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The future of bioinformntics

  • Gribskov, Michael
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2003.10a
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    • pp.1-1
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    • 2003
  • It is clear that computers will play a key role in the biology of the future. Even now, it is virtually impossible to keep track of the key proteins, their names and associated gene names, physical constants(e.g. binding constants, reaction constants, etc.), and hewn physical and genetic interactions without computational assistance. In this sense, computers act as an auxiliary brain, allowing one to keep track of thousands of complex molecules and their interactions. With the advent of gene expression array technology, many experiments are simply impossible without this computer assistance. In the future, as we seek to integrate the reductionist description of life provided by genomic sequencing into complex and sophisticated models of living systems, computers will play an increasingly important role in both analyzing data and generating experimentally testable hypotheses. The future of bioinformatics is thus being driven by potent technological and scientific forces. On the technological side, new experimental technologies such as microarrays, protein arrays, high-throughput expression and three-dimensional structure determination prove rapidly increasing amounts of detailed experimental information on a genomic scale. On the computational side, faster computers, ubiquitous computing systems, high-speed networks provide a powerful but rapidly changing environment of potentially immense power. The challenges we face are enormous: How do we create stable data resources when both the science and computational technology change rapidly? How do integrate and synthesize information from many disparate subdisciplines, each with their own vocabulary and viewpoint? How do we 'liberate' the scientific literature so that it can be incorporated into electronic resources? How do we take advantage of advances in computing and networking to build the international infrastructure needed to support a complete understanding of biological systems. The seeds to the solutions of these problems exist, at least partially, today. These solutions emphasize ubiquitous high-speed computation, database interoperation, federation, and integration, and the development of research networks that capture scientific knowledge rather than just the ABCs of genomic sequence. 1 will discuss a number of these solutions, with examples from existing resources, as well as area where solutions do not currently exist with a view to defining what bioinformatics and biology will look like in the future.

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A Return Bender Automatic Brazing Welding System for Heat Exchangers (열교환기용 리턴 밴더 자동 브레이징 용접 시스템)

  • Lee, Yong-Joong;Kang, Jin-Kap;Lee, Hyung-Woo
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.5 no.2
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    • pp.49-55
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    • 2006
  • In the consideration of the problem occurred by certain return bender brazing welding works that depend only on handworks, the automatization of the whole production line is impossible due to the high dependency of skillful workers. In addition, it is difficult to establish a standardization due to the various heat exchanger model and irregular amount of orders, and the fault reduction is also impossible due to the severe difference in brazing conditions. It is necessary to develop a method, which quantitively analyzes the problem existed in this manual brazing welding of return benders and technically solves that problem, and to lead the improvement of the productivity and cost reduction in order to increase the business competitive power. Then, this will contribute the technical development of automatic welding for Korea's heat exchanger businesses. Thus, this study develops an automatic technology, which automatically controls the flame strength using digital control methods, for various models and produces a sample model. It is possible to increase the productivity and produce uniformed and qualified products by solving the problem existed in manual processes using the developed automatic return bender brazing system. In addition, the brazing condition can be automatically controlled according to the model and line speed, and such an economical operation can reduce the production cost. The developed system is expected to future applications not only heat exchangers in the field of refrigeration and air conditioning, but also other various industrial fields that apply heat exchangers, such as car and boiler industries.

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Evaluation of Fuel Economy and Performance for 2WD and 4WD Hybrid Electric Vehicle Based on Backward Simulation (2륜 및 4륜 구동 하이브리드 전기 자동차의 후방향 시뮬레이션 기반 연비 및 성능 평가)

  • Jeong, Jongryeol;Kim, Hyungkyoon;Kim, Kiyoung;Lim, Wonsik;Cha, Suk Won
    • Transactions of the Korean Society of Automotive Engineers
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    • v.22 no.1
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    • pp.174-182
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    • 2014
  • Recently, not only common types of hybrid electric vehicle (HEV) such as series or parallel but many other types of HEVs including 4WD hybrid electric vehicle have been developed and released. In this study, analysis of fuel economy and driving performance for 2WD and 4WD HEV are conducted using backward simulation based on dynamic programming. To analyze the characteristics of 4WD HEV, tire slip model based on vehicle dynamics was applied to the backward simulation program. As a result, 2WD HEV shows better fuel economy than 4WD HEV because of relatively simple configuration. However, in a severe road condition, 4WD HEV shows better driving performance that 2WD HEV had about 6% of impossible time to follow the driving cycle though the 4WD HEV had no impossible time.

