• Journal of Microbiology and Biotechnology
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• 제31권6호
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• pp.890-901
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• 2021

The 11α-hydroxylation of canrenone can be catalyzed by Aspergillus ochraceus in bioreactors, where the geometry of the impeller greatly influences the biotransformation. In this study, the effects of the blade number and impeller diameter of a Rushton turbine on the 11α-hydroxylation of canrenone were considered. The results of fermentation experiments using a 50 mm four-blade impeller showed that 3.40% and 11.43% increases in the conversion ratio were achieved by increasing the blade number and impeller diameter, respectively. However, with an impeller diameter of 60 mm, the conversion ratio with a six-blade impeller was 14.42% lower than that with a four-blade impeller. Data from cold model experiments with a large-diameter six-blade impeller indicated that the serious leakage of inclusions and a 22.08% enzyme activity retention led to a low conversion ratio. Numerical simulations suggested that there was good gas distribution and high fluid flow velocity when the fluid was stirred by large-diameter impellers, resulting in a high dissolved oxygen content and good bulk circulation, which positively affected hyphal growth and metabolism. However, a large-diameter six-blade impeller created overly high shear compared to a large-diameter four-blade impeller, thereby decreasing the conversion ratio. The average shear rates of the former and latter cases were 43.25 s^-1 and 35.31 s^-1, respectively. We therefore concluded that appropriate shear should be applied in the 11α-hydroxylation of canrenone. Overall, this study provides basic data for the scaled-up production of 11α-hydroxycanrenone.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2001년도 유체기계 연구개발 발표회 논문집
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• pp.54-60
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• 2001

In this research, we developed a computer code that designs a compressor impeller, which serves as an essential component of a vacuum cleaner, and predicted its performance. The TEIS model originally developed by Japikse(1985), and the mean line analysis m combined to design the centrifugal impeller optimally. In this program the inlet geometry is designed by using the mean line analysis, and with assumption of resonable exit blade angle, the optimal geometry is searched by means of TEIS model and iterative scheme. The performance of designed impeller was compared with experimental data, and the far-field noise by the rotating impeller is also predicted.

• International Journal of Fluid Machinery and Systems
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• 제2권2호
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• pp.172-178
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• 2009

This paper reports on an investigation (using RSM with commercial CFD software) of the performance characteristics of the impeller in a centrifugal pump. Geometric parameters of vane plane development were defined with the meridional shape and frontal view of the impeller. The parameters are focused on the blade-angle distributions through the impeller in a fixed meridional geometry. For screening, a $2^k$ factorial design has been used to identify the important design parameters. The objective functions are defined as the total head rise and the total efficiency at the design flow-rate. From the $2^k$ factorial design results, it is found that the incidence angles and the exit blade angle are the most important parameters influencing the performance of the pump.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2002년도 추계학술대회 논문집
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• pp.399-404
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• 2002

An efficient method of machining impeller is presented. In the roughing process, the cutting area is divided into two regions to reduce cutting time and select cutting tools. The regions are determined by characteristic point on the geometry of impeller blade. Then, the tool of the maximum radius is selected in each area. Tool interference in cutting areas is avoided by checking the intersection between cooing tool axis and ruling line on blade surface.

• International Journal of Fluid Machinery and Systems
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• 제4권2호
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• pp.217-222
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• 2011

The rotordynamic fluid forces acting on a closed type impeller in whirling motion were measured and the influence of the clearance geometry on the stability of the impeller was examined. At small positive whirling speed, the rotordynamic forces acted as destabilizing forces for all casings. A small clearance between the shroud of the impeller and the casing caused large fluid force, but did not change the destabilizing region. Radial grooves in the clearance were effective for reducing the fluid forces and destabilizing region due to the reduction of the circumferential velocity without the deterioration of the pump performance. A rotating phenomenon like a rotating stall of the impeller occurred at low flow rate and the resonance between it and the whirling motion led to a sudden increase in force at the whirling speed ratio of 0.7.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2004년도 유체기계 연구개발 발표회 논문집
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• pp.405-410
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• 2004

