• 보존과학연구
• /
• s.25
• /
• pp.119-132
• /
• 2004

Annals of the Joseon Dynasty is the authentic record of the historical facts and events taken place throughout the entire period of 472 years(25 generations, 1392~1863)described in a chronological order. The tremendous volume of the records contains the factual events taken place in almost all the fields of the Joseon Dynasty ranging from politics, economy to history of the dynasty. Not only because of its affluent contents but also with the precision of its records, it was designated as the National Treasure No. 151 in1973 by the Korean government and also registered as the Memory of the World by UNESCO in October 1997.This study is to report a exhaustive investigation results on the conservation state of annals of the Joseon Dynasty, especially Mt. Jeongjoksan edition, under the storage of the Kyujanggak in order to obtain the current condition, and thereby to estimate the any deterioration of the waxed volumes in the future. According to results of the investigation, we are going to verify damage causes of annals of the Joseon Dynasty, and to consider scientific conservation methods for the permanent preservation of invaluable cultural heritage. The major problem with the preservation of annals has arisen particularly from the deterioration of the waxed volumes of the Mt. Jeongjoksan edition. In order to provide for the counter measures for this problem, we have conducted twice investigations(first :1998~1999, second : 2003) to the internal and external conditions of waxed volumes(Annals of King Taejo~Annals of King Myeongjong).The result of the investigation has indicated that the paper quality of the some of the waxed volumes (Annals of King Taejong~Annals of King Sejong) is cracked and folded and the pages are imbedded to each other due to the hardened or congealed wax on the paper. Some of the pages are even getting moldy. And in order to detect as to whether“ there has been any deterioration progressed to the waxed books in the modern storage facility of the Kyujanggak equipped with constant temperature and humidity condition, the first investigation(1998~1999) and the second investigation(2003) have recorded the values of acidity, whiteness and moisture rate of the waxed paper, reporting an observation that there has been no difference on the measuring items. This indicates that no virtual deterioration has been progressed so far to the waxed volumes preserved in the Kyujanggak. Also, except for the causes of deterioration to the paper by insects and microorganisms, the major cause for the paper damage seems to the change of moisture of the paper caused from the alteration of the temperature and humidity of the storage environment. With this understanding in mind, we have conducted an environmental investigation on the three selected points of the storage in the aspects of the temperature, humidity, air current, $CO_2$,HCHO, and $SO_2$.It has been observed that the temperature stood at $16.9^{\circ}C~20.2^{\circ}C$ and the humidity was stable between 53%~56% during the period of the investigation. The concentration of the carbon monoxide and carbon dioxide of the storage were very similar to those in the air. These data lead to presume that there is no problem in the aspect of carbon oxidization. But the concentration of sulfur dioxide, hydrogen sulfide and formaldehyde of the storage were detected a little higher than those of standard. Therefore, we consider that it is necessary to ventilate the internal air of the store room by means of operating air purification devices.

• Clinical and Experimental Pediatrics
• /
• v.52 no.7
• /
• pp.824-831
• /
• 2009

Purpose : We aimed to investigate the efficacy of and functional recovery after intracerebral transplantation of different doses of mouse mesenchymal stem cells (mMSCs) in immature rat brain with hypoxic-ischemic encephalopathy (HIE). Methods : Postnatal 7-days-old Sprague-Dawley rats, which had undergone unilateral HI operation, were given stereotaxic intracerebral injections of either vehicle or mMSCs and then tested for locomotory activity in the 2nd, 4th, 6th, and 8th week of the stem cell injection. In the 8th week, Morris water maze test was performed to evaluate the learning and memory dysfunction for a week. Results : In the open field test, no differences were observed in the total distance/the total duration (F=0.412, P=0.745) among the 4 study groups. In the invisible-platform Morris water maze test, significant differences were observed in escape latency (F=380.319, P<0.01) among the 4 groups. The escape latency in the control group significantly differed from that in the high-dose mMSC and/or sham group on training days 2-5 (Scheffe's test, P<0.05) and became prominent with time progression (F=6.034, P<0.01). In spatial probe trial and visible-platform Morris water maze test, no significant improvement was observed in the rats that had undergone transplantation. Conclusion : Although the rats that received a high dose of mMSCs showed significant recovery in the learning-related behavioral test only, our data support that mMSCs may be used as a valuable source to improve outcome in HIE. Further study is necessary to identify the optimal dose that shows maximal efficacy for HIE treatment.