Shape Factor Analysis of Fresh Red Pepper Affecting the Performance of Unfolding, Arranging and Cutting (전개 .정렬 . 절단 성능에 영향을 미치는 홍고추 형상 요인 분석)

  • 나우정;이승규;송대빈;김영복;이태곤
    • Journal of Biosystems Engineering
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    • v.26 no.6
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    • pp.563-570
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    • 2001
  • To develop a stalk detaching system the effect of shape factor of red pepper affecting the performance of unfolding, arranging and cutting was analysed. The obtained results are as follows : By cutting experiment, it was found that the bending of stalk affected the cutting rate of stalk, and that the bending of body increased the amount of peppers that were expelled from the cutting guide by conveying brush. The ratios, 'bending length of a body/body length'and 'bending length of a stalk/stalk length', could be used as criteria far abnormality of body and stalk of peppers, respectively. As a result of experiment, it was concluded that mechanical treatment would be difficult for the peppers with indexes greater than 0.4 and 0.3 fur body bending and stack bending. respectively. So, these indexes were used as criteria for distinguishing abnormality from normality of peppers. In the unfolding unit, conveyance of peppers was impossible for both of normal and abnormal ones at the inclination angle of 10°, especially, at the frequency of 8.3 Hz peppers maintained stationary state. At the inclination angle of 20°, both of normal and abnormal peppers showed similar tendencies, but abnormal ones showed an accumulation trend gradually with increased feeding speed. In the arranging unit, conveyance of peppers was almost impossible for both of normal and abnormal ones at the inclination angle of 20°, showing almost no difference between the conveyances of normal and abnormal ones. In the case of the inclination angle of 30°, at the condition of the feeding speeds and frequency corresponding 0.06 m/s, 0.08 m/s and 8.3 Hz, respectively, the passing time of the abnormal peppers on the arranging plate increased rapidly.

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Application of RFID Tag to Food Wastes Disposal System of Cheongju City (청주시의 음식물류폐기물 처리시스템을 위한 무선주파수인식태그의 적용)

  • Lee, Sang-Wha
    • The Journal of the Korea Contents Association
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    • v.9 no.1
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    • pp.62-72
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    • 2009
  • In this paper, we propose an application of RFID(Radio Frequency Identification) tag to food wastes disposal system of Cheongju city. The existing system of Cheongju city is monthly fixed amount levy system. The weak point of this system must pay a same commission in spite of each other different food wastes quantity. Also the accurate occurrence quantity of the food wastes and present condition grasp of control are impossible. It will not be able to reflect to a policy decision because does not manage the control of the food waste efficiently. On the other hand, when a food wastes measuring system using RFID is executed tag, it will manage and analyze automatically the obtained data. And collecting, transporting and handling of the food wastes come to be very easy. Also the reproduction and embezzlement of the tag are impossible. As a result of this system, it brings the decrement of the food waste. Therefore the economic effect could be come true and the food wastes is controlled environment-friendly. The food wastes disposal system using RFID tag will be able to contribute in u-city constructions with RFID/USN technology which pursues from the government.

A Study on the Safety Assessment of the replaced Single Buoy Mooring at Ulsan Harbor by Ship Handling Simulator (선박조종시뮬레이터를 이용한 울산항 원유부이이설의 안전성 평가에 관한 연구)

  • 정재용;김원욱;김창제;채양범;강성진
    • Proceedings of the Korea Society for Simulation Conference
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    • 2002.05a
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    • pp.21-32
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    • 2002
  • In accordance with the development plans of Ulsan harbor, Ulsan new harbor will be contructed considering supporting Ulsan harbor as a safe berthing and departure at single buoy mooring(SBM). In this study, we used a full-mission ship handling simulator adopting 300,000 DWT VLCC manoeuvered at the planned Ulsan SBM. Five masters who have had a long experience of ship maneuvering were called to carry out the simulations, of which each scenario were tried one, completed total of 68 times. The marine traffic safety was assessed in terms of 1) the closest point of approach(CPA) to other SBM and breakwater in the vicinity and the probability of crossing the restricted area of the closest SBM and fairway limit, 2) subjective evaluation such as the mental burden and the maneuvering difficulty of shiphanders, and 3) the opinions of shiphandlers. From the result of this simulation, we have a conclusion as follows; First, because crude oil berthing angle is so small by current S-OiL Co. crude oil buoy by SK Co. No 3 crude oil buoy different view SK Co. No 3 crude oil buoy and interference of current KNOC crude oil buoy, Berthing is impossible, and Emergency departing is very dangerous too operation impossible. Second it is desirable that SK Co. No 2 and No 3 Single buoy Mooring that do different view controls position so that to be not put in straight line each other. Third, SK Co. No 1 and 2 single buoy mooring that do different view to Onsanhang berthing and departing is seized by single buoy mooring by external force ship that set sail does faith control need.

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Development of a constant pressure feed system using a constant pressure proportional control mode (정압비례제어방식을 적용한 정압급수장치의 개발)

  • 김주명;김광열;이건기
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.7 no.5
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    • pp.1026-1031
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    • 2003
  • Automatic feed pumps are operated and stopped by a pressure switch. Thus, because of repeated operations and stops of the pumps according to fluctuations of water volume, operation with constant rate and pressure is impossible. Moreover, because of repeated running of the pump, keeping up of constant pressure is impossible and damage and energy loss are weak points of the pimps. To make up for defects of an automatic feed pump, this paper designed and made a static pressure feed system which was composed of a feed water control valve, a flow sensor and a control system. The valve device plays an important part in reducing load of pumps by constant water supply regardless of outflow of water. Outflow of water is determined by infrared diode of the flow sensor. The control system is made of a 8 bit micro-processor and the pump was controled by a specific control algorithm. With the constant pressure feed system, discharge pressure was kept at fixed pressure, accurate operations and stops were smoothly accomplished and the pump was operated with constant pressure. Thus, the constant pressure feed system can be considered as an advanced system which made up for the weak points in the current automatic feed systems.

