• Title/Summary/Keyword: immunology

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Protective effects of Ginsan against Cyclophosphamide-induced immunosuppression in mice

  • Shim, Ji-Young;Ahn, Ji-Yeon;Han, Young-Soo;Jung, In-Sung;Yun, Yeon-Sook;Song, Jie-Young
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.206.1-206.1
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    • 2003

  • The immunomodulator Ginsan has been found previously by us to stimulate the secretion of high levels of IL -1. IL -6 and TNF-alpha in irradiated mice. These cytokines are known to induce proliferation and differentiation of hematopoietic progenitor cells from the spleen and bone marrow and to protect mice from DNA-damaging agents. The present studies were evaluated as a cytoprotective agent against toxicity of the alkylating drugs. (omitted)

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Cloning and Characterization of the IgA Fc Receptor from Swine

  • Chen, Yumei;Liu, Yunchao;Zhang, Gaiping;Feng, Hua;Ji, Pengchao;Wang, Guoqiang;Liu, Chang;Song, Yapeng;Su, Yunfang;Qiao, Songlin;Wang, Aiping
    • Journal of Microbiology and Biotechnology
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    • v.26 no.12
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    • pp.2192-2198
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    • 2016

  • The myeloid-specific IgA Fc receptor ($Fc{\alpha}R$) is a cell surface molecule on immunocytes that provides a fundamental connection between humoral and cellular immunity. In this study, the full-length cDNA sequence of swine $Fc{\alpha}RI$ ($swFc{\alpha}RI$) was isolated and characterized and found to contain a 792-base-pair open reading frame, encoding a 264-amino-acid transmembrane glycoprotein with a predicted molecular mass of 29.4 kDa. The $swFc{\alpha}RI$ shares high amino acid sequence homology (>50%) with its counterparts from cattle, seal, and horse. Rosetting analysis confirmed that COS-7 cells transfected with an $swFc{\alpha}RI$ expression plasmid was able to combine with chicken erythrocytes sensitized with porcine IgA, but not IgG.

  • https://doi.org/10.4014/jmb.1607.07011 인용 PDF KSCI