• Cartoon and Animation Studies
• /
• s.27
• /
• pp.1-30
• /
• 2012

Oshii Mamoru attempts to project the perception of reality about his own modern world as it is through animation. The precedent studies on Oshii Mamoru put their focus on the point that his works have a tendency to represent the devastation of reality as the image of 'a ruin.' In addition, they gave an impression that Oshii Mamoru's animation has gradually developed to expose the 'realistic taste[beauty]' from the design perspective. However, this study is going to put its focus on the point that Mamoru's works were created as an attempt at finding the subversive possibility of the suppressed modern world under the modern capitalism in the aspect of 'everyday life' of the modern world. First, for its analytical purpose, this study intends to do that by dividing the work into the three layers such as space, body and everyday life. In Chapter II, this study, in relation with the issue of 'space' representation, analyzed the space in into the modern, mechanical, compactly capitalized space and also the space just like a closed circuit having the nature of 'repetition.' In Chapter III, this analyzed that suggests the body moving freely between a human named 'Kildren' and the inhuman from the aspect of character's body, through which Mamoru represents the capitalized, reified body of the modern world. In addition, this analyzed the extreme anxiety facing the body into the reflection of the phenomena of 'anxiety' and 'placelessness' consequent on the labor flexibility of the modern world. In Chapter IV, this study, on the basis of the analysis of layers of space & body, analyzed that the 'everyday life' of the modern world was represented in the respects of 'memory' and 'habit', and in the aspects of Mise-en-Sc$\grave{e}$ne, design and direction. In Chapter V, this rooted out the fact that Mamoru suggested the attempt at 'appropriation' based on his perception of reality about such a modern world. Such a finding includes unearthing the fact that Oshii Mamoru's work is raising a question about how to desert and appropriate the modern space. In conclusion of Chapter VI, this drew the conclusion that Oshii Mamoru's work represented the layer of 'everyday life' while dealing with the post-modern themes shown by the existing modern SF genre, provided the 'window' through which people can perceive the 'modern world radically by recommending an attempt at 'appropriation', and blazed a trail in a new realm of creation for animations.

• Tuberculosis and Respiratory Diseases
• /
• v.59 no.6
• /
• pp.631-637
• /
• 2005

Background : Transcriptional factors of the CREB(cAMP Response Element Binding Protein) are involved in the regulation of gene expression in response to a variety of signaling pathways. Proteins produced by the CREB genes play key roles in many physiological processes, including memory and long-term potentiation. The retinoic acid receptor (RAR) axis mediates epithelial cell differentiation and proliferation in many tissues including the lung. Material and method : The RAR and CREB expression levels were examined in 60 adenocarcinomas and 60 squamous cell carcinomas of the lung using immunohistochemical staining. Results : 1) RAR protein expression was found in 58.3%(35/60) of adenocarcinomas and 36.7%(22/60) of squamous cell carcinomas(P<0.05). 2) RAR protein expression was found in 80%(16/20) of well differentiated adenocarcinomas, 60%(12/20) of moderately differentiated adenocarcinomas, and 35%(7/20) of poorly differentiated adenocarcinomas (P<0.01). 3) RAR protein expression was found in 45%(9/20) of well differentiated squamous cell carcinomas, 35%(7/20) of moderately differentiated squamous cell carcinomas, and 30%(6/20) of poorly differentiated squamous cell carcinomas (P>0.05). 4) CREB expression was found in 61.7%(37/60) of adenocarcinomas and 40%(24/60) of squamous cell carcinomas( P<0.05). 5) CREB expression was found in 85%(17/20) of well differentiated adenocarcinomas, 60%(12/20) of moderately differentiated adenocarcinomas, and 40%(8/20) of poorly differentiated adenocarcinomas (P<0.01). 6) CREB expression was found in 45%(9/20) of well differentiated squamous cell carcinomas, 35%(7/20) of moderately differentiated squamous cell carcinomas, and 35%(8/20) of poorly differentiated squamous cell carcinomas(P>0.05). 7) RAR and CREB expression was found in 68.5% of lung cancers, and there was a significant correlation between them(P<0.05). Conclusion : RAR and CREB expression can be used to indirectly determine the malignant potentiality of a cell.

• Journal of The Korean Association For Science Education
• /
• v.40 no.4
• /
• pp.385-398
• /
• 2020

This study aims to examine genetics problem-solving processes of high school students with different learning approaches. Two second graders in high school participated in a task that required solving the complicated pedigree problem. The participants had similar academic achievements in life science but one had a deep learning approach while the other had a surface learning approach. In order to analyze in depth the students' problem-solving processes, each student's problem-solving process was video-recorded, and each student conducted a think-aloud interview after solving the problem. Although students showed similar errors at the first trial in solving the problem, they showed different problem-solving process at the last trial. Student A who had a deep learning approach voluntarily solved the problem three times and demonstrated correct conceptual framing to the three constraints using rule-based reasoning in the last trial. Student A monitored the consistency between the data and her own pedigree, and reflected the problem-solving process in the check phase of the last trial in solving the problem. Student A's problem-solving process in the third trial resembled a successful problem-solving algorithm. However, student B who had a surface learning approach, involuntarily repeated solving the problem twice, and focused and used only part of the data due to her goal-oriented attitude to solve the problem in seeking for answers. Student B showed incorrect conceptual framing by memory-bank or arbitrary reasoning, and maintained her incorrect conceptual framing to the constraints in two problem-solving processes. These findings can help in understanding the problem-solving processes of students who have different learning approaches, allowing teachers to better support students with difficulties in accessing genetics problems.