• Journal of Gastric Cancer
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• v.23 no.2
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• pp.264-274
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• 2023

Purpose: In this study, polymerase chain reaction (PCR)-based microsatellite instability (MSI) testing was comprehensively analyzed and compared with immunohistochemistry (IHC) for mismatch repair (MMR) protein expression in patients with gastric cancer (GC). Materials and Methods: In 5,676 GC cases, PCR-based MSI testing using five microsatellites (BAT-26, BAT-25, D5S346, D2S123, and D17S250) and IHC for MLH1 were performed. Reevaluation of MSI testing/MLH1 IHC and additional IHC for MSH2, MSH6, and PMS2 were performed in discordant/indeterminate cases. Results: Of the 5,676 cases, microsatellite stable (MSS)/MSI-low and intact MLH1 were observed in 5,082 cases (89.5%), whereas MSI-high (MSI-H) and loss of MLH1 expression were observed in 502 cases (8.8%). We re-evaluated the remaining 92 cases (1.6%) with a discordant/indeterminate status. Re-evaluation showed 1) 37 concordant cases (0.7%) (18 and 19 cases of MSI-H/MMR-deficient (dMMR) and MSS/MMR-proficient (pMMR), respectively), 2) 6 discordant cases (0.1%) (3 cases each of MSI-H/pMMR and MSS/dMMR), 3) 14 MSI indeterminate cases (0.2%) (1 case of dMMR and 13 cases of pMMR), and 4) 35 IHC indeterminate cases (0.6%) (22 and 13 cases of MSI-H and MSS, respectively). Finally, MSI-H or dMMR was observed in 549 cases (9.7%), of which 47 (0.8%) were additionally confirmed as MSI-H or dMMR by reevaluation. Sensitivity was 99.3% for MSI testing and 95.4% for MMR IHC. Conclusions: Considering the low incidence of MSI-H or dMMR, discordant/indeterminate results were occasionally identified in GCs, in which case complementary testing is required. These findings could help improve the accuracy of MSI/MMR testing in daily practice.

• Proceedings of the Korean Society for History of Mathematics Conference
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• 2004.10a
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• pp.1.1-1.1
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• 2004

• Journal of the Korean Institute of Educational Facilities
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• v.26 no.2
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• pp.16-20
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• 2019

• Journal of The Korean Digital Architecture Interior Association
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• v.5 no.1
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• pp.17-23
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• 2005

To begin with, this research arranged this concepts by analyzing paper a reference paper. So, the theory was arranged by approaching the ideal, formative and contemporary side. In order to type characteristics expression of organic design, after year 2000 printed in "Interiors" journal analyzed the contents based on interior works. 1. A type of metaphorical expression, order and the imitations of animals and plants. 2. A type of non liner, and dynamical balance and irregularity. 3. A type of mass of indeterminate form. 4. A type of fluidity by a curved line and a curved surface.

• Proceedings of the Korea Concrete Institute Conference
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• 2009.05a
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• pp.193-194
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• 2009

In this study, a simple indeterminate strut-tie model reflecting all characteristics of the ultimate strengths and complicated structural behavior of pre-tensioned concrete deep beams is presented. In addition, a load distribution ratio, defined as a magnitude of load transferred by a vertical truss mechanism, is proposed to help structural designers perform the strength analysis of pre-tensioned concrete deep beams by using the strut-tie model approaches of current design codes.

• Transactions of the Korean Society of Mechanical Engineers
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• v.12 no.4
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• pp.675-681
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• 1988

A simplified FRF(frequency response function) model of an indeterminate cantilever system with viscoelastic material layers is derived. A way to calculate modal damping of the system from the dynamic properties of the viscoelastic material is proposed. The model is experimentally verified.

• Architectural research
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• v.3 no.1
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• pp.71-80
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• 2001

It is quite difficult to calculate the collapse probability of a system such as statically indeterminate structure that has many possible modes or paths to complete failure and the problem has remained essentially unsolved. A structure is synthesized by several components or elements and its capacity to resist the given loads is a function of the capacity of the individual element. Thus it is reasonable to assess the probability of failure of the system based upon those of its elements. This paper proposes an efficient technique to directly assess the reliability of a complex structural system from the reliabilities of its components or elements. The theory for the calculation of the probability of a structural system is presented. The target requirements of the method and the fundamental assumptions governing the method are clearly stated. A portal frame and two trusses are selected to demonstrate the efficiency of the method by comparing the results obtained from the proposed method to those from the existing methods in the literature.

• 대한세포병리학회:학술대회논문집
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• 2007.06a
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• pp.11-11
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• 2007

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.4
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• pp.801-814
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• 2015

In this study, a statically simple indeterminate strut-tie model is proposed for the rational analysis and design of simply supported prestressed concrete beams by reflecting all characteristics of nonlinear structural behavior and load transfer mechanisms. In addition, a load distribution ratio that allows to transform the proposed indeterminate strut-tie model to a determinate model is also suggested to help structural designers conduct the structural analysis and design of simply supported prestressed concrete beams by using the strut-tie model method of current design codes. For verifying of the validity of the proposed model and load distribution ratio, the ultimate strengths of 47 simply supported prestressted concrete beams tested to failure were estimated and the results were compared with those by the strut-tie model methods of current design codes.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.197-200
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• 2008

The RC corbels with the ratio of shear span-to-effective depth less than 1 are commonly used to transfer loads from beams to columns. The ultimate strengths and structural behaviors of RC corbels are controlled by the shear span-to-effective depth ratio, strength of concrete, shape and quantity of the reinforcement, and geometry of corbels. In this study, a simple indeterminate strut-tie model reflecting all characteristics of the ultimate strengths and complicated structural behaviors is presented for the design of RC corbels. In addition, a load distribution ratio, defined as a magnitude of load transferred by a horizontal truss mechanism, is proposed to help structural designers perform the design of RC corbels by using the strut-tie model approaches of current design codes. The ultimate strengths of 30 RC corbels tested to failure are evaluated by using the ACI 318-05's strut-tie model code for the validity check of the proposed indeterminate strut-tie model and load distribution ratio.