2-dimensional impeller's distinctive feature is expected to have an influence on performance and flow characteristics of centrifugal compressor. And new design method is required for 2-dimensional impeller, because the unique geometry cannot be designed using conventional theories. The objective of this study is to advance new design technology for 2-dimensional impeller and to investigate the performance characteristics of designed 2-dimensional centrifugal compressor. The performance test for 2-dimensional impeller is conducted at 35000, 40000 and 45000rpm. Also numerical calculation is applied by using commercial CFD code, FLUENT, and the results are compared with experimental results.

• 융복합기술연구소 논문집
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• 제4권2호
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• pp.61-65
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• 2014

Pressure distribution around rotating impeller blades in centrifugal pump has been main issue for design of efficient and high performance automotive water pump. In addition, pressure losses of inlet water pipes should be considered to reduce additional pressure drop and design high performance engine cooling system. In this paper, pressure distribution inside water pump and pressure drop between inlet and outlet of water pump are investigated numerically to design plastic water pump for clean diesel engine application. And the inlet geometry of water pump was considered to analysis the effect of inlet water pipe geometry on pressure distribution around impeller blades and outlet pressure. The prediction results are compared with experimental data to validate and determine optimal operation condition without water pump cavitation. Major design parameters such as blade angle, volute geometry, system pressure, and coolant flow rate are considered to confirm applying possibility of plastic blades to the clean diesel engine.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2001년도 유체기계 연구개발 발표회 논문집
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• pp.177-184
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• 2001

For two kinds of the multi-stage centrifugal pump with diffuser vanes and return channel vanes the meanline performance prediction is applied to get information of hydraulic performance at each internal flow station, because only flange-to-flange test curves are available. As a first step of redesign fur higher efficiency, the impeller geometry is numerically investigated in the present study. Quasi-3D inviscid loading distributions are obtained, for the two impellers, using the state-of-the-art method of impeller 3D design, which provides a guide to optimal redesign. Full 3D turbulent flow fields are thereafter analyzed, using the specialized CFD code, to confirm the redesign results. The inherent limitation of the traditional graphic method of impeller design, which most of domestic pump manufacturers are now employing, is found.

• 대한기계학회논문집A
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• 제27권11호
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• pp.1917-1924
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• 2003

This paper proposes a roughing path generation method fer machining impeller with 5-axis machining center. Traditional researches are focus on finishing for machining impeller. To achieve efficient machining, roughing method must be studied. The proposed method consists two steps : One is to select optimal tool size and tool attitude by dividing cutting area into two regions to reduce cutting time. The regions are automatically divided by character point on the geometry of impeller blade. After dividing, the tool of the optimal size is selected for each divided region. The other is avoidance of tool interference. Tool interference in cutting areas is avoided by checking the distance between tool axis vector and ruling line on blade surface or approximated plan between ruling line. Using this method, the cutting time is reduced efficiently.

• 한국소음진동공학회논문집
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• 제14권10호
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• pp.939-944
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• 2004

The numerical methods including the performance analysis and the noise prediction of the centrifugal compressor impeller are coupled with the optimization design skill, which consists of response surface method, statistical approach, and genetic algorithm. The flow-field Inside of a centrifugal compressor is obtained numerically by solving Wavier-Stokes equations. and then the propagating noise is estimated from the distributed surface pressure by using Ffowcs Williams-Hawkings formulation. The quadratic response surface model with D-optimal 3-level factorial experimental design points is constructed to optimize the impeller geometry for the advanced centrifugal compressor. The statistical analysis shows that the quadratic model exhibits a reasonable fitting quality resulting in the impeller blade design with high performance and low far-field noise level. The influences of selected design variables, objective functions, and constraints on the impeller performance and the impeller noise are also examined as a result of the optimization process.