OK-432 Intralesional Injection Therapy for Lymphangioma in Children (소아 림프관종의 OK-432 병변내 주사요법)

  • Kim, Kyung-Hun;Kim, Hyun-Hahk;Lee, Suk-Koo;Seo, Jeong-Meen;Chang, Weon-Young;Lee, Byung-Boong
    • Advances in pediatric surgery
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    • v.7 no.2
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    • pp.142-146
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    • 2001
  • Lymphangioma is a congenital malformation of the lymphatic system, commonly seen in the neck. Operation was the treatment of choice but it is difficult to resect the lymphangiomas completely. The aim of this study is to evaluate the result of intralesional injection of OK-432 as a treatment strategy of lymphangioma in children. Medical records of 51 cases of lymphangioma from March 1996 to February 2001 were reviewed retrospectively. Intralesional injection of 0.1mg OK-432 in 10ml normal saline was performed after the aspiration of as much fluid as possible. The location of the lesion was the face and neck in 26 patients, the chest wall in 14, the extremities in 9, and the abdominal wall in 2. The cystic type was present in 45 patients and the cavernous type in 6. Four postoperative recurrent cases were included. Fluid aspiration from the lesion was impossible in 5 patients. Development of fever after injection was observed in 27 patients and local inflammatory reaction was in 5 patients. There was no scar formation at injection sites. Complete shrinkage was observed in 20 patients, remarkable shrinkage in 23, slight shrinkage in 3, and no response in 5. Cystic type or aspiration-possible cases showed better outcome than cavernous type or aspiration-impossible cases. All of four recurrent cases after surgical excision showed at least remarkable shrinkage. These results indicate that intralesional injection of OK-432 is a safe and satisfactory treatment modality of lymphangiomas in children and might be considered as a treatment of choice, even in recurrent cases.

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A New Dictionary Mechanism for Efficient Fault Diagnosis (효율적인 고장진단을 위한 딕셔너리 구조 개발)

  • Kim Sang-Wook;Kim Yong-Joon;Chun Sung-Hoon;Kang Sung-Ho
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.43 no.4 s.346
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    • pp.49-55
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    • 2006
  • In this paper, a fault dictionary for fault locations is considered. The foremost problem in fault diagnosis is the size of the data. As circuits are large, the data for fault diagnosis increase to the point where they are impossible to be stored. The increased information makes it impossible to store the dictionary into storage media. In order to generate the dictionary, j.e. pass-fail dictionary some dictionaries store a portion of the information. The deleted data makes it difficult to diagnose fault models except single stuck-at fault. This paper proposes a new dictionary format. A new format makes a dictionary small size without deleting any informations.

Intermittent Bleeding Method after Replantation o the Distal Phalanx (원위 수지 재접합술 뒤 간헐적 실혈 요법)

  • Lee, Byung-Ho;Park, Chan-Il;Lee, Jun-Mo
    • Archives of Reconstructive Microsurgery
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    • v.20 no.1
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    • pp.38-42
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    • 2011
  • Purpose: To evaluate the effect of intermittent bleeding method in the distal phalanx replantation. Materials and Methods: From January 2007 through June 2009, authors have replanted 117 cases of distal phalangeal amputation in adults at Soo Hospital and Chonbuk National University Hospital. Cases of zone II were 60 cases and zone III 57 according to Allen classification. Male to female ratio was 8.7:1.3. The most common cause was machinery injury in the factory, 98 cases(83.8%), next one was belt injury of the machine, 11 cases(9.4%) and others, 8(6.8%). At least one digital artery and digital nerve were anastomosed under the operating microscope, but vein was impossible to anastomosis as unable to find out in the zone II and III. After anastomosis of one or more digital arteries and nerves, heparine(6,000-10,000 units) was kept to intravenous injection for 24 hours and at the same time fish mouth incision in 2-3 millimeter diameter was made in the distal radial and ulnar margin of the replanted distal phanlanx. From the first 30 minutes to an hour after replantation, incision site was swabbed with heparinized cotton ball for 5 minutes in every 30 to 40 minutes to make sure perfusion for 24 hours, every an hour at the second day, every two hours at the postoperative third to fifth day. Results: 92 cases(78.6%) was completely survived at average postoperative third week follow-up and satisfied with preservation of the finger nail, digit length, good range of motion of the distal interphalangeal joint and acceptable sensibility at average 1.2 years follow-up. Conclusions: Intermittant bleeding method in replantation of crushed distal phalanx impossible to anastomosis of vein at zone II and III of Allen classification was regarded as one of the notable salvage procedure.

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