showed amelioration of ventricular enlargement, suggesting that inhibition of ER stress may be a valuable strategy to combat the progression of cardiomyopathy in Chagas patients.

• Structural Engineering and Mechanics
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• v.69 no.5
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• pp.511-525
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• 2019

This paper presents an analytical study of wave propagation in simply supported graduated functional plates resting on a two-parameter elastic foundation (Pasternak model) using a new theory of high order shear strain. Unlike other higher order theories, the number of unknowns and governing equations of the present theory is only four unknown displacement functions, which is even lower than the theory of first order shear deformation (FSDT). Unlike other elements, the present work includes a new field of motion, which introduces indeterminate integral variables. The properties of the materials are assumed to be ordered in the thickness direction according to the two power law distributions in terms of volume fractions of the constituents. The wave propagation equations in FG plates are derived using the principle of virtual displacements. The analytical dispersion relation of the FG plate is obtained by solving an eigenvalue problem. Numerical examples selected from the literature are illustrated. A good agreement is obtained between the numerical results of the current theory and those of reference. A parametric study is presented to examine the effect of material gradation, thickness ratio and elastic foundation on the free vibration and phase velocity of the FG plate.

• Wind and Structures
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• v.28 no.1
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• pp.49-62
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• 2019

In this paper, an analytical analysis for the study of vibratory behavior and wave propagation of functionally graded plates (FGM) is presented based on a high order shear deformation theory. The manufacture of these plates' defects can appear in the form of porosity. This latter can question and modify the global behavior of such plates. A new shape of the distribution of porosity according to the thickness of the plate was used. The field of displacement of this theory is present of indeterminate integral variables. The modulus of elasticity and the mass density of these plates are assumed to vary according to the thickness of the plate. Equations of motion are derived by the principle of minimization of energies. Analytical solutions of free vibration and wave propagation are obtained for FGM plates simply supported by integrating the analytic dispersion relation. Illustrative examples are given also to show the effects of variation of various parameters such as(porosity parameter, material graduation, thickness-length ratio, porosity distribution) on vibration and wave propagation of FGM plates.

• Earthquakes and Structures
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• v.16 no.5
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• pp.547-561
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• 2019

In this work, a new analytical approach using a theory of a high order hyperbolic shear deformation theory (HSDT) has been developed to study the free vibration of plates of functionally graduated material (FGM). This theory takes into account the effect of stretching the thickness. In contrast to other conventional shear deformation theories, the present work includes a new displacement field that introduces indeterminate integral variables. During the manufacturing process of these plates defects can appear as porosity. The latter can question and modify the global behavior of such plates. The materials constituting the plate are assumed to be gradually variable in the direction of height according to a simple power law distribution in terms of the volume fractions of the constituents. The motion equations are derived by the Hamilton principle. Analytical solutions for free vibration analysis are obtained for simply supported plates. The effects of stretching, the porosity parameter, the power law index and the length / thickness ratio on the fundamental frequencies of the FGM plates are studied in detail.

• Proceedings of the ESK Conference
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• 1992.10a
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• pp.46-53
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• 1992

Finger movements in the sagittal plane mainly consist of flexion and extension about the metacarpophalangeal(MCP) and proximal interphalangeal(PIP) joints. A kinematic finger model was developed with the assumption of constant tendon moment arms. Equations of static equilibrium were derived for the finger model using the principle of virtual work. Equations of static equilibrium for the finger model were indeterminate since only three equations were available for five unknown variables(forces). The number of variables was reduced based on information on muscular activities in finger movements. Then the amounts of forces which muscles exerted to maintain static equilibrium against external loads were computed from the equilibrium equations. The muscular forces were expressed mathematically as functions of finger positions, tendon moment arms, lengths of phalanges, and the magnitude and direction of external load. The external finger strength were computed using the equations of muscular forces and anatomical data. Experiments were performed to measure finger strengths. Measurements were taken in combinations of four finger positions and four directions of force exertions. Validation of the finger models and of procedure to estimate finger strengths was done by comparing the results of computations and experiments. Significang differences were found between the predicted and measured finger strengths. However, the trends of finger strengths with respect to finger positions were similar inboth the predicted and measured. These findings indicate that the finger model and the procedure to predict finger strengths were correctly developed.